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Results for "

UGT1A9

" in MedChemExpress (MCE) Product Catalog:

7

Inhibitors & Agonists

2

Natural
Products

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N4194
    Glabrone

    		PPAR Influenza Virus Infection Metabolic Disease
    Glabrone is an isoflavone found in Glycyrrhiza glabra roots. Glabrone exhibits significant PPAR-γ ligand binding activity. Glabrone is a specific UGT1A9 probe substrate, and its metabolites can block influenza virus release by inhibiting neuraminidase (NA). Glabrone can be used to screen for herb-drug interactions and for anti-influenza virus activity .
    Glabrone
  • HY-125156
    Dapagliflozin-3-O-β-D-glucuronide

    BMS-801576

    		 Endogenous Metabolite Metabolic Disease
    Dapagliflozin-3-O-β-D-glucuronide (BMS-801576) is the metabolite of Dapagliflozin (HY-10450), and is formed in the liver and kidney by uridine diphosphate glucuronosyltransferase-1A9 (UGT1A9). Dapagliflozin is a selective inhibitor for SGLT2, that can be used to improve glycemic control and attenuate type 2 diabetes .
    Dapagliflozin-3-O-β-D-glucuronide
  • HY-N1902R
    4-Hydroxyphenylacetic acid (Standard)

    		Reference Standards Keap1-Nrf2 Endogenous Metabolite Metabolic Disease
    4-Hydroxyphenylacetic acid (Standard) is the analytical standard of 4-Hydroxyphenylacetic acid. This product is intended for research and analytical applications. 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2 . IC50 & Target:Nrf2 In Vivo: 4-Hydroxyphenylacetic acid (6, 12, or 25 mg/kg) increases Nrf2 translocation to the nucleus and enhances the activity of phase II and antioxidant enzymes. The protein levels of nuclear Nrf2 are increased by 170% and 230% in pre-treated 12 and 25 mg/kg 4-Hydroxyphenylacetic acid groups, respectively, compared with the control group.The 4-Hydroxyphenylacetic acid pretreatment at a final dose of 25 mg/kg markedly and selectively up-regulated the target genes of phase II enzymes and resulted in higher up-regulation than that of the control group by 270%, 400%, and 500% or UGT1A1, UGT1A9, and SULT2A1, respectively. 4-Hydroxyphenylacetic acid also suppresses the expression of CYP2E1 .
    4-Hydroxyphenylacetic acid (Standard)
  • HY-RS15433
    UGT1A9 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    UGT1A9 Human Pre-designed siRNA Set A contains three designed siRNAs for UGT1A9 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    UGT1A9 Human Pre-designed siRNA Set A
    UGT1A9 Human Pre-designed siRNA Set A
  • HY-W278777
    Monohexyl phthalate

    		Biochemical Assay Reagents Others
    Monohexyl phthalate is a competitive inhibitor towards UGT1A9, with an IC50 of 12.46 μM and a Ki of 7.47 μM .
    Monohexyl phthalate
  • HY-172338
    Chlorzoxazone-N-glucuronide

    CHZ-N-Glc

    		 Endogenous Metabolite Others
    Chlorzoxazone-N-glucuronide is a phase II metabolite of the skeletal muscle relaxant – Chlorzoxazone. Chlorzoxazone-N-glucuronide can be synthesized via glucuronidation of chlorozoxazone by UGT1A9 .
    Chlorzoxazone-N-glucuronide
  • HY-135541
    Darexaban maleate

    YM150 maleate

    		 Endogenous Metabolite Cardiovascular Disease
    Darexaban maleate (YM150 maleate) is a direct factor Xa inhibitor with activity in preventing venous thromboembolism. The major metabolite of Darexaban maleate in humans is Darexaban glucitol, which acts pharmacologically. The glucitolation reaction of Darexaban maleate is mainly catalyzed by UGT1A9 and UGT1A10 in the human liver and intestine. The K(m) value of Darexaban maleate glucitolation in the liver is greater than 250 μM, while in the intestine it exhibits substrate inhibition kinetics with a K(m) value of 27.3 μM. The unbound K(m) value of Darexaban maleate is significantly reduced by the influence of fatty acid-free bovine serum albumin in both HLM and UGT1A9 .
    Darexaban maleate

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