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Results for "

factor XI

" in MedChemExpress (MCE) Product Catalog:

11

Inhibitors & Agonists

2

Biochemical Assay Reagents

1

Peptides

1

Inhibitory Antibodies

3

Recombinant Proteins

2

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-156613
    Frunexian

    EP-7041

    		 Factor XI Infection
    Frunexian (EP-7041) is a selective and potent inhibitor of coagulation factor XI/activated factor XI, targeting to factor XIa. Frunexian exhibits antithrombotic activity, with no bleeding liability in rat mesenteric arterial puncture model. Frunexian can be used in extracorporeal membrane oxygenation (ECMO) research .
    Frunexian
  • HY-137431
    Asundexian
    4 Publications Verification

    BAY-2433334

    		 Factor Xa Cardiovascular Disease
    Asundexian (BAY 2433334) is an orally active coagulation factor Xia (FXIa) inhibitor. Asundexian binds directly, potently, and reversibly to the active site of FXIa and thereby inhibits its activity. Asundexian inhibits human FXIa in buffer with an IC50 of 1 nM .
    Asundexian
  • HY-107966A
    Heparin calcium (MW 3600-5000)

    Nadroparin calcium (MW 3600-5000)

    		 Thrombin Factor Xa Autophagy Bacterial Cardiovascular Disease Cancer
    Heparin (Nadroparin) calcium (MW 3600-5000) is an anticoagulant which binds reversibly to antithrombin III (ATIII) to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors IX, X, XI, and XII and prevents the transformation of fibrinogen to fibrin .
    Heparin calcium (MW 3600-5000)
  • HY-175735
    Factor XI-IN-2

    		Factor XI Cardiovascular Disease
    Factor XI-IN-2 is a Factor XI activation inhibitor with an IC50 of 20 nM. Factor XI-IN-2 does not directly inhibit the enzymatic activity of FXIa, but specifically binds to the FXI enzyme precursor and allosterically inhibits the process by which it is activated by FXIIa. Factor XI-IN-2 inhibits thrombosis in the rabbit arteriovenous (AV) shunt thrombosis model. Factor XI-IN-2 can be used for the study of antithrombus .
    Factor XI-IN-2
  • HY-143477
    Factor XI-IN-1

    		Factor XI Cardiovascular Disease
    Factor XI-IN-1 (Compound 27) is a factor XI activation inhibitor with an EC50 of 25.14 nM .
    Factor XI-IN-1
  • HY-122142
    Pyr-​Pro-​Arg-​pNA

    S-2366

    		 APC Factor XI Biochemical Assay Reagents Others
    Pyr-Pro-Arg-pNA (S2366) is a chromogenic peptide substrate for Factor XI and Activated protein C (APC). Pyr-Pro-Arg-pNA can induce noncompetitive inhibition of factor XI activation through occupancy of the active site of the factor XIa-light chain. Pyr-Pro-Arg-pNA can be used for measurement of APC amidolytic activity .
    Pyr-​Pro-​Arg-​pNA
  • HY-151196
    FXIa-IN-10

    		Factor Xa Cardiovascular Disease
    FXIa-IN-10 (Compound 3f) is a potent activated factor XI (FXIa) inhibitor with an Ki of 0.17 nM. FXIa-IN-10 has good oral bioavailability .
    FXIa-IN-10
  • HY-P991124
    Cenvacibart

    		Factor XI Cardiovascular Disease
    Cenvacibart is a monoclonal antibody with anticoagulant activity, targeting human coagulation factor XI (F11). Cenvacibart blocks the role of coagulation factor XI in the coagulation cascade, reducing thrombus formation. Cenvacibart is promising for research of thrombotic diseases .
    Cenvacibart
  • HY-122142A
    Pyr-​Pro-​Arg-​pNA hydrochloride

    S-2366 hydrochloride

    		 APC Factor XI Biochemical Assay Reagents Others
    Pyr-Pro-Arg-pNA (S2366) hydrochloride is a chromogenic peptide substrate for Factor XI and Activated protein C (APC). Pyr-Pro-Arg-pNA hydrochloride can induce noncompetitive inhibition of factor XI activation through occupancy of the active site of the factor XIa-light chain. Pyr-Pro-Arg-pNA hydrochloride can be used for measurement of APC amidolytic activity .
    Pyr-​Pro-​Arg-​pNA hydrochloride
  • HY-107966
    Heparin calcium (MW 15000-19000)

    Nadroparin calcium (MW 15000-19000)

    		 Thrombin Factor Xa Autophagy Bacterial Cardiovascular Disease Cancer
    Heparin calcium (MW 15000-19000) is an anticoagulant which binds reversibly to antithrombin III (ATIII) to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors IX, X, XI, and XII and prevents the transformation of fibrinogen to fibrin .
    Heparin calcium (MW 15000-19000)
  • HY-W091734
    Methyl 4-iodo-L-phenylalaninate hydrochloride

    		Amino Acid Derivatives Cardiovascular Disease Neurological Disease
    Methyl 4-iodo-L-phenylalaninate hydrochloride is a Phenylalaninate derivative. Methyl 4-iodo-L-phenylalaninate hydrochloride can be used for the preparation of factor XI modulators used in the research of thrombotic and thromboembolic. Methyl 4-iodo-L-phenylalaninate hydrochloride can also be used for the synthesis of compounds for the research of amyloid-related diseases, such as Alzheimer’s disease .
    Methyl 4-iodo-L-phenylalaninate hydrochloride

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