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Results for "

fetal hemoglobin (HbF)

" in MedChemExpress (MCE) Product Catalog:
Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-100826
    TN1

    		Others Cardiovascular Disease
    TN1 is a potent fetal hemoglobin (HbF) inducer.
    TN1
  • HY-159099
    HbF inducer 2

    		Molecular Glues Histone Acetyltransferase Others
    HbF inducer 3 (Compound dWIZ-2) is an orally active molecular glue, which degrades the WIZ transcription factor (DC50=13 nM in primary human erythroid precursor cell) and induces the expression of fetal hemoglobin (HbF) (EC50=100 nM). HbF inducer 3 exhibits good pharmacokinetic characteristics in cynomolgus monkeys .
    HbF inducer 2
  • HY-15273
    UNC0638
    5+ Cited Publications

    		 VSV Histone Methyltransferase Autophagy Influenza Virus Infection Cancer
    UNC0638 selectively inhibits G9a and GLP histone methyltransferases with IC50 of 15 nM and 19 nM, respectively. UNC0638 inhibits TNBC cell invasion and migration in vitro. UNC0638 is also an inhibitor of EHMT1/2 and induces fetal hemoglobin (HbF) expression in human erythroid progenitor cell culture. In addition, UNC0638 has anti-FMDV (foot-and-mouth disease virus) and anti-VSV (vesicular stomatitis virus) activities, with excellent potency and selectivity against multiple epigenetic and non-epigenetic targets .
    UNC0638
  • HY-145356
    HbF inducer-1

    		Histone Methyltransferase Others
    HbF inducer-1 is an orally bioavailable fetal hemoglobin inducer.
    HbF inducer-1
  • HY-162665
    WIZ degrader 1

    		Histone Methyltransferase Others
    WIZ degrader 1 (Compound 141) is a degrader for widely interspaced zinc finger motifs (WIZ) with an AC50 of 2 nM. WIZ degrader 1 induces the expression of fetal hemoglobin (HbF) with an EC50 of 6 mM. WIZ degrader 1 is used in research of inherited blood disorders .
    WIZ degrader 1
  • HY-159098
    dWIZ-1

    		Molecular Glues Histone Acetyltransferase Others
    dWIZ-1 is a potent WIZ molecular glue degrader. dWIZ-1 recruitments WIZ(ZF7) to cereblon (CRBN) induces WIZ degradation. dWIZ-1 has the potential for the research of sickle cell disease (SCD) .
    dWIZ-1
  • HY-163818
    WIZ degrader 2

    		Histone Methyltransferase Others
    WIZ degrader 2 (Compound 142) is a degrader for widely interspaced zinc finger motifs with an AC50 of 0.011 μM. WIZ degrader 2 induces the expression of fetal hemoglobin (HbF) with an EC50 of 0.038 μM. WIZ degrader 2 can be used in research about inherited blood disorders .
    WIZ degrader 2
  • HY-163819
    WIZ degrader 3

    		Histone Acetyltransferase Cardiovascular Disease
    WIZ degrader 3 (Compound 29) is a degrader for widely interspaced zinc finger motifs (WIZ), with an AC50 of 6.4 nM. WIZ degrader 3 induces the expression of fetal hemoglobin (HbF), with an EC50 of 45 nM. WIZ degrader 3 can be used for the research of blood disorders, such as sickle cell disease and β- thalassemia .
    WIZ degrader 3
  • HY-170831
    DS79932728

    		Histone Methyltransferase GLP Receptor Others
    DS79932728 is an orally active inhibitor for G9a and GLP with IC50 of 12.6 nM and 75.7 nM. DS79932728 induces the production of γ-globin, thereby increasing the level of fetal hemoglobin (HbF). DS79932728 increases F-reticulocytes (F-rets) proportion and exhibits good oral absorption characteristics in cynomolgus monkey models .
    DS79932728
  • HY-110093
    UNC0638 hydrate

    		VSV Histone Methyltransferase Autophagy Influenza Virus Infection Cancer
    UNC0638 hydrate selectively inhibits G9a and GLP histone methyltransferases with IC50 of 15 nM and 19 nM, respectively. UNC0638 hydrate inhibits TNBC cell invasion and migration in vitro. UNC0638 hydrate is also an inhibitor of EHMT1/2 and induces fetal hemoglobin (HbF) expression in human erythroid progenitor cell culture. In addition, UNC0638 hydrate has anti-FMDV (foot-and-mouth disease virus) and anti-VSV (vesicular stomatitis virus) activities, with excellent potency and selectivity against multiple epigenetic and non-epigenetic targets .
    UNC0638 hydrate

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