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Tolcapone 3-β-D-glucuronide

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-126194
    Tolcapone 3-β-D-glucuronide

    Ro 61-1448

    		 Drug Metabolite COMT Amyloid-β Apoptosis Reactive Oxygen Species (ROS) Others
    Tolcapone 3-β-D-glucuronide (Ro 61-1448) is an O-methyl metabolite of Tolcapone (HY-17406) and is pharmacologically inactive. Tolcapone (Ro 40-7592) is a selective, potent and orally active COMT inhibitor with an IC50of 773 nM. Tolcapone can inhibits α-syn and Aβ42 oligomerization and fibrillogenesis. Tolcapone can cause oxidative stress and induce cancer cells apoptosis and ROS production. Tolcapone can be used for the researches of cancer and neurological disease, such as Parkinson disease and neuroblastoma .
    Tolcapone 3-β-D-glucuronide

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