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Results for "

TNP

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aminopeptidase (1) Antibiotic (1) Antifolate (1) Arf Family GTPase (1) Bacterial (2) DNA/RNA Synthesis (1) Drug Derivative (2) Fluorescent Dye (2) IPK Superfamily (1) P2X Receptor (2) P2Y Receptor (1) Small Interfering RNA (siRNA) (2) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (1) Neurological Disease (1)
Oligonucleotides:	Human Pre-designed siRNA Sets (2) siRNAs (2)

Inhibitors & Agonists

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

*TNP*	IPK Superfamily	Cancer
TNP is a competitive, reversible inhibitor of IP6K1 and IP3K, with IC₅₀s of 0.55 μM and 10.2 μM for IP6K1 and IP3K, respectively. TNP competitively binds to the ATP binding site of IP6K, inhibits the generation of 5-IP7, and thus relieves the inhibition of 5-IP7 on the AKT signaling pathway. TNP can enhance insulin sensitivity and promote thermogenesis in adipose tissue. TNP cannot effectively pass through the blood-brain barrier and is mainly used in the study of obesity, type 2 diabetes, and metabolic syndrome. However, TNP also inhibits CYP3A4 and may need further optimization[1][2][3].

TNP-470 1 Publications Verification AGM-1470	Aminopeptidase	Cardiovascular Disease Cancer
TNP-470 is a methionine aminopeptidase-2 inhibitor and also an angiogenesis inhibitor.

TNP-ATP triethylammonium	P2X Receptor	Others
TNP-ATP triethylammonium is a selective P2X receptor antagonist. TNP-ATP triethylammonium shows antinociceptive effects in rats .

Rifasutenizol TNP-2198	Bacterial	Infection
Rifasutenizol (TNP-2198) is a dual-targeted antibacterial agent that has a good antibacterial effect on Helicobacter pylori infection. Rifasutenizol can be used in the study of microaerophilic and anaerobic bacterial infections .

TNP-351	Antifolate	Cancer
TNP-351 is an antifolate. TNP-351, a dihydrofolate reductase (DHFR) inhibitor, has potent antitumor activity against not only leukemia cells but also solid tumor cells in vitro and in vivo .

TNP-β-L-GTP tetrasodium TNP-β-L-Guanosine 5'-triphosphate tetrasodium	Arf Family GTPase	Others
TNP-β-L-GTP (TNP-β-L-Guanosine 5'-triphosphate) tetrasodium is a fluorescent GTP mimetic that can be used to study the binding kinetics and affinity of GTP-binding proteins (such as G proteins and GTPases). TNP-β-L-GTP tetrasodium carries a TNP fluorophore, which changes fluorescence intensity upon protein binding, allowing for quantitative analysis .

TNP-ATP tetrasodium	P2X Receptor P2Y Receptor	Neurological Disease
TNP-ATP is an antagonist of purinergic P2Y1, P2X3, and P2X2/3 receptors (IC₅₀ = 6, 0.9, and 7 nM, respectively, in HEK293 cells expressing human receptors). TNP-ATP reduces acetate-induced calcium flux in 1321N1 cells expressing P2X3 and P2X2/3 receptors (IC₅₀ = 100 and 62 nM, respectively). TNP-ATP dose-dependently attenuates acetate-induced abdominal contractions in a mouse visceral pain model (ED₅₀ = 6.35 µmol/kg) ^[1][2].

TNP1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TNP1 Human Pre-designed siRNA Set A contains three designed siRNAs for TNP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TNP1 Human Pre-designed siRNA Set A TNP1 Human Pre-designed siRNA Set A

TNP2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TNP2 Human Pre-designed siRNA Set A contains three designed siRNAs for TNP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TNP2 Human Pre-designed siRNA Set A TNP2 Human Pre-designed siRNA Set A

Rifaquizinone CBR-2092; TNP-2092	Antibiotic Bacterial DNA/RNA Synthesis	Infection
Rifaquizinone (CBR-2092) is a Rifamycin-Quinolone Hybrid Antibiotic. Rifaquizinone inhibits wild-type S. aureus RNA polymerase with an IC₅₀ of 34 nM. Rifaquizinone is effective against S. aureus infections, with MICs ranged from 0.008 to 0.5 μg/mL for 300 clinical isolates of staphylococci and streptococci .

*8-Bromo TNP-GTP tetrasodium* 8-Bromo TNP-Guanosine 5'-triphosphate tetrasodium	Fluorescent Dye	Others
8-Bromo TNP-GTP (8-Bromo TNP-Guanosine 5'-triphosphate) tetrasodium is a fluorescent TNP-GTP analogue with a TNP fluorophore and a bromo group at the 8-position. 8-Bromo TNP-GTP tetrasodium can be used to analyze the binding activity of GTP-binding proteins (such as Ras and Gα subunits) .

*2-Methylthio TNP-ITP tetrasodium* 2-Methylthio TNP-Inosine 5'-triphosphate tetrasodium	Fluorescent Dye	Others
2-Methylthio TNP-ITP (2-Methylthio TNP-Inosine 5'-triphosphate) tetrasodium is a fluorescent derivative of inosine triphosphate (ITP) with a TNP (2,4,6-trinitrophenyl) fluorophore .

*2-Chloro TNP-ITP tetrasodium* 2-Chloro TNP-Inosine 5'-triphosphate tetrasodium	Drug Derivative	Others
2-Chloro TNP-ITP (2-Chloro TNP-Inosine 5'-triphosphate) tetrasodium is an analog of Inosine-5'-triphosphate trisodium salt (HY-W013706) .

*8-Bromo TNP-ITP tetrasodium* 8-Bromo TNP-Inosine 5'-triphosphate tetrasodium	Drug Derivative	Others
8-Bromo TNP-ITP (8-Bromo TNP-Inosine 5'-triphosphate) tetrasodium is an analog of Inosine-5'-triphosphate trisodium salt (HY-W013706) .

8-Mercaptoguanosine 8-Thioguanosine	Toll-like Receptor (TLR)	Inflammation/Immunology
8-Mercaptoguanosine is an immunoadjuvant that affects the in vivo antibody response to the T-cell-independent antigen TNP-Ficoll. 8-Mercaptoguanosine enhances IgG1, IgG2, and IgG3 antibody responses, but has no effect on IgM antibody responses. 8-Mercaptoguanosine also enhances antibody responses to very weak antigens such as pneumococcal polysaccharide and restores antibody responses in immunodeficient xid mice that are non-reactive to TNP-Ficoll .

TNP1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TNP1 Human Pre-designed siRNA Set A contains three designed siRNAs for TNP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TNP2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TNP2 Human Pre-designed siRNA Set A contains three designed siRNAs for TNP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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