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Results for "

VIM

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Bacterial (16) Beta-lactamase (17) Mitosis (2) Proteasome (2) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (2) Infection (19)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-151424

Vimentin-IN-1	Proteasome Mitosis	Cancer
Vimentin-IN-1 is a FiVe1 derivative, an orally active and selective anticancer agent. FiVe1 binds type III intermediate filament protein vimentin (VIM), to induce hyperphosphorylation of Ser56, resulting selective disruption of mitosis and multinucleation in transformed VIM-expressing mesenchymal cancer cells. Vimentin-IN-1 shows better oral bioavailability and pharmacokinetic profiles than FiVe1 .

HY-146637

VIM-2-IN-1	Beta-lactamase Bacterial	Infection
VIM-2-IN-1 (compound 1dj) is a β-lactamase inhibitor with antibacterial activities. VIM-2-IN-1 has moderate IC₅₀ values of 23 µM, 48 µM and 231 µM for Verona integron-encoded metallo-β-lactamase (VIM-2), German imipenemase-1 (GIM-1) and New Delhi metallo-β-lactamase (NDM-1), respectively .

HY-RS23779

Vim Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Vim Rat Pre-designed siRNA Set A contains three designed siRNAs for Vim gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Vim Rat Pre-designed siRNA Set A Vim Rat Pre-designed siRNA Set A

HY-RS17324

Vim Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Vim Mouse Pre-designed siRNA Set A contains three designed siRNAs for Vim gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Vim Mouse Pre-designed siRNA Set A Vim Mouse Pre-designed siRNA Set A

HY-RS15652

VIM Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
VIM Human Pre-designed siRNA Set A contains three designed siRNAs for VIM gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

VIM Human Pre-designed siRNA Set A VIM Human Pre-designed siRNA Set A

HY-144100

β-Lactamase-IN-7	Beta-lactamase Bacterial	Infection
β-Lactamase-IN-7 (compound 14) is a potent VIM-Type metallo-β-lactamase inhibitor, with K_is of 1.26 μM and 0.54 μM for *VIM-1* and *VIM-4, respectively. β-Lactamase-IN-7 can effectively inhibit Klebsiella pneumoniae* .

HY-143414

Metallo-β-lactamase-IN-6	Beta-lactamase Bacterial	Infection
Metallo-β-lactamase-IN-6 is a potent *VIM*-Type metallo-β-lactamase inhibitor with IC₅₀s of 0.56 μM, 29.50 μM and 5.78 μM for VIM-2, VIM-1 and VIM-5. Metallo-β-lactamase-IN-6 displays potent synergistic antibacterial activity with Meropenem against engineered Escherichia coli strains and intractable clinically isolated Pseudomonas aeruginosa producing VIM-2 MBL .

HY-143415

Metallo-β-lactamase-IN-7	Beta-lactamase Bacterial	Infection
Metallo-β-lactamase-IN-7 is a potent VIM-Type metallo-β-lactamase inhibitor with IC₅₀s of 0.019 μM, 13.64 μM, 0.38 μM for VIM-2, VIM-1 and VIM-5. Metallo-β-lactamase-IN-7 potentiate antibacterial activity of Meropenem against the Gram-negative bacterial strains .

HY-163339

Metallo-β-lactamase-IN-14	Beta-lactamase	Infection
Metallo-β-lactamase-IN-14 (Compound 17e) is a Metallo-β-Lactamase inhibitor. Metallo-β-lactamase-IN-14 shows inhibition activity against VIM-1 and VIM-2. Metallo-β-lactamase-IN-14 has antibacterial activity against Gram-negative (GN) bacteria and P. aeruginosa .

HY-168500

Metallo-β-lactamase-IN-16	Beta-lactamase Bacterial	Infection
Metallo-β-lactamase-IN-16 (compound 18) is a sulfone containing metallo-β-lactamase inhibitor with an anti-bacterial activity. Metallo-β-lactamase-IN-16 inhibits NDM-1 (New Dehli metallo-β-lactamase-1), IMP-1 (imipenemase-1), VIM-1 (Verona integron-encoded metallo-β-lactamase), and VIM-2 with IC₅₀ values of 0.16 nM, 0.23 nM, 0.31 nM and 1.0 nM, respectively .

HY-152105

Metallo-β-lactamase-IN-9	Beta-lactamase Bacterial	Infection
Metallo-β-lactamase-IN-9 (Compound 23) is a pan metallo-beta-lactamase (MBL) inhibitor with IC₅₀s of 35, 269 and 369 nM against NDM-1, *VIM-1* and IMP-1, respectively .

HY-161310

Metallo-β-lactamase-IN-15	Beta-lactamase	Infection
Metallo-β-lactamase-IN-15 (Compound ±13) is a potent MBL inhibitor, the IC₅₀ values for NDM-1、IMP-1 and VIM-2 were 0.29 μM, 0.088 μM and 0.063 μM, respectively .

HY-144259

Metallo-β-lactamase-IN-2	Beta-lactamase Bacterial	Infection
Metallo-β-lactamase-IN-4 (compound 40) is a potent metallo-β-lactamases (MBL) inhibitor, with IC₅₀ values of 0.1 μM (VIM-1), 1.3 μM (NDM-1), and 5.0 μM (IMP-7), respectively .

HY-144262

Metallo-β-lactamase-IN-4	Beta-lactamase Bacterial	Infection
Metallo-β-lactamase-IN-4 (compound 40) is a potent metallo-β-lactamases (MBL) inhibitor, with IC₅₀ values of 0.5 μM (VIM-1), 2.1 μM (NDM-1), and 3.3 μM (IMP-7), respectively .

HY-124757

FiVe1	Proteasome Mitosis	Cancer
FiVe1 is a vimentin (VIM) inhibitor. FiVe1 binds to the rod domain of VIM, causing metaphase VIM disassembly and hyperphosphorylation at Ser56, ultimately leading to mitotic catastrophe, multinucleation, and loss of stemness. FiVe1 has anticancer activity against soft tissue sarcomas. FiVe1 increases the sensitivity of ovarian cancer to Cisplatin (HY-17394). FiVe1 can be used for researches of mesenchymal cancers (including breast cancer and soft tissue sarcoma) and ovarian cancers .

HY-144261

Metallo-β-lactamase-IN-3	Beta-lactamase Bacterial	Infection
Metallo-β-lactamase-IN-3 (compound 35) is a potent metallo-β-lactamases (MBL) inhibitor. Metallo-β-lactamase-IN-3 shows high activity against *VIM-1* and NDM-1, with IC₅₀ of 0.6 and 1.0 μM, respectively. Metallo-β-lactamase-IN-3 does not show inhibition of IMP-7 .

HY-155201

YJ182	Bacterial	Infection
YJ182 is a NDM-1 inhibitor (IC₅₀: 0.23 μM). YJ182 also inhibits IMP-1, VIM-2, GIM-1, and MMP-2, with IC₅₀s of 0.25, 0.61, 0.49, and 6.92 μM respectively. YJ182 can be used for bacterial infection research .

HY-148493

MK-3402	Bacterial	Infection
MK-3402 (Compound303) is a metallo-beta-lactamase inhibitor, with IC₅₀ values of 0.53, 0.25 and 0.169 nM against IMP-1, NDM-1, and *VIM-1*, respectively. MK-3402 can be used in bacterial research and shows a synergistic effect when used in combination with beta-lactam antibiotics .

HY-109124

Taniborbactam Maximum Cited Publications 7 Publications Verification VNRX-5133	Beta-lactamase Bacterial	Infection
Taniborbactam (VNRX-5133) is a reversible and selective boronic acid-containing pan-spectrum β-lactamase inhibitor with IC₅₀s of 8-530 nM. Taniborbactam has IC₅₀s of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2. Taniborbactam is against Gram-negative bacteria .

HY-109124A

Taniborbactam hydrochloride Maximum Cited Publications 7 Publications Verification VNRX-5133 hydrochloride	Beta-lactamase Bacterial	Infection
Taniborbactam hydrochloride (VNRX-5133 hydrochloride) is a reversible and selective boronic acid-containing pan-spectrum β-lactamase inhibitor with IC₅₀s of 8-530 nM. Taniborbactam hydrochloride has IC₅₀s of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2. Taniborbactam hydrochloride is against Gram-negative bacteria .

HY-144659

Metallo-β-lactamase-IN-5	Beta-lactamase Apoptosis Bacterial	Infection
Metallo-β-lactamase-IN-5 (compound 5c) is a potent metallo-β-lactamases (MBL) inhibitor. Metallo-β-lactamase-IN-5 shows inhibitory activity against MBLs NDM-1 and VIM-1. Metallo-β-lactamase-IN-5 inhibits HUVECs with an IC₅₀ of 45 μg/mL. Metallo-β-lactamase-IN-5 plus Imipenem exhibits synergistic antimicrobial activity .

HY-146165

Metallo-β-lactamase-IN-8	Beta-lactamase Bacterial	Infection
Metallo-β-lactamase-IN-8 (compound 17) is a potent, reversible and competitive broad-spectrum inhibitor of metallo-β-lactamases (MβLs), with IC₅₀s of 1.3 μM, 5.7 μM, 9.8 μM, and 9.9 μM for L1, ImiS, IMP-1 and *VIM-2*, respectively. Metallo-β-lactamase-IN-8 exhibits antibacterial activity .

HY-B0368C

epi-D-Captopril epi-D-SQ 14225	Beta-lactamase	Infection
epi-D-Captopril (epi-D-SQ 14225) is a stereoisomer of Captopril (HY-B0368) and an inhibitor of metallo-β-lactamases (MBLs). The IC₅₀ values of epi-D-Captopril against NDM-1, IMP-1, and *VIM-2* are 64 μM, 173 μM, and 5.5 μM, respectively. epi-D-Captopril is expected to be used in the research of diseases caused by MBLs-related drug-resistant bacterial infections .

HY-173472

MBL-IN-5	Bacterial Beta-lactamase	Infection
MBL-IN-5 is a metallo-β-lactamase (MBL) inhibitor. MBL-IN-5 inhibits three clinically relevant B1 subfamily MBLs (NDM-1, VIM-1, and IMP-1) with IC₅₀s of 0.05  nM, 14  nM and 21 nM respectively. MBL-IN-5 remarkably enhances carbapenems’ effectiveness against MBL-producing clinical strains and significantly reduces the bacterial load in a neutropenic murine thigh infection model combined with the IPM antibiotic .

Cat. No.	Compare	Product Name	Species	Source

HY-P73551

	Vimentin Protein, Human (sf9, His) 1 Publications Verification VIM; VIMentin	Human	Sf9 insect cells
	Vimentin, a class-III intermediate filament, predominantly exists in non-epithelial cells, particularly mesenchymal cells. This structural protein forms networks linking the nucleus, endoplasmic reticulum, and mitochondria. Teaming up with LARP6, vimentin stabilizes messenger RNAs (mRNAs) of type I collagen, notably CO1A1 and CO1A2, showcasing its role in regulating extracellular matrix components crucial for cellular structure and integrity. Vimentin Protein, Human (sf9, His) is the recombinant human-derived Vimentin protein, expressed by Sf9 insect cells , with C-His labeled tag.

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HY-P80863

	Phospho-Vimentin (Ser56) Antibody (YA138) VIM; VIMentin	WB, ICC/IF, IP	Human
	Phospho-Vimentin (Ser56) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 54 kDa, targeting to Phospho-Vimentin (Ser56). It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human.

HY-P84016

	Vimentin Antibody (YA3713) FLJ36605; VIM	WB, IHC-P, FC, ELISA	Human, Mouse, Monkey

HY-P84017

	Vimentin Antibody (YA3714) FLJ36605; VIM	WB, IHC-P, FC, ELISA	Human, Mouse, Rat

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Vim Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Vim Rat Pre-designed siRNA Set A contains three designed siRNAs for Vim gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Vim Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Vim Mouse Pre-designed siRNA Set A contains three designed siRNAs for Vim gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

VIM Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
VIM Human Pre-designed siRNA Set A contains three designed siRNAs for VIM gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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