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cardiac output

" in MedChemExpress (MCE) Product Catalog:

35

Inhibitors & Agonists

2

Fluorescent Dye

2

Biochemical Assay Reagents

1

Peptides

5

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-12376
    BAY 41-2272
    3 Publications Verification

    		 Guanylate Cyclase Cardiovascular Disease Inflammation/Immunology
    BAY 41-2272 is an orally active and soluble guanylate cyclases (sGC) activator, which increases sGC activity by 400-fold in synergy with NO. BAY 41-2272 potently unloaded the heart, increased cardiac output, thus can be used for cardiovascular diseases research .
    BAY 41-2272
  • HY-D0711
    Indocyanine green
    Maximum Cited Publications
    27 Publications Verification

    Foxgreen; IC Green; Cardiogreen

    		 Fluorescent Dye Cancer
    Indocyanine green (Foxgreen) is a low toxicic fluorescent agent that has been widely used in medical diagnostics, such as determining cardiac output, hepatic function, and liver blood flow, and for ophthalmic angiography (Ex/Em = 785/813 nm) .
    Indocyanine green
  • HY-106690
    Centhaquin

    Centhaquine; PMZ-2010

    		 Others Cardiovascular Disease Inflammation/Immunology
    Centhaquine (Centhaquin; PMZ-2010) is a novel agent has the potential for treatment of haemorrhagic shock. Centhaquine (Centhaquin; PMZ-2010) can augment cardiac output, reduce systemic vascular resistance in haemorrhagic models .
    Centhaquin
  • HY-12376R
    BAY 41-2272 (Standard)

    		Guanylate Cyclase Cardiovascular Disease Inflammation/Immunology
    BAY 41-2272 (Standard) is the analytical standard of BAY 41-2272. This product is intended for research and analytical applications. BAY 41-2272 is an orally active and soluble guanylate cyclases (sGC) activator, which increases sGC activity by 400-fold in synergy with NO. BAY 41-2272 potently unloaded the heart, increased cardiac output, thus can be used for cardiovascular diseases research .
    BAY 41-2272 (Standard)
  • HY-129706
    LY127210 free base

    		Others Cardiovascular Disease
    LY127210 (free base) is a potent vasodilator with antihypertensive effects that reduces pressure in chloralose-anesthetized spontaneously hypertensive rats primarily by direct arteriolar dilation and to a lesser extent by decreasing cardiac output. LY127210 (free base) reduces blood pressure, heart rate and left ventricular end-diastolic pressure in hypertensive rats by reducing vascular resistance .
    LY127210 free base
  • HY-111018
    FPL 62129

    		Calcium Channel Cardiovascular Disease
    FPL 62129 is an antagonist for calcium channel. FPL 62129 reduces blood pressure and total peripheral resistance, increases the cardiac contractility and cardiac output in anarsthetised beagle model. FPL 62129 also serves as a vasodilator and a direct decelerator .
    FPL 62129
  • HY-105762A
    Etamiphyllin camsylate

    Etamiphylline camsylate

    		 Others Cardiovascular Disease
    Etamiphyllin camsylate (Etamiphylline camsylate) is a cardiac stimulant with oral activity that increases cardiac output without increasing heart rate. Etamiphyllin camsylate is also a respiratory stimulant used for respiratory failure, as Etamiphyllin camsylate relaxes the smooth muscles of the bronchi and bronchioles, thereby opening up the airways to relieve chronic obstructive pulmonary disease .
    Etamiphyllin camsylate
  • HY-B1660
    Guanadrel sulfate

    		Adrenergic Receptor Cardiovascular Disease
    Guanadrel sulfate is an orally active, potent and postganglionic sympathetic inhibitor. Guanadrel sulfate lowers blood pressure by reducing systemic vascular resistance with little effect on cardiac output. Guanadrel sulfate is promising for research of hypertension .
    Guanadrel sulfate
  • HY-P1428A
    RFRP-1(human) TFA

    		Neuropeptide Y Receptor Cardiovascular Disease
    RFRP-1(human) TFA is a potent endogenous NPFF receptor agonist (EC50 values are 0.0011 and 29 nM for NPFF2 and NPFF1, respectively). Attenuates contractile function of isolated rat and rabbit cardiac myocytes. Reduces heart rate, stroke volume, ejection fraction and cardiac output, and increases plasma prolactin levels in rats.
    RFRP-1(human) TFA
  • HY-157655
    Cafedrine-theodrenaline

    		Adrenergic Receptor Cardiovascular Disease
    Cafedrine-theodrenaline can stimulate the cardiovascular system through β-adrenergic receptor mediation, increasing arterial pressure, stroke volume, and cardiac output, while reducing peripheral vascular resistance, thereby supporting overall cardiac function. Cafedrine-theodrenaline helps maintain blood pressure during hypotensive episodes without causing significant tachycardia .
    Cafedrine-theodrenaline
  • HY-A0144A
    Etilefrine hydrochloride

    		Adrenergic Receptor AMPK Akt Cardiovascular Disease
    Etilefrine hydrochloride is a sympathetic nerve agonist and AMPK activator that selectively targets α1/β1 adrenergic receptors. Etilefrine hydrochloride stimulates α1 adrenergic receptors, leading to contraction of vascular smooth muscle and increased peripheral resistance. Etilefrine hydrochloride also stimulates β1 receptors to enhance myocardial contractility and increase heart rate, thereby increasing blood pressure and improving cardiac output. Etilefrine hydrochloride also bidirectionally regulates the AMPK/Akt pathway and modulates the phosphorylation levels. Etilefrine hydrochloride can be used in cardiovascular research, such as postural hypotension, chylothorax, and improving low cardiac output .
    Etilefrine hydrochloride
  • HY-A0144
    Etilefrine

    		Adrenergic Receptor AMPK Akt Cardiovascular Disease
    Etilefrine is a sympathetic nerve agonist and AMPK activator that selectively targets α1/β1 adrenergic receptors. Etilefrine stimulates α1 adrenergic receptors, leading to contraction of vascular smooth muscle and increased peripheral resistance. Etilefrine also stimulates β1 receptors to enhance myocardial contractility and increase heart rate, thereby increasing blood pressure and improving cardiac output. Etilefrine also bidirectionally regulates the AMPK/Akt pathway and modulates the phosphorylation levels. Etilefrine can be used in cardiovascular research, such as postural hypotension, chylothorax, and improving low cardiac output .
    Etilefrine
  • HY-W184837
    m-Nisoldipine

    KR-1008

    		 Calcium Channel Cardiovascular Disease
    m-Nisoldipine (KR-1008) is a dihydropyridine calcium antagonist that can significantly increase cardiac output and heart index, significantly reduce the negative inotropic effect on the myocardium, and has a relatively high selectivity for the thoracic aorta. m-Nisoldipine can be used in the research of cardiovascular diseases .
    m-Nisoldipine
  • HY-D0711R
    Indocyanine green (Standard)

    		Fluorescent Dye Others
    Indocyanine green (Standard) is the analytical standard of Indocyanine green. This product is intended for research and analytical applications. Indocyanine green (Foxgreen) is a low toxicic fluorescent agent that has been widely used in medical diagnostics, such as determining cardiac output, hepatic function, and liver blood flow, and for ophthalmic angiography .
    Indocyanine green (Standard)
  • HY-A0144AR
    Etilefrine hydrochloride (Standard)

    		Reference Standards AMPK Adrenergic Receptor Akt Cardiovascular Disease
    Etilefrine hydrochloride (Standard) is the analytical standard of Etilefrine hydrochloride (HY-A0144A). This product is intended for research and analytical applications. Etilefrine hydrochloride is a sympathetic nerve agonist and AMPK activator that selectively targets α1/β1 adrenergic receptors. Etilefrine hydrochloride stimulates α1 adrenergic receptors, leading to contraction of vascular smooth muscle and increased peripheral resistance. Etilefrine hydrochloride also stimulates β1 receptors to enhance myocardial contractility and increase heart rate, thereby increasing blood pressure and improving cardiac output. Etilefrine hydrochloride also bidirectionally regulates the AMPK/Akt pathway and modulates the phosphorylation levels. Etilefrine hydrochloride can be used in cardiovascular research, such as postural hypotension, chylothorax, and improving low cardiac output .
    Etilefrine hydrochloride (Standard)
  • HY-106973A
    Nolomirole hydrochloride

    CHF 1035

    		 Dopamine Receptor Adrenergic Receptor Cardiovascular Disease
    Nolomirole (CHF 1035) hydrochloride is an orally active and selective DA2 dopaminergic receptor/α2-adrenoceptor agonist. Nolomirole attenuates the heart failure signs in the Monocrotaline (HY-N0750)-induced congestive heart failure model. Nolomirole increases cardiac output .
    Nolomirole hydrochloride
  • HY-106690R
    Centhaquin (Standard)

    		Others Cardiovascular Disease Inflammation/Immunology
    Centhaquin (Standard) is the analytical standard of Centhaquin. This product is intended for research and analytical applications. Centhaquine (Centhaquin; PMZ-2010) is a novel agent has the potential for treatment of haemorrhagic shock. Centhaquine (Centhaquin; PMZ-2010) can augment cardiac output, reduce systemic vascular resistance in haemorrhagic models .
    Centhaquin (Standard)
  • HY-106973
    Nolomirole

    CHF 1035 free base

    		 Dopamine Receptor Adrenergic Receptor Cardiovascular Disease
    Nolomirole (CHF 1035) is an orally active and selective DA2 dopaminergic receptor/α2-adrenoceptor agonist. Nolomirole attenuates the heart failure signs in the Monocrotaline (HY-N0750)-induced congestive heart failure model. Nolomirole increases cardiac output .
    Nolomirole
  • HY-167741
    Chlorisondamine

    		nAChR Cardiovascular Disease Neurological Disease
    Chlorisondamine is a nicotinic antagonist that acts as a ganglionic blocker and has been utilized to evaluate the neurogenic contributions to blood pressure and sympathetic vasomotor tone in animal models. Chlorisondamine has demonstrated antihypertensive properties, primarily being assessed through its effects on blood pressure, cardiac output, and heart rate in various experimental settings, particularly in mice.
    Chlorisondamine
  • HY-D0711S2
    Indocyanine green-d7

    Foxgreen-d7; IC Green-d7; Cardiogreen-d7

    		 Isotope-Labeled Compounds Fluorescent Dye Others
    Indocyanine green-d7 (Foxgreen-d7) is the deuterium labeled Indocyanine green (HY-D0711). Indocyanine green is a low toxicic fluorescent agent that has been widely used in medical diagnostics, such as determining cardiac output, hepatic function, and liver blood flow, and for ophthalmic angiography .
    Indocyanine green-d7
  • HY-133036
    APJ receptor agonist 1

    		Apelin Receptor (APJ) Cardiovascular Disease
    APJ receptor agonist 1, a biphenyl acid derivative, is a potent APJ receptor (APJ-R) agonist (EC50s 0.093 and 0.12 nM for human and rat APJ-R, respectively). APJ receptor agonist 1 displays in vitro potency to apelin-13, the endogenous peptidic ligand for the APJ receptor. APJ receptor agonist 1 has the potential for the research of heart failure .
    APJ receptor agonist 1
  • HY-B1108
    Labetalol hydrochloride
    4 Publications Verification

    AH-5158 hydrochloride; Sch-15719W

    		 Adrenergic Receptor Cardiovascular Disease Inflammation/Immunology Endocrinology
    Labetalol (AH5158) hydrochloride is an orally available, selective α1-adrenergic recepto and non-selective β-adrenergic receptor competitive antagonist. Labetalol hydrochloride is an antihypertensive molecule that partially crosses the blood-brain barrier and has little effect on cardiac output. Labetalol hydrochloride can be used in the study of cardiovascular diseases, such as hypertension during pregnancy .
    Labetalol hydrochloride
  • HY-121383
    Labetalol
    4 Publications Verification

    AH5158; Sch-15719W free base

    		 Adrenergic Receptor Cardiovascular Disease Inflammation/Immunology Endocrinology
    Labetalol (AH5158) is an orally available, selective α1-adrenergic recepto and non-selective β-adrenergic receptor competitive antagonist. Labetalol is an antihypertensive molecule that partially crosses the blood-brain barrier and has little effect on cardiac output. Labetalol can be used in the study of cardiovascular diseases, such as hypertension during pregnancy .
    Labetalol
  • HY-101390B
    Niguldipine free base

    		Calcium Channel Cardiovascular Disease
    Niguldipine free base is a calcium channel blocker with activity in regulating cardiovascular function. Niguldipine free base can reduce systolic and diastolic blood pressure, thereby increasing heart rate and cardiac output. Niguldipine free base exhibits dose-dependent and sustained increases in coronary blood flow. Niguldipine free base also increases perfusion in the kidneys and femoral arteries, but the effect is temporary and to a lesser extent. The effect of Niguldipine free base on myocardial metabolism is not significant .
    Niguldipine free base
  • HY-121383R
    Labetalol (Standard)

    AH5158 (Standard); Sch-15719W free base (Standard)

    		 Adrenergic Receptor Cardiovascular Disease Inflammation/Immunology Endocrinology
    Labetalol (Standard) is the analytical standard of Labetalol. This product is intended for research and analytical applications. Labetalol (AH5158) is an orally available, selective α1-adrenergic recepto and non-selective β-adrenergic receptor competitive antagonist. Labetalol is an antihypertensive molecule that partially crosses the blood-brain barrier and has little effect on cardiac output. Labetalol can be used in the study of cardiovascular diseases, such as hypertension during pregnancy .
    Labetalol (Standard)
  • HY-B1108R
    Labetalol hydrochloride (Standard)
    3 Publications Verification

    AH-5158 hydrochloride(Standard); Sch-15719W (Standard)

    		 Adrenergic Receptor Cardiovascular Disease Inflammation/Immunology Endocrinology
    Labetalol hydrochloride (Standard) is the analytical standard of Labetalol hydrochloride (HY-B1108). This product is intended for research and analytical applications. Labetalol (AH5158) hydrochloride is an orally available, selective α1-adrenergic recepto and non-selective β-adrenergic receptor competitive antagonist. Labetalol hydrochloride is an antihypertensive molecule that partially crosses the blood-brain barrier and has little effect on cardiac output. Labetalol hydrochloride can be used in the study of cardiovascular diseases, such as hypertension during pregnancy .
    Labetalol hydrochloride (Standard)
  • HY-W728545
    Labetalol-d6 hydrochloride

    AH5158-d6 hydrochloride; Sch-15719W-d6

    		 Isotope-Labeled Compounds Cardiovascular Disease Inflammation/Immunology Endocrinology
    Labetalol hydrochloride-d6 (AH-5158 hydrochloride-d6) is deuterium labeled Labetalol hydrochloride (HY-B1108). Labetalol (AH5158) hydrochloride is an orally available, selective α1-adrenergic recepto and non-selective β-adrenergic receptor competitive antagonist. Labetalol hydrochloride is an antihypertensive molecule that partially crosses the blood-brain barrier and has little effect on cardiac output. Labetalol hydrochloride can be used in the study of cardiovascular diseases, such as hypertension during pregnancy .
    Labetalol-d6 hydrochloride
  • HY-134043
    Chlorthalidone Impurity G

    Chlorthalidone EP Impurity G

    		 Carbonic Anhydrase Cardiovascular Disease
    Chlorthalidone Impurity G (Chlorthalidone EP Impurity G) is a potential impurity found in commercial preparations of chlorthalidone with moderate antihypertensive effects. Chlorthalidone is a thiazide diuretic that inhibits the Na+/Cl- cotransporter in the distal tubule of the kidney, thereby preventing sodium and chloride reabsorption, resulting in decreased plasma volume and cardiac output. It also inhibits carbonic anhydrase (CA), including isoenzymes CAVB, VII, IX, XII, and XIII (Kis=2.8-23 nM) and to a lesser extent CAI, CAII, IV, VA, and VI (Ki=138-1,347 nM), mediating vasodilatory activity.
    Chlorthalidone Impurity G
  • HY-B1108S
    Labetalol hydrochloride-d5

    AH-5158 hydrochloride-d5; Sch-15719W-d5

    		 Isotope-Labeled Compounds Cardiovascular Disease Inflammation/Immunology Endocrinology
    Labetalol hydrochloride-d5 (AH-5158 hydrochloride-d5) is deuterium labeled Labetalol hydrochloride (HY-B1108). Labetalol (AH5158) hydrochloride is an orally available, selective α1-adrenergic recepto and non-selective β-adrenergic receptor competitive antagonist. Labetalol hydrochloride is an antihypertensive molecule that partially crosses the blood-brain barrier and has little effect on cardiac output. Labetalol hydrochloride can be used in the study of cardiovascular diseases, such as hypertension during pregnancy .
    Labetalol hydrochloride-d5
  • HY-15746
    Dobutamine hydrochloride
    3 Publications Verification

    		 Adrenergic Receptor Cardiovascular Disease Endocrinology Cancer
    Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion .
    Dobutamine hydrochloride
  • HY-15746A
    Dobutamine

    		Adrenergic Receptor Cardiovascular Disease Endocrinology Cancer
    Dobutamine is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine can increase cardiac output and correct hypoperfusion .
    Dobutamine
  • HY-15746B
    Dobutamine tartrate

    		Adrenergic Receptor Cardiovascular Disease Endocrinology Cancer
    Dobutamine tartrate is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine tartrate is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine tartrate can increase cardiac output and correct hypoperfusion .
    Dobutamine tartrate
  • HY-15746S1
    (rac)-Dobutamine-d6 hydrochloride

    		Isotope-Labeled Compounds Adrenergic Receptor Cardiovascular Disease Endocrinology
    (rac)-Dobutamine-d6 (hydrochloride) is a labelled racemic Dobutamine hydrochloride. Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion .
    (rac)-Dobutamine-d6 hydrochloride
  • HY-15746S
    (rac)-Dobutamine-d4 hydrochloride

    		Isotope-Labeled Compounds Adrenergic Receptor Cardiovascular Disease Endocrinology
    (rac)-Dobutamine-d4 (hydrochloride) is a labelled racemic Dobutamine hydrochloride. Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion .
    (rac)-Dobutamine-d4 hydrochloride
  • HY-15746R
    Dobutamine (hydrochloride) (Standard)

    		Adrenergic Receptor Cardiovascular Disease Endocrinology Cancer
    Dobutamine (hydrochloride) (Standard) is the analytical standard of Dobutamine (hydrochloride). This product is intended for research and analytical applications. Dobutamine hydrochloride is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine hydrochloride is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine hydrochloride can increase cardiac output and correct hypoperfusion .
    Dobutamine (hydrochloride) (Standard)

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