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c-ros oncogene 1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ROS Kinase (2) Anaplastic lymphoma kinase (ALK) (1) Apoptosis (1) c-Met/HGFR (1) PROTACs (1) TAM Receptor (1)
By Research Areas:	Cancer (2)
Click Chemistry:	Azide (1)

2

Inhibitors & Agonists

1

Recombinant Proteins

1

Antibodies

1

Click Chemistry

Targets Recommended: ROS Kinase Reactive Oxygen Species (ROS)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

SIAIS039	PROTACs ROS Kinase Apoptosis	Cancer
SIAIS039 is an orally active c-ros oncogene 1 (ROS1)-specific PROTAC with DC₅₀s of 154.46 nM, 126.47 nM, 143.69 nM for HCC78 cells, Ba/F3 expressing the CD74-ROS1 fusion and Ba/F3 expressing the SDC4-ROS1 fusion, respectively. SIAIS039 suppresses cell proliferation, induces cell cycle arrest and apoptosis, and inhibits clonogenicity against ROS1-positive cells. SIAIS039 demonstrates anti-tumour effects against ROS1-driven tumor growth vivo. SIAIS039 is composed of the ALK inhibitor Brigatinib (HY-12857), a linker EM-12 (HY-138793), and a VHL ligand E3 ubiquitin ligase 1-Butyne (Red: Brigatinib; Blue: VHL ligand; Black: linker) .

SMU-B	ROS Kinase Anaplastic lymphoma kinase (ALK) TAM Receptor c-Met/HGFR	Cancer
SMU-B is the orally active inhibitor for ALK (IC₅₀<0.5 nM), **c-ros oncogene 1 (ROS1), c-MET (IC₅₀=1.87 nM) and AXL (IC₅₀=28.9 nM). SMU-B inhibits the proliferation of MKN45, H1993 and H441 with IC₅₀**s of 0.02 μM, 1.58 μM and 2.82 μM, respectively. SMU-B exhibits antitumor efficacy in mouse models .

Cat. No.	Compare	Product Name	Species	Source

	ROS1 Protein, Human (sf9, His) ros1; ros proto-oncogene 1, receptor tyrosine kinase; ros; MCF3; c-ros-1	Human	Sf9 insect cells
	ROS1 Protein, Human (sf9, His) is the recombinant human-derived ROS1, expressed by Sf9 insect cells , with His labeled tag. ,

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	ROS1 Antibody (YA6747) c ros 1 antibody; c ros antibody; c ros oncogene 1 receptor tyrosine kinase antibody; c ros receptor tyrosine kinase antibody; c ros1 antibody; MCF 3 antibody; MCF3 antibody; oncogene ros antibody; OTTHUMP00000017814 antibody; OTTHUMP00000017815 antibody; c ros 1 antibody; c ros antibody; c ros oncogene 1 receptor tyrosine kinase antibody; c ros receptor tyrosine kinase antibody; c ros1 antibody; MCF 3 antibody; MCF3 antibody; oncogene ros antibody; OTTHUMP00000017814 antibody; OTTHUMP00000017815 antibody; OTTHUMP00000040389 antibody; Proto oncogene c ros 1 protein antibody; Proto oncogene c ros antibody; Proto oncogene tyrosine protein kinase ros antibody; Proto oncogene tyrosine protein kinase ros precursor antibody; Proto-oncogene c-ros-1 antibody; Proto-oncogene tyrosine-protein kinase ros antibody; Receptor tyrosine kinase c ros oncogene 1 antibody; ros 1 antibody; ros 1C antibody; ros antibody; ros proto oncogene 1 , receptor tyrosine kinase antibody; ros_HUMAN antibody; ros1 antibody; ros1C antibody; Transmembrane tyrosine specific protein kinase antibody; v ros avian UR2 sarcoma virus oncogene homolog 1 antibody; v ros UR2 sarcoma virus oncogene homolog 1 antibody	IHC-P	Human

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Cat. No.	Product Name		Classification

SIAIS039		Azide
SIAIS039 is an orally active c-ros oncogene 1 (ROS1)-specific PROTAC with DC₅₀s of 154.46 nM, 126.47 nM, 143.69 nM for HCC78 cells, Ba/F3 expressing the CD74-ROS1 fusion and Ba/F3 expressing the SDC4-ROS1 fusion, respectively. SIAIS039 suppresses cell proliferation, induces cell cycle arrest and apoptosis, and inhibits clonogenicity against ROS1-positive cells. SIAIS039 demonstrates anti-tumour effects against ROS1-driven tumor growth vivo. SIAIS039 is composed of the ALK inhibitor Brigatinib (HY-12857), a linker EM-12 (HY-138793), and a VHL ligand E3 ubiquitin ligase 1-Butyne (Red: Brigatinib; Blue: VHL ligand; Black: linker) .

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