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claudication

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (2) Autophagy (2) Drug Derivative (2) HIV (2) Isotope-Labeled Compounds (3) Phosphodiesterase (PDE) (4) Reference Standards (2) Thrombin (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (7) Inflammation/Immunology (1)

14

Inhibitors & Agonists

2

Natural
Products

3

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Cyclandelate 3,5,5-Trimethylcyclohexyl mandelate	Others	Cardiovascular Disease
Cyclandelate is a vasodilator that can be used in the study of claudication, arteriosclerosis, Raynaud's disease, nocturnal leg cramps, and migraines.

Levocarnitine propionate hydrochloride L-Propionylcarnitine chloride; ST-261	Others	Others
Levocarnitine propionate hydrochloride (L-Propionylcarnitine chloride; ST-261) is used to treat the deterioration of renal function, congestive heart failure, intermittent claudication, and other diseases.

Levocarnitine propionate-d3 hydrochloride L-Propionylcarnitine-d₃ (chloride); ST-261-d₃	Isotope-Labeled Compounds	Others
Levocarnitine propionate-d₃ (hydrochloride) is the deuterium labeled Levocarnitine propionate hydrochloride. Levocarnitine propionate hydrochloride (L-Propionylcarnitine chloride; ST-261) is used to treat the deterioration of renal function, congestive heart failure, intermittent claudication, and other diseases.

Inositol nicotinate (Standard) Inositol niacinate (Standard); Hexanicit (Standard)	Drug Derivative Reference Standards	Cardiovascular Disease
Inositol nicotinate (Standard) is the analytical standard of Inositol nicotinate. This product is intended for research and analytical applications. Inositol nicotinate, with vasodilatory effect, is used in the study of Peripheral arterial disease (PAD) .

Inositol nicotinate Inositol niacinate; Hexanicit	Drug Derivative	Cardiovascular Disease
Inositol nicotinate (Hexanicit) has vasodilating effects and can be used in research on peripheral arterial disease, showing efficacy when taken orally. Inositol nicotinate does not significantly improve triglyceride levels in mice induced by biphenyl esters .

MRS5663	Adenosine Receptor	Cardiovascular Disease
MRS5663 (Compound 3a) is an A3AR agonist, with an EC₅₀ of 5.62 nM for β-arrestin2 recruitment assay. MRS5663 has a cytoprotective effect on skeletal muscle ischemia-reperfusion injury/claudication model .

Parogrelil NT-702 free base; NT-702 free base	Phosphodiesterase (PDE)	Others
Parogrelil (NT-702 free base) is a compound with intermittent claudication inhibitory activity that inhibits PDE3, inhibits platelet aggregation and vasoconstriction, and improves walking distance and plantar surface temperature in a rat experimental model.

Levocarnitine propionate-d5 hydrochloride L-Propionylcarnitine-d₅ (chloride); ST-261-d₅	Isotope-Labeled Compounds	Others
Levocarnitine propionate-d₅ (hydrochloride) is the deuterium labeled Levocarnitine propionate hydrochloride. Levocarnitine propionate hydrochloride (L-Propionylcarnitine chloride; ST-261) is used to treat the deterioration of renal function, congestive heart failure, intermittent claudication, and other diseases.

Levocarnitine propionate-d9 hydrochloride L-Propionylcarnitine-d₉ chloride	Isotope-Labeled Compounds Others	Others
Levocarnitine propionate-d₉ (hydrochloride) (L-Propionylcarnitine-d₉ (chloride)) is deuterium labeled Levocarnitine propionate (hydrochloride). Levocarnitine propionate hydrochloride (L-Propionylcarnitine chloride) is used to study diseases such as renal function deterioration, congestive heart failure, and intermittent claudication .

Parogrelil hydrochloride NM-702; NT-702	Phosphodiesterase (PDE)	Others
Parogrelil (hydrochloride) (NM-702) is a phosphodiesterase inhibitor with activity in inhibiting intermittent claudication. Parogrelil (hydrochloride) selectively inhibits PDE3, inhibits human platelet aggregation in vitro and rat aortic contraction, and improves walking distance and plantar surface temperature in the rat femoral artery ligation model, with better effects than cilostazol.

MRS8028	Adenosine Receptor	Inflammation/Immunology
MRS8028 is an agonist for A3 adenosine receptor (A3AR), which binds hA3AR with K_i of 2.44 nM. MRS8028 is potential for ameliorating ischemia and inflammatory diseases .

Sulodexide	Thrombin	Cardiovascular Disease
Sulodexide is an orally active mixture of glycosaminoglycans composed of low molecular weight heparin (80%) and dermatan sulfate (20%). Sulodexide exhibits antithrombotic activity through interaction with antithrombin III (AT III) and heparin cofactor II (HC II), and inhibition of thrombin formation. Sulodexide exhibits profibrinolytic activity through release of tissue plasminogen activator (tPA). Sulodexide exhibits endothelial protective and anti-inflammatory effect, ameliorates chronic venous disease .

Pentoxifylline 5+ Cited Publications BL-191; PTX; Oxpentifylline	Phosphodiesterase (PDE) Autophagy HIV	Cardiovascular Disease Cancer
Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation .

Pentoxifylline (Standard) BL-191 (Standard); PTX (Standard); Oxpentifylline (Standard)	HIV Autophagy Phosphodiesterase (PDE) Reference Standards	Cardiovascular Disease Cancer
Pentoxifylline (Standard) is the analytical standard of Pentoxifylline. This product is intended for research and analytical applications. Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation .

Cat. No.	Product Name	Category	Target	Chemical Structure

Inositol nicotinate Inositol niacinate; Hexanicit	Cardiovascular Disease Classification of Application Fields Disease Research Fields	Drug Derivative
Inositol nicotinate (Hexanicit) has vasodilating effects and can be used in research on peripheral arterial disease, showing efficacy when taken orally. Inositol nicotinate does not significantly improve triglyceride levels in mice induced by biphenyl esters .

Pentoxifylline 5+ Cited Publications BL-191; PTX; Oxpentifylline	Classification of Application Fields Disease Research Fields Cancer	Phosphodiesterase (PDE) Autophagy HIV
Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation .

Cat. No.	Product Name	Chemical Structure

Levocarnitine propionate-d3 hydrochloride
Levocarnitine propionate-d₃ (hydrochloride) is the deuterium labeled Levocarnitine propionate hydrochloride. Levocarnitine propionate hydrochloride (L-Propionylcarnitine chloride; ST-261) is used to treat the deterioration of renal function, congestive heart failure, intermittent claudication, and other diseases.

Levocarnitine propionate-d5 hydrochloride
Levocarnitine propionate-d₅ (hydrochloride) is the deuterium labeled Levocarnitine propionate hydrochloride. Levocarnitine propionate hydrochloride (L-Propionylcarnitine chloride; ST-261) is used to treat the deterioration of renal function, congestive heart failure, intermittent claudication, and other diseases.

Levocarnitine propionate-d9 hydrochloride
Levocarnitine propionate-d₉ (hydrochloride) (L-Propionylcarnitine-d₉ (chloride)) is deuterium labeled Levocarnitine propionate (hydrochloride). Levocarnitine propionate hydrochloride (L-Propionylcarnitine chloride) is used to study diseases such as renal function deterioration, congestive heart failure, and intermittent claudication .

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