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Spermidine

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amino Acid Derivatives (1) Bacterial (1) Biochemical Assay Reagents (7) Caspase (4) Endogenous Metabolite (8) Isotope-Labeled Compounds (3) mTOR (3) Parasite (4) Reference Standards (2)
By Research Areas:	Cancer (4) Infection (4) Inflammation/Immunology (1) Metabolic Disease (8)
Click Chemistry:	Alkynes (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1776

*Spermidine* Maximum Cited Publications 7 Publications Verification	Endogenous Metabolite	Metabolic Disease
Spermidine maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine significantly decreases the H₂O₂ and O₂ ^.- contents .

HY-170757A

Spermidine-alkyne trihydrochloride	Biochemical Assay Reagents	Others
Spermidine-alkyne trihydrochloride is a Spermidine (HY-B1776) derivative endowed with an alkyne handle. Spermidine-alkyne trihydrochloride is a Spermidine probe, which can be used for the determination of the Spermidine binding to cellular proteins .

HY-W709575

Spermidine-d6 trihydrochloride	Isotope-Labeled Compounds	Others
Spermidine-d6 trihydrochloride is the deuterium labeled Spermidine-d6 (trihydrochloride) (HY-W709575) .

HY-B1776S

Spermidine-d6	Endogenous Metabolite	Metabolic Disease
Spermidine-d₆ is the deuterium labeled Spermidine . Spermidine maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine significantly decreases the H2O2 and O2.- contents .

HY-B1776AS

Spermidine-d8 hydrochloride	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
Spermidine-d₈ (hydrochloride)e is the deuterium labeled Spermidine trihydrochloride. Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H2O2 and O2.- contents .

HY-B1776R

Spermidine (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
Spermidine (Standard) is the analytical standard of Spermidine. This product is intended for research and analytical applications. Spermidine maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine significantly decreases the H2O2 and O2.- contents .

HY-B1776A

Spermidine hydrochloride Maximum Cited Publications 7 Publications Verification	Endogenous Metabolite	Metabolic Disease
Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H₂O₂ and O₂ ^.- contents .

HY-B1776AS1

Spermidine-13C4 hydrochloride 1 Publications Verification	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
Spermidine- ¹³C₄ (hydrochloride) is the ¹³C-labeled Spermidine trihydrochloride. Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H2O2 and O2.- contents .

HY-170757

Spermidine-alkyne	Biochemical Assay Reagents	Others
Spermidine-alkyne is a Spermidine (HY-B1776) derivative endowed with an alkyne handle. Spermidine-alkyne is a Spermidine probe, which can be used for the determination of the Spermidine binding to cellular proteins .

HY-B1776AR

Spermidine hydrochloride (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
Spermidine (hydrochloride) (Standard) is the analytical standard of Spermidine (hydrochloride). This product is intended for research and analytical applications. Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H2O2 and O2.- contents .

HY-N11086

Tris(dihydrocaffeoyl)spermidine	Others	Metabolic Disease
Tris(dihydrocaffeoyl)spermidine is an active compound. Tris(dihydrocaffeoyl)spermidine can be isolated from potato (Solanum tuberosum) tubers. Tris(dihydrocaffeoyl)spermidine can be used for the research of metabolism .

HY-P4757

*N1-Glutathionyl-spermidine* disulfide**	Parasite	Others
N1-Glutathionyl-spermidine disulfide is a substrate of trypanothione reductase .

HY-N12302

N1-Dihydrocaffeoyl, N10-caffeoyl spermidine	Others	Others
N1-Dihydrocaffeoyl, N10-caffeoyl spermidine is a natural product that can be isolated from Lycium ruthenicum Murr. .

HY-N3218

N1,N10-Bis(p-coumaroyl)spermidine	Others	Others
N1,N10-Bis(p-coumaroyl)spermidine is a phenylpropanoid that can be isolated from Fagales pollen .

HY-148433

SpdSyn binder-1	Parasite	Infection Inflammation/Immunology
SpdSyn binder-1 is a weak binder, which binds in the active site of plasmodium falciparum spermidine synthase. SpdSyn binder-1 can be used for the research of malaria .

HY-42213

N1,N4-Bis-Boc-spermidine	Biochemical Assay Reagents	Others
N1,N4-Bis-Boc-spermidine is a linker containing an amino group with two Boc-protected amino groups. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.

HY-42222

N1,N5-Bis-boc-spermidine	Biochemical Assay Reagents	Others
N1,N5-Bis-Boc-spermidine is a linker containing an amino group with two Boc-protected amino groups. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.

HY-114292A

(E)-tri-Pcoumaroylspermidine	Others	Others
(E)-tri-Pcoumaroylspermidine is a spermidine compound, that can be found in the florets of Carthamus tinctorius L .

HY-151150

Trypanothione synthetase-IN-2	Parasite	Infection
Trypanothione synthetase-IN-2 (Compound 3) is a competitive Leishmania infantum trypanothione synthetase (TryS) inhibitor with an IC₅₀ of 5.4 μM when triamine spermidine is as polyamine S .

HY-151148

Trypanothione synthetase-IN-1	Parasite	Infection
Trypanothione synthetase-IN-1 (Compound 1) is a competitive Leishmania infantum trypanothione synthetase (TryS) inhibitor with an IC₅₀ of 14.8 μM when triamine spermidine is as polyamine S .

HY-W099540

OES2-0017	Bacterial	Infection
OES2-0017 shows potent synergy with polyamines and growth-inhibitory effects at the low micromolar range. OES2-0017 inhibits spermine/spermidine acetyltransferase (SpeG) (IC₅₀: 34.82 μM ) and other polyamine detoxification enzymes in low concentrations, perturbed the bacterial membrane in higher concentrations .

HY-W190917

N1, N4-Bisazidospermine bistosylate	Biochemical Assay Reagents	Others
N1, N4-Bisazidospermine bistosylate is a spermine linker containing two azide groups. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. Spermidine is a polyamine that modulates various cellular activities like cellular development and differentiation, stability of DNA, and apoptosis.

HY-122039

Hypusine dihydrochloride	Amino Acid Derivatives	Others
Hypusine dihydrochloride is a natural amino acid found only in the eukaryotic translation initiation factor 5A (eIF-5A). Hypusine is formed by the transfer of the butylamine portion from spermidine to the ϵ-amino group of a specific lysine residue of eIF-5A precursor and by the hydroxylation at carbon 2 of the incoming 4-aminobutyl moiety .

HY-W190953

N1,N12-Di-Boc-spermine	Biochemical Assay Reagents	Others
N1,N12-Di-boc-spermine is a spermine linker containing two a Boc-protected amino groups. The Boc groups can be deprotected under mild acidic conditions to form the free amine. Spermidine is a polyamine that modulates various cellular activities like cellular development and differentiation, stability of DNA, and apoptosis.

HY-W190905

N4,N9-di-Boc-spermine	Biochemical Assay Reagents	Others
N4, N9-di-Boc-spermine is a spermine linker containing two a Boc-protected amino groups and two amine groups. The Boc groups can be deprotected under mild acidic conditions to form the free amine. The amino groups are reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. Spermidine is a polyamine that modulates various cellular activities like cellular development and differentiation, stability of DNA, and apoptosis.

HY-126171

Hypusine	Endogenous Metabolite	Others
Hypusine is a natural amino acid. The post-translational synthesis of hypusine is mainly catalyzed by deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxylase (DOHH) .

HY-13610B

N1,N11-Diethylnorspermine hydrobromide	Caspase	Cancer
N1,N11-Diethylnorspermine hydrobromide is a potent anticancer agent. N1,N11-Diethylnorspermine hydrobromide is a spermine analog that activates polyamine catabolism. N1,N11-Diethylnorspermine hydrobromide induces the release of cytochrome c from mitochondria, resulting in activation of caspase 3. N1,N11-Diethylnorspermine hydrobromide kills glioblastoma multiforme (GBM) cells through induction of SSAT (spermidine/spermine N1-acetyltransferase) coupled with H2O2 production .

HY-13610

N1,N11-Diethylnorspermine	Caspase mTOR	Cancer
N1,N11-Diethylnorspermine (DENSPM tetrahydrochloride) is a potent anticancer agent. N1,N11-Diethylnorspermine activates polyamine catabolism and downregulates mTOR protein. N1,N11-Diethylnorspermine induces the release of cytochrome c from mitochondria, resulting in activation of caspase 3. N1,N11-Diethylnorspermine tetrahydrochloride kills glioblastoma multiforme (GBM) through induction of SSAT (spermidine/spermine N1-acetyltransferase) coupled with H₂O₂ production .

HY-13610A

N1,N11-Diethylnorspermine tetrahydrochloride 4 Publications Verification DENSPM tetrahydrochloride; BENSPM tetrahydrochloride	Caspase mTOR	Cancer
N1, N11-Diethylnorspermine tetrahydrochloride (DENSPM tetrahydrochloride) is a potent anticancer agent. N1,N11-Diethylnorspermine tetrahydrochloride activates polyamine catabolism and downregulates mTOR protein. N1,N11-Diethylnorspermine tetrahydrochloride induces the release of cytochrome c from mitochondria, resulting in activation of caspase 3. N1,N11-Diethylnorspermine tetrahydrochloride kills glioblastoma multiforme (GBM) through induction of SSAT (spermidine/spermine N1-acetyltransferase) coupled with H₂O₂ production .

HY-13610AR

N1,N11-Diethylnorspermine tetrahydrochloride (Standard)	Caspase mTOR	Cancer
N1,N11-Diethylnorspermine (tetrahydrochloride) (Standard) is the analytical standard of N1,N11-Diethylnorspermine (tetrahydrochloride). This product is intended for research and analytical applications. N1, N11-Diethylnorspermine tetrahydrochloride (DENSPM tetrahydrochloride) is a potent anticancer agent. N1,N11-Diethylnorspermine tetrahydrochloride activates polyamine catabolism and downregulates mTOR protein. N1,N11-Diethylnorspermine tetrahydrochloride induces the release of cytochrome c from mitochondria, resulting in activation of caspase 3. N1,N11-Diethylnorspermine tetrahydrochloride kills glioblastoma multiforme (GBM) through induction of SSAT (spermidine/spermine N1-acetyltransferase) coupled with H2O2 production .

*N1-Glutathionyl-spermidine* disulfide**	Parasite	Others
N1-Glutathionyl-spermidine disulfide is a substrate of trypanothione reductase .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1776

*Spermidine* 5+ Cited Publications	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Anti-aging Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Spermidine maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine significantly decreases the H₂O₂ and O₂ ^.- contents .

HY-B1776R

Spermidine (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Reference Standards Endogenous Metabolite
Spermidine (Standard) is the analytical standard of Spermidine. This product is intended for research and analytical applications. Spermidine maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine significantly decreases the H2O2 and O2.- contents .

HY-B1776A

Spermidine hydrochloride 5+ Cited Publications	Structural Classification Natural Products other families Animals Classification of Application Fields Source classification Metabolic Disease Plants Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H₂O₂ and O₂ ^.- contents .

HY-114292A

(E)-tri-Pcoumaroylspermidine	Structural Classification Carthamus tinctorius L. Source classification Phenols Polyphenols Plants Compositae	Others
(E)-tri-Pcoumaroylspermidine is a spermidine compound, that can be found in the florets of Carthamus tinctorius L .

HY-B1776AR

Spermidine hydrochloride (Standard)	Structural Classification Natural Products other families Animals Source classification Plants Endogenous metabolite	Reference Standards Endogenous Metabolite
Spermidine (hydrochloride) (Standard) is the analytical standard of Spermidine (hydrochloride). This product is intended for research and analytical applications. Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H2O2 and O2.- contents .

HY-N11086

Tris(dihydrocaffeoyl)spermidine	Structural Classification Natural Products Source classification Phenols Plants Solanaceae Solanum phureja Juz. & Bukasov	Others
Tris(dihydrocaffeoyl)spermidine is an active compound. Tris(dihydrocaffeoyl)spermidine can be isolated from potato (Solanum tuberosum) tubers. Tris(dihydrocaffeoyl)spermidine can be used for the research of metabolism .

HY-N12302

N1-Dihydrocaffeoyl, N10-caffeoyl spermidine	Structural Classification Source classification Phenols Polyphenols Lycium ruthenicum Murray Plants Solanaceae	Others
N1-Dihydrocaffeoyl, N10-caffeoyl spermidine is a natural product that can be isolated from Lycium ruthenicum Murr. .

HY-N3218

N1,N10-Bis(p-coumaroyl)spermidine	Structural Classification Source classification Phenols Polyphenols Plants Papaveraceae	Others
N1,N10-Bis(p-coumaroyl)spermidine is a phenylpropanoid that can be isolated from Fagales pollen .

Cat. No.	Product Name	Chemical Structure

HY-W709575

Spermidine-d6 trihydrochloride
Spermidine-d6 trihydrochloride is the deuterium labeled Spermidine-d6 (trihydrochloride) (HY-W709575) .

HY-B1776S

Spermidine-d6
Spermidine-d₆ is the deuterium labeled Spermidine . Spermidine maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine significantly decreases the H2O2 and O2.- contents .

HY-B1776AS

Spermidine-d8 hydrochloride
Spermidine-d₈ (hydrochloride)e is the deuterium labeled Spermidine trihydrochloride. Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H2O2 and O2.- contents .

HY-B1776AS1

Spermidine-13C4 hydrochloride 1 Publications Verification
Spermidine- ¹³C₄ (hydrochloride) is the ¹³C-labeled Spermidine trihydrochloride. Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H2O2 and O2.- contents .

Cat. No.	Product Name		Classification

HY-170757

Spermidine-alkyne		Alkynes
Spermidine-alkyne is a Spermidine (HY-B1776) derivative endowed with an alkyne handle. Spermidine-alkyne is a Spermidine probe, which can be used for the determination of the Spermidine binding to cellular proteins .

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Spermidine

Inhibitors & Agonists

Peptides

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Isotope-Labeled Compounds

Click Chemistry

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