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firefly luciferase

" in MedChemExpress (MCE) Product Catalog:

28

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8

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2

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-155945
    Firefly luciferase-IN-1

    		Reactive Oxygen Species (ROS) Others
    Firefly luciferase-IN-1 (compound 48) is a highly potent and reversible inhibitor of firefly luciferase with an IC50 value of 0.25 nM .
    Firefly luciferase-IN-1
  • HY-153082
    Firefly Luciferase circRNA

    		Fluorescent Dye Others
    Firefly Luciferase circRNA will express a luciferase protein, originally isolated from the Photinus pyralis (Firefly). Firefly Luciferase circRNA is ideal for monitoring and optimizing transfection efficiency and is recommended as a positive control for circular RNA transfections.
    Firefly Luciferase circRNA
  • HY-153229
    Firefly luciferase mRNA-LNP
    1 Publications Verification

    		 mRNA Biochemical Assay Reagents Others
    Firefly luciferase mRNA-LNP is a lipid nanoparticle (LNP) containing firefly luciferase mRNA. Firefly luciferase mRNA-LNP exhibits a stable nanostructure, in which LNP plays a key role in effectively protecting and transporting mRNA to cells. Luciferase is a bioluminescent reporter gene for gene regulation and functional studies. Firefly Luciferase mRNA-LNP expresses firefly luciferase protein after entering the cells, which is often used for promoter activity detection or dual fluorescent molecular complementation experiments. Firefly luciferase mRNA-LNP is studied in research for RNA delivery, cell viability, and translation efficiency .
    Firefly luciferase mRNA-LNP
  • HY-158257
    Firefly luciferase-IN-4

    		Fluorescent Dye Others
    Firefly luciferase-IN-4 (CID: 3987260) is an inhibitor of ATP-dependent luciferase (Firefly luciferase). It has nM-level inhibitory activity (pIC< sub>50=6.5) .
    Firefly luciferase-IN-4
  • HY-160873
    Firefly luciferase-IN-5

    		Fluorescent Dye Others
    Firefly luciferase-IN-5 (CID: 16031203) is an inhibitor of ATP-dependent luciferase (Firefly luciferase). It has nM-level inhibitory activity against GRLuc, RLuc8, and RLuc respectively (pIC50=8.5,7.5,5.5) .
    Firefly luciferase-IN-5
  • HY-153080
    Firefly Luciferase mRNA(N1-Me-Pseudo UTP)

    		Fluorescent Dye mRNA Others
    Firefly luciferase mRNA will express a luciferase protein, originally isolated from the Photinus pyralis (Firefly). Firefly Luciferase is a frequently used bioluminescent reporter for gene regulation and function study. It is applicable in assays for gene expression, cell viability and in vivo imaging etc.
    Firefly Luciferase mRNA(N1-Me-Pseudo UTP)
  • HY-P1004A
    Luciferase, firefly

    		Fluorescent Dye Others
    Luciferase, firefly is the light-emitting enzyme responsible for the bioluminescence of fireflies and click beetles.
    Luciferase, firefly
  • HY-153230
    Firefly luciferase circRNA-LNP

    		Liposome Biochemical Assay Reagents Others
    Firefly luciferase circRNA-LNP is a lipid nanoparticle (LNP) containing Firefly luciferase circRNA, suitable for assays of RNA delivery, translation efficiency, cell viability, etc. Luciferase is commonly used as a bioluminescent reporter gene for gene regulation and function studies. Firefly Luciferase circRNA will express firefly luciferase protein after entering the cells, which is often used for promoter activity detection or dual fluorescent molecular complementation experiments. Common luciferase are firefly luciferase and sea kidney luciferase .
    Firefly luciferase circRNA-LNP
  • HY-160869
    Firefly luciferase-IN-2

    		Fluorescent Dye Others
    Firefly luciferase-IN-2 (compound 5j) is an inhibitor of ATP-dependent luciferase (Firefly luciferase), the major light-emitting enzyme in fireflies and kowtow bugs. Firefly luciferase-IN-2 inhibits P. pyralis luciferase with an IC50 of 0.15 μM, while the inhibitory potency against R. reniformis is not significant .
    Firefly luciferase-IN-2
  • HY-160870
    Firefly luciferase-IN-3

    		Fluorescent Dye Others
    Firefly luciferase-IN-3 (CID: 17087944) is an inhibitor of ATP-dependent luciferase (Firefly luciferase) and has nM-level inhibitory activity against NanoLuc (pIC50=7.5) .
    Firefly luciferase-IN-3
  • HY-134956B
    (R)-VT104

    		YAP Cancer
    (R)-VT104 is the R-enantiomer of VT104. (R)-VT104 shows an IC50 value of 0.1-1 μΜ for firefly luciferase. VT104 is an orally active and pan-TEAD auto-palmitoylation inhibitor .
    (R)-VT104
  • HY-158256
    Luciferase-IN-3

    		Fluorescent Dye Others
    Luciferase-IN-3 (compound 5h) is an inhibitor of ATP-dependent luciferase (Firefly luciferase), the major light-emitting enzyme in fireflies and kowtow bugs. Firefly luciferase-IN-2 inhibits P. pyralis luciferase with an IC50 of 3.2 μM, while the inhibitory potency against R. reniformis is not significant .
    Luciferase-IN-3
  • HY-160690
    GW632046X

    		Others Others
    GW632046X is a Fluc (Firefly luciferase) inhibitor with an IC50 value of 0.58 µM .
    GW632046X
  • HY-12591A
    D-Luciferin
    Maximum Cited Publications
    73 Publications Verification

    D-(-)-Luciferin; firefly luciferin; Beetle Luciferin

    		 Fluorescent Dye Others
    D-luciferin is the natural substrate of the enzyme luciferase (Luc) that catalyzes the production of the typical yellowgreen light of fireflies. The 560 nm chemiluminescence from this reaction peaks within seconds, with light output that is proportional to luciferase concentration when the substrate luciferin is present in excess. The luciferase (luc) gene is a popular reporter gene for research and agent screening. Chemiluminescent techniques are virtually background-free, making the luc reporter gene ideal for detecting low-level gene expression. As little as 0.02 pg of luciferase can be reliably measured in a standard scintillation counter. In addition to its role as a reporter of gene expression, luciferase is commonly used in an extremely sensitive assay for ATP . We of er the firefly luciferase (HY-P1004), luciferin free acid (HY-12591A), as well as its water-soluble sodium salts (HY-12591) and potassium salts (HY-12591B) .
    D-Luciferin
  • HY-12591B
    D-Luciferin potassium
    Maximum Cited Publications
    73 Publications Verification

    D-(-)-Luciferin potassium; firefly luciferin potassium; Beetle Luciferin potassium

    		 Fluorescent Dye Others
    D-luciferin potassium is the natural substrate of the enzyme luciferase (Luc) that catalyzes the production of the typical yellowgreen light of fireflies. The 560 nm chemiluminescence from this reaction peaks within seconds, with light output that is proportional to luciferase concentration when the substrate luciferin is present in excess. The luciferase (luc) gene is a popular reporter gene for research and agent screening. Chemiluminescent techniques are virtually background-free, making the luc reporter gene ideal for detecting low-level gene expression. As little as 0.02 pg of luciferase can be reliably measured in a standard scintillation counter. In addition to its role as a reporter of gene expression, luciferase is commonly used in an extremely sensitive assay for ATP . We offer the firefly luciferase (HY-P1004), luciferin free acid (HY-12591A), as well as its water-soluble sodium salts (HY-12591) and potassium salts (HY-12591B) .
    D-Luciferin potassium
  • HY-12591
    D-Luciferin sodium
    Maximum Cited Publications
    73 Publications Verification

    D-(-)-Luciferin sodium; firefly luciferin sodium; Beetle Luciferin sodium

    		 Fluorescent Dye Others
    D-luciferin sodium is the natural substrate of the enzyme luciferase (Luc) that catalyzes the production of the typical yellowgreen light of fireflies. The 560 nm chemiluminescence from this reaction peaks within seconds, with light output that is proportional to luciferase concentration when the substrate luciferin is present in excess. The luciferase (luc) gene is a popular reporter gene for research and agent screening. Chemiluminescent techniques are virtually background-free, making the luc reporter gene ideal for detecting low-level gene expression. As little as 0.02 pg of luciferase can be reliably measured in a standard scintillation counter. In addition to its role as a reporter of gene expression, luciferase is commonly used in an extremely sensitive assay for ATP . We of er the firefly luciferase (HY-P1004), luciferin free acid (HY-12591A), as well as its water-soluble sodium salts (HY-12591) and potassium salts (HY-12591B) .
    D-Luciferin sodium
  • HY-D1904
    D-Luciferin 6'-methyl ether

    		Fluorescent Dye Others
    D-Luciferin 6'-methyl ether sodium salt is a firefly luciferase inhibitor. D-Luciferin 6'-methyl ether sodium salt is a cofactor in Luc-catalyzed synthesis of dinucleoside polyphosphates .
    D-Luciferin 6'-methyl ether
  • HY-111429
    YAP/TAZ inhibitor-1
    5+ Cited Publications

    		 YAP Cancer
    YAP/TAZ inhibitor-1 is a YAP/TAZ inhibitor extracted from patent WO2017058716A1, Compound 1, has an IC50 of <0.100 μΜ in firefly luciferase assay .
    YAP/TAZ inhibitor-1
  • HY-170496
    Fluc-IN-1

    		Wnt Cancer
    Fluc-IN-1 (Compound 3) is an inhibitor for firefly luciferase with an IC50 of 25 nM. Fluc-IN-1 inhibits WNT/β-catenin signaling pathway with an IC50 of 33 nM (measuring by TOPFlash assay) .
    Fluc-IN-1
  • HY-400902
    YAP/TAZ inhibitor-3

    		YAP Cancer
    YAP/TAZ inhibitor-3 (Compound 24) is a YAP/TAZ inhibitor. YAP/TAZ inhibitor-3 shows firefly luciferase inhibitory activity, with an IC50 < 0.1 μM .
    YAP/TAZ inhibitor-3
  • HY-N11422
    Mycaminosyltylonolide

    		Antibiotic Bacterial Infection
    Mycaminosyltylonolide is a potent antibiotic. Mycaminosyltylonolide shows antibacterial activity. Mycaminosyltylonolide inhibits luciferase synthesis .
    Mycaminosyltylonolide
  • HY-N11422R
    Mycaminosyltylonolide (Standard)

    		Reference Standards Antibiotic Bacterial Infection
    Deoxynivalenol (Standard) is the analytical standard of Deoxynivalenol. This product is intended for research and analytical applications. Deoxynivalenol, an orally active mycotoxin of the trichothecenes family, crosses the intestinal mucosa by a paracellular pathway through the tight junctions. The Deoxynivalenol transport is not affected by P-glycoprotein (PgP) or multidrug resistance-associated proteins (MRPs) inhibitors .
    Mycaminosyltylonolide (Standard)
  • HY-P5968
    [Ala28]-β Amyloid(25-35)

    β(25-35)KA

    		 Amyloid-β Neurological Disease
    [Ala28]-β Amyloid(25-35) (β(25-35)KA) is an electrically neutral mutant peptide of Aβ(25-35) that accelerates the aggregation of Firefly Luciferase .
    [Ala28]-β Amyloid(25-35)
  • HY-112641
    AkaLumine

    		Fluorescent Dye Cancer
    AkaLumine is a D-luciferin (HY-12591A) analogue with a Km of 2.06 μM for recombinant firefly luciferase (Fluc) protein. AkaLumine emits near-infrared (NIR) light (λmax=677 nm) in reactions with native Fluc. AkaLumine has high tissue-penetration and increases detection sensitivity from deep-tissue targets .
    AkaLumine
  • HY-112641A
    AkaLumine hydrochloride
    2 Publications Verification

    		 Fluorescent Dye Cancer
    AkaLumine hydrochloride is a D-luciferin (HY-12591A) analogue with a Km of 2.06 μM for recombinant firefly luciferase (Fluc) protein. AkaLumine hydrochloride emits near-infrared (NIR) light (λmax=677 nm) in reactions with native Fluc. AkaLumine hydrochloride has high tissue-penetration and increases detection sensitivity from deep-tissue targets .
    AkaLumine hydrochloride
  • HY-115749
    D-Luciferin 6′-methyl ether

    6′-Methoxyluciferin

    		 Fluorescent Dye Others
    D-Luciferin 6′-methyl ether (6′-Methoxyluciferin; compound 19a) is a potent luciferase from the North American firefly Photinus pyralis (PpyLuc) inhibitor with an IC50 of 0.1 µM. D-Luciferin 6′-methyl ether, a D-luciferin analog, shows non-specific interactions at ATP- and luciferin-binding sites of the PpyLuc active site .
    D-Luciferin 6′-methyl ether
  • HY-115749A
    (Rac)-Luciferin 6′-methyl ether sodium

    (Rac)-6′-Methoxyluciferin sodium

    		 Drug Derivative Others
    D-Luciferin 6′-methyl ether (6′-Methoxyluciferin; compound 19a) sodium is a potent luciferase from the North American firefly Photinus pyralis (PpyLuc) inhibitor with an IC50 of 0.1 μM. D-Luciferin 6′-methyl ether, a D-luciferin analog, shows non-specific interactions at ATP- and luciferin-binding sites of the PpyLuc active site .
    (Rac)-Luciferin 6′-methyl ether sodium
  • HY-172329
    Q1-ALC-0315 iodide

    		Liposome Others
    Q1-ALC-0315 iodide is a cationic quaternary ammonium lipid derivative of the ionizable cationic lipid ALC-0315 (HY-138170). Q1-ALC-0315-based LNPs can be used for lung-targeted mRNA delivery, which demonstrates high-performing firefly luciferase protein expression in the lungs .
    Q1-ALC-0315 iodide

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