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Results for "

frog

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Aminopeptidase (1) Antibiotic (8) Apoptosis (1) Bacterial (15) Biochemical Assay Reagents (1) Bombesin Receptor (1) CRFR (2) Dopamine Receptor (1) Endogenous Metabolite (3) Endothelin Receptor (1) Fungal (10) Histamine Receptor (1) Liposome (1) Melanocortin Receptor (2) Neurokinin Receptor (1) Neuropeptide Y Receptor (1) Opioid Receptor (1) Reactive Oxygen Species (ROS) (1) Reference Standards (1) Sodium Channel (2)
By Research Areas:	Cancer (4) Cardiovascular Disease (6) Endocrinology (6) Infection (22) Inflammation/Immunology (1) Neurological Disease (7)

By Targets:

5-HT Receptor (1)

Aminopeptidase (1)

Antibiotic (8)

Apoptosis (1)

Bacterial (15)

Biochemical Assay Reagents (1)

Bombesin Receptor (1)

CRFR (2)

Dopamine Receptor (1)

Endogenous Metabolite (3)

Endothelin Receptor (1)

Fungal (10)

Histamine Receptor (1)

Liposome (1)

Melanocortin Receptor (2)

Neurokinin Receptor (1)

Neuropeptide Y Receptor (1)

Opioid Receptor (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (1)

Sodium Channel (2)

By Research Areas:

Cancer (4)

Cardiovascular Disease (6)

Endocrinology (6)

Infection (22)

Inflammation/Immunology (1)

Neurological Disease (7)

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P3915

Esculentin 1A	Bacterial	Infection
Esculentin 1A is a frog skin-derived antimicrobial peptide (AMP) with potent in vitro anti-Pseudomonas activity .

HY-P10265

Melanostatin, frog	Melanocortin Receptor	Others
Melanostatin, frog is an inhibitor for α-melanocyte-stimulating hormone (α-MSH) release, with an IC₅₀ of 60 nM .

HY-P3762

ANP (1-30), frog	Endothelin Receptor	Cardiovascular Disease Endocrinology
ANP (1-30), frog is a peptide fragment of atrial natriuretic peptide derived from frog. ANP (1-30), frog has natriuretic, diuretic, and vasorelaxant effects.

HY-P0274

PGLa	Bacterial Antibiotic	Infection
PGLa, a 21-residue peptide, is an antimicrobial peptide. PGLa is a member of the magainin family of antibiotic peptides found in frog skin and its secretions .

HY-P0274A

PGLa TFA	Bacterial Antibiotic	Infection
PGLa TFA, a 21-residue peptide, is an antimicrobial peptide. PGLa TFA is a member of the magainin family of antibiotic peptides found in frog skin and its secretions .

HY-126645

Atelopidtoxin	Sodium Channel	Cardiovascular Disease
Atelopidtoxin (zetekitoxin) is a toxin (LD₅₀=0.016 mg/kg for mice), which can be isolated from Panamanian frog Atelopus zeteki. Atelopidtoxin causes hypotension and ventricular fibrillation in rabbits. Atelopidtoxin an inhibitor for sodium channel .

HY-P5724

Nv-CATH	Bacterial	Infection
Nv-CATH is an antibacterial peptide of frog origin. Nv-CATH has broad-spectrum antibacterial activity against gram-positive and gram-negative bacteria. Nv-CATH significantly protects mice from fatal infections caused by Staphylococcus aureus. Nv-CATH protects mice from bacterial infection through antimicrobial immunoregulatory duality .

HY-101078A

(±)-Epibatidine dihydrochloride CMI 545 dihydrochloride	Dopamine Receptor	Neurological Disease
(±)-Epibatidine (CMI 545) dihydrochloride is an agonist of nicotinic with potent analgetic activity. (±)-Epibatidine (CMI 545) dihydrochloride is an alkaloid originally characterized from frog skin. (±)-Epibatidine (CMI 545) dihydrochloride have little or no activity at a variety of other central receptors, including opioid receptors, muscarinic receptors, adrenergic receptors, dopamine receptors, serotonin receptors, and gamma-aminobutyric acid receptors .

HY-P3645

(Nle4)-α-MSH	Melanocortin Receptor	Others
(Nle4)-α-MSH is a synthetic analogue of α-MSH (HY-P0252), a melanocyte-stimulating hormone. (Nle4)-α-MSH reversibly darkens frog skins and also exhibits prolonged activity after heat-alkali treatment .

HY-W440982A

(Rac)-SOPC (Rac)-PC(18:0/18:1); (Rac)-2-Oleoyl-1-stearoyl-sn-glycero-3-phosphocholine	Liposome	Others
(Rac)-SOPC ((Rac)-PC(18:0/18:1)) ((Rac)-2-Oleoyl-1-stearoyl-sn-glycero-3-phosphocholine) is the racemate of SOPC (HY-W440982). SOPC is an asymmetrical phospholipid with saturated fatty acid (stearic acid/18:0) at sn-1 position and unsaturated fatty acid (oleic acid/18:1) at sn-2 position. SOPC can stabilize the outer segment membrane of frog rods .

HY-P3171

Acetyl-(Cys4,D-Phe7,Cys10)-a-MSH (4-13)	Biochemical Assay Reagents	Others
Acetyl-(Cys4,D-Phe7,Cys10)-a-MSH (4-13) is a melanotropin cyclic peptide. Acetyl-(Cys4,D-Phe7,Cys10)-a-MSH (4-13) ultraprolongs melanotropic activity in frog and lizard skin model with great agonisim. Acetyl-(Cys4,D-Phe7,Cys10)-a-MSH (4-13) exhibits a complete resistance to tryptic degradation .

HY-W424017A

Lophophine hydrochloride	Endogenous Metabolite	Neurological Disease
Lophophine hydrochloride is the drug intermediate of anhalonine and Lophophorine (HY-119478), and can be found in Lophophora diffusa. Anhalonine causes slight sleepiness in frog. Lophophorine causes long-lasting convulsions, reflex excitability, muscle stiffness, and paralysis in rabbit and frog model .

HY-P5728

Aurein 1.1	Bacterial Antibiotic	Infection
Aurein 1.1 is an antibiotic peptide that can be found in the Australian Bell Frogs Litoria raniformis .

HY-P5594

Dermaseptin-S1	Fungal	Infection
Dermaseptin-S1 is an antimicrobial peptide derived from frog skin against filamentous fungi .

HY-P5587

Dermaseptin-S5	Fungal	Infection
Dermaseptin-S5 is an antimicrobial peptide derived from frog skin against filamentous fungi .

HY-P5607

Bombinin	Bacterial Antibiotic Aminopeptidase	Infection
Bombinin is an antimicrobial peptide derived from frog Bombina variegata. Bombinin has a protective effect on aminopeptidase .

HY-P5588

Dermaseptin-S4	Fungal	Infection
Dermaseptin-S4 is an antimicrobial peptide derived from frog skin against filamentous fungi .

HY-P5590

Dermaseptin-S3	Fungal	Infection
Dermaseptin-S3 is an antimicrobial peptide derived from frog skin against filamentous fungi .

HY-P5593

Dermaseptin-S2	Fungal	Infection
Dermaseptin-S2 is an antimicrobial peptide derived from frog skin against filamentous fungi .

HY-P5725

Aurein 2.1	Bacterial Antibiotic	Infection
Aurein 2.1 is an antibiotic peptide that can be found in the Australian Bell Frogs Litoria aurea and Litoria raniformis .

HY-P5585

Dermaseptin-B4	Bacterial	Infection
Dermaseptin-B4 is an antimicrobial peptide derived from the skin secretions of the South American frog Phyllomedusa bicolor .

HY-P0250

Kassinin	Neurokinin Receptor	Neurological Disease Endocrinology
Kassinin is a peptide derived from the Kassina frog. It belongs to tachykinin family of neuropeptides. It is secreted as a defense response, and is involved in neuropeptide signalling.

HY-P0263

Dermaseptin	Bacterial Fungal Antibiotic	Infection
Dermaseptin, a peptide isolated from frog skin, exhibits potent antimicrobial activity against bacteria, fungi, and protozoa at micromolar concentration .

HY-P0263A

Dermaseptin TFA	Bacterial Fungal	Infection
Dermaseptin TFA, a peptide isolated from frog skin, exhibits potent antimicrobial activity against bacteria, fungi, and protozoa at micromolar concentration .

HY-P5638

FLGFVGQALNALLGKL-NH2	Bacterial	Infection
FLGFVGQALNALLGKL-NH2 is an antimicrobial peptide of frog origin. FLGFVGQALNALLGKL-NH2 has activity against Staphylococcus aureus ATCC 29213 (MIC=32 μM) .

HY-P4816

Pseudin-2	Bacterial Fungal	Infection Inflammation/Immunology
Pseudin-2, an AMP thast could be isolated from the skin of the South American paradoxical frog Pseudis paradoxa, exert a potent growth inhibitory effect against Gram-negative bacteria .

HY-129271

Deltorphin Deltorphin A; Dermenkephalin	Opioid Receptor	Others
Deltorphin (Deltorphin A; Dermenkephalin) is a biological active peptide. (Deltorphin A peptide was isolated from skin extracts of the South American frog, Phyllomedusa sauvagei. Deltorphin A is a potent and selective agonist for the delta-opioid receptor.)

HY-167657

Tizolemide	Sodium Channel	Cardiovascular Disease
Tizolemide is a sulphonamide diuretic compound that has alkaline properties and is cleared by a tubular transport system. Tizolemide induces changes of passive transport components across the basolateral membrane of isolated frog skin .

HY-158702

5-HTQ chloride	5-HT Receptor	Neurological Disease
5-HTQ chloride is an indole alkaloid that can be isolated from the skin secretions of the Australian golden bell frog Litoria aurea. 5-HTQ chloride is also a full agonist of the 5-HT receptor .

HY-P2706

Granuliberin R	Histamine Receptor	Endocrinology
Granuliberin R is a new mast cell degranulating peptide comes from amphibian, can be isolated from the skin of frog Rana rugosa. Granuliberin R is a dodecapeptide, can act on rat peritoneal mast cell to liberate granules and release histamine .

HY-P1298

Sauvagine	CRFR	Cardiovascular Disease Neurological Disease Endocrinology
Sauvagine, a 40-amino-acid neuropeptide from the skin of the frog, is a mammalian CRF agonist. Sauvagine is effective at releasing ACTH from rat pituitary cells. Sauvagine possesses a number of pharmacological actions on diuresis, the cardiovascular system and endocrine glands .

HY-P5690

Distinctin	Bacterial	Infection
Distinctin is an antimicrobial peptide. Distinctin can be isolated from frog skin. Distinctin has antibacterial activity against E. faecalis, P. aeruginosa, S. aureus and E. coli (MIC: 14.5, 28.0, 28.0, 14.5 μM) .

HY-P1298A

Sauvagine TFA	CRFR	Cardiovascular Disease Neurological Disease Endocrinology
Sauvagine TFA, a 40-amino-acid neuropeptide from the skin of the frog, is a mammalian CRF agonist. Sauvagine TFA is effective at releasing ACTH from rat pituitary cells. Sauvagine TFA possesses a number of pharmacological actions on diuresis, the cardiovascular system and endocrine glands .

HY-P5937

Caerin 1.1 TFA	Apoptosis	Cancer
Caerin 1.1 TFA is a host defense peptide isolated from the glandular secretions of the Australian tree frog Litoria. Caerin 1.1 TFA inhibits HeLa cell proliferation and mediates apoptosis. Caerin 1.1 TFA may enhance adaptive T cell immune responses .

HY-Y1097

Monomethyl phthalate 2-(Methoxycarbonyl)benzoic acid	Endogenous Metabolite Reactive Oxygen Species (ROS)	Cancer
Monomethyl phthalate is an orally active metabolite of phthalic acid. Monomethyl phthalate, as a urine biomarker after exposure to phthalate, can be used as a detection indicator for thyroid cancer and benign nodules. Monomethyl phthalate reduces the survival rate of young frogs. Monomethyl phthalate induces oxidative damage to red blood cells in rats .

HY-P1685

Ranatensin	Bombesin Receptor	Cardiovascular Disease Endocrinology
Ranatensin is a undecapeptide and a Bombesin Receptor angonist, can be isolated from amphibian skin, such as the frog, Rana pipiens. Ranatensin could maintain the dynamic balance of animal blood pressure, without cross-tachyphylaxis with Angiotensin amide (HY-P2212),Bradykinin (HY-P0206), or Norepinephrine (HY-13715) .

HY-P1629

Temporin A	Bacterial Fungal Antibiotic	Infection
Temporin A is a short alpha-helical antimicrobial peptide isolated from the skin of the frog Rana temporaria. Temporin A is effective against a broad spectrum of Gram-positive bacteria. Temporin A interacts directly with the cell membrane of the microorganism and it is non-toxic to erythrocytes at concentrations that are antimicrobial. Temporin A also has antifungal activities (against yeast-like Candida albicans) .

HY-P0270

Magainin 2 Magainin II	Bacterial Antibiotic Fungal	Infection
Magainin 2 (Magainin II) is an antimicrobial peptide (AMP) isolated from the skin of the African clawed frog Xenopus laevis. Magainin 2 displays antibiotic activity against numerous gram-negative and gram-positive bacteria. Magainin 2 also is active against protozoa . Magainin 2 exerts its cytotoxicity effects by preferential interactions with anionic phospholipids abundant in bacterial membranes .

HY-Y1097R

Monomethyl phthalate (Standard) 2-(Methoxycarbonyl)benzoic acid (Standard)	Reference Standards Endogenous Metabolite	Cancer
Monomethyl phthalate (Standard) is the analytical standard of Monomethyl phthalate. This product is intended for research and analytical applications. Monomethyl phthalate is an orally active metabolite of phthalic acid. Monomethyl phthalate, as a urine biomarker after exposure to phthalate, can be used as a detection indicator for thyroid cancer and benign nodules. Monomethyl phthalate reduces the survival rate of young frogs. Monomethyl phthalate induces oxidative damage to red blood cells in rats.

HY-P2019

Levitide	Neuropeptide Y Receptor	Neurological Disease
Levitide is a neurohormone-like peptide, can be isolated from skin secretions of the South African frog Xenopus laevis. Levitide comes from preprolevitide, is 88 residues long and contains contains the levitide peptide at the C terminus (Glu-Gly-Met-Ile-Gly-Thr-Leu-Thr-Ser-Lys-Arg-Ile-Lys-Gln-NH2) and the putative signal sequence at the N terminus .

Cat. No.	Product Name	Target	Research Area