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T-type currents

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By Targets:	Calcium Channel (14) Drug Isomer (1) Endogenous Metabolite (6) Isotope-Labeled Compounds (2) Reference Standards (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (3) Metabolic Disease (4) Neurological Disease (7)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: C-type Lectin-like Receptors (CTLRs) Scavenger Receptor Class B type I (SR-BI） PCSK9

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-50707

(Rac)-TTA-P2 (Rac)-T-type calcium channel inhibitor	Calcium Channel Drug Isomer	Neurological Disease
(Rac)-TTA-P2 is the isomer of TTA-P2 (HY-10035), and can be used as an experimental control. TTA-P2 (T-Type calcium channel inhibitor) is a potent inhibitor of T-Type calcium channel. TTA-P2 penetrates well the CNS and blocks the native T-type currents in deep cerebellar nuclear neurons, the window current is completely abolished both for wild-type and mutant Cav3.1 channels. TTA-P2 has the potential for the research of neurology disease .

HY-10035A

(R)-TTA-P2	Calcium Channel	Neurological Disease
(R)-TTA-P2 is the isomer of TTA-P2 (HY-10035), and can be used as an experimental control. TTA-P2 (T-Type calcium channel inhibitor) is a potent inhibitor of T-Type calcium channel. TTA-P2 penetrates well the CNS and blocks the native T-type currents in deep cerebellar nuclear neurons, the window current is completely abolished both for wild-type and mutant Cav3.1 channels. TTA-P2 has the potential for the research of neurology disease .

HY-15553A

Mibefradil dihydrochloride Maximum Cited Publications 12 Publications Verification Ro 40-5967 dihydrochloride	Calcium Channel	Cardiovascular Disease Cancer
Mibefradil dihydrochloride (Ro 40-5967 dihydrochloride) is a calcium channel blocker with moderate selectivity for T-type Ca ²⁺ channels (IC₅₀s of 2.7 μM and 18.6 μM for T-type and L-type currents, respectively) .

HY-120597

SAK3	Calcium Channel	Neurological Disease
SAK3 is a potent T-type voltage-gated Ca ²⁺ channels (T-VGCCs) enhancer. SAK3 enhances Cav3.1 and Cav3.3 T-type Ca ²⁺ channel currents. Acute SAK3 administration improves memory deficits in olfactory-bulbectomized mice . SAK3 inhibits amyloid β plaque formation in APP-KI mice by activating the proteasome activity .

HY-W032013

1-Octanol 1 Publications Verification Octanol	Calcium Channel Endogenous Metabolite	Neurological Disease Metabolic Disease
1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC₅₀ of 4 μM for native T-currents . 1-Octanol is a highly attractive biofuel with diesel-like properties .

HY-W032013S

1-Octanol-d17 Octanol-d₁₇	Calcium Channel Endogenous Metabolite	Metabolic Disease
1-Octanol-d₁₇ is the deuterium labeled 1-Octanol . 1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC₅₀ of 4 μM for native T-currents . 1-Octanol is a highly attractive biofuel with diesel-like properties .

HY-15553

Mibefradil Ro 40-5967	Calcium Channel	Cardiovascular Disease Cancer
Mibefradil (Ro 40-5967) is a calcium channel blocker with moderate selectivity for T-type Ca ²⁺ channels displaying IC₅₀s of 2.7 μM and 18.6 μM for T-type and L-type currents, respectively .

HY-W032013S1

1-Octanol-d2 Octanol-d₂	Calcium Channel Endogenous Metabolite	Metabolic Disease
1-Octanol-d₂ is the deuterium labeled 1-Octanol . 1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC₅₀ of 4 μM for native T-currents . 1-Octanol is a highly attractive biofuel with diesel-like properties .

HY-W032013R

1-Octanol (Standard) Octanol (Standard)	Reference Standards Calcium Channel Endogenous Metabolite	Neurological Disease Metabolic Disease
1-Octanol (Standard) is the analytical standard of 1-Octanol. This product is intended for research and analytical applications. 1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC₅₀ of 4 μM for native T-currents . 1-Octanol is a highly attractive biofuel with diesel-like properties .

HY-W032013S3

1-Octanol-d5 Octanol-d₅	Calcium Channel Endogenous Metabolite Isotope-Labeled Compounds	Others
1-Octanol-d₅ is deuterated labeled 1-Octanol (HY-W032013). 1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC50 of 4 μM for native T-currents . 1-Octanol is a highly attractive biofuel with diesel-like properties .

HY-W032013S2

1-Octanol-d2-1 Octanol-d₂-1	Calcium Channel Endogenous Metabolite Isotope-Labeled Compounds	Others
1-Octanol-d₂-1 is deuterated labeled 1-Octanol (HY-W032013). 1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC50 of 4 μM for native T-currents . 1-Octanol is a highly attractive biofuel with diesel-like properties .

HY-106761

Oxodipine	Calcium Channel	Cardiovascular Disease Others
Oxodipine, a dihydropyridine-type calcium antagonist, inhibits KCl-induced aortic contraction in rabbits and reduces cardiac force in less potent rat ventricular test-paper contractions. In rat cultured neonatal ventricular myocytes, Oxodipine reduces L-type Ca currents (I) with an IC₅₀ of 0.24 μM, and against T-type Ca currents (I) with an IC₅₀ of 0.41 μM. Oxodipine causes constipation in mice and gingival hyperplasia in dogs .

HY-118030

RQ-00311651	Calcium Channel	Neurological Disease
RQ-00311651 is a T-type calcium channel blocker that specifically targets the Cav3.2 isoform with a role in neuropathic and visceral pain. RQ-00311651 significantly inhibits T currents in HEK293 cells expressing human Cav3.1 or Cav3.2. RQ-00311651 also inhibited high potassium-induced calcium signaling. RQ-00311651 also inhibits antiallergic properties in rats and mice with neuropathic pain induced by spinal nerve injury or Paclitaxel (HY-B0015). Oral and intraperitoneal injection (10-20 mg/kg) inhibits Cerulein (HY-A0190)-induced acute pancreatitis and cyclophosphamide-induced cystitis in mice .

HY-10035

TTA-P2 3 Publications Verification T-type calcium channel inhibitor	Calcium Channel	Neurological Disease
TTA-P2 (T-Type calcium channel inhibitor) is a selective, orally active, and BBB-penetrant T-type calcium channel blocker (IC₅₀ = 22 nM). TTA-P2 reduces mechanical hypersensitivity and alleviates acute as well as chronic pain. TTA-P2 significantly reduces firing rates in temporal lobe epilepsy (TLE) neurons to control levels and suppresses synaptically evoked burst firing. TTA-P2 can be studied in research for neurological diseases such as tremor and absence epilepsy < sup>[4] .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W032013

1-Octanol 1 Publications Verification Octanol	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Calcium Channel Endogenous Metabolite
1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC₅₀ of 4 μM for native T-currents . 1-Octanol is a highly attractive biofuel with diesel-like properties .

HY-W032013R

1-Octanol (Standard) Octanol (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Reference Standards Calcium Channel Endogenous Metabolite
1-Octanol (Standard) is the analytical standard of 1-Octanol. This product is intended for research and analytical applications. 1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC₅₀ of 4 μM for native T-currents . 1-Octanol is a highly attractive biofuel with diesel-like properties .

Cat. No.	Product Name	Chemical Structure

HY-W032013S

1-Octanol-d17
1-Octanol-d₁₇ is the deuterium labeled 1-Octanol . 1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC₅₀ of 4 μM for native T-currents . 1-Octanol is a highly attractive biofuel with diesel-like properties .

HY-W032013S1

1-Octanol-d2
1-Octanol-d₂ is the deuterium labeled 1-Octanol . 1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC₅₀ of 4 μM for native T-currents . 1-Octanol is a highly attractive biofuel with diesel-like properties .

HY-W032013S3

1-Octanol-d5
1-Octanol-d₅ is deuterated labeled 1-Octanol (HY-W032013). 1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC50 of 4 μM for native T-currents . 1-Octanol is a highly attractive biofuel with diesel-like properties .

HY-W032013S2

1-Octanol-d2-1
1-Octanol-d₂-1 is deuterated labeled 1-Octanol (HY-W032013). 1-Octanol (Octanol), a saturated fatty alcohol, is a T-type calcium channels (T-channels) inhibitor with an IC50 of 4 μM for native T-currents . 1-Octanol is a highly attractive biofuel with diesel-like properties .

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T-type currents

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
Products