Search Result
Results for "
alkylating agent
" in MedChemExpress (MCE) Product Catalog:
3
Biochemical Assay Reagents
13
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-W019815
-
ENU; N-Nitroso-N-ethylurea
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DNA/RNA Synthesis
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Neurological Disease
Cancer
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N-Ethyl-N-nitrosourea (ENU) is a DNA alkylating agent. N-Ethyl-N-nitrosourea induces leukemia by alkylating nucleobases, disrupting DNA, and resulting in bone marrow suppression and the formation of leukemic cells. N-Ethyl-N-nitrosourea is teratogenic in vivo, inducing tumor formation and paw malformations in pregnant rats. N-Ethyl-N-nitrosourea cause central nervous system (CNS) tumors and genetic disorders .
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-
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- HY-B0181
-
-
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- HY-115826
-
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Biochemical Assay Reagents
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Cancer
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AB-163 is an alkylating agent with anti-tumor activity. AB-163 exerts LD50s of 198 (p.o.) and 159 (i.p.) mg/kg in ICR/Ha male mice and can be utilized in cancer research .
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- HY-105815
-
|
DNA Alkylator/Crosslinker
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Cancer
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Chlornaphazine, a nitrogen mustard derivative, is a bifunctional alkylating agent. Chlornaphazine is an antineoplastic agent, which can be used for the study of polycythemia vera and Hodgkin’s disease .
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-
-
- HY-19412
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NSC-281612
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DNA Alkylator/Crosslinker
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Cancer
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DMS-612 (NSC-281612) is an alkylating agent with anti-renal cell carcinoma activity. DMS-612 can be used in cancer research .
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-
-
- HY-N15366
-
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DNA Alkylator/Crosslinker
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Cancer
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N-Acetoxy-IQ is a DNA alkylating agent that can covalently bind to DNA, especially guanine residues. N-Acetoxy-IQ exerts mutagenic and carcinogenic activities by forming DNA adducts. N-Acetoxy-IQ is promising for research of cancers .
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-
- HY-B0078A
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Imidazole Carboxamide citrate
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Apoptosis
Antibiotic
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Cancer
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Dacarbazine citrate is a cell cycle nonspecific antineoplastic alkylating agent. Dacarbazine citrate inhibits T and B lymphoblastic response, with IC50 values of 50 and 10 μg/mL, respectively. Dacarbazine Citrate can be used for the research of apoptosis and various cancers such as metastatic malignant melanoma .
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-
-
- HY-127005
-
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DNA Alkylator/Crosslinker
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Cancer
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Ritrosulfan is a member of the alkylating sugar alcohol. Ritrosulfan is a hydrolyzing alkylating agent with anti-tumor activity .
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-
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- HY-B0181A
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ENT-50852 hydrochloride; RB-1515 hydrochloride; WR-95704 hydrochloride
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DNA Alkylator/Crosslinker
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Cancer
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Altretamine hydrochloride is an alkylating antineoplastic agent.
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-
-
- HY-B0733
-
-
-
- HY-17576
-
-
-
- HY-16325A
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-
-
- HY-16325
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SM-11355 hydrate
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DNA Alkylator/Crosslinker
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Cancer
|
Miriplatin hydrate (SM-11355 hydrate) is a chemotherapy agent which belongs to the class of alkylating agents.
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-
-
- HY-17574
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-
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- HY-N0780
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-
-
- HY-13669
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-
-
- HY-17419
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-
-
- HY-W587524
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-
-
- HY-U00155
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NSC172112; NSC268497
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DNA Alkylator/Crosslinker
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Cancer
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NCI172112 is a classical bifunctional alkylating agent synthesized in an effort to develop antitumor agents effective against CNS tumors.
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-
-
- HY-Y0643
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Pivaloyloxymethyl chloride
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Biochemical Assay Reagents
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Others
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Pivaloyloxymethyl chloride can be used as electrolyte solvent for lithium batteries, or used as alkylating agent to improve the biomembrane transport of an agent .
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-
-
- HY-W740674
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-
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- HY-17420
-
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DNA Alkylator/Crosslinker
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Cancer
|
Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant.
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-
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- HY-17420A
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Cyclophosphamide monohydrate
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DNA Alkylator/Crosslinker
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Cancer
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Cyclophosphamide hydrate is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.
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- HY-34477
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Iodoacetamide
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DNA Alkylator/Crosslinker
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Others
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2-Iodoacetamide (Iodoacetamide), an alkylating agent, is a commonly used agent for alkylation of cysteine during sample preparation for proteomics .
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- HY-161051
-
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NAMPT
DNA Alkylator/Crosslinker
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Cancer
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Anticancer agent 177 (Compound 11b) is a NAMPT inhibitor and DNA alkylating agent. Anticancer agent 177 has antitumor activity in vitro and in vivo .
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- HY-16513
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VAL-083
1 Publications Verification
Dianhydrodulcitol; Dianhydrogalactitol
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DNA Alkylator/Crosslinker
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Cancer
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VAL-083 is an alkylating agent that creates N7 methylation on DNA, with antitumor activity.
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- HY-16117A
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-
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- HY-136327
-
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DNA Alkylator/Crosslinker
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Cancer
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Phenylacetic acid mustard is the major metabolite of the cancer chemotherapeutic agent Chlorambucil (HY-13593). Chlorambucil is an alkylating agent with antitumor activity .
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- HY-16503
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NSC 39069; Treosulphan
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DNA Alkylator/Crosslinker
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Cancer
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Treosulfan (NSC 39069) is a bifunctional alkylating agent with activity in ovarian cancer and other solid tumor types.
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- HY-B0181R
-
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DNA Alkylator/Crosslinker
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Cancer
|
Altretamine (Standard) is the analytical standard of Altretamine. This product is intended for research and analytical applications. Altretamine is an alkylating antineoplastic agent.
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- HY-W415824A
-
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Endogenous Metabolite
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Cancer
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Mannomustine dihydrochloride is an alkylating agent with antineoplastic activity. Mannomustine dihydrochloride causes severe bone marrow depression. Mannomustine dihydrochloride is a powerful vesicant.
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- HY-128873
-
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ADC Cytotoxin
DNA Alkylator/Crosslinker
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Cancer
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Duocarmycin GA is an antibody agent conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin GA can be used against multi-agent resistant cell lines.
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- HY-107770
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ADC Cytotoxin
DNA Alkylator/Crosslinker
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Cancer
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Duocarmycin MB is an antibody agent conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin MB can be used against multi-agent resistant cell lines.
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- HY-18987
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ADC Cytotoxin
DNA Alkylator/Crosslinker
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Cancer
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Duocarmycin MA is an antibody agent conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin MA can be used against multi-agent resistant cell lines.
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- HY-16232
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D 19575; Glucosylifosfamide mustard
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Others
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Cancer
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Glufosfamide is a novel alkylating agent in which the active metabolite of isophosphoramide mustard is glycosidically linked to β-D-glucose.
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- HY-13733
-
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DNA Alkylator/Crosslinker
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Cancer
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Procarbazine Hydrochloride is an orally active alkylating agent, with anticancer activity. Procarbazine Hydrochloride can be used in Hodgkin's disease research .
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- HY-13733A
-
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DNA Alkylator/Crosslinker
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Cancer
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Procarbazine is an orally active alkylating agent, with anticancer activity. Procarbazine can be used in Hodgkin's disease research .
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- HY-17419A
-
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Others
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Cancer
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(R)-Ifosfamide is a chemotherapeutic agent primarily used in the treatment of aggressive tumors such as rhabdomyosarcoma, exhibiting alkylating activity that interferes with DNA replication.
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- HY-13739
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MCNU
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DNA Alkylator/Crosslinker
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Cancer
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Ranimustine (MCNU) is a nitrosourea alkylating agent, can be used for research of chronic myelogenous leukemia and polycythemia vera .
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- HY-119696
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-
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- HY-114577
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Isophosphoramide mustard tromethamine; IPM tromethamine; ZIO-201 tromethamine
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DNA Alkylator/Crosslinker
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Cancer
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Palifosfamide (tromethamine) is a synthetic alkylating agent with potential antineoplastic activity. As the stabilized active metabolite of ifosfamide, palifosfamide (tromethamine) irreversibly alkylates and crosslinks DNA through GC base pairs. This leads to an inhibition of DNA replication and ultimately cell death. Compared to ifosfamide, palifosfamide (tromethamine) is less toxic.
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- HY-13730
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N-Methylmitomycin C; NSC-56410; U-14743
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DNA Alkylator/Crosslinker
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Cancer
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Porfiromycin (N-Methylmitomycin C) is a bioreductive alkylating agent that preferentially kill hypoxic tumor cells relative to other aerobic counterparts .
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- HY-19577
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PTT119
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DNA Alkylator/Crosslinker
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Infection
Cancer
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Ambamustine (PTT119) is a new bifunctional alkylating agent and induces DNA damage by alkylating mechanisms. Ambamustine interferes with late steps in murine mammary tumor virus (MuMTV) processing and maturation and reduces production of the B-type retrovirus MuMTV. Ambamustine possesses cytolytic and antiviral activities .
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- HY-128957
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SYD985
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Drug-Linker Conjugates for ADC
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Cancer
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Vc-seco-DUBA (SYD985) is a agent-linker conjugate for ADC with potent antitumor activity by using DUBA (DNA alkylating agent), linked via the ADC linker Vc-seco .
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- HY-17419S1
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-
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- HY-13567S
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-
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- HY-N0780R
-
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Apoptosis
Autophagy
Bacterial
Endogenous Metabolite
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Cancer
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Isoalantolactone (Standard) is the analytical standard of Isoalantolactone. This product is intended for research and analytical applications. Isoalantolactone is an apoptosis inducer, which also acts as an alkylating agent.
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- HY-17420S1
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-
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- HY-136289
-
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Drug-Linker Conjugates for ADC
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Cancer
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MB-VC-MGBA is a agent-linker conjugate for ADC with potent antitumor activity by using MGBA (minor-groove-binding DNA-alkylating agent), linked via the ADC linker MB-VC .
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- HY-17574R
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- HY-17419R
-
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DNA Alkylator/Crosslinker
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Cancer
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Ifosfamide (Standard) is the analytical standard of Ifosfamide. This product is intended for research and analytical applications. Ifosfamide is an alkylating chemotherapeutic agent with activity against a wide range of tumors.
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- HY-13669R
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CCNU (Standard); NSC 79037 (Standard)
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DNA Alkylator/Crosslinker
Autophagy
Apoptosis
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Cancer
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Lomustine (Standard) is the analytical standard of Lomustine. This product is intended for research and analytical applications. Lomustine (CCNU; NSC 79037) is a DNA alkylating agent, with antitumor activity.
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- HY-128880
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- HY-128881
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- HY-17420S
-
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DNA Alkylator/Crosslinker
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Cancer
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Cyclophosphamide-d4 is the deuterium labeled Cyclophosphamide. Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant .
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- HY-17420AS
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Isotope-Labeled Compounds
DNA Alkylator/Crosslinker
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Cancer
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Cyclophosphamide-d8 (hydrate) is the deuterium labeled Cyclophosphamide hydrate. Cyclophosphamide hydrate is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities .
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- HY-128904
-
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Drug-Linker Conjugates for ADC
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Cancer
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MC-Val-Cit-PAB-duocarmycin chloride is a agent-linker conjugate for ADC with potent antitumor activity by using Duocarmycin (a DNA minor groove binding alkylating agent), linked via the ADC linker MC-Val-Cit-PAB.
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- HY-B0245
-
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DNA Alkylator/Crosslinker
Apoptosis
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Inflammation/Immunology
Cancer
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Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .
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- HY-W012890
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Valeric acid hydrazide
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Biochemical Assay Reagents
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Others
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Pentanehydrazide (Valeric acid hydrazide) is a biochemical reagent that can act as an effective alkylating agent in the copper-catalyzed oxidative cyclization of N-arylacrylamides and participate in the tandem acylation reaction .
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- HY-16123
-
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DNA Alkylator/Crosslinker
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Cancer
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Canfosfamide (hydrochloride) is a prodrug that upon activation by glutathione s-transferase P1-1 (GSTP1-1) yields an anticancer alkylating agent and a glutathione derivative.
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- HY-17420AR
-
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DNA Alkylator/Crosslinker
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Cancer
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Cyclophosphamide (hydrate) (Standard) is the analytical standard of Cyclophosphamide (hydrate). This product is intended for research and analytical applications. Cyclophosphamide hydrate is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.
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- HY-N9279
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Monocrotaline pyrrole; MCTP; 3,8-Didehydromonocrotaline
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DNA Alkylator/Crosslinker
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Others
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Dehydromonocrotaline (Monocrotaline pyrrole) is the metabolite of Monocrotaline (HY-N0750). Dehydromonocrotaline is an alkylating agent, that reacts with DNA, exhibits cytotoxicity, and induces liver and lung damage .
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- HY-34477S1
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Iodoacetamide-d4
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DNA Alkylator/Crosslinker
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Others
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2-Iodoacetamide-d4 is the deuterium labeled 2-Iodoacetamide . 2-Iodoacetamide (Iodoacetamide), an alkylating agent, is a commonly used agent for alkylation of cysteine during sample preparation for proteomics .
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- HY-128612
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MNNG
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DNA Alkylator/Crosslinker
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Cancer
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Methylnitronitrosoguanidine (MNNG) is an orally active alkylating agent with toxic and mutagenic effects. Methylnitronitrosoguanidine can as a carcinogen and mutagen . 50% water content, specifications are based on dry weight.
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- HY-101002
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SarCNU; Sarmustine
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Apoptosis
DNA Alkylator/Crosslinker
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Cancer
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Sarcosinamide chloroethylnitrosourea is an orally active alkylating agent. Sarcosinamide chloroethylnitrosourea can induce apoptosis by promoting DNA alkylation. Sarcosinamide chloroethylnitrosourea can be used in cancer-related research .
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- HY-14429
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MGI 114; 6-Hydroxymethylacylfulvene; NSC 683863
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DNA Alkylator/Crosslinker
Apoptosis
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Cancer
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(-)-Irofulven (MGI 114), an Illudin S analog, is a DNA alkylating agent. (-)-Irofulven inhibits the replication of DNA, induces tumor cells apoptosis, and has potent antitumor activity .
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- HY-13593
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CB-1348; WR-139013
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DNA Alkylator/Crosslinker
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Cancer
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Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease .
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- HY-121261
-
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Necroptosis
Apoptosis
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Cancer
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Antineoplastic agent-1 is an alkylating agent and a genotoxic agent that can induce DNA damage. Antineoplastic agent-1 can lead to irreversible damage and progressive death of liver cells due to necroptosis and apoptosis. Antineoplastic agent-1 can cause alkylation damage to hematopoietic cells and stromal cells in the bone marrow. Antineoplastic agent-1 can be used in tumor research .
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- HY-148091
-
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DNA Alkylator/Crosslinker
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Cancer
|
Duocarmycin analog-2 is a potent DNA alkylating agent. Duocarmycin analog-2 can be used of synthetic immunoconjugate. Duocarmycin analog-2 has antitumor activity .
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- HY-13641
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Myelobromol; DBM
|
DNA Alkylator/Crosslinker
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Cancer
|
Mitobronitol (Myelobromol; DBM) is a brominated analog of mannitol, also known as an anticancer agent that is classified as an alkylating agent. Mitobronitol has potential for myelosuppression associated with significantly decreased risk for several complications of allogeneic bone marrow transplantation in accelerated chronic granulocytic leukemia .
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- HY-101150
-
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DNA Alkylator/Crosslinker
ADC Cytotoxin
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Cancer
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DGN462, a potent DNA-alkylating agent, shows anti-tumor activity, such as acute myeloid leukemia (AML). DGN462 can be used as a cytotoxic component of antibody-drug conjugates (ADCs) .
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- HY-B0077
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SDX-105
|
DNA Alkylator/Crosslinker
Apoptosis
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Cancer
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Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties .
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- HY-101150A
-
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DNA Alkylator/Crosslinker
ADC Cytotoxin
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Cancer
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sulfo-DGN462 sodium is degraded to DGN462 in culture medium and plasma. DGN462, a potent DNA-alkylating agent, shows anti-tumor activity, such as acute myeloid leukemia (AML) .
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- HY-111397
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NSC 615291; U-77779
|
DNA Alkylator/Crosslinker
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Cancer
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Bizelesin (NSC 615291; U-77779) is an AT-specific DNA alkylating agent that can generate DNA interstrand crosslinks, effectively inhibit DNA replication, and has potential anticancer activity .
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- HY-13733R
-
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DNA Alkylator/Crosslinker
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Cancer
|
Procarbazine (Hydrochloride) (Standard) is the analytical standard of Procarbazine (Hydrochloride). This product is intended for research and analytical applications. Procarbazine Hydrochloride is an orally active alkylating agent, with anticancer activity. Procarbazine Hydrochloride can be used in Hodgkin's disease research .
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- HY-119696R
-
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Drug Metabolite
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Neurological Disease
Cancer
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MTIC (Standard) is the analytical standard of MTIC. This product is intended for research and analytical applications. MTIC, the active metabolite of Temozolomide (TMZ), is a DNA alkylating agent. MTIC has antitumor activity
[1][2][3][4].
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- HY-B0245S
-
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DNA Alkylator/Crosslinker
Apoptosis
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Inflammation/Immunology
Cancer
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Busulfan-d8 is a deuterium labeled Busulfan. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .
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- HY-131085
-
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Drug-Linker Conjugates for ADC
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Cancer
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Desmethyl Vc-seco-DUBA consists a cleavable ADC linker (Desmethyl Vc-seco) and a DNA alkylating agent (DUBA). Desmethyl Vc-seco-DUBA can be used in the synthesis of antibody-drug conjugates (ADCs) .
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- HY-W111005
-
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DNA Alkylator/Crosslinker
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Cancer
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1-Chloromethylpyrene is an alkylating agent that enters the DNA double helix structure through intercalation, forms covalent bonds with electrophilic groups, resulting in DNA cross-linking, thereby inhibiting the proliferation of tumor cells .
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- HY-13567
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SDX-105 free base
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DNA Alkylator/Crosslinker
Apoptosis
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Cancer
|
Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties .
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- HY-139453A
-
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DNA Alkylator/Crosslinker
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Cancer
|
LP-284 is a potent DNA alkylating agent that kills solid tumours. LP-284 can be used in the studies of hematologic cancers with compromised DNA repair, such as mantle cell lymphoma (MCL) .
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- HY-W004702
-
-
- HY-105019
-
Melphalan flufenamide
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DNA Alkylator/Crosslinker
Apoptosis
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Cancer
|
Melflufen (Melphalan flufenamide), a dipeptide proagent of Melphalan, is an alkylating agent. Melflufen shows antitumor activity against multiple myeloma (MM) cells and inhibits angiogenesis. Melflufen induces irreversible DNA damage and cytotoxicity in MM cells .
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- HY-167635
-
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MDM-2/p53
Drug Derivative
ATM/ATR
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Cancer
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Decarbamoylmitomycin C, an analog of Mitomycin C (MC), is an DNA-alkylating agent. Decarbamoylmitomycin C (DMC) activates p53-independent ataxia telangiectasia and rad3 related protein (ATR) chromatin eviction .
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- HY-B0078B
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Imidazole Carboxamide hydrochloride
|
Antibiotic
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Cancer
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Dacarbazine hydrochloride is a cell cycle nonspecific antineoplastic alkylating agent. Dacarbazine hydrochloride inhibits T and B lymphoblastic response, with IC50 values of 50 and 10 μg/mL, respectively. Dacarbazine hydrochloride can be used for the research of metastatic malignant melanoma .
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- HY-135901
-
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ADC Cytotoxin
Bacterial
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Cancer
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Py-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Py-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity .
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- HY-105019A
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Melphalan flufenamide hydrochloride
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DNA Alkylator/Crosslinker
Apoptosis
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Cancer
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Melflufen (Melphalan flufenamide) hydrochloride, a dipeptide proagent of Melphalan, is an alkylating agent. Melflufen hydrochloride shows antitumor activity against multiple myeloma (MM) cells and inhibits angiogenesis. Melflufen hydrochloride induces irreversible DNA damage and cytotoxicity in MM cells .
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- HY-U00447
-
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MDM-2/p53
DNA Alkylator/Crosslinker
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Cancer
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PK11000 is an alkylating agent, and stabilizes the DNA-binding domain of both WT and mutant p53 proteins by covalent cysteine modification without compromising DNA binding. PK11000 has anti-tumor activities .
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- HY-13593S
-
CB-1348-d8; WR-139013-d8
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Isotope-Labeled Compounds
DNA Alkylator/Crosslinker
|
Cancer
|
Chlorambucil-d8 is the deuterium labeled Chlorambucil. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease .
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-
- HY-B0078
-
Imidazole Carboxamide
|
Nucleoside Antimetabolite/Analog
Apoptosis
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Cancer
|
Dacarbazine is a nonspecific antineoplastic (antineoplastic) alkylating agent. Dacarbazine inhibits T and B lymphocyte responses with IC50 of 50 and 10 μg/mL, respectively. Dacarbazine can be used in the study of metastatic malignant melanoma .
|
-
- HY-W105731
-
Decamethylene diiodide
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Endogenous Metabolite
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Others
|
1,10-Diiododecane (Decamethylene diiodide) serves as a crosslinking reagent for tetrabutylammonium polygalacturonic acid and acts as an alkylating agent in the synthesis of both symmetrical and unsymmetrical bis-cryptophanes, in addition to being utilized for the production of decane at a temperature of 20°C.
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-
- HY-13593S1
-
CB-1348-d8-1; WR-139013-d8-1
|
Isotope-Labeled Compounds
DNA Alkylator/Crosslinker
|
Cancer
|
Chlorambucil-d8-1 is the deuterium labeled Chlorambucil. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease .
|
-
- HY-136291
-
|
Drug-Linker Conjugates for ADC
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Cancer
|
Sulfo-SPDB-DGN462 is a agent-linker conjugate for ADC. Sulfo-SPDB-DGN462 consists a toxin DGN462 (HY-101150) conjugated to the cleavable Sulfo-SPDB linker. DGN462, a potent DNA-alkylating agent, shows anti-tumor activity, such as acute myeloid leukemia (AML).
|
-
- HY-13593R
-
CB-1348 (Standard); WR-139013 (Standard)
|
Reference Standards
DNA Alkylator/Crosslinker
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Cancer
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Chlorambucil (Standard) is the analytical standard of Chlorambucil. This product is intended for research and analytical applications. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease .
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- HY-135900
-
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ADC Cytotoxin
Bacterial
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Cancer
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Aniline-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Aniline-MPB-amino-C3-PBD is a sequence-selective DNA minor-groove binding agent. Aniline-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity .
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- HY-B0077S1
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SDX-105-d8
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Isotope-Labeled Compounds
DNA Alkylator/Crosslinker
Apoptosis
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Cancer
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Bendamustine-d8 (hydrochloride) is deuterium labeled Bendamustine (hydrochloride). Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties .
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- HY-12457
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CC-1065; NSC 298223
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Antibiotic
DNA/RNA Synthesis
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Infection
Cancer
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Rachelmycin (CC-1065) is an antitumor antibiotic and a DNA-alkylating agent. Rachelmycin has cytotoxic potency that can be used as a cytotoxin to synthesis ADC. Rachelmycin effectively inhibits DNA synthesis. Rachelmycin can be used for cancer and infection research .
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- HY-17364
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Temozolomide
Maximum Cited Publications
131 Publications Verification
NSC 362856; CCRG 81045; TMZ
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DNA Alkylator/Crosslinker
Autophagy
Apoptosis
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Cancer
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Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects .
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- HY-16398
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DNA Alkylator/Crosslinker
DNA/RNA Synthesis
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Cancer
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Pipobroman is a bromide derivative of piperazine and acts as an alkylating agent. Pipobroman plays its role by inhibiting DNA and RNA polymerase or by reducing pyrimidine nucleotide incorporation into DNA. Pipobroman can be used for the cancer research, including polycythemia vera, myeloproliferative neoplasm, and AML et.al .
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- HY-W588285
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3-MG
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DNA/RNA Synthesis
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Others
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3-Methylguanine is a DNA damage product caused by alkylation. 3-Methylguanine is cytotoxic and causes cell death by inhibiting DNA replication. 3-Methylguanine can be used to study the mechanism of DNA damage caused by alkylating agents and its repair pathways .
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- HY-13703
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- HY-13567S1
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SDX-105-d8 free base
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DNA Alkylator/Crosslinker
Apoptosis
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Cancer
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Bendamustine-d8 is the deuterium labeled Bendamustine . Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties .
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- HY-B0077R
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DNA Alkylator/Crosslinker
Apoptosis
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Cancer
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Bendamustine (hydrochloride) (Standard) is the analytical standard of Bendamustine (hydrochloride). This product is intended for research and analytical applications. Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties .
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- HY-W018326
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DNA/RNA Synthesis
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Cancer
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Temozolomide acid is a carboxylic acid derivative of Temozolomide (HY-17364) with anticancer activity. Temozolomide is a DNA alkylating agent, methylating the guanine and adenine bases of DNA, causing breaks in DNA double strand, cell cycle arrest, and eventually cell death. Temozolomide acid is promising for research of glioblastoma and brain cancer .
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- HY-W800828
-
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Biochemical Assay Reagents
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Others
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Iodoacetamido-PEG3-NHS ester is a PEG reagent containing an Iodoacetamide group and a Boc-protected amino group. The iodoacetamide group is an alkylating agent that can be used to bind covalently with the thiol group. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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- HY-17364S
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DNA Alkylator/Crosslinker
Autophagy
Apoptosis
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Cancer
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Temozolomide-d3 is the deuterium labeled Temozolomide. Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects .
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- HY-W190947
-
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Biochemical Assay Reagents
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Others
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Iodoacetamido-PEG8-acid is a PEG reagent containing an Iodoacetamide group and a carboxlic acid moiety. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The iodoacetamide group is an alkylating agent that can be used to bind covalently with the thiol group.
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- HY-124573
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TH-3424
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DNA Alkylator/Crosslinker
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Cancer
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OBI-3424 (TH-3424) is a proagent that is selectively converted by AKR1C3 (aldo-keto reductase 1C3) to a potent DNA-alkylating agent. OBI-3424 can be used for hepatocellular carcinoma, castrate-resistant prostate cancer, and acute lymphoblastic leukemia (ALL) research .
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-
- HY-B0078R
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Imidazole Carboxamide (Standard)
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Apoptosis
Nucleoside Antimetabolite/Analog
|
Cancer
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Dacarbazine (Standard) is the analytical standard of Dacarbazine. This product is intended for research and analytical applications. Dacarbazine is a nonspecific antineoplastic (antineoplastic) alkylating agent. Dacarbazine inhibits T and B lymphocyte responses with IC50 of 50 and 10 μg/mL, respectively. Dacarbazine can be used in the study of metastatic malignant melanoma .
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- HY-17364R
-
|
DNA Alkylator/Crosslinker
Autophagy
Apoptosis
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Cancer
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Temozolomide (Standard) is the analytical standard of Temozolomide. This product is intended for research and analytical applications. Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects .
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- HY-136731
-
|
DNA/RNA Synthesis
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Cancer
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APE1-IN-1 is a potent and blood-brain barrier (BBB) penetrant apurinic/apyrimidinic (AP) endonuclease 1 (APE1) inhibitor with an IC50 value of 2 μM. APE1-IN-1 can potentiate the cytotoxicity of the alkylating agents Methylmethane sulfonate and Temozolomide (HY-17364) to cancer cells .
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- HY-13703A
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ACNU
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DNA Alkylator/Crosslinker
DNA/RNA Synthesis
Apoptosis
p38 MAPK
JNK
AP-1
|
Cancer
|
Nimustine hydrochloride (ACNU) is the hydrochloride salt form of Nimustine (HY-13703). Nimustine hydrochloride is an alkylating agent, which induces DNA double-strand breaks (DSBs) and inter-strand crosslinks (ICLs), thereby activating the DNA damage response (DDR) signaling pathway. Nimustine hydrochloride activates p38 MAPK/JNK signaling pathway, and exhibits antitumor activity .
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- HY-132451S
-
|
Isotope-Labeled Compounds
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Cancer
|
(R,S)-4-Hydroxy Cyclophosphamide-d4 Preparation Kit is the deuterium labeled (R,S)-4-Hydroxy Cyclophosphamide Preparation Kit. (R,S)-4-Hydroxy Cyclophosphamide is an isomer of 4-Hydroxycyclophosphamide, the active metabolite of the cytotoxic alkylating agent Cyclophosphamide (HY-17420) .
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-
- HY-34758
-
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DNA Alkylator/Crosslinker
|
Cancer
|
N-Nitroso-N-methylurea (NMU;MNU;NMH) is a potent carcinogen, mutagen and teratogenand. N-Nitroso-N-methylurea is a direct-acting alkylating agent that interacts with DNA. N-Nitroso-N-methylurea targets multiple animal organs to cause various cancer and/or degenerative disease. N-Nitroso-N-methylurea is also a precursor in the synthesis of diazomethane .
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- HY-153792
-
|
FLAP
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Cancer
|
FEN1-IN-7 (compound 16) is a selective inhibitor of Flap endonuclease-1 (FEN1, IC50=18 nM), involving in mammalian cells to repair DNA damage. FEN1-IN-7 also targets to related endonuclease, xeroderma pigmentosum G (XPG) with an IC50 value of 3.04 μM. FEN1-IN-7 increases the cellular sensitivity of cancer cells to potent DNA alkylating agents or methylating agents .
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- HY-16124
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TLK-286; TER286
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DNA-PK
Apoptosis
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Cancer
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Canfosfamide (TLK-286, TER286) is a glutathione analogue prodrug that is activated by glutathione S-transferase P1-1 and induces apoptosis. Canfosfamide also inhibits the catalytic kinase activity of DNA-dependent protein kinase (DNA-PK). Canfosfamide produces an anticancer alkylating agent and a glutathione derivative after activation. Canfosfamide can be used to research malignancies .
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- HY-12455
-
|
ADC Cytotoxin
Apoptosis
Caspase
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Cancer
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Duocarmycin A, which is one of well-known antitumor antibiotics, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results HLC-2 cells typically apoptotic changes, including chromatin condensation, sub-G1 accumulation in DNA histogram pattern, and decrease in procaspase-3 and 9 levels .
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- HY-121372
-
|
Estrogen Receptor/ERR
|
Cancer
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Lactandrate is a D-high nitrogen steroid alkylating agent. It can interact with the ligand-binding domain (LBD) of estrogen receptor-alpha (ERα). Lactandrate has a growth inhibitory effect on breast cancer cells, with a GI50 value ranging from 5 to 65 μM. It shows anti-tumor activity in mouse breast tumors (MXT and CD8F1) as well as in human xenograft MX-1 .
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- HY-129356A
-
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Antibiotic
ADC Cytotoxin
DNA Alkylator/Crosslinker
Apoptosis
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Cancer
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(S)-Seco-Duocarmycin SA is the S-enantiomer of Seco-Duocarmycin SA (HY-129356). Seco-Duocarmycin SA is a DNA alkylating agent. Seco-Duocarmycin SA is an antitumor antibiotic (IC50 = 10 pM). Seco-Duocarmycin SA can induce a concentration-dependent increase in apoptotic cell death. Seco-Duocarmycin SA can lead to significant cell cycle arrest in S and G2/M phases. Seco-Duocarmycin SA acts as an ADC cytotoxin for antibody-drug conjugates .
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- HY-W015854
-
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Biochemical Assay Reagents
Apoptosis
DNA Alkylator/Crosslinker
|
Neurological Disease
Cancer
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Ethyl methanesulfonate is an orally active biochemical agent. Ethyl methanesulfonate induces Apoptosis. Ethyl methanesulfonate acts on DNA, alkylating it and causing changes in DNA structure, which in turn triggers a series of biological effects such as mutation and cell death. Ethyl methanesulfonate induces kidney and nervous system tumors. Ethyl methanesulfonate is widely used in the field of genetic toxicology research and is often used to induce gene mutations in organisms to study gene function, the mechanism of genetic diseases, and the effects of environmental mutagenic factors, etc .
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-
-
-
HY-L112
-
|
153 compounds
|
Chemotherapy is one of the most common treatments for cancer. It can be used alone for some types of cancer or in combination with other treatments such as radiation or surgery. Chemotherapy drugs usually target cells at different phases of the cell cycle and inhibit tumor proliferation and avoid cancer cell invasion and metastasis. It is a cancer treatment method that kills cancer cells with drugs.
Chemotherapeutic agents can be classified into alkylating agents, antimetabolites, antimicrotubular agents, antibiotics, etc. according to the mechanism of action. MCE offers a unique collection of 153 chemotherapy drugs, which is a useful tool for cancer treatment research.
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Cat. No. |
Product Name |
Type |
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- HY-Y0643
-
Pivaloyloxymethyl chloride
|
Biochemical Assay Reagents
|
Pivaloyloxymethyl chloride can be used as electrolyte solvent for lithium batteries, or used as alkylating agent to improve the biomembrane transport of an agent .
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-
- HY-W004702
-
|
Biochemical Assay Reagents
|
Methyl methanesulfonate is an alkylating agent which transfers methyl groups, and induces DNA damage. Methyl methanesulfonate is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
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-
- HY-W015854
-
|
Biochemical Assay Reagents
|
Ethyl methanesulfonate is an orally active biochemical agent. Ethyl methanesulfonate induces Apoptosis. Ethyl methanesulfonate acts on DNA, alkylating it and causing changes in DNA structure, which in turn triggers a series of biological effects such as mutation and cell death. Ethyl methanesulfonate induces kidney and nervous system tumors. Ethyl methanesulfonate is widely used in the field of genetic toxicology research and is often used to induce gene mutations in organisms to study gene function, the mechanism of genetic diseases, and the effects of environmental mutagenic factors, etc .
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Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-105019
-
Melphalan flufenamide
|
DNA Alkylator/Crosslinker
Apoptosis
|
Cancer
|
Melflufen (Melphalan flufenamide), a dipeptide proagent of Melphalan, is an alkylating agent. Melflufen shows antitumor activity against multiple myeloma (MM) cells and inhibits angiogenesis. Melflufen induces irreversible DNA damage and cytotoxicity in MM cells .
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Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
Chemical Structure |
-
- HY-17419S1
-
|
Ifosfamide-d4 is the deuterium labeled Ifosfamide. Ifosfamide is an alkylating chemotherapeutic agent with activity against a wide range of tumors .
|
-
-
- HY-17420S
-
|
Cyclophosphamide-d4 is the deuterium labeled Cyclophosphamide. Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant .
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-
-
- HY-34477S1
-
|
2-Iodoacetamide-d4 is the deuterium labeled 2-Iodoacetamide . 2-Iodoacetamide (Iodoacetamide), an alkylating agent, is a commonly used agent for alkylation of cysteine during sample preparation for proteomics .
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-
-
- HY-B0245S
-
|
Busulfan-d8 is a deuterium labeled Busulfan. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .
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-
-
- HY-13567S
-
|
Bendamustine-d4 is the deuterium labeled Bendamustine. Bendamustine is a DNA cross-linking agent that causes DNA breaks, with alkylating and antimetabolite properties.
|
-
-
- HY-17420S1
-
|
Cyclophosphamide-d8 is deuterium labeled Cyclophosphamide. Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant.
|
-
-
- HY-17420AS
-
|
Cyclophosphamide-d8 (hydrate) is the deuterium labeled Cyclophosphamide hydrate. Cyclophosphamide hydrate is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities .
|
-
-
- HY-13593S
-
|
Chlorambucil-d8 is the deuterium labeled Chlorambucil. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease .
|
-
-
- HY-13593S1
-
|
Chlorambucil-d8-1 is the deuterium labeled Chlorambucil. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease .
|
-
-
- HY-B0077S1
-
|
Bendamustine-d8 (hydrochloride) is deuterium labeled Bendamustine (hydrochloride). Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties .
|
-
-
- HY-13567S1
-
|
Bendamustine-d8 is the deuterium labeled Bendamustine . Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties .
|
-
-
- HY-17364S
-
|
Temozolomide-d3 is the deuterium labeled Temozolomide. Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects .
|
-
-
- HY-132451S
-
|
(R,S)-4-Hydroxy Cyclophosphamide-d4 Preparation Kit is the deuterium labeled (R,S)-4-Hydroxy Cyclophosphamide Preparation Kit. (R,S)-4-Hydroxy Cyclophosphamide is an isomer of 4-Hydroxycyclophosphamide, the active metabolite of the cytotoxic alkylating agent Cyclophosphamide (HY-17420) .
|
-
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