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asialoglycoprotein receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Biochemical Assay Reagents (3) Drug Intermediate (1) Liposome (2) LYTACs (11) Transthyretin (TTR) (2)
By Research Areas:	Cancer (4) Cardiovascular Disease (1) Metabolic Disease (4) Neurological Disease (2)
Click Chemistry:	DBCO (1)
Oligonucleotides:	Pegylated Lipids (1) Antisense Oligonucleotides (2) Cholesterol (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Recombinant Proteins

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-147354

TriGalNAc CBz	LYTACs	Cardiovascular Disease
TriGalNAc CBz is a GalNAc derivative and tri-GalNAc is an asialoglycoprotein receptor (ASGPR) ligand. TriGalNAc CBz can be used for mRNA drug delivery as well as lysosomal targeted chimerism (LYTAC) studies .

HY-148118A

Tri-GalNAc(OAc)3 TFA	LYTACs	Cancer
Tri-GalNAc(OAc)3 TFA is a trivalent N-acetylgalactosamine (GalNAc) derivative that can be used to synthesize GalNAc-LYTAC. Tri-GalNAc is a specific ligand targeting the asialoglycoprotein receptor (ASGPR), mediating the endocytosis and transport of cell surface proteins (such as EGFR, HER2) to lysosomes for degradation by lysosomal targeting chimeras (LYTACs). Tri-GalNAc significantly reduces the level of target proteins and inhibits downstream signaling pathways (such as EGFR-mediated Akt and MAPK signals). Tri-GalNAc(OAc)3 TFA can be used for hepatocyte targeting studies, and can degrade carcinogenic membrane proteins and inhibit tumor cell proliferation in liver cancer cell models .

HY-139482

tri-GalNAc-COOH	LYTACs	Cancer
tri-GalNAc-COOH is an asialoglycoprotein receptor (ASGPR) ligand that can be used for LYsosome TArgeting Chimera (LYTAC) research .

HY-157950

DSPE-PEG2000-triGalNAc ammonium	Liposome	Cancer
DSPE-PEG2K-triGalNAc is a polar lipid composed of DSPE and tri-N-acetylgalactosamine that can be used to construct liposomes target to asialoglycoprotein receptor (ASGPR).

HY-156994

ASGPR ligand-1	LYTACs	Others
ASGPR ligand-1 is an asialoglycoprotein receptor (ASGPR) ligand compound. ASGPR ligand-1 can be used for kinds of diseases research .

HY-164863

β-GalNAc-PEG4-Azide	Biochemical Assay Reagents	Others
β-GalNAc-PEG4-Azide is an **asialoglycoprotein receptor** ligand with PEG4 linker and azide group that can be utilized in onward click chemistry .

HY-142885

M-MoDE-A (2)	LYTACs	Others
M-MoDE-A (2) is a bifunctional small molecule that mediates the degradation of extracellular proteins through the asialoglycoprotein receptor (ASGPR).

HY-142881

D-MoDE-A (1)	LYTACs	Others
D-MoDE-A (1) is a bifunctional small molecule that mediates the degradation of extracellular proteins through the asialoglycoprotein receptor (ASGPR).

HY-153527

GalNac-L96 analog	LYTACs	Metabolic Disease
GalNAc-L96 analog is an intermediate in the synthesis of the asialoglycoprotein receptor (ASGPR) ligand GalNAc-L96 (HY-147012).

HY-153184

GalNAc-L96 free base	Others	Others
GalNAc-L96 free base is a triantennary GalNAc ligand that can be used for the synthesis of GalNAc-siRNA . GalNAc is a ligand of ASGPR (asialoglycoprotein receptor).

HY-147012

GalNAc-L96	Drug Intermediate	Others
GalNAc-L96, a triantennary N-acetylgalactosamine (GalNAc), is a ligand of asialoglycoprotein receptor (ASGPR). GalNAc-L96 can be used to synthesize GalNAc-siRNA and can be used for oligonucleotide delivery .

HY-173247

GalNAc-NAG37 phosphoramidite	Biochemical Assay Reagents	Others
GalNAc-NAG37 phosphoramidite, a N-acetylgalactosamine (GalNAc) derivative, is a ligand of asialoglycoprotein receptor (ASGPR). GalNAc-NAG37 phosphoramidite can be used to synthesize GalNAc-siRNA and can be used for oligonucleotide delivery .

HY-147102

tri-GalNAc biotin	LYTACs	Metabolic Disease
tri-GalNAc biotin is a biotinylated ASGPR (Asialoglycoprotein receptor) ligand. tri-GalNAc biotin promotes cellular uptake of neutravidin (NA) via ASGPR. tri-GalNAc biotin delivers neutravidin to lysosomes for degradation. tri-GalNAc biotin can be used for research of LYsosome TArgeting Chimera (LYTAC) .

HY-112752

Gal-C4-Chol	Liposome	Others
Gal-C4-Chol is a glycosylated cholesterol derivative. Gal-C4-Chol can be used as a ligand for asialoglycoprotein receptors (ASGPR) to prepare Galactosylated (Gal) liposomes. Gal-C4-Chol can be used to prepare simple lipid-based nanoparticles .

HY-148476

Tri-GalNAc-DBCO	LYTACs Biochemical Assay Reagents	Metabolic Disease
Tri-GalNAc-DBCO is a synthetic ligand composed of three GalNAc units linked to DBCO. Tri-GalNAc-DBCO can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing an azide group. Tri-GalNAc-DBCO specifically binds to the asialoglycoprotein receptor (ASGPR). Tri-GalNAc-DBCO directs the conjugated molecule to the lysosome for degradation via receptor-mediated endocytosis. Tri-GalNAc-DBCO can be used in the study of liver-related diseases .

HY-145368B

Tri-GalNAc(OAc)3-Perfluorophenyl	LYTACs	Metabolic Disease
Tri-GalNAc(OAc)3-Perfluorophenyl is a pentafluorophenyl modified Tri-GalNAc(OAc)3 (HY-148118), a tri-GalNAc ligand that can be used for the synthesis of GalNAc-LYTAC. GalNAc-LYTAC engages the asialoglycoprotein receptor for targeted protein degradation.Tri-GalNAc(OAc)3-Perfluorophenyl can be used for the study of liver metabolism .

HY-148118

Tri-GalNAc(OAc)3	LYTACs	Cancer
Tri-GalNAc(OAc)3is a trivalent N-acetylgalactosamine (GalNAc) derivative that can be used to synthesize GalNAc-LYTAC. Tri-GalNAc is a specific ligand targeting the asialoglycoprotein receptor (ASGPR), mediating the endocytosis and transport of cell surface proteins (such as EGFR, HER2) to lysosomes for degradation by lysosomal targeting chimeras (LYTACs). Tri-GalNAc significantly reduces the level of target proteins and inhibits downstream signaling pathways (such as EGFR-mediated Akt and MAPK signals). Tri-GalNAc(OAc)3can be used for hepatocyte targeting studies, and can degrade carcinogenic membrane proteins and inhibit tumor cell proliferation in liver cancer cell models .

HY-148089A

Eplontersen sodium	Transthyretin (TTR)	Neurological Disease
Eplontersen sodium the sodium salt form of Eplontersen (HY-148089). Eplontersen sodium is a triantennary N-acetyl galactosamine (GalNAc₃-7a)-conjugated antisense oligonucleotide targeting transthyretin (TTR) mRNA to inhibit production of both variant and wild-type TTR protein. Misfolded TTR induces amyloid fibrils formation in the heart and peripheral nerves, leads to amyloid TTR (ATTR) amyloidosis diseases .

HY-148089

Eplontersen	Transthyretin (TTR)	Neurological Disease
Eplontersen is a triantennary N-acetyl galactosamine (GalNAc₃-7a)-conjugated antisense oligonucleotide targeting transthyretin (TTR) mRNA to inhibit production of both variant and wild-type TTR protein. Misfolded TTR induces amyloid fibrils formation in the heart and peripheral nerves, leads to amyloid TTR (ATTR) amyloidosis diseases .

Cat. No.	Product Name	Type

HY-173247

GalNAc-NAG37 phosphoramidite	Gene Sequencing and Synthesis
GalNAc-NAG37 phosphoramidite, a N-acetylgalactosamine (GalNAc) derivative, is a ligand of asialoglycoprotein receptor (ASGPR). GalNAc-NAG37 phosphoramidite can be used to synthesize GalNAc-siRNA and can be used for oligonucleotide delivery .

HY-112752

Gal-C4-Chol	Drug Delivery
Gal-C4-Chol is a glycosylated cholesterol derivative. Gal-C4-Chol can be used as a ligand for asialoglycoprotein receptors (ASGPR) to prepare Galactosylated (Gal) liposomes. Gal-C4-Chol can be used to prepare simple lipid-based nanoparticles .

Species:	Human (3) Mouse (4)
Tag:	His (5) SUMO (1) Fc (2)
Source:	HEK293 (6) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P7610

	ASGR1/ASGPR1 Protein, Human (HEK293, His) rHuASGR1, His; asialoglycoprotein receptor 1, ASGR1,	Human	HEK293
	ASGR1/ASGPR1 Protein, Human (HEK293, His), a recombinant human Asialoglycoprotein Receptor 1 produced in HEK293 cells, has a His tag. Asialoglycoprotein receptor 1 is a specific cell-surface marker for isolating hepatocytes derived from human pluripotent stem cells.

HY-P75498

	ASGR1/ASGPR1 Protein, Mouse (HEK293, His) ASGPR; ASGPR1; ASGR1; asialoglycoprotein receptor 1; CLEC4H1; Hepatic lectin H1; MHL1	Mouse	HEK293
	ASGR1/ASGPR1 proteins play a crucial role in cellular processes by mediating endocytosis of desialylated plasma glycoproteins and recognizing terminal galactose and N-acetylgalactosamine. It promotes ligand internalization and formation of complexes that are transported to sorting organelles. ASGR1/ASGPR1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ASGR1/ASGPR1 protein, expressed by HEK293 , with N-His labeled tag.

HY-P76736

	ASGR2/ASGPR2 Protein, Human (HEK293, His) Asgr2; Asgr-2; asialoglycoprotein receptor 2; ASGP-R 2; ASGPR 2; Hepatic lectin 2; HL-2; mHL-2	Human	HEK293
	ASGR2 mediates endocytosis of desialylated glycoproteins, recognizing galactose and N-acetylgalactosamine units. Ligand binding leads to internalization and sorting organelle transport, followed by receptor return to the cell membrane. The receptor is suggested to function as a dimer. ASGR2 also interacts with LASS2. ASGR2/ASGPR2 Protein, Human (HEK293, His) is the recombinant human-derived ASGR2 protein, expressed by HEK293 , with N-His labeled tag.

HY-P704413

	ASGR1/ASGPR1 Protein, Human (HEK293, hFc) rHuASGR1, His; asialoglycoprotein receptor 1, ASGR1,	Human	HEK293
	ASGR1/ASGPR1 mediates endocytosis of desialylated glycoproteins, recognizing galactose and N-acetylgalactosamine units. Ligand binding leads to internalization and sorting organelle transport, followed by receptor return to the cell membrane. ASGR1/ASGPR1 interacts with LASS2. ASGR1/ASGPR1 Protein, Human (HEK293, hFc) is the recombinant human-derived ASGR1/ASGPR1 protein, expressed by HEK293, with N-hFc labeled tag.

HY-P704414

	ASGR1/ASGPR1 Protein, Mouse (HEK293, hFc) ASGPR; ASGPR1; ASGR1; asialoglycoprotein receptor 1; CLEC4H1; Hepatic lectin H1; MHL1	Mouse	HEK293
	ASGR1/ASGPR1 proteins play a crucial role in cellular processes by mediating endocytosis of desialylated plasma glycoproteins and recognizing terminal galactose and N-acetylgalactosamine. It promotes ligand internalization and formation of complexes that are transported to sorting organelles. ASGR1/ASGPR1 Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived ASGR1/ASGPR1 protein, expressed by HEK293, with N-hFc labeled tag.

HY-P77555

	ASGR1/ASGPR1 Protein, Mouse (Biotinylated, HEK293, His) ASGPR; ASGPR1; ASGR1; asialoglycoprotein receptor 1; CLEC4H1; Hepatic lectin H1; MHL1	Mouse	HEK293
	ASGR1/ASGPR1 proteins play a crucial role in cellular processes by mediating endocytosis of desialylated plasma glycoproteins and recognizing terminal galactose and N-acetylgalactosamine. It promotes ligand internalization and formation of complexes that are transported to sorting organelles. ASGR1/ASGPR1 Protein, Mouse (Biotinylated, HEK293, His) is the recombinant mouse-derived ASGR1/ASGPR1 protein, expressed by HEK293 , with N-His labeled tag.

HY-P72091

	ASGR2/ASGPR2 Protein, Mouse (His-SUMO) Asgr2; Asgr-2; asialoglycoprotein receptor 2; ASGP-R 2; ASGPR 2; Hepatic lectin 2; HL-2; mHL-2	Mouse	E. coli
	ASGR2/ASGPR2 proteins are critical in cellular processes, mediating the endocytosis of desialylated plasma glycoproteins. It recognizes terminal galactose and N-acetylgalactosamine, promotes ligand internalization, and forms complexes that are transported to sorting organelles. ASGR2/ASGPR2 Protein, Mouse (His-SUMO) is the recombinant mouse-derived ASGR2/ASGPR2 protein, expressed by E. coli , with N-10*His, N-SUMO labeled tag.

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Cat. No.	Product Name		Classification

HY-148476

Tri-GalNAc-DBCO		DBCO
Tri-GalNAc-DBCO is a synthetic ligand composed of three GalNAc units linked to DBCO. Tri-GalNAc-DBCO can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing an azide group. Tri-GalNAc-DBCO specifically binds to the asialoglycoprotein receptor (ASGPR). Tri-GalNAc-DBCO directs the conjugated molecule to the lysosome for degradation via receptor-mediated endocytosis. Tri-GalNAc-DBCO can be used in the study of liver-related diseases .

Cat. No.	Product Name		Classification

HY-157950

DSPE-PEG2000-triGalNAc ammonium		Pegylated Lipids
DSPE-PEG2K-triGalNAc is a polar lipid composed of DSPE and tri-N-acetylgalactosamine that can be used to construct liposomes target to asialoglycoprotein receptor (ASGPR).

HY-148089A

Eplontersen sodium		Antisense Oligonucleotides
Eplontersen sodium the sodium salt form of Eplontersen (HY-148089). Eplontersen sodium is a triantennary N-acetyl galactosamine (GalNAc₃-7a)-conjugated antisense oligonucleotide targeting transthyretin (TTR) mRNA to inhibit production of both variant and wild-type TTR protein. Misfolded TTR induces amyloid fibrils formation in the heart and peripheral nerves, leads to amyloid TTR (ATTR) amyloidosis diseases .

HY-112752

Gal-C4-Chol		Cholesterol
Gal-C4-Chol is a glycosylated cholesterol derivative. Gal-C4-Chol can be used as a ligand for asialoglycoprotein receptors (ASGPR) to prepare Galactosylated (Gal) liposomes. Gal-C4-Chol can be used to prepare simple lipid-based nanoparticles .

HY-148089

Eplontersen		Antisense Oligonucleotides
Eplontersen is a triantennary N-acetyl galactosamine (GalNAc₃-7a)-conjugated antisense oligonucleotide targeting transthyretin (TTR) mRNA to inhibit production of both variant and wild-type TTR protein. Misfolded TTR induces amyloid fibrils formation in the heart and peripheral nerves, leads to amyloid TTR (ATTR) amyloidosis diseases .

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