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Pathways Recommended:	Antibody-drug Conjugate/ADC Related

Results for "

antineoplastic drugs

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibody-Drug Conjugates (ADCs) (1) Drug Intermediate (3) Drug Metabolite (1) Drug-Linker Conjugates for ADC (1) ADC Payload (1) Apoptosis (4) Autophagy (1) DNA Alkylator/Crosslinker (4) DNA/RNA Synthesis (3) EGFR (1) Endogenous Metabolite (3) Ferroptosis (1) Isotope-Labeled Compounds (1) Lipoxygenase (1) Microtubule/Tubulin (2) Pyroptosis (1) STING (1) Topoisomerase (1)
By Research Areas:	Cancer (13) Inflammation/Immunology (5) Metabolic Disease (3)

Inhibitors & Agonists

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Drug Metabolite Drug Intermediate Drug Isomer Drug Derivative Antibody-Drug Conjugates (ADCs) Radionuclide-Drug Conjugates (RDCs) Peptide-Drug Conjugates (PDCs) Drug-Linker Conjugates for ADC

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-131468

Picoplatin AMD473; ZD0473	DNA/RNA Synthesis	Cancer
Picoplatin (AMD473) is a platinum-based antineoplastic agent. Picoplatin is specifically to circumvent thiol-mediated drug resistance by sterically hindering its reaction with glutathione (GSH) while still retaining the ability to form cytotoxic lesions with DNA .

HY-W010255A

Phenylglyoxylic acid sodium Benzoylformic acid sodium	Endogenous Metabolite Drug Intermediate	Metabolic Disease Inflammation/Immunology
Phenylglyoxylic acid sodium (Benzoylformic acid sodium) is a metabolite of ethylbenzene and styrene (EB/S) and can be used as a biomarker of exposure to EB/S in human. Phenylglyoxylic acid sodium can be used as drug intermediate for synthesis of antineoplastic compounds .

HY-W010255

Phenylglyoxylic acid Benzoylformic acid	Endogenous Metabolite Drug Intermediate	Metabolic Disease Inflammation/Immunology
Phenylglyoxylic acid (Benzoylformic acid) is a metabolite of ethylbenzene and styrene (EB/S) and can be used as a biomarker of exposure to EB/S in human. Phenylglyoxylic acid can be used as drug intermediate for synthesis of antineoplastic compounds .

HY-147408

Rezetecán SHR9265	Topoisomerase ADC Payload	Cancer
Rezetecán (SHR9265) is a topoisomerase I inhibitor. In addition, Rezetecán can be used to synthesize Trastuzumab rezetecan, an antineoplastic agent. Rezetecán can be used as a cytotoxic payload (ADC Cytotoxin) in antibody-drug conjugates (ADCs) .

HY-P99334

Vorsetuzumab mafodotin Anti-Human CD70 Recombinant Antibody; SGN-75	Antibody-Drug Conjugates (ADCs) Microtubule/Tubulin	Cancer
Vorsetuzumab mafodotin (SGN-75) is an Auristatin-based anti-CD70 *antibody-drug* conjugate (ADC)*. Vorsetuzumab mafodotin consists of a humanized monoclonal antibody, Vorsetuzumab and an ADC cytotoxin MMAF. Vorsetuzumab mafodotin has antineoplastic* activity .

HY-17394

Cisplatin 600+ Cited Publications cis-Platinum; CDDP; cis-Diaminodichloroplatinum	DNA Alkylator/Crosslinker Ferroptosis Autophagy Pyroptosis Lipoxygenase	Cancer
Cisplatin (CDDP) is an antineoplastic chemotherapy agent by cross-linking with DNA and causing DNA damage in cancer cells. Cisplatin activates ferroptosis and induces autophagy .

HY-16372

CP 461 OSI-461	Apoptosis Microtubule/Tubulin	Cancer
CP-461 (OSI-461) is a selective apoptotic antineoplastic drug (SAAND) by engaging tubulin on colchicine site

HY-W190927

MC-Val-Cit-Doxorubicin	Drug-Linker Conjugates for ADC	Cancer
MC-Val-Cit-Doxorubicin is drug-linker conjugate for ADC. The maleimide can conjugate with thiol containing molecules. Doxorubicin is an anthracycline antibiotic with antineoplastic activity

HY-152861

Dazostinag TAK-676 free base	STING	Cancer
Dazostinag (TAK-676 free base) is an agonist of stimulator of interferon genes (STING) protein with antineoplastic activity. Dazostinag can serve as a playload to synthesis *antibody-drug* conjugates (ADCs)** .

HY-13550A

Ametantrone acetate NSC 196473 acetate; NSC 290813 acetate	DNA/RNA Synthesis	Cancer
Ametantrone acetate (NSC 196473 acetate) is an antineoplastic drug with topoisomerase II inhibitory activity. Ametantrone acetate causes covalent cross-linking of DNA. The pharmacokinetic profile of Ametantrone acetate has been confirmed in clinical trials, and its elimination pathway in the body indicates the existence of a major metabolic pathway .

HY-138627B

AST5902 mesylate	EGFR Drug Metabolite	Cancer
AST5902 mesylate is a principal metabolite of Alflutinib, exhibiting significant antineoplastic activity. AST5902 mesylate contributes to the overall pharmacological effects in the treatment of non-small cell lung cancer. AST5902 mesylate is involved in the response to activating EGFR mutations and can help overcome EGFR T790M drug-resistant mutations.

HY-W750144

Phenylglyoxylic acid-13C8 Benzoylformic acid-¹³C₈	Isotope-Labeled Compounds Endogenous Metabolite Drug Intermediate	Metabolic Disease
Phenylglyoxylic acid- ¹³C₈ (Benzoylformic acid- ¹³C₈) is the ¹³C-labeled Phenylglyoxylic acid (HY-W010255). Phenylglyoxylic acid (Benzoylformic acid) is a metabolite of ethylbenzene and styrene (EB/S) and can be used as a biomarker of exposure to EB/S in human. Phenylglyoxylic acid can be used as drug intermediate for synthesis of antineoplastic compounds .

HY-B0245R

Busulfan (Standard)	DNA Alkylator/Crosslinker Apoptosis	Inflammation/Immunology Cancer
Busulfan (Standard) is the analytical standard of Busulfan. This product is intended for research and analytical applications. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .

HY-B0245S

Busulfan-d8	DNA Alkylator/Crosslinker Apoptosis	Inflammation/Immunology Cancer
Busulfan-d₈ is a deuterium labeled Busulfan. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .

HY-B0245

Busulfan 10+ Cited Publications	DNA Alkylator/Crosslinker Apoptosis	Inflammation/Immunology Cancer
Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .

HY-U00279B

Nitracrine hydrochloride	DNA/RNA Synthesis	Cancer
Nitracrine hydrochloride is a platinum-based antineoplastic drug with selective toxicity to hypoxic cells. Nitracrine hydrochloride exhibits significant cytotoxicity against the Chinese hamster ovary cell line AA8 under hypoxic conditions. Nitracrine hydrochloride exerts its effect by binding to the insertion of DNA and forming covalent adducts. The cytotoxicity of Nitracrine hydrochloride under hypoxic conditions is related to its reductive metabolism to form alkylated substances. At the same time, it may enhance the reactivity to DNA through the insertion of DNA, thereby improving the efficacy. Nitracrine hydrochloride can also inhibit RNA synthesis, contributing to its anti-tumor effect .

Cat. No.	Product Name	Target	Research Area

HY-P99334

Vorsetuzumab mafodotin Anti-Human CD70 Recombinant Antibody; SGN-75	Antibody-Drug Conjugates (ADCs) Microtubule/Tubulin	Cancer
Vorsetuzumab mafodotin (SGN-75) is an Auristatin-based anti-CD70 *antibody-drug* conjugate (ADC)*. Vorsetuzumab mafodotin consists of a humanized monoclonal antibody, Vorsetuzumab and an ADC cytotoxin MMAF. Vorsetuzumab mafodotin has antineoplastic* activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W010255

Phenylglyoxylic acid Benzoylformic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Drug Intermediate
Phenylglyoxylic acid (Benzoylformic acid) is a metabolite of ethylbenzene and styrene (EB/S) and can be used as a biomarker of exposure to EB/S in human. Phenylglyoxylic acid can be used as drug intermediate for synthesis of antineoplastic compounds .

Cat. No.	Product Name	Chemical Structure

HY-B0245S

Busulfan-d8
Busulfan-d₈ is a deuterium labeled Busulfan. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .

HY-W750144

Phenylglyoxylic acid-13C8
Phenylglyoxylic acid- ¹³C₈ (Benzoylformic acid- ¹³C₈) is the ¹³C-labeled Phenylglyoxylic acid (HY-W010255). Phenylglyoxylic acid (Benzoylformic acid) is a metabolite of ethylbenzene and styrene (EB/S) and can be used as a biomarker of exposure to EB/S in human. Phenylglyoxylic acid can be used as drug intermediate for synthesis of antineoplastic compounds .

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antineoplastic drugs

Inhibitors & Agonists

Inhibitory Antibodies

NaturalProducts

Isotope-Labeled Compounds

Natural
Products