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c-MYC/BCL2 ligand 1

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-174403

    Bcl-2 Family c-Myc Apoptosis Cancer
    c-MYC/BCL2 ligand 1 (iodide) is a dual-targeting c-MYC/Bcl-2 G4 ligand with Kd values of 0.90 μM (c-MYC G4) and 0.56μM (Bcl-2 G4). c-MYC/BCL2 ligand 1 (iodide) inhibits c-MYC and Bcl-2 gene transcription by binding to G4-forming sequences and downregulates their protein expression. c-MYC/BCL2 ligand 1 (iodide) inhibits suppresses migration, induces caspase-dependent apoptosis, and triggers cell cycle G1 arrest in MCF-7 cells. c-MYC/BCL2 ligand 1 (iodide) significantly suppresses tumor growth in a 4T1 syngeneic model with no observable toxicity. c-MYC/BCL2 ligand 1 (iodide) can be used for the research of breast Cancer[1].
    c-MYC/BCL2 ligand 1 iodide

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