Search Result

Results for "

chemosensitization

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Apoptosis (9) ATP-binding cassette (ABC) transporters (1) Bacterial (1) Carbonic Anhydrase (1) Caspase (1) Deubiquitinase (1) DNA Alkylator/Crosslinker (1) DNA Methyltransferase (4) DNA-PK (1) DNA/RNA Synthesis (2) Drug Derivative (1) Drug Metabolite (1) Fungal (3) HBV (1) Isotope-Labeled Compounds (4) Keap1-Nrf2 (1) Mitochondrial Metabolism (1) Mitosis (1) NF-κB (1) P-glycoprotein (8) PARP (1) PI3K (1) Sirtuin (2)
By Research Areas:	Cancer (30) Cardiovascular Disease (2) Infection (4) Inflammation/Immunology (3) Metabolic Disease (3) Neurological Disease (6)

By Targets:

Antibiotic (1)

Apoptosis (9)

ATP-binding cassette (ABC) transporters (1)

Bacterial (1)

Carbonic Anhydrase (1)

Caspase (1)

Deubiquitinase (1)

DNA Alkylator/Crosslinker (1)

DNA Methyltransferase (4)

DNA-PK (1)

DNA/RNA Synthesis (2)

Drug Derivative (1)

Drug Metabolite (1)

Fungal (3)

HBV (1)

Isotope-Labeled Compounds (4)

Keap1-Nrf2 (1)

Mitochondrial Metabolism (1)

Mitosis (1)

NF-κB (1)

P-glycoprotein (8)

PARP (1)

PI3K (1)

Sirtuin (2)

By Research Areas:

Cancer (30)

Cardiovascular Disease (2)

Infection (4)

Inflammation/Immunology (3)

Metabolic Disease (3)

Neurological Disease (6)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-103721

SIRT6-IN-2	Sirtuin	Cancer
SIRT6-IN-2 (Compound 5) is a selective SIRT6 inhibitor (IC₅₀: 34 μM). SIRT6-IN-2 increases acetylation of H3K9 and increases glucose uptake in cultured cells. SIRT6-IN-2 also reduces T cell proliferation. SIRT6-IN-2 has immunosuppressive and chemosensitizing effects .

HY-B0106

Levetiracetam 1 Publications Verification UCB L059	DNA Methyltransferase	Neurological Disease Cancer
Levetiracetam, an antiepileptic agent, binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Levetiracetam modulates HDAC levels ultimately silencing MGMT, thus increasing Temozolomide effectiveness. A chemosensitizer agent .

HY-B0106R

Levetiracetam (Standard)	DNA Methyltransferase	Neurological Disease Cancer
Levetiracetam (Standard) is the analytical standard of Levetiracetam. This product is intended for research and analytical applications. Levetiracetam, an antiepileptic agent, binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Levetiracetam modulates HDAC levels ultimately silencing MGMT, thus increasing Temozolomide effectiveness. A chemosensitizer agent .

HY-101453

Ceefourin 1	P-glycoprotein	Cancer
Ceefourin 1 is a potent and highly selective multidrug resistance protein 4 (MRP4) inhibitor. Ceefourin 1 inhibits transport of a broad range of MRP4 substrates, yet is highly selective for MRP4 over other ABC transporters. Ceefourin 1 is a benzothiazol and primarily as a chemosensitizer for high-risk neuroblastoma .

HY-136934

Reversin 205 [Boc-Glu(Obzl)]2-Lys-Ome	P-glycoprotein	Cancer
Reversin 205 ([Boc-Glu(Obzl)]2-Lys-Ome) is a P-glycoprotein (ABCB1) inhibitor. Reversin 205 is a peptide chemosensitizer .

HY-157448

CBR1-IN-6	Apoptosis	Cancer
CBR1-IN-6 (compound 1a) is a CBR1 inhibitor with chemosensitizing and cardioprotective activities .

HY-N2104

Daurinoline	Others	Cancer
Daurinoline is an alkaloid that can be isolated from the roots of Menispermum dauricum. Daurinoline may be a potential anti-tumor agent or chemosensitizer for chemo-resistant NSCLC research .

HY-123401

DDRI-18	DNA/RNA Synthesis	Cancer
DDRI-18 is a DNA damage response inhibitor that inhibits the non-homologous end-joining (NHEJ) DNA repair process. DDRI-18 is an effective chemosensitizing agent .

HY-14688

CEP-8983	PARP	Cancer
CEP-8983 is a PARP-1 and PARP-2 inhibitor (IC₅₀: 20 and 6 nM). CEP-8983 is an effective chemosensitizing agent, and can sensitize chemotherapy-resistant cell lines and subcutaneous xenografts to Temozolomide (HY-17364) and Camptothecin (HY-16560) .

HY-120432

CaMdr1p-IN-1	Fungal ATP-binding cassette (ABC) transporters	Infection
CaMdr1p-IN-1 (Compound A) is an inhibitor for the major facilitator superfamily transporter CaMdr1p. CaMdr1p-IN-1 exhibits chemosensitizing efficacy. CaMdr1p-IN-1 synergizes with Fluconazole (HY-B0101), that inhibits CaMdr1p overexpressing Candida albicans with MIC of 10 μM .

HY-17384

Valspodar 15+ Cited Publications PSC 833	P-glycoprotein	Cancer
Valspodar (PSC 833) is a selective P-glycoprotein inhibitor that has been used as an experimental cancer treatment and chemosensitizer.

HY-13574A

Biricodar 1 Publications Verification VX-710	P-glycoprotein	Cancer
Biricodar (VX-710) is a modulator of P-glycoprotein and MRP-1; shows effective chemosensitizing activity in multidrug resistant cells.

HY-114410

CCI-006	Mitochondrial Metabolism	Cancer
CCI-006 is a selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells, by inhibits mitochondrial respiration resulting in insurmountable mitochondrial depolarization and a pro-apoptotic unfolded protein response (UPR) in a subset of MLL-r leukemia cells .

HY-W014118

α-Hexylcinnamaldehyde	Drug Derivative	Cancer
α-Hexylcinnamaldehyde, a compound derived from Cinnamaldehyde. α-Hexylcinnamaldehyde has the potential antimutagenic and chemosensitizing properties. α-Hexylcinnamaldehyde is widely used as an ingredient in many personal care, and as an additive in food and the pharmaceutical industry .

HY-159982

SH7s	Carbonic Anhydrase	Cancer
SH7s is a potent carbonic anhydrases inhibitor, with K_is of 15.9 and 55.2 nM for hCA IX and hCA XII, respectively. SH7s is also a hypoxia-mediated chemo-sensitizing agent in colorectal cancer cells .

HY-145967

FT709 1 Publications Verification	Deubiquitinase Mitosis	Cancer
FT709 is a potent and selective USP9X inhibitor, an IC₅₀ of 82 nM. USP9X has been linked with centrosome function, chromosome alignment during mitosis, EGF receptor degradation, chemo-sensitization, and circadian rhythms .

HY-135336S

(R)-Verapamil-d7 hydrochloride (R)-(+)-Verapamil-d₇ hydrochloride	P-glycoprotein Isotope-Labeled Compounds Apoptosis	Cancer
(R)-Verapamil-d₇ (hydrochloride) is a deuterium labeled (R)-Verapamil hydrochloride. (R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is a P-Glycoprotein inhibitor. (R)-Verapamil hydrochloride blocks MRP1 mediated transport, resulting in chemosensitization of MRP1-overexpressing cells to anticancer agents .

HY-W702292

(R)-(+)-Verapamil-d6 hydrochloride	Isotope-Labeled Compounds Apoptosis P-glycoprotein	Cancer
(R)-(+)-Verapamil-d₆ (hydrochloride) is deuterium labeled (R)-Verapamil (hydrochloride). (R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is a P-Glycoprotein inhibitor. (R)-Verapamil hydrochloride blocks MRP1 mediated transport, resulting in chemosensitization of MRP1-overexpressing cells to anticancer agents .

HY-13574

Biricodar dicitrate VX 710-3	P-glycoprotein	Cancer
Biricodar dicitrate (VX 710-3) is the dicitrate salt form of Biricodar (HY-13574A). Biricodar dicitrate is an inhibitor for P-glycoprotein and multidrug resistance-associated protein 1 (MRP-1), which increases the accumulation of chemotherapy drugs within cancer cells and shows effective chemosensitizing activity in multidrug resistant cells .

HY-B0106S

Levetiracetam-d6 UCB L059-d₆	Isotope-Labeled Compounds DNA Methyltransferase	Neurological Disease Cancer
Levetiracetam-d₆ is the deuterium labeled Levetiracetam. Levetiracetam, an antiepileptic agent, binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Levetiracetam modulates HDAC levels ultimately silencing MGMT, thus increasing Temozolomide effectiveness. A chemosensitizer agent .

HY-B0106S1

Levetiracetam-d3 UCB L059-d₃	DNA Methyltransferase	Neurological Disease Cancer
Levetiracetam-d₃ is the deuterium labeled Levetiracetam. Levetiracetam, an antiepileptic agent, binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Levetiracetam modulates HDAC levels ultimately silencing MGMT, thus increasing Temozolomide effectiveness. A chemosensitizer agent .

HY-W014118R

α-Hexylcinnamaldehyde (Standard)	Others	Cancer
α-Hexylcinnamaldehyde (Standard) is the analytical standard of α-Hexylcinnamaldehyde. This product is intended for research and analytical applications. α-Hexylcinnamaldehyde, a compound derived from Cinnamaldehyde. α-Hexylcinnamaldehyde has the potential antimutagenic and chemosensitizing properties. α-Hexylcinnamaldehyde is widely used as an ingredient in many personal care, and as an additive in food and the pharmaceutical industry .

HY-12772R

Hydroxy Itraconazole (Standard)	Fungal Drug Metabolite	Others
Levetiracetam (Standard) is the analytical standard of Levetiracetam. This product is intended for research and analytical applications. Levetiracetam, an antiepileptic agent, binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Levetiracetam modulates HDAC levels ultimately silencing MGMT, thus increasing Temozolomide effectiveness. A chemosensitizer agent .

HY-W014118S

α-Hexylcinnamaldehyde-d5	Isotope-Labeled Compounds	Cancer
α-Hexylcinnamaldehyde-d₅ is deuterated labeled α-Hexylcinnamaldehyde (HY-W014118). α-Hexylcinnamaldehyde, a compound derived from Cinnamaldehyde. α-Hexylcinnamaldehyde has the potential antimutagenic and chemosensitizing properties. α-Hexylcinnamaldehyde is widely used as an ingredient in many personal care, and as an additive in food and the pharmaceutical industry .

HY-111193

Declopramide 3-Chloroprocainamide	NF-κB Apoptosis	Cancer
Declopramide (3-Chloroprocainamide) is an orally active antitumor agent, which inhibits proliferation of cancer cells HL60 and K562, and inhibits tumor growth of human brain astrocytoma (T24) in mouse model. Declopramide induces apoptosis, inhibits NF-κB through inhibition of IκBα degradation. Declopramide serves also as chemosensitizer in research .

HY-N0669

Stevioside 3 Publications Verification	Apoptosis	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Stevioside is an orally active sweetener that can be isolated from Stevia rebaudiana, with antihypertensive, antihyperglycemic, antioxidant, anti-inflammatory and anti-tumor activities .

HY-N0669R

Stevioside (Standard)	Apoptosis	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Stevioside (Standard) is the analytical standard of Stevioside. This product is intended for research and analytical applications. Stevioside is an orally active sweetener that can be isolated from Stevia rebaudiana, with antihypertensive, antihyperglycemic, antioxidant, anti-inflammatory and anti-tumor activities .

HY-172771

Multi-target kinase inhibitor 4	PI3K DNA-PK P-glycoprotein	Cancer
Multi-target kinase inhibitor 4 (Compound 2) is a PI3K/DNA-PK inhibitor and potent chemosensitizer that can increase the amount of DNA double strand breaks induced by Doxorubicin (HY-15142A). Multi-target kinase inhibitor 4, is an efficient inhibitor of multidrug resistance (MDR) that exhibits inhibitory activity toward P-glycoprotein-mediated drug efflux. Multi-target kinase inhibitor 4 can be loaded into PEG-coated LNPs .

HY-107454

OSS_128167 20+ Cited Publications	Sirtuin HBV	Infection Metabolic Disease Inflammation/Immunology Cancer
OSS_128167 is a potent selective sirtuin 6 (SIRT6) inhibitor with IC₅₀s of 89 μM, 1578 μM and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-HBV activity that inhibits HBV transcription and replication. OSS_128167 has anti-cancer, anti-inflammation and anti-viral effects .

HY-W040129

Chromomycin A3 1 Publications Verification	DNA Alkylator/Crosslinker DNA/RNA Synthesis Apoptosis Caspase	Infection Neurological Disease Cancer
Chromomycin A3 is an inhibitor that selectively binds to GC-rich DNA sequences. Chromomycin A3 targets the DNA minor groove after forming a dimer with Mg ²⁺. Chromomycin A3 inhibits DNA replication and transcription, blocks the binding of Sp1 transcription factor to target gene promoters, downregulates the expression of anti-apoptotic proteins such as FLIP, Mcl-1, and XIAP, and induces S-phase cycle arrest and caspase-dependent apoptosis in tumor cells. Chromomycin A3 can antagonize oxidative stress induced by glutathione depletion and neuronal apoptosis induced by Camptothecin (HY-15660). Chromomycin A3 can be used in basic research on malignant tumors such as cholangiocarcinoma, and is a potential chemosensitizer and GC-rich region probe .

HY-W040129R

Chromomycin A3 (Standard)	Bacterial Fungal Apoptosis Antibiotic	Infection Neurological Disease Cancer
Chromomycin A3 (Standard) is the analytical standard of Chromomycin A3 (HY-W040129). This product is intended for research and analytical applications. Chromomycin A3 is an inhibitor that selectively binds to GC-rich DNA sequences. Chromomycin A3 targets the DNA minor groove after forming a dimer with Mg ²⁺. Chromomycin A3 inhibits DNA replication and transcription, blocks the binding of Sp1 transcription factor to target gene promoters, downregulates the expression of anti-apoptotic proteins such as FLIP, Mcl-1, and XIAP, and induces S-phase cycle arrest and caspase-dependent apoptosis in tumor cells. Chromomycin A3 can antagonize oxidative stress induced by glutathione depletion and neuronal apoptosis induced by Camptothecin (HY-15660). Chromomycin A3 can be used in basic research on malignant tumors such as cholangiocarcinoma, and is a potential chemosensitizer and GC-rich region probe .

HY-19543

Brusatol Maximum Cited Publications 32 Publications Verification NSC 172924	Keap1-Nrf2 Apoptosis	Cancer
Brusatol (NSC?172924) is a unique inhibitor of the Nrf2 pathway that sensitizes a broad spectrum of cancer cells to Cisplatin and other chemotherapeutic agents. Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Brusatol can be developed into an adjuvant chemotherapeutic agent . Brusatol increases cellular apoptosis .

Cat. No.	Product Name	Target	Research Area