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Results for "

chemotherapeutic agents

" in MedChemExpress (MCE) Product Catalog:

By Targets:	17β-HSD (1) ADC Cytotoxin (2) Akt (2) Aldose Reductase (2) Aminoacyl-tRNA Synthetase (1) Antibiotic (4) Antifolate (2) Apoptosis (16) Aurora Kinase (1) Autophagy (6) Bacterial (5) Caspase (1) Dihydrofolate reductase (DHFR) (1) DNA Alkylator/Crosslinker (10) DNA-PK (1) DNA/RNA Synthesis (3) Drug Metabolite (3) Drug-Linker Conjugates for ADC (1) EAAT (1) EGFR (3) Endogenous Metabolite (4) Enterovirus (1) Epigenetic Reader Domain (1) GSK-3 (1) HDAC (1) Influenza Virus (1) Isotope-Labeled Compounds (4) Keap1-Nrf2 (1) Liposome (1) Microtubule/Tubulin (1) MMP (1) Necroptosis (1) NF-κB (1) Nucleoside Antimetabolite/Analog (2) P-glycoprotein (3) Parasite (1) PKC (2) Topoisomerase (4) Virus Protease (1)
By Research Areas:	Cancer (51) Infection (10) Inflammation/Immunology (11) Metabolic Disease (1)
Oligonucleotides:	Nucleosides and their Analogs (2) C (1) U (1) Cationic Lipids (1)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108391

C8-Ceramide N-Octanoyl-D-erythro-sphingosine	Apoptosis PKC Autophagy	Inflammation/Immunology Cancer
C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) is a cell-permeable analog of naturally occurring ceramides. C8-Ceramide has anti-proliferation properties and acts as a potent chemotherapeutic agent. C8-Ceramide stimulates dendritic cells to promote T cell responses upon virus infections. C8-Ceramide induces slight activation of protein kinase (PKC) in vitro .

HY-B1022

Dimesna 1 Publications Verification BNP-7787	Drug Metabolite	Cancer
Dimesna combined with anticancer chemotherapeutic agents to reduce nephrotoxicity.

HY-17419

Ifosfamide 5+ Cited Publications	DNA Alkylator/Crosslinker	Cancer
Ifosfamide is an alkylating chemotherapeutic agent with activity against a wide range of tumors.

HY-13585

Carmustine 5+ Cited Publications BCNU	DNA Alkylator/Crosslinker	Cancer
Carmustine is an antitumor chemotherapeutic agent, which works by akylating DNA and RNA.

HY-W014233

L-Histidinol dihydrochloride	Endogenous Metabolite Aminoacyl-tRNA Synthetase	Cancer
L-Histidinol dihydrochloride is an orally active histidyl-tRNA synthetase inhibitor. L-Histidinol dihydrochloride interferes with the initiation stage of protein synthesis, thus affecting cell proliferation and metabolism. L-Histidinol dihydrochloride has the effect of modulating the sensitivity of tumor cells to chemotherapeutic agents. L-Histidinol dihydrochloride reduces the toxicity of certain chemotherapeutic agents to normal tissues and enhance the sensitivity of tumor cells to chemotherapeutic agents .

HY-13761

Teniposide 10+ Cited Publications VM26	Topoisomerase	Cancer
Teniposide is a podophyllotoxin derivative, acts as a topoisomerase II inhibitor, and used as a chemotherapeutic agent.

HY-13747

Semustine 1 Publications Verification	DNA Alkylator/Crosslinker	Cancer
Semustine is a DNA alkylator, binds to DNA, and acts as a cancer chemotherapeutic agent .

HY-B1782

Sulfamoxole	Bacterial Antibiotic	Infection
Sulfamoxole is a broad- spectrum chemotherapeutic antimicrobial *agent*. Sulfamoxole can be used for the study of pediatric infections .

HY-136327

Phenylacetic acid mustard	DNA Alkylator/Crosslinker	Cancer
Phenylacetic acid mustard is the major metabolite of the cancer chemotherapeutic agent Chlorambucil (HY-13593). Chlorambucil is an alkylating* agent* with antitumor activity .

HY-115932

Aurora kinase-IN-1	Aurora Kinase Apoptosis	Cancer
Aurora kinase-IN-1 (Compound 9) is a potent inhibitor of aurora kinase. Aurora kinase-IN-1 upregulates the expression of G1 cell cycle inhibitory proteins including p21 and p27, and G1 progressive cyclin D1, and downregulates G1-to-S progressive cyclins, resulting in cell cycle arrest at the G1/S boundary. Aurora kinase-IN-1 also induces apoptosis. Aurora kinase-IN-1 is a lead compound for chemotherapeutic agents .

HY-19543

Brusatol 30+ Cited Publications NSC 172924	Keap1-Nrf2 Apoptosis	Cancer
Brusatol (NSC?172924) is a unique inhibitor of the Nrf2 pathway that sensitizes a broad spectrum of cancer cells to Cisplatin and other chemotherapeutic agents. Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Brusatol can be developed into an adjuvant chemotherapeutic agent . Brusatol increases cellular apoptosis .

HY-17419A

(R)-Ifosfamide	Others	Cancer
(R)-Ifosfamide is a chemotherapeutic agent primarily used in the treatment of aggressive tumors such as rhabdomyosarcoma, exhibiting alkylating activity that interferes with DNA replication.

HY-17419S1

Ifosfamide-d4	Isotope-Labeled Compounds DNA Alkylator/Crosslinker	Cancer
Ifosfamide-d₄ is the deuterium labeled Ifosfamide. Ifosfamide is an alkylating chemotherapeutic agent with activity against a wide range of tumors .

HY-13585S

Carmustine-d8	Isotope-Labeled Compounds DNA Alkylator/Crosslinker	Cancer
Carmustine-d₈ is the deuterium labeled Carmustine. Carmustine is an antitumor chemotherapeutic agent, which works by akylating DNA and RNA .

HY-B0147A

Pefloxacin mesylate 2 Publications Verification Pefloxacinium mesylate	Bacterial Antibiotic	Infection
Pefloxacin mesylate is a an antibacterial agent and prevents bacterial DNA replication by inhibiting DNA gyrase (topoisomerse) Target: DNA gyrase Pefloxacin is a synthetic chemotherapeutic agent used to treat severe and life-threatening bacterial infections.

HY-119172

NSC-60339	Bacterial	Infection Inflammation/Immunology Cancer
NSC-60339, an efflux pump inhibitor and a substrate of AcrAB-TolC, is a polybasic terephthalic acid derivative studied as a potential cancer chemotherapeutic agent .

HY-13585R

Carmustine (Standard)	DNA Alkylator/Crosslinker	Cancer
Carmustine (Standard) is the analytical standard of Carmustine. This product is intended for research and analytical applications. Carmustine is an antitumor chemotherapeutic agent, which works by akylating DNA and RNA.

HY-17419R

Ifosfamide (Standard)	DNA Alkylator/Crosslinker	Cancer
Ifosfamide (Standard) is the analytical standard of Ifosfamide. This product is intended for research and analytical applications. Ifosfamide is an alkylating chemotherapeutic agent with activity against a wide range of tumors.

HY-B0147B

Pefloxacin mesylate dihydrate Pefloxacinium mesylate dihydrate	Bacterial Antibiotic	Infection
Pefloxacin mesylate dehydrate is a an antibacterial agent and prevents bacterial DNA replication by inhibiting DNA gyrase (topoisomerse) Target: DNA gyrase Pefloxacin is a synthetic chemotherapeutic agent used to treat severe and life-threatening bacterial infections.

HY-13761R

Teniposide (Standard)	Topoisomerase	Cancer
Teniposide (Standard) is the analytical standard of Teniposide. This product is intended for research and analytical applications. Teniposide is a podophyllotoxin derivative, acts as a topoisomerase II inhibitor, and used as a chemotherapeutic agent.

HY-B0245

Busulfan 10+ Cited Publications	DNA Alkylator/Crosslinker Apoptosis	Inflammation/Immunology Cancer
Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .

HY-B1782R

Sulfamoxole (Standard)	Bacterial Antibiotic	Infection
Sulfamoxole (Standard) is the analytical standard of Sulfamoxole. This product is intended for research and analytical applications. Sulfamoxole is a broad- spectrum chemotherapeutic antimicrobial agent. Sulfamoxole can be used for the study of pediatric infections .

HY-162569

Ru-TRZ2	Apoptosis Necroptosis	Cancer
Ru-TRZ2 is a potent ruthenium-based chemotherapeutic agent. Ru-TRZ2 induces apoptosis and necroptosis. Ru-TRZ2 shows antitumor activity .

HY-N7029

3',4',5',5,7-Pentamethoxyflavone	Others	Cancer
3',4',5',5,7-Pentamethoxyflavone, a natural flavonoid extracted from Rutaceae plants, sensitizes chemoresistant cancer cells to chemotherapeutic agents by inhibition of Nrf2 pathway .

HY-108251S

Methotrexate metabolite-d3 DAMPA-d₃	Isotope-Labeled Compounds Antifolate Drug Metabolite	Inflammation/Immunology
Methotrexate metabolite-d₃ is the deuterium labeled Methotrexate metabolite. Methotrexate metabolite (DAMPA), the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist that is widely used as an immunosuppressant and chemotherapeutic agent .

HY-14596

Genistein Maximum Cited Publications 53 Publications Verification NPI 031L	EGFR Autophagy Apoptosis Endogenous Metabolite	Cancer
Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis.

HY-B0245S

Busulfan-d8	DNA Alkylator/Crosslinker Apoptosis	Inflammation/Immunology Cancer
Busulfan-d₈ is a deuterium labeled Busulfan. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .

HY-108251R

Methotrexate metabolite (Standard) DAMPA (Standard)	Antifolate Drug Metabolite Dihydrofolate reductase (DHFR) Parasite	Infection Inflammation/Immunology
Methotrexate metabolite (Standard) is the analytical standard of Methotrexate metabolite. This product is intended for research and analytical applications. Methotrexate metabolite (DAMPA), the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist that is widely used as an immunosuppressant and chemotherapeutic agent .

HY-W048496

2'-O-(2-Methoxyethyl)-cytidine	Nucleoside Antimetabolite/Analog	Cancer
2'-O-(2-Methoxyethyl)-cytidine is a synthetic oligonucleotide conversed from uridine. 2'-O-(2-Methoxyethyl)-uridine has the potential for chemotherapeutic agents development .

HY-W048495

2'-O-(2-Methoxyethyl)-uridine	Nucleoside Antimetabolite/Analog	Cancer
2'-O-(2-Methoxyethyl)-uridine is a synthetic oligonucleotide conversed from uridine. 2'-O-(2-Methoxyethyl)-uridine has the potential for chemotherapeutic agents development .

HY-108315

6-Aminochrysene 6-Chrysenamine	Others	Inflammation/Immunology Cancer
6-Aminochrysene (6-Aminochrysene) is an aromatic amine used as a chemotherapeutic agent in the treatment of splenomegaly, myeloid leukemia, and breast cancer. 6-Aminochrysene is activated by CYP450 in rat liver .

HY-17013A

Dofequidar fumarate 2 Publications Verification MS-209	P-glycoprotein	Cancer
Dofequidar fumarate (MS-209) is an orally active quinoline compoundthat blocks P-glycoprotein (P-gp) and multidrug resistance-associated protein-1 (MDR-1). Dofequidar fumarate has highly potent reversing effect on multidrug-resistant tumor cells. Dofequidar fumarate competitively inhibits ABCB1/P-gp, ABCC1/MRP-1, blocks the efflux of chemotherapeutic agents, increases the drug concentration in cancer cells, and enhances the chemotherapeutic effect .

HY-17013

Dofequidar 2 Publications Verification MS-209 free base	P-glycoprotein	Cancer
Dofequidar (MS-209 free base) is an orally active quinoline compoundthat blocks P-glycoprotein (P-gp) and multidrug resistance-associated protein-1 (MDR-1). Dofequidar has highly potent reversing effect on multidrug-resistant tumor cells. Dofequidar competitively inhibits ABCB1/P-gp, ABCC1/MRP-1, blocks the efflux of chemotherapeutic agents, increases the drug concentration in cancer cells, and enhances the chemotherapeutic effect .

HY-17013D

Dofequidar sesquifumarate MS-209 sesquifumarate	P-glycoprotein	Cancer
Dofequidar (MS-209) sesquifumarate is an orally active quinoline compoundthat blocks P-glycoprotein (P-gp) and multidrug resistance-associated protein-1 (MDR-1). Dofequidar sesquifumarate has highly potent reversing effect on multidrug-resistant tumor cells. Dofequidar sesquifumarate competitively inhibits ABCB1/P-gp, ABCC1/MRP-1, blocks the efflux of chemotherapeutic agents, increases the drug concentration in cancer cells, and enhances the chemotherapeutic effect .

HY-14596S

Genistein-d4 NPI 031L-d₄	EGFR Autophagy Apoptosis Endogenous Metabolite	Cancer
Genistein-d₄ is the deuterium labeled Genistein. Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis .

HY-14596R

Genistein (Standard) Maximum Cited Publications 53 Publications Verification NPI 031L (Standard)	EGFR Autophagy Apoptosis Endogenous Metabolite	Cancer
Genistein (Standard) is the analytical standard of Genistein. This product is intended for research and analytical applications. Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis.

HY-167735

Salvizol Bisdequalinium diacetate	Others	Infection
Salvizol (Bisdequalinium diacetate) is a chemotherapeutic agent with a broad spectrum of bactericidal activity, effective in the apical third of root canals. Salvizol possesses the ability to dissolve organic dentin matrix, facilitating mineralization and tubule exposure. Salvizol maintains a neutral pH, ensuring biological compatibility while exhibiting significant cleansing potency.

HY-164401

QBS10072S	EAAT	Cancer
QBS10072S is a bifunctional chemotherapeutic agent, through combination of a cytotoxin and a selective LAT1 transporter substrate. QBS10072S exhibits cytotoxicity in MDA-MB-231 cell and antitumor efficacy in mice. QBS10072S is blood-brain barrier (BBB) penetrable .

HY-130751

DODAP	Liposome	Inflammation/Immunology
DODAP is a cationic lipid utilized as the lipid component in liposomes (pKa = 5.59 in TNS binding tests). DODAP is employed for encapsulating siRNA and delivering immunostimulated chemotherapeutic agents both in vitro and in vivo. DODAP holds great promise for research in vaccines and inflammation .

HY-147271

Mal-PEG8-Val-Ala-PAB-Exatecan	Drug-Linker Conjugates for ADC Topoisomerase	Cancer
Mal-PEG8-Val-Ala-PAB-Exatecan (Compound 9b) is an antibody-drug conjugate linker (ADC linker) that binds to Nectin-4 polypeptides conjugated to chemotherapeutic agents. Mal-PEG8-Val-Ala-PAB-Exatecan can be used for cancer research .

HY-161098

Apoptosis inducer 14	Apoptosis	Cancer
Apoptosis inducer 14 (Compd 7f), a chemotherapeutic agent, induces intrinsic and extrinsic apoptotic death mediated P53. Apoptosis inducer 14 exhibits IC₅₀ values of 193.93 μg/mL, 6.76 μg/mL and 222.67 μg/mL in A549, HCT116 and HF84 cells, respectively .

HY-N3446

IVHD-valtrate	Apoptosis	Cancer
IVHD-valtrate, an active Valeriana jatamansi derivative, is against human ovarian cancer cells in vitro and in vivo. IVHD-valtrate induces cancer cells apoptosis and arrests the ovarian cancer cells in the G2/M phase. IVHD-valtrate has the potential to be a novel chemotherapeutic agent for the human ovarian cancer research .

HY-120574

TH1338	ADC Cytotoxin Topoisomerase	Cancer
TH1338 (compound 3b), an orally active camptothecin derivative and a potent chemotherapeutic agent for cancer, demonstrates excellent cytotoxic potency against human tumor cell lines in vitro. TH1338 (compound 3b) possesses significant brain penetration, favorable efflux pump properties, and hematological toxicity profile .

HY-150650

S07-2001	Aldose Reductase	Cancer
S07-2001 is a potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC₅₀ value of 2.08 μM. S07-2001 enhances the activity of Doxorubicin against cancer cells. S07-2001 has potential as a chemotherapeutic potentiator for cancer agent resistance .

HY-16965

TH287 2 Publications Verification	DNA/RNA Synthesis	Cancer
TH287 is a potent and selective inhibitor of MTH1, with an IC₅₀ of 0.8 nM. TH287 is highly selective towards MTH1, with no relevant inhibition of MTH2, NUDT5, NUDT12, NUDT14, NUDT16, dCTPase, dUTPase and ITPA at 100 μM. TH287 could act as a chemotherapeutic agent for cancer research .

HY-16965A

TH287 hydrochloride	DNA/RNA Synthesis	Cancer
TH287 hydrochloride is a potent and selective inhibitor of MTH1, with an IC₅₀ of 0.8 nM. TH287 hydrochloride is highly selective towards MTH1, with no relevant inhibition of MTH2, NUDT5, NUDT12, NUDT14, NUDT16, dCTPase, dUTPase and ITPA at 100 μM. TH287 hydrochloride could act as a chemotherapeutic agent for cancer research .

HY-19824

3PO 20+ Cited Publications	Autophagy	Cancer
3PO is an inhibitor of PFKFB3. 3PO attenuates the proliferation of several cancer cell lines with IC₅₀s of 1.4-24 μmol/L. 3PO suppresses glucose uptake and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD ⁺ and NADH. 3PO can be used for the research of cancer .

HY-106072

Vinzolidine LY 104208	Microtubule/Tubulin	Cancer
Vinzolidine is a semisynthetic derivative of the catharanthus alkaloid. Vinzolidine exerts its cytotoxic effect on tumor cells by interfering with microtubulin polymerization, thereby inhibiting cell division. Vinzolidine can be utilized in research to investigate synergistic effects when combined with other chemotherapeutic agents or biologic therapies, as well as to study cancer cells' tolerance or resistance to these treatments, and to explore approaches to overcome such obstacles .

HY-19542S1

C6 Ceramide-d11 C6-Cer-d₁₁; N-Hexanoylsphingosine-d₁₁	Apoptosis Isotope-Labeled Compounds	Cancer
C6 Ceramide-d₁₁ is deuterated labeled C6 Ceramide (HY-19542). C6-ceramide, a ceramide pathway activator, shows activity against a variety of cancer cell lines. C6-ceramide can be used as an adjuvant for chemotherapeutic agents, to enhance anti-tumor effects .

HY-158166

DNA-PK-IN-13	DNA-PK	Inflammation/Immunology Cancer
DNA-PK-IN-13 (Compound SK10) is a DNA-PK inhibitor that exhibits potent inhibitory activity (IC₅₀= 0.11 nM). DNA-PK-IN-13 regulates tumor cell proliferation by decreasing the expression level of γH2A.X and enhancing the sensitivity of tumor cells to chemotherapeutic agents. DNA-PK-IN-13 is suitable for oncology studies .

Cat. No.	Product Name

HY-L112

Chemotherapy Drug Library

151 compounds

Chemotherapy is one of the most common treatments for cancer. It can be used alone for some types of cancer or in combination with other treatments such as radiation or surgery. Chemotherapy drugs usually target cells at different phases of the cell cycle and inhibit tumor proliferation and avoid cancer cell invasion and metastasis. It is a cancer treatment method that kills cancer cells with drugs.

Chemotherapeutic agents can be classified into alkylating agents, antimetabolites, antimicrotubular agents, antibiotics, etc. according to the mechanism of action. MCE offers a unique collection of 151 chemotherapy drugs, which is a useful tool for cancer treatment research.

HY-L213

Anti-Cancer Approved Drug Library

278 compounds

The anti-cancer drug library meticulously collects all drugs approved by FDA and other major national drug regulatory authorities for cancer treatment. These drugs cover a variety of cancer types, including but not limited to lung cancer, breast cancer, colorectal cancer, leukemia, and other common cancers. The library includes a wide range of drugs, from classic chemotherapeutic agents to cutting-edge targeted therapies and immunotherapies. It contains various types of drug compounds with different mechanisms of action. There are cytotoxic drugs that directly kill cancer cells, as well as drugs that work by modulating the tumor microenvironment, inhibiting tumor angiogenesis, and activating the immune system. This diversity provides researchers with a broad range of perspectives and options for intervention strategies.

This library can be used for basic research on cancer treatment, exploring new targets and new mechanisms of drug action; Conducting drug reuse research to look for potential therapeutic effects of existing drugs on other cancer types or diseases; Or conducting research into combination drugs to optimize cancer treatment.

MCE has collected 278 small-molecule compounds with cancer indications, which are good tools for drug repurposing.

Cat. No.	Product Name	Type

HY-130751

DODAP	Drug Delivery
DODAP is a cationic lipid utilized as the lipid component in liposomes (pKa = 5.59 in TNS binding tests). DODAP is employed for encapsulating siRNA and delivering immunostimulated chemotherapeutic agents both in vitro and in vivo. DODAP holds great promise for research in vaccines and inflammation .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W014233

L-Histidinol dihydrochloride	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Aminoacyl-tRNA Synthetase
L-Histidinol dihydrochloride is an orally active histidyl-tRNA synthetase inhibitor. L-Histidinol dihydrochloride interferes with the initiation stage of protein synthesis, thus affecting cell proliferation and metabolism. L-Histidinol dihydrochloride has the effect of modulating the sensitivity of tumor cells to chemotherapeutic agents. L-Histidinol dihydrochloride reduces the toxicity of certain chemotherapeutic agents to normal tissues and enhance the sensitivity of tumor cells to chemotherapeutic agents .

HY-19543

Brusatol 30+ Cited Publications NSC 172924	Structural Classification Simaroubaceae Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Disease Research Fields Brucea javanica (L.) Merr. Cancer	Keap1-Nrf2 Apoptosis
Brusatol (NSC?172924) is a unique inhibitor of the Nrf2 pathway that sensitizes a broad spectrum of cancer cells to Cisplatin and other chemotherapeutic agents. Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Brusatol can be developed into an adjuvant chemotherapeutic agent . Brusatol increases cellular apoptosis .

HY-N7029

3',4',5',5,7-Pentamethoxyflavone	Structural Classification Flavonoids Classification of Application Fields Flavones Leguminosae Source classification Bauhinia championii (Benth.) Benth. Plants Disease Research Fields Cancer	Others
3',4',5',5,7-Pentamethoxyflavone, a natural flavonoid extracted from Rutaceae plants, sensitizes chemoresistant cancer cells to chemotherapeutic agents by inhibition of Nrf2 pathway .

HY-14596

Genistein Maximum Cited Publications 53 Publications Verification NPI 031L	Structural Classification Classification of Application Fields Anti-aging Source classification Plants Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Microorganisms Leguminosae Glycine max (L.) merr Sunscreen Phenols Polyphenols Cosmetic Research Glycyrrhiza uralensis Fisch. Disease Research Fields Isoflavones Cancer	EGFR Autophagy Apoptosis Endogenous Metabolite
Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis.

HY-14596R

Genistein (Standard) Maximum Cited Publications 53 Publications Verification NPI 031L (Standard)	Structural Classification Classification of Application Fields Anti-aging Source classification Plants Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Leguminosae Glycine max (L.) merr Sunscreen Phenols Cosmetic Research Glycyrrhiza uralensis Fisch. Disease Research Fields Cancer	EGFR Autophagy Apoptosis Endogenous Metabolite
Genistein (Standard) is the analytical standard of Genistein. This product is intended for research and analytical applications. Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis.

HY-N3387

Licoricidin	Structural Classification Natural Products Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Inflammation/Immunology Disease Research Fields	Apoptosis NF-κB Akt MMP
Licoricidin (LCD) is isolated from Glycyrrhiza uralensis Fisch, possesses anti-cancer activities. Licoricidin (LCD) inhibit SW480 cells (IC₅₀=7.2 μM) by inducing cycle arrest, apoptosis and autophagy, and is a potential chemopreventive or chemotherapeutic agent against colorectal cancer . Licoricidin (LCD) inhibits Lung Metastasis by inhibition of tumor angiogenesis and lymphangiogenesis as well as changes in the local microenvironment of tumor tissues the anticarcinogenic effect . Licoricidin enhanced gemcitabine-induced cytotoxicity in Osteosarcoma (OS) cells by inactivation of the Akt and NF-κB pathways in vitro and in vivo . Licoricidin blocks UVA-induced photoaging via ROS scavenging, limits the activity of MMP-1, it can be considered as an active ingredient in new topically applied anti-ageing formulations .

HY-N3446

IVHD-valtrate	Structural Classification Natural Products Classification of Application Fields Source classification Valeriana officinalis Linn. Plants Valerianaceae Disease Research Fields Cancer	Apoptosis
IVHD-valtrate, an active Valeriana jatamansi derivative, is against human ovarian cancer cells in vitro and in vivo. IVHD-valtrate induces cancer cells apoptosis and arrests the ovarian cancer cells in the G2/M phase. IVHD-valtrate has the potential to be a novel chemotherapeutic agent for the human ovarian cancer research .

Cat. No.	Product Name	Chemical Structure

HY-17419S1

Ifosfamide-d4
Ifosfamide-d₄ is the deuterium labeled Ifosfamide. Ifosfamide is an alkylating chemotherapeutic agent with activity against a wide range of tumors .

HY-13585S

Carmustine-d8
Carmustine-d₈ is the deuterium labeled Carmustine. Carmustine is an antitumor chemotherapeutic agent, which works by akylating DNA and RNA .

HY-B0245S

Busulfan-d8
Busulfan-d₈ is a deuterium labeled Busulfan. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .

HY-14596S

Genistein-d4
Genistein-d₄ is the deuterium labeled Genistein. Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis .

HY-108251S

Methotrexate metabolite-d3
Methotrexate metabolite-d₃ is the deuterium labeled Methotrexate metabolite. Methotrexate metabolite (DAMPA), the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist that is widely used as an immunosuppressant and chemotherapeutic agent .

HY-19542S1

C6 Ceramide-d11
C6 Ceramide-d₁₁ is deuterated labeled C6 Ceramide (HY-19542). C6-ceramide, a ceramide pathway activator, shows activity against a variety of cancer cell lines. C6-ceramide can be used as an adjuvant for chemotherapeutic agents, to enhance anti-tumor effects .

Cat. No.	Product Name		Classification

HY-W048496

2'-O-(2-Methoxyethyl)-cytidine		Nucleosides and their Analogs C
2'-O-(2-Methoxyethyl)-cytidine is a synthetic oligonucleotide conversed from uridine. 2'-O-(2-Methoxyethyl)-uridine has the potential for chemotherapeutic agents development .

HY-W048495

2'-O-(2-Methoxyethyl)-uridine		Nucleosides and their Analogs U
2'-O-(2-Methoxyethyl)-uridine is a synthetic oligonucleotide conversed from uridine. 2'-O-(2-Methoxyethyl)-uridine has the potential for chemotherapeutic agents development .

HY-130751

DODAP		Cationic Lipids
DODAP is a cationic lipid utilized as the lipid component in liposomes (pKa = 5.59 in TNS binding tests). DODAP is employed for encapsulating siRNA and delivering immunostimulated chemotherapeutic agents both in vitro and in vivo. DODAP holds great promise for research in vaccines and inflammation .

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chemotherapeutic agents

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