c-Met/HGFR

By Targets:	c-Met/HGFR (6) VEGFR (2)
By Research Areas:	Cancer (4) Inflammation/Immunology (2) Neurological Disease (1)

Targets Recommended: c-Met/HGFR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12423A

Pamufetinib mesylate TAS-115 mesylate	VEGFR c-Met/HGFR	Cancer
Pamufetinib (TAS-115) mesylate is a potent VEGFRand hepatocyte growth factor receptor (c-Met/HGFR)-targeted kinase inhibitor, with IC₅₀s of 30 and 32 nM for rVEGFR2 and rMET, respectively.

HY-12423

Pamufetinib TAS-115	VEGFR c-Met/HGFR	Cancer
Pamufetinib (TAS-115) is a potent VEGFR and hepatocyte growth factor receptor (c-Met/HGFR)-targeted kinase inhibitor with IC₅₀s of 30 and 32 nM for rVEGFR2 and rMET, respectively.

HY-132814

Fosgonimeton ATH-1017	c-Met/HGFR	Neurological Disease
Fosgonimeton (ATH-1017) is a hepatocyte growth factor receptor (c-Met/HGFR) agonist. Fosgonimeton has neuroprotective effects in both LPS (HY-D1056) -induced neuroinflammation and Aβ-induced AD models .

HY-P991177

*Anti-c-Met/HGFR* Antibody**	c-Met/HGFR	Cancer
Anti-c-Met/HGFR Antibody is a humanized IgG1 monoclonal antibody that targets *c-Met*. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-148803

Vabametkib	c-Met/HGFR	Cancer
Vabametkib is a potent inhibitor of hepatocyte growth factor receptor (HGFR). Vabametkib inhibits Hs746T cells proliferation and inhibits *c-Met* with an IC₅₀ value of 7 nM. Vabametkib can be used as an antineoplastic agent .

HY-P990661

SAIT-301	c-Met/HGFR	Inflammation/Immunology
SAIT-301 is a humanized antibody expressed in CHO cells, targeting *HGFR/c-Met*. SAIT-301 has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for SAIT-301 can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

Cat. No.	Product Name

HY-L016

Protein Tyrosine Kinase Compound Library	1,304 compounds
Protein tyrosine kinases (PTKs) are key signaling molecules and important drug targets. Two classes of PTKs are present in cells: the transmembrane receptor PTKs (RTKs) and the nonreceptor PTKs. The RTK family includes the receptors for insulin and for many growth factors, such as EGFR, FGFR, PDGFR, VEGFR, and NGFR. RTKs are transmembrane glycoproteins that are activated by the binding of their ligands, and they transduce the extracellular signal to the cytoplasm by phosphorylating tyrosine residues on the receptors themselves (autophosphorylation) and on downstream signaling proteins. Their principal functions of PTKs involve the regulation of multicellular aspects of the organism. Cell to cell signals concerning growth, differentiation, adhesion, motility, and death are frequently transmitted through tyrosine kinases. In humans, tyrosine kinases have been demonstrated to play significant roles in the development of many disease states, including diabetes and cancers. MCE designs a unique collection of 1,304 compounds that act as a useful tool for PTKs-related drug screening and disease research.

Protein Tyrosine Kinase Compound Library

1,304 compounds

Protein tyrosine kinases (PTKs) are key signaling molecules and important drug targets. Two classes of PTKs are present in cells: the transmembrane receptor PTKs (RTKs) and the nonreceptor PTKs. The RTK family includes the receptors for insulin and for many growth factors, such as EGFR, FGFR, PDGFR, VEGFR, and NGFR. RTKs are transmembrane glycoproteins that are activated by the binding of their ligands, and they transduce the extracellular signal to the cytoplasm by phosphorylating tyrosine residues on the receptors themselves (autophosphorylation) and on downstream signaling proteins. Their principal functions of PTKs involve the regulation of multicellular aspects of the organism. Cell to cell signals concerning growth, differentiation, adhesion, motility, and death are frequently transmitted through tyrosine kinases. In humans, tyrosine kinases have been demonstrated to play significant roles in the development of many disease states, including diabetes and cancers.

MCE designs a unique collection of 1,304 compounds that act as a useful tool for PTKs-related drug screening and disease research.

HY-L101

Anti-Liver Cancer Compound Library	2,344 compounds
Liver cancer is one of the leading malignancies which occupies the second position in cancer deaths worldwide, becoming serious threat to human health. Hepatocellular carcinoma (HCC), also known as hepatoma is the most common type accounting for approximately 90% of all liver cancers. Current evidence indicates that during hepatocarcinogenesis, two main pathogenic mechanisms prevail: (1) cirrhosis associated with hepatic regeneration after tissue damage caused by hepatitis infection, toxins or metabolic influences, and (2) mutations occurring in single or multiple oncogenes or tumor suppressor genes. Both mechanisms have been linked with alterations in several important cellular signaling pathways. These include the RAF/MEK/ERK pathway, PI3K/AKT/mTOR pathway, WNT/b-catenin pathway, insulin-like growth factor pathway, c-MET/HGFR pathway , etc. MCE offers a unique collection of 2,344 compounds with identified and potential anti-liver cancer activity. MCE anti-liver cancer compound library is a useful tool for anti-liver cancer drugs screening and other related research.

Anti-Liver Cancer Compound Library

2,344 compounds

Liver cancer is one of the leading malignancies which occupies the second position in cancer deaths worldwide, becoming serious threat to human health. Hepatocellular carcinoma (HCC), also known as hepatoma is the most common type accounting for approximately 90% of all liver cancers.

Current evidence indicates that during hepatocarcinogenesis, two main pathogenic mechanisms prevail: (1) cirrhosis associated with hepatic regeneration after tissue damage caused by hepatitis infection, toxins or metabolic influences, and (2) mutations occurring in single or multiple oncogenes or tumor suppressor genes. Both mechanisms have been linked with alterations in several important cellular signaling pathways. These include the RAF/MEK/ERK pathway, PI3K/AKT/mTOR pathway, WNT/b-catenin pathway, insulin-like growth factor pathway, c-MET/HGFR pathway , etc.

MCE offers a unique collection of 2,344 compounds with identified and potential anti-liver cancer activity. MCE anti-liver cancer compound library is a useful tool for anti-liver cancer drugs screening and other related research.

Cat. No.	Product Name	Target	Research Area

HY-P991177

*Anti-c-Met/HGFR* Antibody**	c-Met/HGFR	Cancer
Anti-c-Met/HGFR Antibody is a humanized IgG1 monoclonal antibody that targets *c-Met*. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990432

*Anti-HGFR/c-Met* Antibody**	Inhibitory Antibodies	Inflammation/Immunology

HY-P990661

SAIT-301	c-Met/HGFR	Inflammation/Immunology
SAIT-301 is a humanized antibody expressed in CHO cells, targeting *HGFR/c-Met*. SAIT-301 has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for SAIT-301 can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

Recombinant Proteins Recommended:

c-Met/HGFR

Species:	Human (5) Mouse (1) Cynomolgus (1)
Tag:	His (6) Avi (2) Fc (1)
Source:	HEK293 (7)

Cat. No.	Compare	Product Name	Species	Source

HY-P70714

	HGFR Protein, Human (HEK293, His) Hepatocyte growth factor receptor; HGF receptor; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met; Met	Human	HEK293
	The HGFR protein is a receptor tyrosine kinase that transduces signals by binding to hepatocyte growth factor/HGF ligand. It regulates proliferation, scattering, morphogenesis, and cell survival. HGFR Protein, Human (HEK293, His) is the recombinant human-derived HGFR protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70715

	HGFR Protein, Human (HEK293, Fc) Hepatocyte growth factor receptor; HGF receptor; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met; Met	Human	HEK293
	The HGFR protein is a receptor tyrosine kinase that transduces signals by binding to hepatocyte growth factor/HGF ligand. It regulates proliferation, scattering, morphogenesis, and cell survival. HGFR Protein, Human (HEK293, Fc) is the recombinant human-derived HGFR protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P78490

	HGFR Protein, Human (HEK293, His-Avi) Met; oncogene Met; HGF R; HGF/SF receptor; AUTS9; cMet; Met (c-Met); RCCP2; SF receptor	Human	HEK293
	The HGFR protein is a receptor tyrosine kinase that transduces signals by binding to hepatocyte growth factor/HGF ligand. It regulates proliferation, scattering, morphogenesis, and cell survival. HGFR Protein, Human (HEK293, His-Avi) is the recombinant human-derived HGFR protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P701263

	FITC-Labeled HGFR Protein, Human (HEK293, His) Met; AUTS9; HGFR; RCCP2; c-Met	Human	HEK293
	The HGFR protein is a receptor tyrosine kinase that transduces signals by binding to hepatocyte growth factor/HGF ligand. It regulates proliferation, scattering, morphogenesis, and cell survival. FITC-Labeled HGFR Protein, Human (HEK293, His) is the recombinant human-derived FITC-Labeled HGFR protein, expressed by HEK293 , with His labeled tag.

HY-P72376

	HGFR Protein, Human (Biotinylated, HEK293, His-Avi) Hepatocyte growth factor receptor; Proto-oncogene c-Met; SF receptor; Tyrosine-protein kinase Met; Met	Human	HEK293
	The HGFR protein is a receptor tyrosine kinase that transduces signals by binding to hepatocyte growth factor/HGF ligand. It regulates proliferation, scattering, morphogenesis, and cell survival. HGFR Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived HGFR protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag.

HY-P703800

	HGFR Protein, Cynomolgus (HEK293, His) Met; oncogene Met; HGF R; HGF/SF receptor; AUTS9; cMet; Met (c-Met); RCCP2; SF receptor	Cynomolgus	HEK293

HY-P703728

	HGFR Protein, Mouse (907a.a, HEK293, His) Hepatocyte growth factor receptor; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met; Met; HGF receptor	Mouse	HEK293

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HY-P84014

	MET Antibody (YA3711) HGFR; AUTS9; RCCP2; c-Met; DFNB97	WB, IHC-P, ICC/IF, FC, ELISA	Human, Monkey

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