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Results for "

convulsant

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (2) Amino Acid Decarboxylase (2) Amino Acid Derivatives (1) Chloride Channel (2) Dopamine Receptor (1) Drug Derivative (1) Endogenous Metabolite (1) GABA Receptor (8) Glutaminase (1) Opioid Receptor (1) Reference Standards (2)
By Research Areas:	Metabolic Disease (1) Neurological Disease (16)

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Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W023493

DL-Allylglycine 2-Aminopent-4-enoic acid	Amino Acid Derivatives	Neurological Disease
DL-Allylglycine (2-Aminopent-4-enoic acid) is a glutamate decarboxylase (GAD) inhibitor. DL-Allylglycine has convulsant activity that can be used in studies to induce epileptic seizures .

HY-121469

Dioxone	Drug Derivative	Neurological Disease
Dioxone is a substance possessing convulsant properties qualitatively similar to leptazol and bemegride. Dioxone is orally active .

HY-W015595

L-Allylglycine hydrochloride 1 Publications Verification L-2-Allylglycine hydrochloride	Amino Acid Decarboxylase GABA Receptor	Neurological Disease
L-Allylglycine (L-2-Allylglycine) hydrochloride is an amino acid derivative. L-Allylglycine hydrochloride is an inhibitor for glutamate decarboxylase (GAD) that reduces the GABA biosynthesis in the brain. L-Allylglycine hydrochloride exhibits convulsant activity .

HY-W012906

L-Allylglycine 1 Publications Verification L-2-Allylglycine	Amino Acid Decarboxylase GABA Receptor	Neurological Disease
L-Allylglycine (L-2-Allylglycine) is an amino acid derivative. L-Allylglycine is an inhibitor for glutamate decarboxylase (GAD) that reduces the GABA biosynthesis in the brain. L-Allylglycine exhibits convulsant activity .

HY-B1494

Picrotoxinin 3 Publications Verification	Chloride Channel GABA Receptor	Neurological Disease
Picrotoxinin, a potent convulsant, is a chloride channel blocker. Picrotoxinin is a noncompetitive GABA_A receptor antagonist, which negatively modulates the action of GABA on GABA_A receptors. Picrotoxinin inhibits α₁β₂γ_2L GABA_A receptor with an IC₅₀ of 1.15 μM .

HY-101139B

Xanthine amine congener trihydrochloride XAC trihydrochloride	Adenosine Receptor	Neurological Disease
Xanthine amine congener trihydrochloride (XAC dihydrochloride) is a potent Adenosine A1 receptor and A2?receptor antagonist with IC₅₀ values of 1.8 and 114 nM, respectively. Xanthine amine congener acts as a convulsant agent in mice model .

HY-110303

Xanthine amine congener dihydrochloride XAC dihydrochloride	Adenosine Receptor	Neurological Disease
Xanthine amine congener dihydrochloride (XAC dihydrochloride) is a potent Adenosine A1 receptor and A2 receptor antagonist with IC₅₀ values of 1.8 and 114 nM, respectively. Xanthine amine congener acts as a convulsant agent in mice model .

HY-114300

DSP-0565	GABA Receptor	Neurological Disease
DSP-0565 (compound 17a) is a strong, broad-spectrum anti-epileptic agent (AED) candidate with unique GABAergic function. DSP-0565 shows anti-convulsant activity in various models (scPTZ, MES, 6 Hz and amygdala kindling) with good safety margin .

HY-171182

D3017	Endogenous Metabolite	Neurological Disease
D3017 is the main metabolite of D2624, which has oral bioactivity and anti-convulsant effects. D3017 ED₅₀ value is 1.5 mg/kg in mice, and it can be used for research on severe generalized tonic-clonic seizures (grand mal) and complex partial epilepsy .

HY-B1494R

Picrotoxinin (Standard)	Reference Standards Chloride Channel GABA Receptor	Neurological Disease
Picrotoxinin (Standard) is the analytical standard of Picrotoxinin. This product is intended for research and analytical applications. Picrotoxinin, a potent convulsant, is a chloride channel blocker. Picrotoxinin is a noncompetitive GABAA receptor antagonist, which negatively modulates the action of GABA on GABAA receptors. Picrotoxinin inhibits α1β2γ2L GABAA receptor with an IC₅₀ of 1.15 μM .

HY-160978

Timelotem KC-7507 free base	GABA Receptor	Neurological Disease
Timelotem (KC-7507 free base) is a representative of a class of 1, 2-cyclo1, 4-benzodiazepines. Timelotem shows significant antipsychotic properties. Timelotem produces sedative, anti-anxiety and anti-convulsant effects by enhancing the action of the neurotransmitter gamma-aminobutyric acid (GABA). Timelotem can be used in studies of schizophrenia and other mental disorders .

HY-N0219R

Bicuculline (Standard) (+)-Bicuculline (Standard)	Reference Standards GABA Receptor	Neurological Disease
Bicuculline (Standard) is the analytical standard of Bicuculline. This product is intended for research and analytical applications. Bicuculline ((+)-Bicuculline) is A competing neurotransmitter GABAA receptor antagonist (IC₅₀=2 μM). Bicuculline also blocks Ca2+ activating potassium (SK) channels and subsequently blocks slow post-hyperpolarization (slow AHP). Bicuculline has anticonvulsant activity. Bicuculline can be used to induce seizures in mice .

HY-161005

TETS-Methyl benzoate	Others	Metabolic Disease
TETS-Methyl benzoate(compound 2j) is a haptendirectly conjugated to the carrier protein via carboxylic acid function using the standard activated ester method .

HY-107751

BW373U86 SNC86	Opioid Receptor	Neurological Disease
BW373U86 (SNC86) is a δ-opioid receptor agonist with an IC₅₀ of 1.49 nM. BW373U86 shows antidepressant-like effects .

HY-N0219

Bicuculline Maximum Cited Publications 27 Publications Verification (+)-Bicuculline	GABA Receptor	Neurological Disease
Bicuculline ((+)-Bicuculline) is A competing neurotransmitter GABA_A receptor antagonist (IC₅₀=2 μM). Bicuculline also blocks Ca ²⁺ activating potassium (SK) channels and subsequently blocks slow post-hyperpolarization (slow AHP). Bicuculline has anticonvulsant activity. Bicuculline can be used to induce seizures in mice .

HY-19545

SCH-23390 R-(+)-SCH-23390	Dopamine Receptor	Neurological Disease
SCH-23390 is a dopamine D1-like receptor antagonist (with K_i values of 0.2 nM and 0.3 nM for the D1 and D5 receptor subtypes, respectively). SCH-23390 can shorten the latency period for cocaine-induced lever pressing behavior in rats. SCH-23390 can also eliminate generalized seizures caused by chemical convulsants, such as arecoline (HY-B0726A) and strychnine, and is used in research on neurological disorders related to the dopamine system .

HY-B1692

L-Methionine-DL-sulfoximine 2 Publications Verification MSX; MSO	Glutaminase	Neurological Disease
L-Methionine-DL-sulfoximine (MSX; MSO), a highly specific and irreversible inhibitor of Glutamine synthetase (GS), is also a potent convulsant which metabolically and morphologically primarily affects astroglia. L-Methionine-DL-sulfoximine has been employed to inhibit the Gln-dependent ammonia-stimulated neuronal toxicity in vitro, potentiating Gln deficit-dependent depression. L-Methionine-DL-sulfoximine tremendously increases the rate of release of fixed nitrogen in cyanobacteria. L-Methionine-DL-sulfoximine is a promising candidate for research in biofertilizers and convulsive seizures (CS) .

Cat. No.	Product Name	Target	Research Area

HY-W023493

DL-Allylglycine 2-Aminopent-4-enoic acid	Amino Acid Derivatives	Neurological Disease
DL-Allylglycine (2-Aminopent-4-enoic acid) is a glutamate decarboxylase (GAD) inhibitor. DL-Allylglycine has convulsant activity that can be used in studies to induce epileptic seizures .

HY-W015595

L-Allylglycine hydrochloride 1 Publications Verification L-2-Allylglycine hydrochloride	Amino Acid Decarboxylase GABA Receptor	Neurological Disease
L-Allylglycine (L-2-Allylglycine) hydrochloride is an amino acid derivative. L-Allylglycine hydrochloride is an inhibitor for glutamate decarboxylase (GAD) that reduces the GABA biosynthesis in the brain. L-Allylglycine hydrochloride exhibits convulsant activity .

HY-W012906

L-Allylglycine 1 Publications Verification L-2-Allylglycine	Amino Acid Decarboxylase GABA Receptor	Neurological Disease
L-Allylglycine (L-2-Allylglycine) is an amino acid derivative. L-Allylglycine is an inhibitor for glutamate decarboxylase (GAD) that reduces the GABA biosynthesis in the brain. L-Allylglycine exhibits convulsant activity .

Picrotoxinin 3 Publications Verification	Structural Classification Natural Products other families Source classification Plants	Chloride Channel GABA Receptor
Picrotoxinin, a potent convulsant, is a chloride channel blocker. Picrotoxinin is a noncompetitive GABA_A receptor antagonist, which negatively modulates the action of GABA on GABA_A receptors. Picrotoxinin inhibits α₁β₂γ_2L GABA_A receptor with an IC₅₀ of 1.15 μM .

Bicuculline 25+ Cited Publications (+)-Bicuculline	Alkaloids Structural Classification Source classification Lamprocapnos spectabilis (L.) Fukuhara Plants Isoquinoline Alkaloids Papaveraceae	GABA Receptor
Bicuculline ((+)-Bicuculline) is A competing neurotransmitter GABA_A receptor antagonist (IC₅₀=2 μM). Bicuculline also blocks Ca ²⁺ activating potassium (SK) channels and subsequently blocks slow post-hyperpolarization (slow AHP). Bicuculline has anticonvulsant activity. Bicuculline can be used to induce seizures in mice .

Picrotoxinin (Standard)	Structural Classification Natural Products other families Source classification Plants	Reference Standards Chloride Channel GABA Receptor
Picrotoxinin (Standard) is the analytical standard of Picrotoxinin. This product is intended for research and analytical applications. Picrotoxinin, a potent convulsant, is a chloride channel blocker. Picrotoxinin is a noncompetitive GABAA receptor antagonist, which negatively modulates the action of GABA on GABAA receptors. Picrotoxinin inhibits α1β2γ2L GABAA receptor with an IC₅₀ of 1.15 μM .

Bicuculline (Standard) (+)-Bicuculline (Standard)	Alkaloids Structural Classification Source classification Lamprocapnos spectabilis (L.) Fukuhara Plants Isoquinoline Alkaloids Papaveraceae	Reference Standards GABA Receptor
Bicuculline (Standard) is the analytical standard of Bicuculline. This product is intended for research and analytical applications. Bicuculline ((+)-Bicuculline) is A competing neurotransmitter GABAA receptor antagonist (IC₅₀=2 μM). Bicuculline also blocks Ca2+ activating potassium (SK) channels and subsequently blocks slow post-hyperpolarization (slow AHP). Bicuculline has anticonvulsant activity. Bicuculline can be used to induce seizures in mice .

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convulsant

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