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Results for "

aminopyridine

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (1) Apoptosis (1) Autophagy (1) Biochemical Assay Reagents (4) c-Met/HGFR (1) Cholinesterase (ChE) (1) Drug Metabolite (1) Endogenous Metabolite (1) Endothelin Receptor (1) FLT3 (1) GCGR (3) GLP Receptor (2) GnRH Receptor (1) Isotope-Labeled Compounds (1) Melanocortin Receptor (1) Parasite (1) Potassium Channel (3) Radionuclide-Drug Conjugates (RDCs) (2) Renin (1) Sodium Channel (2) Somatostatin Receptor (3) Trk Receptor (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (1) Endocrinology (2) Inflammation/Immunology (1) Metabolic Disease (7) Neurological Disease (5)

By Targets:

Amyloid-β (1)

Apoptosis (1)

Autophagy (1)

Biochemical Assay Reagents (4)

c-Met/HGFR (1)

Cholinesterase (ChE) (1)

Drug Metabolite (1)

Endogenous Metabolite (1)

Endothelin Receptor (1)

FLT3 (1)

GCGR (3)

GLP Receptor (2)

GnRH Receptor (1)

Isotope-Labeled Compounds (1)

Melanocortin Receptor (1)

Parasite (1)

Potassium Channel (3)

Radionuclide-Drug Conjugates (RDCs) (2)

Renin (1)

Sodium Channel (2)

Somatostatin Receptor (3)

Trk Receptor (1)

By Research Areas:

Cancer (6)

Cardiovascular Disease (1)

Endocrinology (2)

Inflammation/Immunology (1)

Metabolic Disease (7)

Neurological Disease (5)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W008188

3-Hydroxy-4-aminopyridine	Endogenous Metabolite	Metabolic Disease
3-Hydroxy-4-aminopyridine is an endogenous metabolite.

HY-W002874

*Methyl 3-aminopyridine-4-carboxylate*	Biochemical Assay Reagents	Others
Methyl 3-aminopyridine-4-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W005558

*6-Aminopyridine-3-boronic acid*	Biochemical Assay Reagents	Others
6-Aminopyridine-3-boronic acid is a boronic acid derivative. Boronic acid derivatives are widely used in organic synthesis for carbon-carbon bond formation. In Suzuki coupling, aryl halides and boronic acid aryl or vinyl esters or boronic acid are coupled using Pd(PPh3)4. It can be used as a pharmaceutical intermediate ^{[1] ^.}

HY-W002540

6-Aminopicolinic acid	Biochemical Assay Reagents	Others
6-Aminopyridine-2-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W003145

Methyl 2-aminoisonicotinate Methyl 2-aminopyridine-4-carboxylate	Biochemical Assay Reagents	Others
Methyl 2-aminoisonicotinate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W195933

*6-Aminopyridine-3-thioamide*	Others
6-Aminopyridine-3-thioamide is a compound with anti-tumor activity that can inhibit the activity of specific enzymes, thereby affecting cell proliferation and survival. 6-Aminopyridine-3-thioamide has also been studied for the inhibition of neurodegenerative diseases and has shown the potential to improve neurological function. The structural characteristics of 6-Aminopyridine-3-thioamide make it an important bioactive molecule in compound development.

HY-123237

KRC-108	c-Met/HGFR FLT3 Trk Receptor Apoptosis Autophagy	Cancer
KRC-108, an aminopyridine, is an orally active multiple kinase inhibitor with IC₅₀s of 80 nM, 23 nM, 3 nM, 70 nM, 30 nM, 39 nM for c-Met, c-Met M1250T, c-Met Y1230D, Ron, Flt3 and TrkA, respectively. KRC-108 induces cell cycle arrest, apoptotic cell death, and autophagy. KRC-108 exhibits anti-tumor activity in vivo in HT29 colorectal cancer, NCI-H441 lung cancer xenograft models in athymic BALB/c nu/nu mice .

HY-137208

Chondroitin disaccharide Δdi-0S sodium	Drug Metabolite	Inflammation/Immunology
Chondroitin disaccharide Δdi-0S sodium is an unsaturated disaccharide produced by the degradation of Chondroitin sulfate (HY-B2162). Chondroitin disaccharide Δdi-0S sodium produces fluorescent pyridylamino derivative with 2-aminopyridine, which can be used in studies about the metabolic pathway of Chondroitin sulfate and related disease mechanisms .

HY-106017

Nerispirdine	Potassium Channel Sodium Channel	Neurological Disease
Nerispirdine is an ion channel inhibitor with IC₅₀s of 3.6, 3.7 and 11.9 μM against K(v)1.1, K(v)1.2 and voltage-dependent Na(+) channel, respectively. Nerispirdine is a 4-aminopyridine (4-AP, HY-B0604) derivative and can be utilized in research on neurological disorders .

HY-108578

RuBi-4AP	Potassium Channel	Neurological Disease
RuBi-4AP, a derivative of 4-aminopyridine (4AP; HY-B0604), is a caged K_v channel blocker. RuBi-4AP contains a photolabile protecting group, allowing its effect to be controlled precisely in both space and time with light. RuBi-4AP can be used for the research of neuronal excitability, synaptic transmission, and signal propagation .

HY-Y1770S

*2-Amino-5-bromopyridine-d3* 5-Bromo-2-pyridinamine-d₃; 5-Bromo-2-aminopyridine-d₃	Isotope-Labeled Compounds	Others
2-Amino-5-bromopyridine-d₃ is the deuterium labeled 2-Amino-5-bromopyridine .

HY-P2075

EMD 55068	Renin	Endocrinology
EMD 55068 is a renin antagonist. EMD 55068 inhibits the uptake of taurocholate .

HY-P2336A

CCZ01048 TFA 2 Publications Verification	Melanocortin Receptor	Cancer
CCZ01048 TFA, a α-MSH analogue, exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a K_i of 0.31 nM. CCZ01048 TFA shows rapid internalization into B16F10 melanoma cells and high in vivo stability. CCZ01048 TFA is a promising candidate for PET imaging of malignant melanoma .

HY-P10472

Azaline B	GnRH Receptor	Endocrinology
Azaline B is an antagonist for gonadotropin-releasing hormone (GnRH) with IC₅₀ of 1.37 nM, Azaline B can be used in research of sex hormone-related pathological states, ovulation induction and male contraception .

HY-P4757

N1-Glutathionyl-spermidine disulfide	Parasite	Others
N1-Glutathionyl-spermidine disulfide is a substrate of trypanothione reductase .

HY-P10341

ZP3022	GCGR	Metabolic Disease
ZP3022 is a dual agonist of glucagon-like peptide-1 (GLP-1) and gastrin that has the ability to sustainably improve glycemic control. Additionally, ZP3022 can effectively increase β-cell mass, promote β-cell proliferation, and enhance the function of pancreatic islets. ZP3022 can be used in anti-diabetic research .

HY-W027553

Ipidacrine NIK-247 free base	Cholinesterase (ChE) Potassium Channel Sodium Channel	Neurological Disease Metabolic Disease
Ipidacrine is orally active and brain-penetrant AChE and BuChE inhibitors with IC₅₀ values of 1 μM and 1.9 μM, respectively, which is also a partial agonist of M2-cholinergic receptors and a reversible cholinesterase inhibitor. Ipidacrine has a stimulating effect on neuromuscular transmission and excitation along the nerve fibres with a moderately anti-pain effect. Ipidacrine is an aminopyridines and is structurally similar to Tacrine (HY-111338). Ipidacrine is effective in various amnesia models, improves erectile function and inhibits K ⁺ and Na ⁺-channels in the neuronal membrane in diabetic rats. Ipidacrine is promising for research of Alzheimer’s disease, ischaemic stroke, idiopathic neuropathy of the facial nerve, diabetes mellitus-induced erectile dysfunction and other deficits in central or peripheral cholinergic deseases .

HY-P10876

mcK6A1	Amyloid-β	Neurological Disease
mcK6A1 is an inhibitor for the aggregation of amyloid-β (Aβ), that selectively binds to the 16KLVFFA21 segment of Aβ42, forms an extended β-folded structure, and inhibits the formation of Aβ42 oligomers. mcK6A1 can be used in research of Alzheimer's disease and other amyloid-related diseases .

HY-P4146

Survodutide BI 456906	GLP Receptor GCGR	Metabolic Disease
Survodutide (BI 456906) is a potent, selective glucagon receptor/GLP-1 receptor (GCGR/GLP-1R) dual agonist with EC₅₀s of 0.52 nM and 0.33 nM in CHO-K1 cells, respectively. Survodutide, a 29-amino-acid peptide, is a potent acylated peptide containing a C18 fatty acid. Survodutide has robust anti-obesity efficacy achieved by increasing energy expenditure and decreasing food intake .

HY-P4146A

Survodutide TFA BI 456906 TFA	GLP Receptor GCGR	Metabolic Disease
Survodutide (BI 456906) TFA is a potent, selective glucagon receptor/GLP-1 receptor (GCGR/GLP-1R) dual agonist with EC₅₀s of 0.52 nM and 0.33 nM in CHO-K1 cells, respectively. Survodutide TFA, a 29-amino-acid peptide, is a potent acylated peptide containing a C18 fatty acid. Survodutide TFA has robust anti-obesity efficacy achieved by increasing energy expenditure and decreasing food intake .

HY-P2434

AP102	Somatostatin Receptor	Neurological Disease Metabolic Disease Cancer
AP102 is a dual SSTR2/SSTR5-specific somatostatin analog (SSA). AP102 is a disulfide-bridged octapeptide SSA containing synthetic iodinated amino acids. AP102 binds with subnanomolar affinity to SSTR2 and SSTR5 (IC₅₀: 0.63 and 0.65 nM, respectively). AP102 does not bind to SSTR1 or SSTR3. AP102 can be used for acromegaly and neuroendocrine tumors research .

HY-P5362A

NODAGA-LM3 TFA	Radionuclide-Drug Conjugates (RDCs) Somatostatin Receptor	Cancer
NODAGA-LM3 TFA can be labeled by ⁶⁸Ga for PET imaging. ⁶⁸Ga-NODAGA-LM3 TFA is a SSTR2 antagonist, and can be used for imaging of SSTR positive paragangliomas. NODAGA-LM3 TFA can be labeled with [68Ga] for the synthesis/research of Radionuclide-Drug Conjugates (RDCs) .

HY-P5362

NODAGA-LM3	Radionuclide-Drug Conjugates (RDCs) Somatostatin Receptor	Cancer
NODAGA-LM3 can be labeled by ⁶⁸Ga for PET imaging. ⁶⁸Ga-NODAGA-LM3 is a SSTR2 antagonist, and can be used for imaging of SSTR positive paragangliomas. NODAGA-LM3 can be labeled with [68Ga] for the synthesis/research of Radionuclide-Drug Conjugates (RDCs) .

HY-105168

TAK 044	Endothelin Receptor	Cardiovascular Disease
TAK 044 is an antagonist of Endothelin Receptor. TAK 044 strongly inhibits ET-induced deterioration in various animal models. TAK 044 can be used in study ET-related diseases such as acute myocardial infarction,acute renal failure, acute hepatic malfunction, and subarachnoid hemorrhage .

*Methyl 3-aminopyridine-4-carboxylate*	Biochemical Assay Reagents
Methyl 3-aminopyridine-4-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

6-Aminopicolinic acid	Biochemical Assay Reagents
6-Aminopyridine-2-carboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Methyl 2-aminoisonicotinate Methyl 2-aminopyridine-4-carboxylate	Biochemical Assay Reagents
Methyl 2-aminoisonicotinate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Cat. No.	Product Name	Target	Research Area