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Pathways Recommended:	Membrane Transporter/Ion Channel

Results for "

glutamate-gated chloride channel

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Chloride Channel (8) Antibiotic (2) Apoptosis (2) Bacterial (2) Cytochrome P450 (2) GABA Receptor (6) Insecticide (2) Isotope-Labeled Compounds (5) P-glycoprotein (2) Parasite (14) Reference Standards (4)
By Research Areas:	Infection (15) Neurological Disease (6)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Chloride Channel Glutamate Dehydrogenase (GLDH) HCN Channel mGluR iGluR EAAT Calcium Channel CRAC Channel TRP Channel Sodium Channel Potassium Channel Piezo Channel

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-109077

Tigolaner BAY-1272858	GABA Receptor Parasite Chloride Channel	Infection Neurological Disease
Tigolaner (BAY-1272858) acts on γ-aminobutyric acid (GABA) and glutamate-gated chloride channels. Tigolaner has antiparasitic activity .

HY-108690

Fluxametamide 2 Publications Verification	GABA Receptor	Others
Fluxametamide is an insecticide with wide spectrum, acts as an antagonist of GABA- and glutamate-gated chloride channels, with IC₅₀ of 1.95 nM and 225 nM for M. domestica GABACls and GluCls.

HY-107212

Selamectin	Parasite Chloride Channel P-glycoprotein Bacterial	Infection
Selamectin, a semi-synthetic macrocyclic lactone, is a potent parasiticide and anthelminthic. Selamectin activates **glutamate-gated chloride channels in neurons and pharyngeal muscles to prevent heartworm, Lymphatic filariae, and nematode infection. Selamectin is also a potent P-glycoprotein substrate and a P-glycoprotein inhibitor with an IC₅₀** of 120 nM .

HY-B0778

Milbemycin oxime 1 Publications Verification	Antibiotic Parasite	Infection
Milbemycin oxime is an orally active macrolide with broad-spectrum antiparasitic activity. Milbemycin oxime is a mixture of oximes consisting of oxime derivatives corresponding to milbemycin A4 and A3. Milbemycin oxime binds to glutamate-gated chloride channels and has inhibitory potency against intestinal nematodes and lung/heart worms .

HY-177552

4''-Oxoavermectin B1a	GABA Receptor Chloride Channel Insecticide	Infection
4''-Oxoavermectin B1a is a potentiator targeting GABA (γ-aminobutyric acid) and **glutamate-gated chloride channels** with insecticidal and acaricidal activities. 4''-Oxoavermectin B1a is promising for research of agricultural pests .

HY-W783593

Avermectin A1a	Parasite	Infection
Avermectin A1a is a potent and broad-spectrum antiparasitic agent. Avermectin A1a targets nematodes and arthropods by binding to their glutamate-gated chloride channels to block nerve signal transmission and induce paralysis. Avermectin A1a can be used for the study of parasitic infection .

HY-106439

BTG 1640 ABIO-08/01	Chloride Channel	Neurological Disease
BTG 1640 (ABIO-08/01) is a potent anxiolytic isoxazoline. BTG 1640 is a selective inhibitor of GABA- and glutamate-gated chloride channels .

HY-109077S

Tigolaner-d4	Isotope-Labeled Compounds GABA Receptor Parasite Chloride Channel	Infection Neurological Disease
Tigolaner-d₄ is deuterium labeled Tigolaner. Tigolaner (BAY-1272858) acts on γ-aminobutyric acid (GABA) and glutamate-gated chloride channels. Tigolaner has antiparasitic activity .

HY-Z8942

Avermectin B2a	Insecticide Parasite Chloride Channel	Infection
Avermectin B2a is an insecticide targeting glutamate-gated chloride channels (GluCls). Avermectin B2a causes hyperpolarization of nematode/insect neurons and subsequent paralysis/death. Avermectin B2a is promising for research of agricultural pests .

HY-107212R

Selamectin (Standard)	Reference Standards Parasite Chloride Channel P-glycoprotein Bacterial	Infection
Selamectin (Standard) is the analytical standard of Selamectin. This product is intended for research and analytical applications. Selamectin, a semi-synthetic macrocyclic lactone, is a potent parasiticide and anthelminthic. Selamectin activates **glutamate-gated chloride channels in neurons and pharyngeal muscles to prevent heartworm, Lymphatic filariae, and nematode infection. Selamectin is also a potent P-glycoprotein substrate and a P-glycoprotein inhibitor with an IC₅₀** of 120 nM .

HY-15308B

Δ2-Avermectin B1a	Parasite Chloride Channel	Neurological Disease
Δ²-Avermectin B₁ₐ (Compound 3) is an antiparasitic agent targeting glutamate-gated chloride channels (GluCls) in the neuromuscular system of invertebrates. Δ²-Avermectin B₁ₐ enhances chloride ion influx, leading to hyperpolarization of the neuromuscular cell membrane, inhibition of neural signal transmission, and ultimately paralysis and death of parasites. Δ²-Avermectin B₁ₐ is promising for research of agricultural pests .

HY-B0778R

Milbemycin oxime (Standard)	Reference Standards Antibiotic Parasite	Infection
Milbemycin oxime (Standard) is the analytical standard of Milbemycin oxime. This product is intended for research and analytical applications. Milbemycin oxime is an orally active macrolide with broad-spectrum antiparasitic activity. Milbemycin oxime is a mixture of oximes consisting of oxime derivatives corresponding to milbemycin A4 and A3. Milbemycin oxime binds to glutamate-gated chloride channels and has inhibitory potency against intestinal nematodes and lung/heart worms .

HY-16973

Fluralaner Maximum Cited Publications 6 Publications Verification A1443; AH252723	Parasite	Infection
Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and *L-glutamate* gated chloride channels.

HY-B0822

Fipronil	GABA Receptor Cytochrome P450 Apoptosis	Neurological Disease
Fipronil is a broad-spectrum insecticide effective against Lepidoptera species as well as thrips, locusts, ants, cockroaches, fleas and ticks. Fipronil selectively inhibits GABA receptor with IC₅₀s of 30 nM and 1600 nM for cockroach and rat GABA receptors, respectively. **Glutamate-gated chloride channels (GluCls), which are present in cockroaches but not in mammals, are sensitive to the blocking effect of Fipronil. Fipronil also induces apoptosis** in HepG2 cells and promotes the expression of CYP1A1 and CYP3A4 mRNA in human hepatocytes .

HY-B0822R

Fipronil (Standard)	Reference Standards GABA Receptor Cytochrome P450 Apoptosis	Neurological Disease
Fipronil (Standard) is the analytical standard of Fipronil. This product is intended for research and analytical applications. Fipronil is a broad-spectrum insecticide effective against Lepidoptera species as well as thrips, locusts, ants, cockroaches, fleas and ticks. Fipronil selectively inhibits GABA receptor with IC₅₀s of 30 nM and 1600 nM for cockroach and rat GABA receptors, respectively. **Glutamate-gated chloride channels (GluCls), which are present in cockroaches but not in mammals, are sensitive to the blocking effect of Fipronil. Fipronil also induces apoptosis** in HepG2 cells and promotes the expression of CYP1A1 and CYP3A4 mRNA in human hepatocytes .

HY-16973R

Fluralaner (Standard) A1443 (Standard); AH252723 (Standard)	Reference Standards Parasite	Infection
Fluralaner (Standard) is the analytical standard of Fluralaner. This product is intended for research and analytical applications. Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and *L-glutamate* gated chloride channels.

HY-16973S4

Fluralaner-d3 A1443-d₃; AH252723-d₃	Isotope-Labeled Compounds	Infection
Fluralaner-d₃ (A1443-d₃) is deuterium labeled Fluralaner. Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and *L-glutamate* gated chloride channels.

HY-16973S5

Fluralaner-d2 A1443-d₂; AH252723-d₂	Isotope-Labeled Compounds Parasite	Infection
Fluralaner-d₂ (A1443-d₂) is deuterium labeled Fluralaner. Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and *L-glutamate* gated chloride channels.

HY-16973S3

Fluralaner-d5 A1443-d₅; AH252723-d₅	Isotope-Labeled Compounds Parasite	Infection
Fluralaner-d₅ (A1443-d₅) is deuterium labeled Fluralaner. Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and *L-glutamate* gated chloride channels .

HY-16973S

Fluralaner-13C2,15N,d3 A1443-¹³C₂,¹⁵N,d₃; AH252723-¹³C₂,¹⁵N,d₃	Isotope-Labeled Compounds Parasite	Infection
Fluralaner- ¹³C₂, ¹⁵N,d₃ is the deuterium, ¹³C-, and 15-labeled Fluralaner. Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and L-glutamate gated chloride channels.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0778

Milbemycin oxime 1 Publications Verification	Infection Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Antibiotic Parasite
Milbemycin oxime is an orally active macrolide with broad-spectrum antiparasitic activity. Milbemycin oxime is a mixture of oximes consisting of oxime derivatives corresponding to milbemycin A4 and A3. Milbemycin oxime binds to glutamate-gated chloride channels and has inhibitory potency against intestinal nematodes and lung/heart worms .

HY-W783593

Avermectin A1a	Structural Classification Microorganisms Antibiotics Source classification	Parasite
Avermectin A1a is a potent and broad-spectrum antiparasitic agent. Avermectin A1a targets nematodes and arthropods by binding to their glutamate-gated chloride channels to block nerve signal transmission and induce paralysis. Avermectin A1a can be used for the study of parasitic infection .

HY-Z8942

Avermectin B2a	Structural Classification Microorganisms Antibiotics Source classification	Insecticide Parasite Chloride Channel
Avermectin B2a is an insecticide targeting glutamate-gated chloride channels (GluCls). Avermectin B2a causes hyperpolarization of nematode/insect neurons and subsequent paralysis/death. Avermectin B2a is promising for research of agricultural pests .

HY-B0778R

Milbemycin oxime (Standard)	Natural Products Microorganisms Source classification	Reference Standards Antibiotic Parasite
Milbemycin oxime (Standard) is the analytical standard of Milbemycin oxime. This product is intended for research and analytical applications. Milbemycin oxime is an orally active macrolide with broad-spectrum antiparasitic activity. Milbemycin oxime is a mixture of oximes consisting of oxime derivatives corresponding to milbemycin A4 and A3. Milbemycin oxime binds to glutamate-gated chloride channels and has inhibitory potency against intestinal nematodes and lung/heart worms .

Cat. No.	Product Name	Chemical Structure

HY-16973S

Fluralaner-13C2,15N,d3
Fluralaner- ¹³C₂, ¹⁵N,d₃ is the deuterium, ¹³C-, and 15-labeled Fluralaner. Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and L-glutamate gated chloride channels.

HY-109077S

Tigolaner-d4
Tigolaner-d₄ is deuterium labeled Tigolaner. Tigolaner (BAY-1272858) acts on γ-aminobutyric acid (GABA) and glutamate-gated chloride channels. Tigolaner has antiparasitic activity .

HY-16973S4

Fluralaner-d3
Fluralaner-d₃ (A1443-d₃) is deuterium labeled Fluralaner. Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and *L-glutamate* gated chloride channels.

HY-16973S5

Fluralaner-d2
Fluralaner-d₂ (A1443-d₂) is deuterium labeled Fluralaner. Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and *L-glutamate* gated chloride channels.

HY-16973S3

Fluralaner-d5
Fluralaner-d₅ (A1443-d₅) is deuterium labeled Fluralaner. Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and *L-glutamate* gated chloride channels .

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glutamate-gated chloride channel

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
Products