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Results for "

acyl-CoA: cholesterol acyltransferase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (29) Endogenous Metabolite (2) ERK (2) Fungal (1) Isotope-Labeled Compounds (1) NF-κB (1) Parasite (1) Phytohormone (1) Reactive Oxygen Species (3) Reference Standards (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (11) Infection (6) Inflammation/Immunology (3) Metabolic Disease (13)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Acyltransferase Acetyl-CoA synthetase Malonyl-CoA Decarboxylase Stearoyl-CoA Desaturase (SCD) HMG-CoA Reductase (HMGCR) Acetyl-CoA Carboxylase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N3806

Enniatin B	Acyltransferase ERK	Infection Cardiovascular Disease Cancer
Enniatin B is a Fusarium mycotoxin. Enniatin B inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC₅₀ of 113 μM in an enzyme assay using rat liver microsomes . Enniatins B decreases the activation of ERK (p44/p42) .

HY-N10224

Terpendole C	Acyltransferase	Metabolic Disease
Terpendole C, produced by Albophoma yamanashiensis, shows potent inhibitory activity against acyl-CoA: cholesterol acyltransferase (ACAT) .

HY-N14614

Pyripyropene B	Acyltransferase	Metabolic Disease
Pyripyropene B is a powerful acyl-CoA: cholesterol acyltransferase 2 (ACAT2) inhibitor found in the fungus Aspergillus fumigatus FO 1289. Pyripyropene B inhibits acyl-CoA: cholesterol acyltransferase with an IC₅₀ of 117 nM .

HY-N10234

Phenylpyropene A	Acyltransferase	Infection
Phenylpyropene A, a fungal metabolite, is a potent acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor with an IC₅₀ of 0.8 μM .

HY-N8331

Terpendole I	Acyltransferase Endogenous Metabolite	Cancer
Terpendole I, a fungal indoloditerpene, is a ACAT (acyl-CoA: cholesterol acyltransferase) inhibitor (IC₅₀=145 µM) .

HY-N14968

Enniatin F	Parasite Fungal	Infection
Enniatin F has insecticidal and antifungal activity. Enniatin F also can inhibit acyl-CoA, cholesterol acyltransferase (ACAT) .

HY-N6702

Enniatin A	Acyltransferase	Infection Cardiovascular Disease
Enniatin A is a Fusarium mycotoxin. Enniatin A inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC₅₀ of 22 μM in an enzyme assay using rat liver microsomes .

HY-N15411

Helminthosporol	Acyltransferase Phytohormone	Metabolic Disease
Helminthosporol is a natural plant growth-regulator that can promote the growth of rice and lettuce seedlings. Helminthosporol can also inhibit the activity of acyl-CoA: cholesterol acyltransferase (ACAT) in rat liver microsomes and the synthesis of cholesterol esters in macrophages .

HY-169813

Yakuchinone B	Acyltransferase	Cardiovascular Disease
Yakuchinone B is an Acyl-CoA: cholesterol O-acyltransferase (ACAT) inhibitor with hypocholesterolemic activity, which is found in the seeds of Zingiberaceae. Yakuchinone B inhibits rat hepatic ACAT with an IC₅₀ value of 20.6 μM. Yakuchinone B is promising for research of hypercholesterolemia and atherosclerosis .

HY-19183

E-5324	Acyltransferase	Metabolic Disease
E-5324 is potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT) with IC₅₀s of 44 to 190 nM.

HY-16281

Lecimibide DuP 128	Acyltransferase	Metabolic Disease
Lecimibide (DuP 128) is a potent and specific acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor for antihyperlipidemia research .

HY-101627

YM17E	Acyltransferase	Metabolic Disease
YM17E is an inhibitor of acyl CoA:cholesterol acyltransferase (ACAT), with IC₅₀ of 44 nM in rabbit liver microsomes in vitro.

HY-122078

FR-190809	Acyltransferase	Metabolic Disease
FR-190809 is a potent, nonadrenotoxic, orally efficacious acyl-CoA:cholesterol O-acyltransferase (ACAT) inhibitor, with an IC₅₀ of 45 nM .

HY-126455

Penicillide Vermixocin A	Acyltransferase	Metabolic Disease
Penicillide (Vermixocin A), isolated from Talaromyces derxii cultivated on rice, shows inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT) .

HY-100400A

K-604 dihydrochloride 5 Publications Verification	Acyltransferase	Cardiovascular Disease
K-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT-1) inhibitor with an IC₅₀ of 0.45±0.06 μM.

HY-106902

F-1394	Acyltransferase	Cardiovascular Disease
F-1394 is an orally active acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor that inhibits dietary cholesterol absorption in mice. F-1394 can be used in cardiovascular disease research .

HY-107571

VULM 1457	Acyltransferase	Cardiovascular Disease Metabolic Disease
VULM 1457 is a potent inhibitor of cholesterol acyltransferase (acyl-CoA). VULM1457 significantly reduces production and secretion of adrenomedullin (AM) and down-regulates AM receptors on human hepatoblastic cells. VULM 1457 has remarkable hypolipidaemic activity and improves the overall myocardial ischaemia-reperfusion injury outcomes. VULM 1457 has the potential for the research of diabetes mellitus and hypercholesterolaemia .

HY-121254

GERI-BP002-A	Acyltransferase	Cancer
GERI-BP002-A is an inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT) produced by Aspergillus fumigatus F93, which can be used in cancer research .

HY-121762

NTE-122 dihydrochloride	Acyltransferase	Cardiovascular Disease
NTE-122 (dihydrochloride) is an inhibitor of acyl-CoA:cholesterol *acyltransferase* (ACAT), with the IC₅₀ in liver and aorta of cholesterol-fed rabbits of 7.6nM, 4.4nM and 9.6 nM, respectively, that plays an important role in atherosclerosis .

HY-107396

YM-750	Acyltransferase	Cardiovascular Disease
YM-750 is a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor (IC₅₀=0.18 μM). ACAT catalyzes the formation of cholesteryl esters from cholesterol and long-chain fatty-acyl-coenzyme A .

HY-119265

LDL-IN-4	Acyltransferase	Metabolic Disease
LDL-IN-4 (Compound 2) inhibits human acyl-CoA:cholesterol acyltransferase-1 and -2 activities. LDL-IN-4 inhibits copper-mediated low density lipoprotein (LDL) oxidation, with an IC₅₀ of 3 μM. LDL-IN-4 has anti-atherosclerotic biological activity .

HY-N3807

Enniatin B1 1 Publications Verification	Acyltransferase ERK NF-κB	Infection Cardiovascular Disease Cancer
Enniatin B1 is a Fusarium mycotoxin. Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC₅₀ of 73 μM in an enzyme assay using rat liver microsomes . Enniatin B1 crosss the blood-brain barrier . Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation .

HY-118486

LDL-IN-1	Acyltransferase	Metabolic Disease
LDL-IN-1 (Compound 1) is an antioxidant, and is active against copper mediated LDL oxidation (IC₅₀ = 52 μM). LDL-IN-1 is also an **Acyl-CoA:cholesterol acyltransferase-1 and -2 (ACAT-1/2**) inhibitor, with IC₅₀s of 60 μM. LDL-IN-1 can be used for anti-atherosclerotic research .

HY-167664

KY-455	Acyltransferase	Metabolic Disease
KY-455 is a novel inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT). KY-455 inhibita rabbit intestinal, hepatic, macrophage and adrenal ACAT with IC₅₀ values of 0.4, 0.9, 2.9 and 4.1 μmol/L, respectively.

HY-121407

Lateritin	Acyltransferase	Infection Cancer
Lateritin is a potent inhibitor of **acyl-CoA:cholesterol acyltransferase (ACAT*), isolated from the mycelial cake of Gibberella lateritium* IFO 7188 . Lateritin also inhibits the growth of a mini-panel of human cancer cell lines, gram-positive bacteria, and Candida albicans .

HY-100400AR

K-604 dihydrochloride (Standard)	Reference Standards Acyltransferase	Cardiovascular Disease
K-604 (dihydrochloride) (Standard) is the analytical standard of K-604 (dihydrochloride). This product is intended for research and analytical applications. K-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT-1) inhibitor with an IC50 of 0.45±0.06 μM.

HY-133968

24-Methylenecholesterol Ostreasterol	Acyltransferase Reactive Oxygen Species	Inflammation/Immunology
24-Methylenecholesterol (Ostreasterol) is a regulator targeting acyl-CoA cholesterol acyltransferase (ACAT) with anti-aging and neuroprotective effects. 24-Methylenecholesterol mimics the effects of nerve growth factor (NGF), can extend yeast lifespan through an anti-oxidative stress mechanism, and exhibits neuroprotective activity in PC12 cells. 24-Methylenecholesterol can reduce intracellular reactive oxygen species (ROS) and malondialdehyde (MDA) levels, activate anti-oxidative stress pathways (such as UTH1, SOD-related genes), and promote synaptic growth .

HY-120984

Oleic Acid-2,6-diisopropylanilide	Endogenous Metabolite	Metabolic Disease
AcylCoA:cholesterol acyltransferase (ACAT) is an intracellular cholesteryl ester synthase tied closely to the absorption of dietary cholesterol.1 Oleic acid-2,6-diisopropylanilide is an inhibitor of acylCoA:cholesterol acyltransferase with an IC₅₀ of 7 nM.2 When co-administered to rabbits or rats fed a high fat, high cholesterol diet, oleic acid-2,6-diisopropylanilide decreased low density lipoproteins and elevated high density lipoprotein levels when administered at 0.05%.

HY-133968R

24-Methylenecholesterol (Standard) Ostreasterol (Standard)	Acyltransferase Reactive Oxygen Species	Inflammation/Immunology
24-Methylenecholesterol (Ostreasterol) (Standard) is the analytical standard of 24-Methylenecholesterol (HY-133968). This product is intended for research and analytical applications. 24-Methylenecholesterol (Ostreasterol) is a regulator targeting acyl-CoA cholesterol acyltransferase (ACAT) with anti-aging and neuroprotective effects. 24-Methylenecholesterol mimics the effects of nerve growth factor (NGF), can extend yeast lifespan through an anti-oxidative stress mechanism, and exhibits neuroprotective activity in PC12 cells. 24-Methylenecholesterol can reduce intracellular reactive oxygen species (ROS) and malondialdehyde (MDA) levels, activate anti-oxidative stress pathways (such as UTH1, SOD-related genes), and promote synaptic growth .

HY-133968S1

24-Methylenecholesterol-13C Ostreasterol-¹³C	Isotope-Labeled Compounds Acyltransferase Reactive Oxygen Species	Inflammation/Immunology
24-Methylenecholesterol- ¹³C (Ostreasterol- ¹³C) is the ¹³C labeled 24-Methylenecholesterol (HY-133968) . 24-Methylenecholesterol (Ostreasterol) is a regulator targeting acyl-CoA cholesterol acyltransferase (ACAT) with anti-aging and neuroprotective effects. 24-Methylenecholesterol mimics the effects of nerve growth factor (NGF), can extend yeast lifespan through an anti-oxidative stress mechanism, and exhibits neuroprotective activity in PC12 cells. 24-Methylenecholesterol can reduce intracellular reactive oxygen species (ROS) and malondialdehyde (MDA) levels, activate anti-oxidative stress pathways (such as UTH1, SOD-related genes), and promote synaptic growth .

HY-U00369

FCE 28654	Acyltransferase	Cardiovascular Disease
FCE 28654 is an inhibitor of acylCoA: cholesterol acyltransferase (ACAT), weakly inhibiting ACAT in microsomes from rabbit aorta and intestine, and monkey liver, with IC₅₀s of 2.55, 1.08 and 5.69 μM, respcetively.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3806

Enniatin B	Infection Cardiovascular Disease Alkaloids Microorganisms Classification of Application Fields Source classification Disease Research Fields	Acyltransferase ERK
Enniatin B is a Fusarium mycotoxin. Enniatin B inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC₅₀ of 113 μM in an enzyme assay using rat liver microsomes . Enniatins B decreases the activation of ERK (p44/p42) .

HY-N10224

Terpendole C	Alkaloids Microorganisms Classification of Application Fields Source classification Metabolic Disease Disease Research Fields Indole Alkaloids	Acyltransferase
Terpendole C, produced by Albophoma yamanashiensis, shows potent inhibitory activity against acyl-CoA: cholesterol acyltransferase (ACAT) .

HY-N14614

Pyripyropene B	Structural Classification Natural Products Microorganisms Ketones, Aldehydes, Acids Source classification	Acyltransferase
Pyripyropene B is a powerful acyl-CoA: cholesterol acyltransferase 2 (ACAT2) inhibitor found in the fungus Aspergillus fumigatus FO 1289. Pyripyropene B inhibits acyl-CoA: cholesterol acyltransferase with an IC₅₀ of 117 nM .

HY-N10234

Phenylpyropene A	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	Acyltransferase
Phenylpyropene A, a fungal metabolite, is a potent acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor with an IC₅₀ of 0.8 μM .

HY-N8331

Terpendole I	Alkaloids Microorganisms Classification of Application Fields Terpenoids Source classification Diterpenoids Disease Research Fields Indole Alkaloids Cancer	Acyltransferase Endogenous Metabolite
Terpendole I, a fungal indoloditerpene, is a ACAT (acyl-CoA: cholesterol acyltransferase) inhibitor (IC₅₀=145 µM) .

HY-N14968

Enniatin F	Structural Classification Natural Products Microorganisms Source classification	Parasite Fungal
Enniatin F has insecticidal and antifungal activity. Enniatin F also can inhibit acyl-CoA, cholesterol acyltransferase (ACAT) .

HY-N6702

Enniatin A	Cardiovascular Disease Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields	Acyltransferase
Enniatin A is a Fusarium mycotoxin. Enniatin A inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC₅₀ of 22 μM in an enzyme assay using rat liver microsomes .

HY-N15411

Helminthosporol	Structural Classification Terpenoids Sesquiterpenes Source classification Artemisia desertorum Spreng. Plants Compositae	Acyltransferase Phytohormone
Helminthosporol is a natural plant growth-regulator that can promote the growth of rice and lettuce seedlings. Helminthosporol can also inhibit the activity of acyl-CoA: cholesterol acyltransferase (ACAT) in rat liver microsomes and the synthesis of cholesterol esters in macrophages .

HY-169813

Yakuchinone B	Structural Classification Monophenols Source classification Phenols Plants Alpinia oxyphylla Miq. Zingiberaceae	Acyltransferase
Yakuchinone B is an Acyl-CoA: cholesterol O-acyltransferase (ACAT) inhibitor with hypocholesterolemic activity, which is found in the seeds of Zingiberaceae. Yakuchinone B inhibits rat hepatic ACAT with an IC₅₀ value of 20.6 μM. Yakuchinone B is promising for research of hypercholesterolemia and atherosclerosis .

HY-126455

Penicillide Vermixocin A	Monophenols Microorganisms Classification of Application Fields Source classification Phenols Metabolic Disease Disease Research Fields	Acyltransferase
Penicillide (Vermixocin A), isolated from Talaromyces derxii cultivated on rice, shows inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT) .

HY-121254

GERI-BP002-A	Structural Classification Natural Products Microorganisms Source classification	Acyltransferase
GERI-BP002-A is an inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT) produced by Aspergillus fumigatus F93, which can be used in cancer research .

HY-N3807

Enniatin B1 1 Publications Verification	Infection Cardiovascular Disease Alkaloids Structural Classification Microorganisms Classification of Application Fields Other Alkaloids Source classification Disease Research Fields	Acyltransferase ERK NF-κB
Enniatin B1 is a Fusarium mycotoxin. Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC₅₀ of 73 μM in an enzyme assay using rat liver microsomes . Enniatin B1 crosss the blood-brain barrier . Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation .

HY-133968

24-Methylenecholesterol Ostreasterol	Structural Classification Classification of Application Fields Anti-aging Marine natural products Source classification Other marine organisms Plants Microorganisms other families Animals Inflammation/Immunology Disease Research Fields Steroids	Acyltransferase Reactive Oxygen Species
24-Methylenecholesterol (Ostreasterol) is a regulator targeting acyl-CoA cholesterol acyltransferase (ACAT) with anti-aging and neuroprotective effects. 24-Methylenecholesterol mimics the effects of nerve growth factor (NGF), can extend yeast lifespan through an anti-oxidative stress mechanism, and exhibits neuroprotective activity in PC12 cells. 24-Methylenecholesterol can reduce intracellular reactive oxygen species (ROS) and malondialdehyde (MDA) levels, activate anti-oxidative stress pathways (such as UTH1, SOD-related genes), and promote synaptic growth .

HY-133968R

24-Methylenecholesterol (Standard) Ostreasterol (Standard)	Structural Classification Microorganisms other families Animals Marine natural products Source classification Other marine organisms Plants Steroids	Acyltransferase Reactive Oxygen Species
24-Methylenecholesterol (Ostreasterol) (Standard) is the analytical standard of 24-Methylenecholesterol (HY-133968). This product is intended for research and analytical applications. 24-Methylenecholesterol (Ostreasterol) is a regulator targeting acyl-CoA cholesterol acyltransferase (ACAT) with anti-aging and neuroprotective effects. 24-Methylenecholesterol mimics the effects of nerve growth factor (NGF), can extend yeast lifespan through an anti-oxidative stress mechanism, and exhibits neuroprotective activity in PC12 cells. 24-Methylenecholesterol can reduce intracellular reactive oxygen species (ROS) and malondialdehyde (MDA) levels, activate anti-oxidative stress pathways (such as UTH1, SOD-related genes), and promote synaptic growth .

Cat. No.	Product Name	Chemical Structure

HY-133968S1

24-Methylenecholesterol-13C

24-Methylenecholesterol- ¹³C (Ostreasterol- ¹³C) is the ¹³C labeled 24-Methylenecholesterol (HY-133968) . 24-Methylenecholesterol (Ostreasterol) is a regulator targeting acyl-CoA cholesterol acyltransferase (ACAT) with anti-aging and neuroprotective effects. 24-Methylenecholesterol mimics the effects of nerve growth factor (NGF), can extend yeast lifespan through an anti-oxidative stress mechanism, and exhibits neuroprotective activity in PC12 cells. 24-Methylenecholesterol can reduce intracellular reactive oxygen species (ROS) and malondialdehyde (MDA) levels, activate anti-oxidative stress pathways (such as UTH1, SOD-related genes), and promote synaptic growth .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81246

	DGAT1 Antibody (YA3508) ACAT related gene product 1; ACAT-related gene product 1; acyl coenzyme A:cholesterol acyltransferase related gene 1; acyl-CoA retinol O-fatty-acyltransferase; acyl-CoA:diacylglycerol acyltransferase; ARAT; ARGP1; C75990; D15Ertd23e; Dgat; DGAT1; DGAT1_HUMAN; Diacylglycerol O acyltransferase 1; Diacylglycerol O-acyltransferase 1; Diglyceride acyltransferase; EC 2.3.1.20; hCG_24006; MGC139064; Retinol O fatty acyltransferase.	WB, IHC-P, IHC-F, ICC/IF, ELISA	Human
	DGAT1 Antibody is a rabbit-derived non-conjugated IgG antibody, targeting DGAT1, with a predicted molecular weight of 55 kDa (observed band size: 55 kDa). DGAT1 Antibody can be used for WB,IHC-P,IP experiments in human backgrounds.

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acyl-CoA: cholesterol acyltransferase

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Antibodies

Natural
Products