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Isoforms Recommended: Txk
Results for "

TXK

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

1

Fluorescent Dye

1

Recombinant Proteins

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-10644
    Lck inhibitor 2

    		Src Inflammation/Immunology
    Lck inhibitor 2 is a multi-target tyrosine kinase inhibitor with IC50s of 13nM, 9nM, 3nM, 26nM and 2nM for Lck, Btk, Lyn, Btk and Txk respectively.
    Lck inhibitor 2
  • HY-D2415
    BODIPY-FL staurosporine

    		Fluorescent Dye Others
    BODIPY-FL staurosporine (Compound 8a) is a fluorescence probe based on staurosporine, exhibiting high specificity towards tyrosine kinases (TK) and tyrosine kinase-like (TKL) family kinases. BODIPY-FL staurosporine has the potential to develop binding assays for kinases that are not recommended for use with Kinase Tracer 236, such as PIM3, CDC42BPG, MAP2K7, TXK, and SIK3. BODIPY-FL staurosporine can be a powerful tool for analyzing kinase selectivity in kinase drug discovery .
    BODIPY-FL staurosporine
  • HY-139481
    TL-895
    1 Publications Verification

    		 Btk BMX Kinase Interleukin Related TNF Receptor Inflammation/Immunology Cancer
    TL-895 is a potent, orally active, ATP-competitive, and highly selective irreversible BTK inhibitor. TL-895 is active against recombinant BTK (average IC50: 1.5 nM) and inhibits only three additional kinases BLK, BMX (IC50 = 1.6 nM) and TXK with IC50 within tenfold of BTK activity. TL-895 inhibits BTK auto-phosphorylation at the Y223 phosphorylation site (IC50: 1-10 nM). The TL-895 effectively inhibits the production of inflammatory factors such as IL-8, IL-1β, MCP-1 and TNF-α by monocytes or macrophages, and reduces the chemotactic migration of MF cells towards SDF-1. TL-895 is used be for studies of chronic lymphocytic leukemia (CLL), myelofibrosis (MF), and B-cell malignancies .
    TL-895
  • HY-RS22085
    Txk Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Txk Mouse Pre-designed siRNA Set A contains three designed siRNAs for Txk gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Txk Mouse Pre-designed siRNA Set A
    Txk Mouse Pre-designed siRNA Set A
  • HY-RS28605
    Txk Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others
    Txk Rat Pre-designed siRNA Set A contains three designed siRNAs for Txk gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Txk Rat Pre-designed siRNA Set A
    Txk Rat Pre-designed siRNA Set A
  • HY-RS15285
    TXK Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    TXK Human Pre-designed siRNA Set A contains three designed siRNAs for TXK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    TXK Human Pre-designed siRNA Set A
    TXK Human Pre-designed siRNA Set A
  • HY-145373
    BMS-986143

    		Btk Inflammation/Immunology
    BMS-986143 is an orally active, reversible BTK inhibitor with an IC50 of 0.26 nM. BMS-986143 also inhibits TEC, BLK, BMX, TXK FGR, YES1, ITK with IC50s of 3 nM, 5 nM, 7 nM, 10 nM, 15 nM,19 nM, 21 nM, respectively. BMS-986143 can be used for the research of autoimmune diseases .
    BMS-986143
  • HY-174129
    TM471-1

    		Btk Apoptosis Cancer
    TM471-1 is an orally active and covalent Bruton's tyrosine kinase (BTK) inhibitor with IC50 values of 1.3 nM (BTK WT), >40,000 nM (BTK C481S), 7.9 nM (TEC) and 12.4 nM (TXK). TM471-1 inhibits cell growth in vivo and in vitro, arrests cell cycle at G0/G1 phase and induces cell apoptosis .
    TM471-1

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