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Results for "

cathepsin cleavable

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (13) Apoptosis (1) Beta-secretase (2) Biochemical Assay Reagents (1) Drug-Linker Conjugates for ADC (6) Fluorescent Dye (1) Ser/Thr Protease (1) Topoisomerase (3)
By Research Areas:	Cancer (19) Inflammation/Immunology (1) Neurological Disease (2)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Targets Recommended: Cathepsin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-20336

Mc-Val-Cit-PABC-PNP 4 Publications Verification Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate	ADC Linker	Others Inflammation/Immunology Cancer
Mc-Val-Cit-PABC-PNP is a cathepsin cleavable linker for antibody-drug conjugates (ADCs) which couples the antibody element to the effecting compound. Mc-Val-Cit-PABC-PNP can be used in the synthesis of ADCs .

HY-129362

Phe-Lys(Fmoc)-PAB	ADC Linker	Cancer
Phe-Lys(Fmoc)-PAB is a cathepsin cleavable ADC linker used for the antibody-drug conjugates (ADCs) .

HY-129349

Phe-Lys(Trt)-PAB	ADC Linker	Cancer
Phe-Lys(Trt)-PAB is a cathepsin cleavable ADC linker used for the antibody-drug conjugates (ADCs) .

HY-136547

Boc-Val-Ala-PAB	ADC Linker	Others
Boc-Val-Ala-PAB is a cathepsin *cleavable* ADC linker that is used for making antibody-drug conjugate (ADCs) .

HY-W190913

DBCO-PEG4-Val-Cit-PAB-PNP	ADC Linker	Cancer
DBCO-PEG4-Val-Cit-PAB-PNP is a cleavable ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. PNP can be substituted by amine-containing payload. DBCO enable click chemistry with azide molecules.

HY-132973

MC-Val-Cit-PAB-NH-C2-NH-Boc	ADC Linker	Cancer
MC-Val-Cit-PAB-NH-C2-NH-Boc is a cathepsin cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-W071967

Alloc-Val-Ala-pAB	ADC Linker	Cancer
Alloc-Val-Ala-PAB is a peptide cleavable linker used in the synthesis of antibody-drug conjugates (ADCs). The Val-Ala will specifically be cleaved by Cathepsin B. The Alloc group is stable to treatment with piperidine and TFA, but can be easily removed under mild conditions by palladium catalyzed allyl transfer.

HY-48668

AcLys-PABC-VC-Aur0101 intermediate-1	ADC Linker	Cancer
AcLys-PABC-VC-Aur0101 intermediate-1 is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate .

HY-W591373

DBCO-PEG4-Val-Ala-PAB	ADC Linker	Cancer
DBCO-PEG4-Val-Ala-PAB is a cleavable ADC linker. The Val-Ala linkers can be cleaved by Cathepsin B. The DBCO groups is commonly used for Click Chemistry reactions. PEG spacer improves the compound's aqueous solubility.

HY-149931

BMV109	Fluorescent Dye	Cancer
BMV109 is a quenched probe that becomes fluorescent when cleaved and covalently bound by active cathepsin proteases. BMV109 can be exploited for tumor imaging .

HY-W591374

DBCO-PEG4-Val-Ala-PAB-PNP	ADC Linker	Cancer
DBCO-PEG4-Val-Ala-PAB-PNP is a cleavable ADC linker. The Val-Ala linkers can be cleaved by Cathepsin B. The DBCO groups is commonly used for Click Chemistry reactions. PEG spacer improves the compound's aqueous solubility. PNP is a good leaving group.

HY-160756A

Val-Cit-Exatecan TFA	Drug-Linker Conjugates for ADC	Cancer
Val-Cit-Exatecan TFA is an agent-linker conjugate for ADC. Val-Cit-Exatecan TFA is composed of a DNA topoisomerase I Exatecan (HY-13631) and a cathepsin cleavable ADC linker .

HY-P5377

Abz-HPGGPQ-EDDnp cathepsin K substrate	Ser/Thr Protease	Others
Abz-HPGGPQ-EDDnp (Cathepsin K substrate) is a biological active peptide. (Cathepsins are a class of globular lysosomal proteases, playing a vital role in mammalian cellular turnover. They degrade polypeptides and are distinguished by their substrate specificities. Cathepsin K is the lysosomal cysteine protease involved in bone remodeling and resorption. It has potential as a drug target in autoimmune diseases and osteoporosis.This FRET peptide can be used to monitor selectively cathepsin K activity in physiological fluids and cell lysates. Abz-HPGGPQ-EDDnp [where Abz represents o-aminobenzoic acid and EDDnp represents N -(2, 4-dinitrophenyl)-ethylenediamine], a substrate initially developed for trypanosomal enzymes, is efficiently cleaved at the Gly-Gly bond by cathepsin K. This peptide is resistant to hydrolysis by cathepsins B, F, H, L, S and V, Ex/Em=340 nm/420 nm.)

HY-W800814

Azido-PEG8-Amido-Val-Cit-PAB	ADC Linker	Cancer
Azido-PEG8-Amido-Val-Cit-PAB is a cleavable ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell. Azido will react with DBCO, BCN or other alkyne groups through click chemistry. PEG spacer increases aqueous solubility. Reagent grade, for research purpose.

HY-153031

Val-Cit-PAB-Exatecan Val-Cit-PAB-DX8951	Drug-Linker Conjugates for ADC Topoisomerase	Cancer
Val-Cit-PAB-Exatecan (Val-Cit-PAB-DX8951) is a agent-linker conjugate for ADC. Val-Cit-PAB-Exatecan is composed of a DNA topoisomerase I DX-8951 (HY-13631) and a cathepsin cleavable ADC linker .

HY-W591479

MC-Val-Ala-NHS ester	ADC Linker	Cancer
MC-Val-Ala-NHS ester is a cleavable ADC linker with a malimide group and an NHS ester group. The Val-Ala linkers can be cleaved by Cathepsin B. Maleimide group is reactive toward thiol groups. MC is reactive with thiol moieties. The NHS ester is able to react specifically and efficiently with amines (e.g. the side chain of lysine residues or aminosilane-coated surfaces) at neutral or slightly basic condition to form a covalent bond.

HY-145929

MC-Val-Cit-PAB-Exatecan MC-Val-Cit-PAB-DX8951	Drug-Linker Conjugates for ADC Topoisomerase	Cancer
MC-Val-Cit-PAB-Exatecan (MC-Val-Cit-PAB-DX8951) is a agent-linker conjugate for ADC. MC-Val-Cit-PAB-Exatecan is composed of a DNA topoisomerase I DX-8951 (HY-13631) and a cathepsin cleavable ADC linker.

HY-153031A

Val-Cit-PAB-Exatecan TFA Val-Cit-PAB-DX8951 TFA	Drug-Linker Conjugates for ADC Topoisomerase	Cancer
Val-Cit-PAB-Exatecan (Val-Cit-PAB-DX8951) TFA is a agent-linker conjugate for ADC. Val-Cit-PAB-Exatecan TFA is composed of a DNA topoisomerase I DX-8951 (HY-13631) and a cathepsin cleavable ADC linker .

HY-20336G

Mc-Val-Cit-PABC-PNP	ADC Linker	Cancer
Mc-Val-Cit-PABC-PNP GMP is a GMP grade Mc-Val-Cit-PABC-PNP (HY-20336). Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC linker. Mc-Val-Cit-PABC-PNP can be used in the synthesis of antibody-drug conjugates (ADCs) .

HY-112786

MC-Val-Cit-PAB-MMAF 2 Publications Verification Vc-MMAF	Drug-Linker Conjugates for ADC	Cancer
MC-Val-Cit-PAB-MMAF (Vc-MMAF) is a drug-linker conjugate for ADC by using the tubulin inhibitor, MMAF (HY-15579), linked via cathepsin cleavable MC-Val-Cit-PAB (HY-78738). MC-Val-Cit-PAB-MMAF shows antitumor activity .

HY-W076556

Alloc-Val-Ala-OH ((Allyloxy)carbonyl)-L-valyl-L-alanine	Biochemical Assay Reagents	Others
Alloc-Val-Ala-OH (((Allyloxy)carbonyl)-L-valyl-L-alanine) is a building block in the synthesis of Tesirine, a clinical antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. The Val-Ala will specifically be cleaved by Cathepsin B. The Alloc group is stable to treatment with piperidine and TFA, but can be easily removed under mild conditions by palladium catalyzed allyl transfer.

HY-13240A

LY2886721 hydrochloride	Beta-secretase	Neurological Disease
LY2886721 hydrochloride is a potent, selective and orally active *beta-site amyloid precursor protein cleaving* enzyme 1 (BACE1) inhibitor with an IC₅₀ of 20.3 nM for recombinant human BACE1*. LY2886721 hydrochloride is selectivity against cathepsin* D, pepsin, and renin, but lacking selectivity against BACE2 (IC₅₀ of 10.2 nM). LY2886721 hydrochloride can across blood-brain barrier and has the potential for Alzheimer's disease treatment .

HY-13240

LY2886721 2 Publications Verification	Beta-secretase	Neurological Disease
LY2886721 is a potent, selective and orally active *beta-site amyloid precursor protein cleaving* enzyme 1 (BACE1) inhibitor with an IC₅₀ of 20.3 nM for recombinant human BACE1*. LY2886721 is selectivity against cathepsin* D, pepsin, and renin, but lacking selectivity against BACE2 (IC₅₀ of 10.2 nM). LY2886721 can across blood-brain barrier and has the potential for Alzheimer's disease treatment .

HY-171509

Mal-N(Me)-C6-N(Me)-PNU-159682	Drug-Linker Conjugates for ADC Apoptosis	Cancer
Mal-N(Me)-C6-N(Me)-PNU-159682 (Compound 27), an agent-linker conjugate for ADC, consists the ADC linker Mal-N(Me)-C6-N(Me) and a potent ADC cytotoxin PNU-159682. Mal-N(Me)-C6-N(Me)-PNU-159682 (Compound 27) selectively delivers the payload to CD46-expressing cells, where the linker is cleaved by cathepsin B to release PNU-159682, inducing DNA damage and apoptosis. Mal-N(Me)-C6-N(Me)-PNU-159682 shows durable tumor regression in xenograft (PDX) models of non-small cell lung cancer (NSCLC) and colorectal cancer (CRC) .

Mc-Val-Cit-PABC-PNP (GMP)	Fluorescent Dye
Mc-Val-Cit-PABC-PNP GMP is a GMP grade Mc-Val-Cit-PABC-PNP (HY-20336). Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC linker. Mc-Val-Cit-PABC-PNP can be used in the synthesis of antibody-drug conjugates (ADCs) .

Mc-Val-Cit-PABC-PNP (GMP)	Biochemical Assay Reagents
Mc-Val-Cit-PABC-PNP GMP is a GMP grade Mc-Val-Cit-PABC-PNP (HY-20336). Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC linker. Mc-Val-Cit-PABC-PNP can be used in the synthesis of antibody-drug conjugates (ADCs) .

Cat. No.	Product Name	Target	Research Area

HY-P5377

Abz-HPGGPQ-EDDnp cathepsin K substrate	Ser/Thr Protease	Others
Abz-HPGGPQ-EDDnp (Cathepsin K substrate) is a biological active peptide. (Cathepsins are a class of globular lysosomal proteases, playing a vital role in mammalian cellular turnover. They degrade polypeptides and are distinguished by their substrate specificities. Cathepsin K is the lysosomal cysteine protease involved in bone remodeling and resorption. It has potential as a drug target in autoimmune diseases and osteoporosis.This FRET peptide can be used to monitor selectively cathepsin K activity in physiological fluids and cell lysates. Abz-HPGGPQ-EDDnp [where Abz represents o-aminobenzoic acid and EDDnp represents N -(2, 4-dinitrophenyl)-ethylenediamine], a substrate initially developed for trypanosomal enzymes, is efficiently cleaved at the Gly-Gly bond by cathepsin K. This peptide is resistant to hydrolysis by cathepsins B, F, H, L, S and V, Ex/Em=340 nm/420 nm.)

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