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engraftment

" in MedChemExpress (MCE) Product Catalog:

4

Inhibitors & Agonists

1

Inhibitory Antibodies

1

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-125662A
    BMX-001

    		Reactive Oxygen Species (ROS) Apoptosis Metabolic Disease
    BMX-001, a novel redox-active metalloporphyrin, improves islet function and engraftment in a murine transplant model. BMX-001 reduces apoptosis in human and murine islets. BMX-001 significantly improves static-glucose stimulated insulin secretion (sGSIS) responses in murine islets. BMX-001 can significantly restore euglycemia in murine islet studies in the presence of the MnSOD. BMX-001 reduces the generation of ROS in a murine islet isolation and culture model .
    BMX-001
  • HY-139938
    (±)11(12)-EET methyl ester

    11,12-EET methyl ester; (±)11,12-EpETrE methyl ester

    		 G2A (GPR132) Cardiovascular Disease Inflammation/Immunology
    (±)11(12)-EET methyl ester (11,12-EET methyl ester) is a type of epoxyeicosatrienoic acid (EET). EETs are endogenous lipid signaling molecules with cardioprotective and vasodilatory actions. (±)11(12)-EET methyl ester binds to and activates GPR132. (±)11(12)-EET methyl ester enhances hematopoietic induction and engraftment in mice and zebrafish .
    (±)11(12)-EET methyl ester
  • HY-139938S
    (±)11(12)-EET methyl ester-d11

    11,12-EET methyl ester-d11; (±)11,12-EpETrE methyl ester-d11

    		 Isotope-Labeled Compounds G2A (GPR132) Cardiovascular Disease Inflammation/Immunology
    (±)11(12)-EET-d11 methyl ester (11,12-EET methyl ester-d11) is the deuterium labeled (±)11(12)-EET methyl ester (HY-139938). (±)11(12)-EET methyl ester is a type of epoxyeicosatrienoic acid (EET). EETs are endogenous lipid signaling molecules with cardioprotective and vasodilatory actions. (±)11(12)-EET methyl ester binds to and activates GPR132. (±)11(12)-EET methyl ester enhances hematopoietic induction and engraftment in mice and zebrafish .
    (±)11(12)-EET methyl ester-d11
  • HY-P991641
    IMC-EB10

    LY3012218

    		 FLT3 p38 MAPK STAT PI3K Akt Cancer
    IMC-EB10 (LY3012218) is an anti-FLT3 monoclonal antibody. IMC-EB10 binds to FLT3 with high affinity (Kd = 158 pM) and blocks the binding of FLT3 ligand to FLT3 (IC50 ≈ 10 nM), thereby inhibiting MAPK, STAT5, and PI3K/Akt signaling in leukemia cells. IMC-EB10 can enhance the anti-leukemic effect of Methotrexate (HY-14519) and inhibit leukemias expressing wild-type or ITD-mutated FLT3 receptors. IMC-EB10 prolongs the survival of acute lymphoblastic leukemia (ALL) cells and primary leukemia samples and reduces engraftment in non-obese diabetic/severe combined immunodeficiency patients. IMC-EB10 is indicated for leukemia research .
    IMC-EB10

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