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Pathways Recommended: Stem Cell/Wnt Cell Cycle/DNA Damage
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cell mitosis

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W014240
    Chlorpropham
    1 Publications Verification

    		 Herbicide Mitosis Others
    Chlorpropham is a carbamate herbicide and plant growth regulator. Chlorpropham inhibits mitosis and cell division by interfering with the organisation of the spindle microtubules .
    Chlorpropham
  • HY-100368
    MELK-8a
    3 Publications Verification

    NVS-MELK8a

    		 PDGFR Haspin Kinase MELK Mitosis Cancer
    MELK-8a (NVS-MELK8a) is a highly potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor with IC50 of 2 nM. MELK-8a also inhibits Flt3 (ITD), Haspin, PDGFRα with IC50s of 0.18, 0.19, and 0.42 μM, respectively. MELK plays an essential role in regulating cell mitosis in a subset of cancer cells .
    MELK-8a
  • HY-151424
    Vimentin-IN-1

    		Proteasome Mitosis Cancer
    Vimentin-IN-1 is a FiVe1 derivative, an orally active and selective anticancer agent. FiVe1 binds type III intermediate filament protein vimentin (VIM), to induce hyperphosphorylation of Ser56, resulting selective disruption of mitosis and multinucleation in transformed VIM-expressing mesenchymal cancer cells. Vimentin-IN-1 shows better oral bioavailability and pharmacokinetic profiles than FiVe1 .
    Vimentin-IN-1
  • HY-103711
    Estramustine
    1 Publications Verification

    		 Microtubule/Tubulin Mitosis Cancer
    Estramustine is an antineoplastic agent. Estramustine depolymerizes microtnbules by binding to tubulin 1, exhibits antimitotic activity with an IC50 value of ~16 μM for mitosis of DU 145 cells. Estramustine blocks cells at mitosis in prostate tumor xenografts .
    Estramustine
  • HY-156437
    NBI-961

    		Apoptosis Ser/Thr Protease NEKs Mitosis Cancer
    NBI-961 is a potent NEK2 inhibitor that inhibits proteasomal degradation. NBI-961 induces G2/mitosis arrest and apoptosis in diffuse large B cell lymphoma (DLBCL) cells .
    NBI-961
  • HY-124790
    KSP-IA

    		Kinesin Mitosis Cancer
    KSP-IA (compound 17) is a potent kinesin spindle protein (KSP) inhibitor with an IC50 value of 3.6 nM. KSP-IA inhibits cell mitosis .
    KSP-IA
  • HY-W014240R
    Chlorpropham (Standard)

    		Herbicide Mitosis Reference Standards Others
    Chlorpropham (Standard) is the analytical standard of Chlorpropham. This product is intended for research and analytical applications. Chlorpropham is a carbamate herbicide and plant growth regulator. Chlorpropham inhibits mitosis and cell division by interfering with the organisation of the spindle microtubules .
    Chlorpropham (Standard)
  • HY-164454
    AJI-100

    		Aurora Kinase STAT JAK Mitosis Inflammation/Immunology
    AJI-100 is a dual-target inhibitor of Aurora kinase A and JAK2 with IC50 values of 12.7 nM and 18.5 nM, respectively. AJI-100 directly blocks Aurora kinase A to inhibit T cell mitosis and cell polarity, and inhibits JAK2 activation to inhibit STAT3 phosphorylation, thereby reducing the differentiation of TH1 and TH17 cells. AJI-100 can be used in studies on regulating immune responses and preventing graft-versus-host disease (GVHD) .
    AJI-100
  • HY-118327
    Maleuric acid

    N-carbamylmaleamic acid

    		 DNA/RNA Synthesis Mitosis Cancer
    Maleuric acid has cytotoxicity on Ehrlich ascites tumor cells by preventing the entry of preprophase cells into mitosis.
    Maleuric acid
  • HY-103711R
    Estramustine (Standard)

    		Microtubule/Tubulin Mitosis Reference Standards Cancer
    Estramustine (Standard) is the analytical standard of Estramustine. This product is intended for research and analytical applications. Estramustine is an antineoplastic agent. Estramustine depolymerizes microtnbules by binding to tubulin 1, exhibits antimitotic activity with an IC50 value of ~16 μM for mitosis of DU 145 cells. Estramustine blocks cells at mitosis in prostate tumor xenografts .
    Estramustine (Standard)
  • HY-156958
    S-72

    		Apoptosis STAT Microtubule/Tubulin Mitosis Inflammation/Immunology
    S-72 inhibits tubulin polymerization and further triggers mitosis-phase cell cycle arrest and cell apoptosis, in addition to suppressing STAT3 signaling .
    S-72
  • HY-16036A
    ALB-109564 hydrochloride

    12'-Methylthiovinblastine hydrochloride

    		 Microtubule/Tubulin Mitosis Cancer
    ALB-109564 (12'-Methylthiovinblastine) hydrochloride, a tubulin inhibitor, is a cytotoxic agent designed to kill cancer cells by disrupting mitosis .
    ALB-109564 hydrochloride
  • HY-P3840
    Head activator neuropeptide

    		Mitosis Neurological Disease Cancer
    Head activator neuropeptide is a mitogen for mammalian cell lines of neuronal or neuroendocrine origin. Head activator neuropeptide signals by binding GPR37 and stimulates cells to enter mitosis .
    Head activator neuropeptide
  • HY-B2050
    Trifluralin

    		Herbicide Microtubule/Tubulin Others
    Trifluralin is a selective, preemergence, soil-applied herbicide providing control of many important annual grass and broadleaf weed species. Trifluralin prevents weed growth by inhibiting root development through the interruption of mitosis. Trifluralin binds to tubulin and results in the failure of spindle apparatus and cell plate formation. Trifluralin inhibits radicle development on roots. Trifluralin inhibits cell mitosis. Trifluralin is considered to be neurotoxic and haematotoxic .
    Trifluralin
  • HY-B2050S
    Trifluralin-d14

    		Isotope-Labeled Compounds Microtubule/Tubulin Others
    Trifluralin-d14 is the deuterium labeled Trifluralin. Trifluralin is a selective, preemergence, soil-applied herbicide providing control of many important annual grass and broadleaf weed species. Trifluralin prevents weed growth by inhibiting root development through the interruption of mitosis. Trifluralin binds to tubulin and results in the failure of spindle apparatus and cell plate formation. Trifluralin inhibits radicle development on roots. Trifluralin inhibits cell mitosis. Trifluralin is considered to be neurotoxic and haematotoxic .
    Trifluralin-d14
  • HY-101071
    (S)-Monastrol

    (+)-Monastrol

    		 Kinesin Mitosis Cancer
    (S)-Monastrol ((+)-Monastrol) is an allosteric inhibitor of the mitotic kinesin Eg5 that exhibits an antiproliferative effect against several cancer cell lines. (S)-Monastrol arrests mammalian cells in mitosis with monopolar spindles .
    (S)-Monastrol
  • HY-129715
    MPI-0441138

    		Apoptosis Mitosis Cancer
    MPI-0441138 is an inducer of apoptosis and an inhibitor of mitosis. MPI-0441138 can induce DNA breaks and induce cytochrome c translocation, leading to tumor cell death .
    MPI-0441138
  • HY-B2050R
    Trifluralin (Standard)

    		Reference Standards Microtubule/Tubulin Herbicide Others
    Trifluralin (Standard) is the analytical standard of Trifluralin. This product is intended for research and analytical applications. Trifluralin is a selective, preemergence, soil-applied herbicide providing control of many important annual grass and broadleaf weed species. Trifluralin prevents weed growth by inhibiting root development through the interruption of mitosis. Trifluralin binds to tubulin and results in the failure of spindle apparatus and cell plate formation. Trifluralin inhibits radicle development on roots. Trifluralin inhibits cell mitosis. Trifluralin is considered to be neurotoxic and haematotoxic .
    Trifluralin (Standard)
  • HY-116915
    Synstab A

    		Microtubule/Tubulin Mitosis Cancer
    Synstab A is a mitosis modulator to promote interactions between α- and β-tubulin. Synstab A can polymerizes microtubules from purified tubulin, and produces microtubule bundles in interphase cells .
    Synstab A
  • HY-111425
    SSE15206

    		Apoptosis Microtubule/Tubulin Mitosis Cancer
    SSE15206 is a microtubule polymerization inhibitor (GI50 = 197 nM in HCT116 cells) that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation in cancer cells .
    SSE15206
  • HY-W014240S1
    Chlorpropham-d7

    		Isotope-Labeled Compounds Mitosis Others
    Chlorpropham-d7 is the deuterium labeled Chlorpropham . Chlorpropham is a carbamate herbicide and plant growth regulator. Chlorpropham inhibits mitosis and cell division by interfering with the organisation of the spindle microtubules .
    Chlorpropham-d7
  • HY-10919
    C-1311

    		Topoisomerase Mitosis Cancer
    C-1311 shows to inhibit the catalytic activity of DNA topoisomerase II in vitro and in tumour cells. C-1311 prolongs G2 arrest followed by G2 to M transit and cell death during mitosis in the process of mitotic catastrophe .
    C-1311
  • HY-13520
    Nocodazole
    Maximum Cited Publications
    94 Publications Verification

    Oncodazole; R17934

    		 Bcr-Abl Autophagy Microtubule/Tubulin Apoptosis Mitosis Cancer
    Nocodazole (Oncodazole) is a rapidly-reversible inhibitor of microtubule. Nocodazole binds to β-tubulin and disrupts microtubule assembly/disassembly dynamics, which prevents mitosis and induces apoptosis in tumor cells. Nocodazole inhibits Bcr-Abl.
    Nocodazole
  • HY-N0488A
    Vincristine

    Leurocristine; NSC-67574; 22-Oxovincaleukoblastine

    		 Microtubule/Tubulin Antibiotic Mitosis Cancer
    Vincristine (Leurocristine) is a microtubule-destabilizing agent (MDA). Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine is used to research hematologic cancers, such as leukemia and lymphoma, and childhood sarcomas .
    Vincristine
  • HY-169581
    DIM-C-pPhtBu

    		Reactive Oxygen Species (ROS) Mitosis Cancer
    DIM-C-pPhtBu is an orally active endoplasmic reticulum stress activator. DIM-C-pPhtBu induces mitochondrial and lysosome dysfunction, excessive mitosis, ROS production, and unfolded protein response-mediated cell death in neck cancer cells. DIM-C-pPhtBu has antitumor activity .
    DIM-C-pPhtBu
  • HY-13589
    Cemadotin

    LU103793 free base

    		 Microtubule/Tubulin Mitosis Cancer
    Cemadotin (LU103793) is a water-soluble synthetic analogue of Dolastatin 15 (HY-P1126) that inhibits cell proliferation in vitro and the growth of tumor xenografts in mice. Cemadotin blocks cells at mitosis, and exhibits Ki value of 1 μM for inhibiting tubulin. Cemadotin can be used to research anticancer .
    Cemadotin
  • HY-13589A
    Cemadotin hydrochloride

    LU103793 hydrochloride

    		 Microtubule/Tubulin Mitosis Cancer
    Cemadotin (LU103793) hydrochloride is a water-soluble synthetic analogue of Dolastatin 15 (HY-P1126) that inhibits cell proliferation in vitro and the growth of tumor xenografts in mice. Cemadotin hydrochloride blocks cells at mitosis, and exhibits Ki value of 1 μM for inhibiting tubulin. Cemadotin hydrochloride can be used to research anticancer .
    Cemadotin hydrochloride
  • HY-12564
    Phthalazinone pyrazole

    		Aurora Kinase Apoptosis Mitosis Cancer
    Phthalazinone pyrazole is a potent, selective, and orally active inhibitor of Aurora-A kinase with an IC50 of 0.031 μM. Phthalazinone pyrazole can arrests mitosis and subsequently inhibit tumor growth via apoptosis of proliferating cells. Phthalazinone pyrazole suppresses the epithelial-mesenchymal transition (EMT) during the differentiation of hepatocyte-like cells (HLCs) from human embryonic stem cells .
    Phthalazinone pyrazole
  • HY-B2062
    Chlorthal-dimethyl
    1 Publications Verification

    Dimethyl tetrachloroterephthalate

    		 Biochemical Assay Reagents Mitosis Others
    Chlorthal-dimethyl (Dimethyl tetrachloroterephthalate) is a plant growth regulator. Chlorthal-dimethyl affects cell division and differentiation, interfering with the normal development of vascular tissue. Chlorthal-dimethyl causes localized swelling of tomato hypocotyls and disrupts normal mitosis in germinating millet seedlings .
    Chlorthal-dimethyl
  • HY-100789
    ON1231320
    1 Publications Verification

    		 Apoptosis Polo-like Kinase (PLK) Mitosis Cancer
    ON1231320 is a highly specific polo like kinase 2 (PLK2) inhibitor with an IC50 of 0.31 μM. ON1231320 blocks tumor cell cycle progression in the G2/M phase in mitosis, causing apoptotic cell death. ON1231320, an arylsulfonyl pyrido-pyrimidinone, has antitumor activity .
    ON1231320
  • HY-15995
    Tubulysin A
    1 Publications Verification

    TubA

    		 Antibiotic Microtubule/Tubulin ADC Payload Mitosis Cancer
    Tubulysin A (TubA) is an anticancer and antiangiogenic agent with anti-microtubule, anti-mitosis and anti-proliferative activity against a variety of cancer cells with IC50 values in the pmol range. It can induce apoptosis of cancer cells and has no effect on normal cells. Tubulysins are a group of potent cytotoxins consisting of nine members (A-I). Tubulysin A can synthesize ADC as ADC Cytotoxin .
    Tubulysin A
  • HY-155459
    Tubulin polymerization-IN-57

    		Microtubule/Tubulin Mitosis Cancer
    Tubulin polymerization-IN-57 (compound 5a) is a tubulin inhibitor and is an α-naphthoxy-substituted carbendazim (HY-13582) derivative. Tubulin polymerization-IN-57 induces mitotic arrest and inhibits cancer cell proliferation .
    Tubulin polymerization-IN-57
  • HY-112136
    TAO Kinase inhibitor 1
    3 Publications Verification

    CP 43

    		 MAP3K Mitosis Cancer
    TAO Kinase inhibitor 1 (compound 43) is a selective, ATP-competitive thousand-and-one amino acid kinases (TAOK) inhibitor with IC50s of 11 to 15 nM for TAOK1 and 2, respectively. TAO Kinase inhibitor 1 delays mitosis and induces mitotic cell death .
    TAO Kinase inhibitor 1
  • HY-13520R
    Nocodazole (Standard)

    		Bcr-Abl Autophagy Microtubule/Tubulin Apoptosis Mitosis Cancer
    Nocodazole (Standard) is the analytical standard of Nocodazole. This product is intended for research and analytical applications. Nocodazole (Oncodazole) is a rapidly-reversible inhibitor of microtubule. Nocodazole binds to β-tubulin and disrupts microtubule assembly/disassembly dynamics, which prevents mitosis and induces apoptosis in tumor cells. Nocodazole inhibits Bcr-Abl.
    Nocodazole (Standard)
  • HY-13691
    MKC-1

    Ro-31-7453

    		 Apoptosis Akt mTOR Microtubule/Tubulin Mitosis Cancer
    MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins including tubulin and members of the importin β family .
    MKC-1
  • HY-171184
    EAPB0503

    		PARP Bcr-Abl Apoptosis Mitosis Cancer
    EAPB0503 is a quinoline compound with anti-tumor activity, showing strong cytotoxicity against melanoma cells in vitro (IC50=200 nM). EAPB0503 can induce specific cell cycle arrest in mitosis of CML cells and directly activate apoptosis, leading to an increase in the G0 cell population, disruption of mitochondrial membrane potential, PARP cleavage, and DNA fragmentation. EAPB0503 also reduces the levels of BCR-ABL protein .
    EAPB0503
  • HY-13627
    Estramustine phosphate sodium
    1 Publications Verification

    		 Apoptosis Microtubule/Tubulin Mitosis Inflammation/Immunology Endocrinology Cancer
    Estramustine phosphate sodium, an estradiol analog, is an orally active antimicrotubule chemotherapy agent. Estramustine phosphate sodium depolymerises microtubules by binding to microtubule associated proteins (MAPs) and/or to tubulin. Estramustine phosphate sodium can interfere mitosis, trigger cell death and induce apoptosis, which can be used for the research of cancer like prostate cancer .
    Estramustine phosphate sodium
  • HY-13627A
    Estramustine phosphate

    		Apoptosis Microtubule/Tubulin Mitosis Inflammation/Immunology Endocrinology Cancer
    Estramustine phosphate, an estradiol analog, is an orally active antimicrotubule chemotherapy agent. Estramustine phosphate depolymerises microtubules by binding to microtubule associated proteins (MAPs) and/or to tubulin. Estramustine phosphate can interfere mitosis, trigger cell death and induce apoptosis, which can be used for the research of cancer like prostate cancer .
    Estramustine phosphate
  • HY-13224
    AZD4877

    		Kinesin Apoptosis Mitosis Cancer
    AZD4877 is another isostere to Ispinesib (HY-50759)and also a kinesin spindle protein (Eg5) inhibitor with IC50 of 2 nM.AZD4877 arrests cell mitosis, leads to the formation of the monopolar spindle phenotype and induces apoptosis. AZD4877 inhibits circulating peripheral blood mononuclear cells (PBMCs) and has anti-cancer activity .
    AZD4877
  • HY-W543137
    PT-ttpy

    		G-quadruplex DNA/RNA Synthesis Mitosis Cancer
    Pt-ttpy, a metallo-organic complex and potent G-quadruplex ligand, effectively triggers substantial telomere-related DNA damage in cancer cells by inhibiting telomerase and/or telomere functions, while also causing various chromatin abnormalities during mitosis, such as chromatin bridges, ultrafine bridges (UFBs), and double-stranded breaks (DSBs).
    PT-ttpy
  • HY-124761
    Poloppin

    		Polo-like Kinase (PLK) Autophagy Mitosis Cancer
    Poloppin is a potent, cell penetrant inhibitor of the mitotic Polo-like kinase (PLK) (IC50=26.9 μM) and prevents the protein-protein interaction via the Polo-box domain (PBD) (Kd= 29.5 μM). Poloppin selectively kills cells expressing mutant KRAS, enhancing death in mitosis. Poloppin is used for the study of KRAS-mutant cancers as single agents, or in combination with c-MET inhibitors .
    Poloppin
  • HY-155841
    Tubulin polymerization-IN-46

    		Microtubule/Tubulin Mitosis Cancer
    Tubulin polymerization-IN-46 (compound 9q) is a microtubule/Tubulin inhibitor that inhibits tubulin polymerization and induces apoptosis. Tubulin polymerization-IN-46 inhibits mitosis and arrests MCF-7 cells in the G2/M phase. Tubulin polymerization-IN-46 has anti-proliferative activity against MCF-7 breast cancer cells with an IC50 of 10 nM .
    Tubulin polymerization-IN-46
  • HY-105740
    Trenimon

    		DNA/RNA Synthesis Cancer
    Trenimon is a compound with anti-cancer effects. Trenimon shows mutagenic actions in many species by inducing point and chromosomal mutations, sister-chromatid exchanges, recombination phenomena and phage induction. Trenimon can be used for the research of cancer .
    Trenimon
  • HY-125956
    Aurkin A

    		Aurora Kinase Apoptosis Cancer
    Aurkin A is an allosteric inhibitor for the interaction between Aurora A Kinase (also known also Aurka) and TPX2, through targeting the TPX2 binding sites with Kd of 3.77 μM. Aurkin A can disrupt polyploidy induced by Alisertib (HY-10971) and increase apoptosis of tumor cells. Aurkin A can be used in research on mitosis and cancer .
    Aurkin A
  • HY-12797
    GF 15

    		Microtubule/Tubulin Mitosis Cancer
    GF 15 is an inhibitor of centrosomal clustering during cell mitosis, with an EC50 value of 900 nM for inducing multipolar spindles. GF 15 is a derivative of griseofulvin that inhibits tubulin polymerization at concentrations above 25 μM. GF 15 inhibits tumor growth and significantly prolongs survival in mouse xenograft models of human colon cancer and multiple myeloma .
    GF 15
  • HY-NP187
    Phytolacca americana Lectin

    PWM

    		 Biochemical Assay Reagents Mitosis
    Phytolacca americana Lectin (PWM) is a lectin that specific for N-acetylglucosamine-containing saccharides. Phytolacca americana Lectin stimulates peripheral lymphocytes to undergo mitosis by binding to their cell surfaces. Phytolacca americana Lectin can be used as a probe to specifically bind to biological molecules. Phytolacca americana Lectin is a biomaterial or organic compound that can be used in life science research .
    Phytolacca americana Lectin
  • HY-164519
    PF-7006

    		Apoptosis Mps1 Mitosis Cancer
    PF-7006 is an Mps1 kinase inhibitor with a Ki value of 0.27 nM and an IC50 value of 2.5 nM. PF-7006 interferes with cell cycle checkpoints by inhibiting the catalytic activity of Mps1, reducing histone H3 levels, and shortening the duration of mitosis, leading to apoptosis in cancer cells. Combined use of PF-7006 with Palbociclib (HY-50767) increases cancer cell tolerance to PF-7006. PF-7006 can be used for breast cancer research .
    PF-7006
  • HY-W130878
    4-Octylphenol

    		Complement System Toll-like Receptor (TLR) NF-κB Inflammation/Immunology
    4-Octylphenol is a hormone disruptor that has gender-specific effects on male reproductive cells, significantly reducing the mitotic index and the number of spermatogonia. 4-Octylphenol can cause inflammatory damage to fish gills by activating the complement system through the C3a/C3aR axis and the C5a/C5aR1 axis, this leads to complement activation and causes immune suppression due to the imbalance between Th1/Th2 cells and regulatory T cells (Treg)/Th17 cells, as well as inflammatory damage via the Toll-like receptor 7 (Toll-like Receptor (TLR))/IκBα/NF-κB pathway .
    4-Octylphenol
  • HY-B2062R
    Chlorthal-dimethyl (Standard)

    Dimethyl tetrachloroterephthalate (Standard)

    		 Drug Intermediate Mitosis Reference Standards Others
    Chlorthal-dimethyl (Standard) is the analytical standard of Chlorthal-dimethyl. This product is intended for research and analytical applications. Chlorthal-dimethyl (Dimethyl tetrachloroterephthalate) is a plant growth regulator. Chlorthal-dimethyl affects cell division and differentiation, interfering with the normal development of vascular tissue. Chlorthal-dimethyl causes localized swelling of tomato hypocotyls and disrupts normal mitosis in germinating millet seedlings .
    Chlorthal-dimethyl (Standard)
  • HY-150084
    (±)14,15-Epoxyeicosatrienoic acid

    (±)14(15)-EET

    		 Cytochrome P450 Mitosis Cancer
    (±)14,15-Epoxyeicosatrienoic acid ((±)14(15)-EET) is the Cytochrome P450 metabolite of arachidonic acid. While CYP3A4 may be involved in breast cancer cell growth, (±)14,15-Epoxyeicosatrienoic acid may promote mitosis and anchorage-dependent cloning through STAT3 affected by CYP3A4. (±)14,15-Epoxyeicosatrienoic acid exhibits STAT3-dependent cell growth promotion and may also participate in the autocrine/paracrine pathway that drives cell growth .
    (±)14,15-Epoxyeicosatrienoic acid

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