TET3

Isoforms Recommended:	TET3

By Targets:	Apoptosis (1) Endogenous Metabolite (1) Isotope-Labeled Compounds (1) Small Interfering RNA (siRNA) (3) STAT (1) TET Protein (2)
By Research Areas:	Cancer (3) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-120395

UC-514321 1 Publications Verification	STAT Apoptosis TET Protein	Inflammation/Immunology Cancer
UC-514321, a structural analog of NSC370284 with higher activity, directly targets *STAT3/5* and represses *TET1* expression, but not TET2 or TET3. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity .

HY-W018324

5-Hydroxymethylcytosine 5hmC	Endogenous Metabolite	Neurological Disease Metabolic Disease Cancer
5-Hydroxymethylcytosine (5hmC) is an oxidized forms of 5-methylcytosine (5mC) in mammalian DNA. 5-Hydroxymethylcytosine is produced from 5mC in an enzymatic pathway involving three 5mC oxidases, Ten-eleven translocation (TET)1, TET2, and TET3. The conversion of 5mC into 5hmC can be the first step in a pathway leading towards DNA demethylation. 5-Hydroxymethylcytosine is associated with gene transcription and frequently used as a mark to investigate dynamic DNA methylation conversion during mammalian development. 5-Hydroxymethylcytosine can be used for the study of non-small cell lung cancer (NSCLC), neurodegenerative diseases (Alzheimer’s, Parkinson’s) and hematological malignancies (acute myeloid leukemia, myelodysplastic syndromes) .

HY-402410

TETi76 1 Publications Verification	TET Protein	Cancer
TETi76 is an orally active *TET* family inhibitor with IC₅₀ values ??of 1.5, 9.4 and 8.8 μM for *TET1, TET2* and *TET3, respectively. TETi76 competitively binds to the active site of TET* enzymes, reduces cytosine hydroxymethylation and restricts clonal growth of *TET2* mutants in vitro and in vivo, but does not affect the growth of normal hematopoietic precursor cells. TETi76 can be used for leukemia research .

HY-RS18373

Tet3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tet3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tet3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tet3 Mouse Pre-designed siRNA Set A Tet3 Mouse Pre-designed siRNA Set A

HY-RS24852

Tet3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tet3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tet3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tet3 Rat Pre-designed siRNA Set A Tet3 Rat Pre-designed siRNA Set A

HY-RS14386

TET3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TET3 Human Pre-designed siRNA Set A contains three designed siRNAs for TET3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TET3 Human Pre-designed siRNA Set A TET3 Human Pre-designed siRNA Set A

HY-W018324S

5-Hydroxymethylcytosine-13C,d2 5hmC-¹³C,d₂	Isotope-Labeled Compounds	Neurological Disease
5-Hydroxymethylcytosine- ¹³C,d₂ is the ¹³C and deuterium labeled 5-Hydroxymethylcytosine (HY-W018324). 5-Hydroxymethylcytosine (5hmC) is an oxidized forms of 5-methylcytosine (5mC) in mammalian DNA. 5-Hydroxymethylcytosine is produced from 5mC in an enzymatic pathway involving three 5mC oxidases, Ten-eleven translocation (TET)1, TET2, and TET3. The conversion of 5mC into 5hmC can be the first step in a pathway leading towards DNA demethylation. 5-Hydroxymethylcytosine is associated with gene transcription and frequently used as a mark to investigate dynamic DNA methylation conversion during mammalian development. 5-Hydroxymethylcytosine can be used for the study of non-small cell lung cancer (NSCLC), neurodegenerative diseases (Alzheimer’s, Parkinson’s) and hematological malignancies (acute myeloid leukemia, myelodysplastic syndromes) ^[3] .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W018324

5-Hydroxymethylcytosine 5hmC	Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
5-Hydroxymethylcytosine (5hmC) is an oxidized forms of 5-methylcytosine (5mC) in mammalian DNA. 5-Hydroxymethylcytosine is produced from 5mC in an enzymatic pathway involving three 5mC oxidases, Ten-eleven translocation (TET)1, TET2, and TET3. The conversion of 5mC into 5hmC can be the first step in a pathway leading towards DNA demethylation. 5-Hydroxymethylcytosine is associated with gene transcription and frequently used as a mark to investigate dynamic DNA methylation conversion during mammalian development. 5-Hydroxymethylcytosine can be used for the study of non-small cell lung cancer (NSCLC), neurodegenerative diseases (Alzheimer’s, Parkinson’s) and hematological malignancies (acute myeloid leukemia, myelodysplastic syndromes) .

Cat. No.	Product Name	Chemical Structure

HY-W018324S

5-Hydroxymethylcytosine-13C,d2
5-Hydroxymethylcytosine- ¹³C,d₂ is the ¹³C and deuterium labeled 5-Hydroxymethylcytosine (HY-W018324). 5-Hydroxymethylcytosine (5hmC) is an oxidized forms of 5-methylcytosine (5mC) in mammalian DNA. 5-Hydroxymethylcytosine is produced from 5mC in an enzymatic pathway involving three 5mC oxidases, Ten-eleven translocation (TET)1, TET2, and TET3. The conversion of 5mC into 5hmC can be the first step in a pathway leading towards DNA demethylation. 5-Hydroxymethylcytosine is associated with gene transcription and frequently used as a mark to investigate dynamic DNA methylation conversion during mammalian development. 5-Hydroxymethylcytosine can be used for the study of non-small cell lung cancer (NSCLC), neurodegenerative diseases (Alzheimer’s, Parkinson’s) and hematological malignancies (acute myeloid leukemia, myelodysplastic syndromes) ^[3] .

5-Hydroxymethylcytosine-13C,d2

5-Hydroxymethylcytosine- ¹³C,d₂ is the ¹³C and deuterium labeled 5-Hydroxymethylcytosine (HY-W018324). 5-Hydroxymethylcytosine (5hmC) is an oxidized forms of 5-methylcytosine (5mC) in mammalian DNA. 5-Hydroxymethylcytosine is produced from 5mC in an enzymatic pathway involving three 5mC oxidases, Ten-eleven translocation (TET)1, TET2, and TET3. The conversion of 5mC into 5hmC can be the first step in a pathway leading towards DNA demethylation. 5-Hydroxymethylcytosine is associated with gene transcription and frequently used as a mark to investigate dynamic DNA methylation conversion during mammalian development. 5-Hydroxymethylcytosine can be used for the study of non-small cell lung cancer (NSCLC), neurodegenerative diseases (Alzheimer’s, Parkinson’s) and hematological malignancies (acute myeloid leukemia, myelodysplastic syndromes) ^[3] .

Cat. No.	Product Name		Classification

HY-RS18373

Tet3 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Tet3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tet3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS24852

Tet3 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Tet3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tet3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS14386

TET3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TET3 Human Pre-designed siRNA Set A contains three designed siRNAs for TET3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
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