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Results for "

TIMP1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) FOXO (1) FXR (1) HMG-CoA Reductase (HMGCR) (1) Integrin (1) Interleukin Related (1) MMP (1) Pyroptosis (1) Small Interfering RNA (siRNA) (3) TGF-β Receptor (1) YTHDF (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (2) Endocrinology (1) Inflammation/Immunology (3) Metabolic Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-151932

FXR agonist 3	FXR	Inflammation/Immunology
FXR agonist 3 is an anti-NASH agent, acting by activating FXR. FXR agonist 3 inhibits *COL1A1, TGF-β1, α-SMA* and *TIMP1* expression with anti-fibrogenic activity. FXR agonist 3 significantly reduces liver steatosis and inflammation, improves liver fibrosis level ^[1].

HY-154919

DC-Y13-27 4 Publications Verification	YTHDF FOXO MMP Pyroptosis Interleukin Related	Endocrinology Cancer
DC-Y13-27 is a DC-Y13 derivative and YTHDF2 inhibitor (K_D: 37.9 μM). DC-Y13-27 inhibits YTHDF2, restores FOXO3 and *TIMP1* protein levels, and reduces *MMP1/3/7/9* expression. DC-Y13-27 induces Pyroptosis and increases *IL-1β* secretion. DC-Y13-27 reduces intervertebral disc degeneration and enhances the response to radiotherapy in colon cancer and melanoma. DC-Y13-27 has antitumor activity against breast cancer ^[1] .

HY-47888

PLN-1474	Integrin	Inflammation/Immunology
PLN-1474 (compound 1) is an orally active and selective ανβ1 integrin inhibitor with an IC50 value of <50 nM. PLN-1474 reduces levels of pSMAD3/SMAD3 in liver, hepatic collagen gene expression and hepatic OHP concentration in liver fibrosis mouse model. PLN-1474 can be used for the research of preventing, delaying or researching a fibrotic or cirrhotic disease or disorder.

HY-RS16840

Timp1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Timp1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Timp1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Timp1 Mouse Pre-designed siRNA Set A Timp1 Mouse Pre-designed siRNA Set A

HY-RS23282

Timp1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Timp1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Timp1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Timp1 Rat Pre-designed siRNA Set A Timp1 Rat Pre-designed siRNA Set A

HY-RS14538

TIMP1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TIMP1 Human Pre-designed siRNA Set A contains three designed siRNAs for TIMP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TIMP1 Human Pre-designed siRNA Set A TIMP1 Human Pre-designed siRNA Set A

HY-172258

5-HT2B antagonist-2	5-HT Receptor	Cancer
5-HT2B antagonist-2 (Compound 19c) is a 5HT_2B receptor antagonist with an IC₅₀ of 1.09 nM. 5-HT2B antagonist-2 can downregulate the expression of fibrosis-related genes α-SMA, Timp1, Col1a1, and Col3a1, and significantly reduce the deposition of fibrosis, thereby reducing the fibrotic area and inhibiting the fibrotic process in CCl4-induced liver fibrosis mouse models. 5-HT2B antagonist-2 can be used in the study of immune inflammatory-related diseases, particularly in the research of pulmonary fibrosis diseases ^[1].

HY-162902

ALK5-IN-82	TGF-β Receptor	Cardiovascular Disease
ALK5-IN-82 is a potent and selective inhibitor against activin receptor-like kinase 5 (ALK5) with an IC₅₀ value of 9.1 nM. ALK5-IN-82 inhibits the protein expression of α-smooth muscle actin (α-SMA), collagen I and tissue inhibitor of metalloproteinase 1 (TIMP-1)/matrix metalloproteinase 13 (MMP-13) in transforming growth factor-β-induced human umbilical vein endothelial cells. ALK5-IN-82 is promising for research of cardiac fibrosis ^[1].

HY-147195

QH536	HMG-CoA Reductase (HMGCR)	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
QH536 (Compound 29) is a potent HMGCR degrader with an EC₅₀ of 0.22 μM. QH536 has no side-effect of inducing cholesterol accumulation in cells. QH536 shows anti-inflammatory and can be used for cardiovascular disease and nonalcoholic steatohepatitis research ^[1].

Recombinant Proteins Recommended:

TIMP-1

Species:	Human (3) Rat (1) Mouse (1)
Tag:	His (1) Tag Free (3) Fc (1)
Source:	HEK293 (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P73441

	TIMP-1 Protein, Rat (HEK293) Metalloproteinase Inhibitor 1; EPA; TIMP-1; CLGI; TIMP	Rat	HEK293
	The IgG3 Fc protein is the constant region of an immunoglobulin heavy chain that acts as a receptor for a specific antigen. TIMP-1 Protein, Rat (HEK293) is the recombinant rat-derived TIMP-1 protein, expressed by HEK293 , with tag free.

HY-P73597

	TIMP-1 Protein, Human (HEK293) Metalloproteinase Inhibitor 1; EPA; TIMP-1; CLGI; TIMP	Human	HEK293
	The TIMP-1 protein forms a one-to-one complex with the target metalloprotease, irreversibly inactivating it by binding to the catalytic zinc cofactor. It inhibits multiple MMPs, activates cell signaling through CD63 and ITGB1, and interacts with MMP1, MMP3, MMP10, and MMP13. TIMP-1 Protein, Human (HEK293) is the recombinant human-derived TIMP-1 protein, expressed by HEK293 , with tag free.

HY-P71110

	TIMP-1 Protein, Mouse (HEK293) Metalloproteinase Inhibitor 1; Erythroid-Potentiating Activity; EPA; Fibroblast collagenase Inhibitor; Collagenase Inhibitor; Tissue Inhibitor of Metalloproteinases 1; TIMP-1; TIMP1; CLGI; TIMP	Mouse	HEK293
	TIMP-1 is a metalloproteinase inhibitor that irreversibly inactivates collagenase and other metalloproteinases by binding to their catalytic zinc cofactor.It regulates MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16 and affects cellular processes such as differentiation, migration and cell death.TIMP-1 Protein, Mouse (HEK293) is the recombinant mouse-derived TIMP-1 protein, expressed by HEK293 , with tag free.

HY-P73596

	TIMP-1 Protein, Human (HEK293, Fc) Metalloproteinase Inhibitor 1; EPA; TIMP-1; CLGI; TIMP	Human	HEK293
	The TIMP-1 protein forms a one-to-one complex with the target metalloprotease, irreversibly inactivating it by binding to the catalytic zinc cofactor. It inhibits multiple MMPs, activates cell signaling through CD63 and ITGB1, and interacts with MMP1, MMP3, MMP10, and MMP13. TIMP-1 Protein, Human (HEK293, Fc) is the recombinant human-derived TIMP-1 protein, expressed by HEK293 , with N-hFc labeled tag.

HY-P71055

	TIMP-1 Protein, Human (HEK293, His) Metalloproteinase Inhibitor 1; Erythroid-Potentiating Activity; EPA; Fibroblast collagenase Inhibitor; Collagenase Inhibitor; Tissue Inhibitor of Metalloproteinases 1; TIMP-1; TIMP1; CLGI; TIMP	Human	HEK293
	The TIMP-1 protein forms a one-to-one complex with the target metalloprotease, irreversibly inactivating it by binding to the catalytic zinc cofactor. It inhibits multiple MMPs, activates cell signaling through CD63 and ITGB1, and interacts with MMP1, MMP3, MMP10, and MMP13. TIMP-1 Protein, Human (HEK293, His) is the recombinant human-derived TIMP-1 protein, expressed by HEK293 , with C-His labeled tag.

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HY-P81133

	TIMP-1 Antibody (YA3543) Clgi; Collagenase inhibitor; EPA; EPO; Erythroid Potentiating Activity; Fibroblast collagenase inhibitor; FLJ90373; HC; Human Collagenase Inhibitor; Metalloproteinase inhibitor 1; Metalloproteinase inhibitor 1 precursor; OTTHUMP00000023214; TIMP 1; TIMP; TIMP metallopeptidase inhibitor 1; TIMP1 protein; Tissue Inhibitor of Metalloproteinase 1; Tissue inhibitor of metalloproteinases; Ttissue inhibitor of metalloproteinase 1 erythroid potentiating activity collagenase inhibitor.	WB, IHC-P, ICC/IF	Human
	TIMP-1 Antibody is an unconjugated, approximately 21 kDa, rabbit-derived, anti-TIMP-1 monoclonal antibody. TIMP-1 Antibody can be used for: WB, IHC-P, ICC/IF expriments in human background without labeling.

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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Timp1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Timp1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Timp1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Timp1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Timp1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Timp1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

TIMP1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TIMP1 Human Pre-designed siRNA Set A contains three designed siRNAs for TIMP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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