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Thymidine Phosphorylase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (5) Biochemical Assay Reagents (1) DNA/RNA Synthesis (7) Drug Metabolite (4) Isotope-Labeled Compounds (3) Nucleoside Antimetabolite/Analog (13) Orthopoxvirus (2) Phosphatase (3) Reference Standards (1) Thymidylate Synthase (3)
By Research Areas:	Cancer (19) Cardiovascular Disease (1) Infection (3)

Inhibitors & Agonists

Biochemical Assay Reagents

Isotope-Labeled Compounds

Targets Recommended: Phosphorylase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0307

Idoxuridine 5+ Cited Publications 5-Iodo-2′-deoxyuridine; 5-IUdR; IdUrd	Phosphatase Orthopoxvirus	Infection Cancer
Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) is an iodinated thymidine analogue that competitively inhibits *phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase* and affecting viral replication. Idoxuridine against feline herpesvirus has the IC₅₀ value of 4.3 μM . Idoxuridine shows anti-orthopoxvirus activity.

HY-A0063A

Tipiracil 5 Publications Verification	Thymidylate Synthase Nucleoside Antimetabolite/Analog	Cancer
Tipiracil is a thymidine phosphorylase (TPase) inhibitor.

HY-A0063

Tipiracil hydrochloride 5 Publications Verification	Nucleoside Antimetabolite/Analog	Cancer
Tipiracil (hydrochloride) is a thymidine phosphorylase inhibitor (TPI), used for cancer research.

HY-B0016

Capecitabine Maximum Cited Publications 22 Publications Verification	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Apoptosis	Cancer
Capecitabine is an oral proagent that is converted to its active metabolite, 5-FU, by thymidine phosphorylase.

HY-W008907

5'-O-Tritylthymidine 5-OTT	Apoptosis	Cancer
5'-O-Tritylthymidine is an inhibitor of TK-2 and inhibits angiogenesis . 5'-O-Tritylthymidine targets FAK-Mdm-2 interactions, decreasing cell viability and increasing apoptosis.

HY-P2916

**Thymidine phosphorylase**	Biochemical Assay Reagents	Others
Thymidine phosphorylase is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-147969

Antiangiogenic agent 2	Nucleoside Antimetabolite/Analog	Cancer
Antiangiogenic agent 2 (compound 3b) is a potent **thymidine phosphorylase inhibitor, with an IC₅₀** of 39.71 μM. Antiangiogenic agent 2 shows anti-angiogenic activity .

HY-B0307A

Idoxuridine hydrate 5-Iodo-2′-deoxyuridine hydrate; 5-IUdR hydrate; IdUrd hydrate	Phosphatase	Infection Cancer
Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) hydrate is an iodinated thymidine analogue that competitively inhibits *phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase* and affecting viral replication. Idoxuridine against feline herpesvirus has the IC₅₀ value of 4.3 μM .

HY-B0307R

Idoxuridine (Standard)	Phosphatase Orthopoxvirus	Infection Cancer
Idoxuridine (Standard) is the analytical standard of Idoxuridine. This product is intended for research and analytical applications. Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) is an iodinated thymidine analogue that competitively inhibits phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase and affecting viral replication. Idoxuridine against feline herpesvirus has the IC₅₀ value of 4.3 μM . Idoxuridine shows anti-orthopoxvirus activity.

HY-A0063R

Tipiracil (hydrochloride) (Standard)	Nucleoside Antimetabolite/Analog	Cancer
Tipiracil (hydrochloride) (Standard) is the analytical standard of Tipiracil (hydrochloride). This product is intended for research and analytical applications. Tipiracil (hydrochloride) is a thymidine phosphorylase inhibitor (TPI), used for cancer research.

HY-B0016S

Capecitabine-d11	Isotope-Labeled Compounds DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Apoptosis	Cancer
Capecitabine-d₁₁ is the deuterium labeled Capecitabine. Capecitabine is an oral proagent that is converted to its active metabolite, 5-FU, by thymidine phosphorylase .

HY-B0016R

Capecitabine (Standard)	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Apoptosis	Cancer
Capecitabine (Standard) is the analytical standard of Capecitabine. This product is intended for research and analytical applications. Capecitabine is an oral proagent that is converted to its active metabolite, 5-FU, by thymidine phosphorylase.

HY-B0021S

Doxifluridine-d2 Ro 21-9738-d₂; 5-Fluoro-5'-deoxyuridine-d₂; 5'-DFUR-d₂	Nucleoside Antimetabolite/Analog	Cancer
Doxifluridine-d₂ is the deuterium labeled Doxifluridine . Doxifluridine is a thymidine phosphorylase activator for PC9-DPE2 cells with IC₅₀ of 0.62 μM.

HY-W012670

2-Deoxy-L-ribose	Apoptosis	Cancer
2-Deoxy-L-ribose is a stereoisomer of 2-Deoxy-d-ribose that inhibits 2-Deoxy-d-ribose anti-apoptotic effects. 2-Deoxy-L-ribose suppresses metastasis of tumor cells overexpressing thymidine phosphorylase .

HY-77537

7-Deazaxanthine 7DX	Thymidylate Synthase	Cardiovascular Disease
7-Deazaxanthine (7DX) is an inhibitor of thymidine phosphorylase (TPase). 7-Deazaxanthine inhibits TPase reaction in a concentration-dependent manner with an IC₅₀ value of 40 μM. 7-Deazaxanthine also has a significant angiogenesis inhibitory effect .

HY-102071

KIN59 5'-O-Tritylinosine; 5'-O-Trityl-inosine	Nucleoside Antimetabolite/Analog	Cancer
KIN59 (5’-O-Tritylinosine) is a potent **thymidine phosphorylase** allosteric inhibitor. KIN59 inhibits FGF2-stimulated cell growth. KIN59 inhibits the expression of p-FGFR1, P-Akt in FGF2 (10 ng/mL) stimulated cells. KIN59 shows anti-tumor activity .

HY-16478

Trifluridine/tipiracil hydrochloride mixture 1 Publications Verification TAS-102; FTD/TPI	Nucleoside Antimetabolite/Analog Thymidylate Synthase	Cancer
Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a potent and orally active nucleoside antitumor agent. The composition of Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a 1:0.5 mixture (on a molar basis) of alpha,alpha,alpha-tri-fluorothymidine (FTD) and thymidine phosphorylase inhibitor (TPI). Trifluridine/tipiracil hydrochloride mixture (TAS-102) shows the antitumor activity mainly via the inhibition of thymidylate synthase (TS) and incorporation into DNA .

HY-W009538

5'-Deoxy-5-fluorocytidine 5-Fluoro-5'-deoxycytidine	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Drug Metabolite	Cancer
5'-Deoxy-5-fluorocytidine (5-Fluoro-5'-deoxycytidine) is a cytidine analog and metabolite of Capecitabine (HY-B0016). 5'-Deoxy-5-fluorocytidine is converted from Capecitabine by carboxylesterase in the liver. 5'-Deoxy-5-fluorocytidine is deaminated by cytidine deaminase to generate 5'-deoxy-5-fluorouridine, which is finally converted into 5-fluorouracil (HY-90006) by thymidine phosphorylase in tumor tissues to exert anti-tumor effects. 5'-Deoxy-5-fluorocytidine is used in the researches for solid tumors such as colorectal cancer, non-small cell lung cancer and breast cancer .

HY-W009538S

5'-Deoxy-5-fluorocytidine-d3 5-Fluoro-5'-deoxycytidine-d₃	Nucleoside Antimetabolite/Analog Isotope-Labeled Compounds DNA/RNA Synthesis Drug Metabolite	Cancer
5'-Deoxy-5-fluorocytidine-d₃ is deuterated labeled 5'-Deoxy-5-fluorocytidine (HY-W009538). 5'-Deoxy-5-fluorocytidine (5-Fluoro-5'-deoxycytidine) is a cytidine analog and metabolite of Capecitabine (HY-B0016). 5'-Deoxy-5-fluorocytidine is converted from Capecitabine by carboxylesterase in the liver. 5'-Deoxy-5-fluorocytidine is deaminated by cytidine deaminase to generate 5'-deoxy-5-fluorouridine, which is finally converted into 5-fluorouracil (HY-90006) by thymidine phosphorylase in tumor tissues to exert anti-tumor effects. 5'-Deoxy-5-fluorocytidine is used in the researches for solid tumors such as colorectal cancer, non-small cell lung cancer and breast cancer .

HY-W009538R

5'-Deoxy-5-fluorocytidine (Standard) 5-Fluoro-5'-deoxycytidine (Standard)	Nucleoside Antimetabolite/Analog Reference Standards DNA/RNA Synthesis Drug Metabolite	Cancer
5'-Deoxy-5-fluorocytidine (Standard) is the analytical standard of 5'-Deoxy-5-fluorocytidine (HY-W009538). This product is intended for research and analytical applications. 5'-Deoxy-5-fluorocytidine (5-Fluoro-5'-deoxycytidine) is a cytidine analog and metabolite of Capecitabine (HY-B0016). 5'-Deoxy-5-fluorocytidine is converted from Capecitabine by carboxylesterase in the liver. 5'-Deoxy-5-fluorocytidine is deaminated by cytidine deaminase to generate 5'-deoxy-5-fluorouridine, which is finally converted into 5-fluorouracil (HY-90006) by thymidine phosphorylase in tumor tissues to exert anti-tumor effects. 5'-Deoxy-5-fluorocytidine is used in the researches for solid tumors such as colorectal cancer, non-small cell lung cancer and breast cancer .

HY-W009538S1

5'-Deoxy-5-fluorocytidine-13C5 5-Fluoro-5'-deoxycytidine-¹³C₅	Isotope-Labeled Compounds DNA/RNA Synthesis Drug Metabolite	Cancer
5'-Deoxy-5-fluorocytidine-13C5 is the ¹³C labeled isotope of 5'-Deoxy-5-fluorocytidine (HY-W009538). 5'-Deoxy-5-fluorocytidine (5-Fluoro-5'-deoxycytidine) is a cytidine analog and metabolite of Capecitabine (HY-B0016). 5'-Deoxy-5-fluorocytidine is converted from Capecitabine by carboxylesterase in the liver. 5'-Deoxy-5-fluorocytidine is deaminated by cytidine deaminase to generate 5'-deoxy-5-fluorouridine, which is finally converted into 5-fluorouracil (HY-90006) by thymidine phosphorylase in tumor tissues to exert anti-tumor effects. 5'-Deoxy-5-fluorocytidine is used in the researches for solid tumors such as colorectal cancer, non-small cell lung cancer and breast cancer .

Cat. No.	Product Name	Type

HY-W008907

5'-O-Tritylthymidine 5-OTT	Gene Sequencing and Synthesis
5'-O-Tritylthymidine is an inhibitor of TK-2 and inhibits angiogenesis . 5'-O-Tritylthymidine targets FAK-Mdm-2 interactions, decreasing cell viability and increasing apoptosis.

HY-W012670

2-Deoxy-L-ribose	Carbohydrates
2-Deoxy-L-ribose is a stereoisomer of 2-Deoxy-d-ribose that inhibits 2-Deoxy-d-ribose anti-apoptotic effects. 2-Deoxy-L-ribose suppresses metastasis of tumor cells overexpressing thymidine phosphorylase .

Cat. No.	Product Name	Chemical Structure

HY-B0016S

Capecitabine-d11
Capecitabine-d₁₁ is the deuterium labeled Capecitabine. Capecitabine is an oral proagent that is converted to its active metabolite, 5-FU, by thymidine phosphorylase .

HY-B0021S

Doxifluridine-d2
Doxifluridine-d₂ is the deuterium labeled Doxifluridine . Doxifluridine is a thymidine phosphorylase activator for PC9-DPE2 cells with IC₅₀ of 0.62 μM.

HY-W009538S

5'-Deoxy-5-fluorocytidine-d3
5'-Deoxy-5-fluorocytidine-d₃ is deuterated labeled 5'-Deoxy-5-fluorocytidine (HY-W009538). 5'-Deoxy-5-fluorocytidine (5-Fluoro-5'-deoxycytidine) is a cytidine analog and metabolite of Capecitabine (HY-B0016). 5'-Deoxy-5-fluorocytidine is converted from Capecitabine by carboxylesterase in the liver. 5'-Deoxy-5-fluorocytidine is deaminated by cytidine deaminase to generate 5'-deoxy-5-fluorouridine, which is finally converted into 5-fluorouracil (HY-90006) by thymidine phosphorylase in tumor tissues to exert anti-tumor effects. 5'-Deoxy-5-fluorocytidine is used in the researches for solid tumors such as colorectal cancer, non-small cell lung cancer and breast cancer .

5'-Deoxy-5-fluorocytidine-d3

5'-Deoxy-5-fluorocytidine-d₃ is deuterated labeled 5'-Deoxy-5-fluorocytidine (HY-W009538). 5'-Deoxy-5-fluorocytidine (5-Fluoro-5'-deoxycytidine) is a cytidine analog and metabolite of Capecitabine (HY-B0016). 5'-Deoxy-5-fluorocytidine is converted from Capecitabine by carboxylesterase in the liver. 5'-Deoxy-5-fluorocytidine is deaminated by cytidine deaminase to generate 5'-deoxy-5-fluorouridine, which is finally converted into 5-fluorouracil (HY-90006) by thymidine phosphorylase in tumor tissues to exert anti-tumor effects. 5'-Deoxy-5-fluorocytidine is used in the researches for solid tumors such as colorectal cancer, non-small cell lung cancer and breast cancer .

HY-W009538S1

5'-Deoxy-5-fluorocytidine-13C5
5'-Deoxy-5-fluorocytidine-13C5 is the ¹³C labeled isotope of 5'-Deoxy-5-fluorocytidine (HY-W009538). 5'-Deoxy-5-fluorocytidine (5-Fluoro-5'-deoxycytidine) is a cytidine analog and metabolite of Capecitabine (HY-B0016). 5'-Deoxy-5-fluorocytidine is converted from Capecitabine by carboxylesterase in the liver. 5'-Deoxy-5-fluorocytidine is deaminated by cytidine deaminase to generate 5'-deoxy-5-fluorouridine, which is finally converted into 5-fluorouracil (HY-90006) by thymidine phosphorylase in tumor tissues to exert anti-tumor effects. 5'-Deoxy-5-fluorocytidine is used in the researches for solid tumors such as colorectal cancer, non-small cell lung cancer and breast cancer .

5'-Deoxy-5-fluorocytidine-13C5

5'-Deoxy-5-fluorocytidine-13C5 is the ¹³C labeled isotope of 5'-Deoxy-5-fluorocytidine (HY-W009538). 5'-Deoxy-5-fluorocytidine (5-Fluoro-5'-deoxycytidine) is a cytidine analog and metabolite of Capecitabine (HY-B0016). 5'-Deoxy-5-fluorocytidine is converted from Capecitabine by carboxylesterase in the liver. 5'-Deoxy-5-fluorocytidine is deaminated by cytidine deaminase to generate 5'-deoxy-5-fluorouridine, which is finally converted into 5-fluorouracil (HY-90006) by thymidine phosphorylase in tumor tissues to exert anti-tumor effects. 5'-Deoxy-5-fluorocytidine is used in the researches for solid tumors such as colorectal cancer, non-small cell lung cancer and breast cancer .

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