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Pathways Recommended: Stem Cell/Wnt Cell Cycle/DNA Damage
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Transformed sinusoidal endothelial cells (TSECs)

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-173564
    DW34

    		Epigenetic Reader Domain Necroptosis Inflammation/Immunology
    DW34 is an orally active pan-BRD4-D1 biased inhibitor with additional BRD4-D2 inhibitive activity. DW34 displays comparable inhibitive efficacy to I-BET151 (HY-13235) (EC50 = 0.16 μM) with low nanomolar EC50 values of 0.14 μM. DW34 significantly reduces liver inflammation induced by LPS (HY-D1056) and APAP (HY-66005) via reducing chemokine expression and cellular necrosis .
    DW34

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