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XJZ-06-462

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-169369

    XJZ-06-462

    MDM-2/p53 Apoptosis Cancer
    TRAP-1 (XJZ-06-462) is a selective p53 Y220C transcriptional activator. TRAP-1 can engage p53 Y220C and BRD4 in a ternary complex, which potently activates mutant p53 and triggers robust p53 target gene transcription. TRAP-1 rapidly upregulates p21 and other p53 target genes in pancreatic cell lines with p53 Y220C. TRAP-1 exhibits higher antiproliferative activity in BxPC-3 (p53 Y220C) cells than in A549 cells (p53 WT), with IC50 values of 0.531 μM and 3.94 μM, respectively. TRAP-1 can be used for the study of p53 Y220C-bearing cancer.
    TRAP-1

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