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Holo-Bovine Transferrin, a blood-plasma glycoprotein, is a target ligand for transferrinreceptor. Holo-Bovine Transferrin can bind to and mediate the transport of iron .
Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) is a mouse-derived IgG2a κ type antibody, targeting to mouse/rat CD71/TfR1. Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) targets the transferrinreceptor and binds to an extracellular domain for the transferrinreceptor. Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) can be used for the research in drug delivery, especially for drug delivery to the brain .
Anti-CD71 Antibody (OKT-9) is a kind of mouse IgG1 κ chimeric antibody, targeting to human CD71. Anti-CD71 Antibody (OKT-9) can recognize CD71 also known as Transferrinreceptor protein 1 (TfR1). Anti-CD71 Antibody (OKT-9) can be used for the detections of immunohistochemistry, immunofluorescence and flow cytometry in cancer, such as leukemia and lymphoma .
Apo-Bovine Transferrin refers to iron free Transferrin (HY-P3267), serves as Transferrinreceptor ligand and mediates iron release from endothelial cells. Apo-Transferrin can directly bind to hephaestin, which can convert Fe 2+ to Fe 3+. Apo-Transferrin mediates iron efflux most likely in cooperation with ferroportin 1. Apo-Bovine Transferrin can be used in neuroretinal research .
DSPE-PEG2000-T7 is a PEG compound which composed of DSPE and a transferrinreceptor (TfR) peptide (T7). T7 (HAIYPRH) specifically binds to TfR (transferrinreceptor). DSPE-PEG2000-T7 can be used for drug delivery .
Cy3-Transferrin is a fluorescent labeling reagent that combines Cy3 (HY-D0822) fluorescent dye and Transferrin (HY-P3267). The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. Cy3 has an emission maximum around 562-570 nm. Transferrin, a blood-plasma glycoprotein, is a target ligand for transferrinreceptor. Transferrin can bind to and mediate the transport of iron .
Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD71/TfR1. Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) can deplete CD71 + cells and inhibit transferrinreceptor. Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) can be used for the researches of cancer, infection, inflammation and immunology, such as lung cancer, lymphocytic choriomeningitis virus (LCMV) infection and Cardiac allograft .
Holo Transferrin (Bovine) (HTF (Bovine)) is a glycoprotein that acts as a growth factor. Binding of Holo Transferrin (Bovine) to its receptor is necessary for cells to initiate and maintain their DNA synthesis .
DSPE-PEG3400-T7 is a PEG compound which composed of DSPE and a transferrinreceptor (TfR) peptide (T7). T7 (HAIYPRH) specifically binds to TfR (transferrinreceptor). DSPE-PEG3400-T7 can be used for drug delivery .
DSPE-PEG5000-T7 is a PEG compound which composed of DSPE and a transferrinreceptor (TfR) peptide (T7). T7 (HAIYPRH) specifically binds to TfR (transferrinreceptor). DSPE-PEG5000-T7 can be used for drug delivery .
DSPE-PEG1000-T7 is a PEG compound which composed of DSPE and a transferrinreceptor (TfR) peptide (T7). T7 (HAIYPRH) specifically binds to TfR (transferrinreceptor). DSPE-PEG1000-T7 can be used for drug delivery .
HAIYPRH hydrochloride, a targeting ligand, can specially bind to transferrinreceptor (TfR). HAIYPRH hydrochloride can mediate the transport of nanocarriers across the blood-brain barrier .
Pabinafusp alfa (JR-141) is a transferrinreceptor-targeting antibody consisting of Iduronate 2-sulfatase (HY-P76399) and an anti-human transferrinreceptor antibody. Pabinafusp alfa is blood-brain permeable and prevents heparan sulfate (HS) deposition in the central nervous system of mucopolysaccharidosis II (MPS II) mice. Pabinafusp alfa improves learning and prevents central nervous system neuronal damage in mice .
DSPE-PEG3400-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrinreceptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells .
DSPE-PEG5000-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrinreceptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells .
DSPE-PEG1000-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrinreceptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells .
DSPE-PEG2000-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrinreceptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells .
Ap44mSe is a selenosemicarbazone that effectively depletes cellular Fe, resulting in transferrinreceptor-1 up-regulation, ferritin down-regulation, and increased expression of the potent metastasis suppressor, N-myc downstream regulated gene-1. Ap44mSe forms redox active Cu complexes that target the lysosome to induce lysosomal membrane permeabilization .
Delpacibart braxlosiran (Del-desiran), an antibody oligonucleotide conjugate (AOC), consists of a monoclonal antibody (Delpacibart) (HY-P990051) that binds to the transferrinreceptor 1 (TfR1) conjugated with a siRNA targeting DMPK (DM1 protein kinase) mRNA. Delpacibart braxlosiran is used for the study of myotonic dystrophy type 1 (DM1) .
BCY17901 is a potent irreversible transferrinreceptor 1 (TfR1) inhibitor (Ki=12 nM). BCY17901 inhibits TfR1-mediated endocytosis and iron transport, and suppresses the proliferation of tumor cells dependent on iron metabolism. BCY17901 can be used in the research of solid tumors (such as breast cancer, glioblastoma) and neurodegenerative diseases .
BCY17901 TFA is a potent irreversible transferrinreceptor 1 (TfR1) inhibitor (Ki=12 nM). BCY17901 TFA inhibits TfR1-mediated endocytosis and iron transport, and suppresses the proliferation of tumor cells dependent on iron metabolism. BCY17901 TFA can be used in the research of solid tumors (such as breast cancer, glioblastoma) and neurodegenerative diseases .
(1R)-cis-Bifenthrin is a widely used pyrethroid pesticide with activity that reduces motor coordination. (1R)-cis-Bifenthrin has a significant impact on the motor function of ParKin-/- mice, as shown by increased pole climbing time and wheel running Time decreases. Exposure of (1R)-cis-Bifenthrin resulted in a significant reduction in tyrosine hydroxylase-positive cell counts and protein expression. (1R)-cis-Bifenthrin caused increased expression of mitophagy-related proteins LC3B and p62. (1R)-cis-Bifenthrin has a lower binding energy with transferrin and transferrinreceptor 2, showing stronger interactions. The biological effects of (1R)-cis-Bifenthrin show relationships with mitophagy and ferroptosis-related pathways .
Trontinemab (RG6102) is a brain-penetrant, anti-amyloid, bispecific and humanizedized IgG1-κ antibody, targeting to Aβ plaques and transferrinreceptor 1 (TFR1). Trontinemab binds to fibrillar Aβ as well as Aβ plaques triggering plaque clearance by engaging immune cells on Alzheimer disease (AD) brain sections. Trontinemab also shows specific affinity to cynomolgus and human TFR1 .
HDAC11-IN-3 (Compound A9) is a selective HDAC11 inhibitor (IC50: 4.1 nM). HDAC11-IN-3 has inhibitory effects on U937 and OCI-AML2 acute myeloid leukemia (AML) cell lines (IC50: 10 μM). HDAC11-IN-3 has significant anti-AML activity, inducing apoptosis, cell cycle arrest, and differentiation. HDAC11-IN-3 upregulates the iron transporters transferrin (TF) and transferrinreceptor (TFRC), and activates the p62-Keap1-Nrf2-HMOX1 pathway, which together lead to increased intracellular iron levels and induce ferroptosis in AML cells. HDAC11-IN-3 can be used alone or in combination with Cytarabine (HY-13605) for AML research .
Rostudirsen, one of the components of Zeleciment rostudirsen (HY-177485), is a phosphorodiamidate morpholino oligomer. Zeleciment rostudirsen consists of Rostudirsen (HY-177484) conjugated to a fragment antibody (Fab), Zeleciment (HY-P990780), which binds to the transferrinreceptor 1 (TfR1) that is highly expressed in muscle. It is designed to enable targeted muscle tissue delivery and promote exon skipping in the nucleus, allowing muscle cells to create internally shortened, near full-length dystrophin protein.
Delpacibart braxlosiran (Del-brax), an antibody oligonucleotide conjugate (AOC), consists of a monoclonal antibody (Delpacibart) (HY-P990051) that binds to the transferrinreceptor 1 (TfR1) conjugated with a siRNA targeting DUX4 (Double homeobox protein) mRNA. It is used for the study of Facioscapulohumeral Muscular Dystrophy (FSHD). The abnormal expression of DUX4 protein leads to changes in gene expression in muscle cells that are associated with the life-long, progressive loss of muscle function in patients with FSHD .
TfR-1-IN-1 (compound C4) is an inhibitor of transferrinreceptor 1 (TfR-1) with anticancer activity. TfR-1-IN-1 strongly increases intracellular iron (II) levels as a driving force for the induction of ferroptosis. TfR-1-IN-1 significantly reduces the metabolic activity of ovarian cancer (A2780cis), breast cancer (MDA-MB 231), and leukemia (HL-60) cell lines with IC50 values of 0.51, 0.46, and 0.48 μM, respectively .
Anti-CD71/TfR1 Antibody (JR-141 antibody (uncoupled from iduronate 2-sulfatase)) is a humanized anti-human transferrinreceptor (CD71; TfR) antibody. Anti-CD71/TfR1 Antibody is the antibody part of the fusion protein Pabinafusp alfa (HY-P99797). The recommend isotype control of Anti-CD71/TfR1 Antibody: Human IgG1 kappa, Isotype Control (HY-P99001) .
Cy3-Transferrin is a fluorescent labeling reagent that combines Cy3 (HY-D0822) fluorescent dye and Transferrin (HY-P3267). The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. Cy3 has an emission maximum around 562-570 nm. Transferrin, a blood-plasma glycoprotein, is a target ligand for transferrinreceptor. Transferrin can bind to and mediate the transport of iron .
Holo-Bovine Transferrin, a blood-plasma glycoprotein, is a target ligand for transferrinreceptor. Holo-Bovine Transferrin can bind to and mediate the transport of iron .
Apo-Bovine Transferrin refers to iron free Transferrin (HY-P3267), serves as Transferrinreceptor ligand and mediates iron release from endothelial cells. Apo-Transferrin can directly bind to hephaestin, which can convert Fe 2+ to Fe 3+. Apo-Transferrin mediates iron efflux most likely in cooperation with ferroportin 1. Apo-Bovine Transferrin can be used in neuroretinal research .
DSPE-PEG2000-T7 is a PEG compound which composed of DSPE and a transferrinreceptor (TfR) peptide (T7). T7 (HAIYPRH) specifically binds to TfR (transferrinreceptor). DSPE-PEG2000-T7 can be used for drug delivery .
Holo Transferrin (Bovine) (HTF (Bovine)) is a glycoprotein that acts as a growth factor. Binding of Holo Transferrin (Bovine) to its receptor is necessary for cells to initiate and maintain their DNA synthesis .
DSPE-PEG3400-T7 is a PEG compound which composed of DSPE and a transferrinreceptor (TfR) peptide (T7). T7 (HAIYPRH) specifically binds to TfR (transferrinreceptor). DSPE-PEG3400-T7 can be used for drug delivery .
DSPE-PEG5000-T7 is a PEG compound which composed of DSPE and a transferrinreceptor (TfR) peptide (T7). T7 (HAIYPRH) specifically binds to TfR (transferrinreceptor). DSPE-PEG5000-T7 can be used for drug delivery .
DSPE-PEG1000-T7 is a PEG compound which composed of DSPE and a transferrinreceptor (TfR) peptide (T7). T7 (HAIYPRH) specifically binds to TfR (transferrinreceptor). DSPE-PEG1000-T7 can be used for drug delivery .
DSPE-PEG3400-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrinreceptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells .
DSPE-PEG5000-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrinreceptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells .
DSPE-PEG1000-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrinreceptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells .
DSPE-PEG2000-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrinreceptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells .
HAIYPRH hydrochloride, a targeting ligand, can specially bind to transferrinreceptor (TfR). HAIYPRH hydrochloride can mediate the transport of nanocarriers across the blood-brain barrier .
BCY17901 TFA is a potent irreversible transferrinreceptor 1 (TfR1) inhibitor (Ki=12 nM). BCY17901 TFA inhibits TfR1-mediated endocytosis and iron transport, and suppresses the proliferation of tumor cells dependent on iron metabolism. BCY17901 TFA can be used in the research of solid tumors (such as breast cancer, glioblastoma) and neurodegenerative diseases .
BCY17901 is a potent irreversible transferrinreceptor 1 (TfR1) inhibitor (Ki=12 nM). BCY17901 inhibits TfR1-mediated endocytosis and iron transport, and suppresses the proliferation of tumor cells dependent on iron metabolism. BCY17901 can be used in the research of solid tumors (such as breast cancer, glioblastoma) and neurodegenerative diseases .
Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) is a mouse-derived IgG2a κ type antibody, targeting to mouse/rat CD71/TfR1. Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) targets the transferrinreceptor and binds to an extracellular domain for the transferrinreceptor. Anti-Mouse/Rat CD71/TfR1 Antibody (OX-26) can be used for the research in drug delivery, especially for drug delivery to the brain .
Anti-CD71 Antibody (OKT-9) is a kind of mouse IgG1 κ chimeric antibody, targeting to human CD71. Anti-CD71 Antibody (OKT-9) can recognize CD71 also known as Transferrinreceptor protein 1 (TfR1). Anti-CD71 Antibody (OKT-9) can be used for the detections of immunohistochemistry, immunofluorescence and flow cytometry in cancer, such as leukemia and lymphoma .
Pabinafusp alfa (JR-141) is a transferrinreceptor-targeting antibody consisting of Iduronate 2-sulfatase (HY-P76399) and an anti-human transferrinreceptor antibody. Pabinafusp alfa is blood-brain permeable and prevents heparan sulfate (HS) deposition in the central nervous system of mucopolysaccharidosis II (MPS II) mice. Pabinafusp alfa improves learning and prevents central nervous system neuronal damage in mice .
Trontinemab (RG6102) is a brain-penetrant, anti-amyloid, bispecific and humanizedized IgG1-κ antibody, targeting to Aβ plaques and transferrinreceptor 1 (TFR1). Trontinemab binds to fibrillar Aβ as well as Aβ plaques triggering plaque clearance by engaging immune cells on Alzheimer disease (AD) brain sections. Trontinemab also shows specific affinity to cynomolgus and human TFR1 .
Anti-CD71/TfR1 Antibody (JR-141 antibody (uncoupled from iduronate 2-sulfatase)) is a humanized anti-human transferrinreceptor (CD71; TfR) antibody. Anti-CD71/TfR1 Antibody is the antibody part of the fusion protein Pabinafusp alfa (HY-P99797). The recommend isotype control of Anti-CD71/TfR1 Antibody: Human IgG1 kappa, Isotype Control (HY-P99001) .
Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD71/TfR1. Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) can deplete CD71 + cells and inhibit transferrinreceptor. Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) can be used for the researches of cancer, infection, inflammation and immunology, such as lung cancer, lymphocytic choriomeningitis virus (LCMV) infection and Cardiac allograft .
TFRC protein promotes cellular iron uptake through receptor-mediated endocytosis. TFRC is essential for erythroid and nervous system development and plays a crucial role in iron homeostasis. TFRC Protein, Human (HEK293, His) is the recombinant human-derived TFRC protein, expressed by HEK293 , with N-6*His labeled tag.
TFRC protein promotes cellular iron uptake through receptor-mediated endocytosis. TFRC is essential for erythroid and nervous system development and plays a crucial role in iron homeostasis. TFRC Protein, Human (HEK293, hFc) is the recombinant human-derived TFRC protein, expressed by HEK293 , with C-hFc labeled tag.
TFRC is a key protein in cellular iron uptake, coordinating receptor-mediated endocytosis of the ligand transferrin into specialized endosomes, where endosomal acidification triggers iron release.TFRC actively regulates T and B cell proliferation through iron uptake.TFRC Protein, Mouse (HEK293, His) is the recombinant mouse-derived TFRC protein, expressed by HEK293 , with N-8*His labeled tag.
BCY17901 TFA is a potent irreversible transferrinreceptor 1 (TfR1) inhibitor (Ki=12 nM). BCY17901 TFA inhibits TfR1-mediated endocytosis and iron transport, and suppresses the proliferation of tumor cells dependent on iron metabolism. BCY17901 TFA can be used in the research of solid tumors (such as breast cancer, glioblastoma) and neurodegenerative diseases .
DSPE-PEG2000-T7 is a PEG compound which composed of DSPE and a transferrinreceptor (TfR) peptide (T7). T7 (HAIYPRH) specifically binds to TfR (transferrinreceptor). DSPE-PEG2000-T7 can be used for drug delivery .
DSPE-PEG5000-T7 is a PEG compound which composed of DSPE and a transferrinreceptor (TfR) peptide (T7). T7 (HAIYPRH) specifically binds to TfR (transferrinreceptor). DSPE-PEG5000-T7 can be used for drug delivery .
DSPE-PEG1000-T7 is a PEG compound which composed of DSPE and a transferrinreceptor (TfR) peptide (T7). T7 (HAIYPRH) specifically binds to TfR (transferrinreceptor). DSPE-PEG1000-T7 can be used for drug delivery .
DSPE-PEG5000-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrinreceptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells .
DSPE-PEG1000-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrinreceptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells .
DSPE-PEG2000-THRPPMWSPVWP is a PEG compound which composed of DSPE and a transferrinreceptor (TfR) peptide (THRPPMWSPVWP). THRPPMWSPVWP binds to the TfR and is subsequently internalized into TfR-expressing cells .
Rostudirsen, one of the components of Zeleciment rostudirsen (HY-177485), is a phosphorodiamidate morpholino oligomer. Zeleciment rostudirsen consists of Rostudirsen (HY-177484) conjugated to a fragment antibody (Fab), Zeleciment (HY-P990780), which binds to the transferrinreceptor 1 (TfR1) that is highly expressed in muscle. It is designed to enable targeted muscle tissue delivery and promote exon skipping in the nucleus, allowing muscle cells to create internally shortened, near full-length dystrophin protein.
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