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Results for "

SpCas9

" in MedChemExpress (MCE) Product Catalog:

5

Inhibitors & Agonists

2

Recombinant Proteins

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-148730
    BRD7586
    1 Publications Verification

    		 Bacterial Cancer
    BRD7586 is a potent and selective Streptococcus pyogenes Cas9 (SpCas9) inhibitor. BRD7586 specifically engages SpCas9 but not Cas12a in cells and enhances SpCas9 specificity at multiple loci. BRD7586 inhibits SpCas9 at multiple genomic loci irrespective of the mode of SpCas9 delivery .
    BRD7586
  • HY-136251
    BRD0539

    		Bacterial Infection
    BRD0539 is a Streptococcus pyogenes Cas9 (SpCas9) inhibitor with an IC50 of 22 μM in an in vitro DNA cleavage assay .
    BRD0539
  • HY-E70219
    SpCas9 D10A Nickase

    		Biochemical Assay Reagents Others
    SpCas9 D10A Nickase is a mutant of the Cas9 protein. SpCas9 D10A Nickase retains the function of a cleavage domain of Cas9 nuclease and specifically cleaves the target single strand to form a nick. SpCas9 D10A Nickase reduces off-target effects .
    SpCas9 D10A Nickase
  • HY-174500
    eSpCas9 mRNA

    		mRNA Others
    The eSpCas9 mRNA expresses enhanced-specificity SpCas9 protein, with sequence originally from Slaymaker et al Science. 2015 Dec 1.
    eSpCas9 mRNA
  • HY-165604
    C14-490

    		Liposome Others
    C14-490, an ionizable cationic lipid (pKa = 5.94), is used for the synthesis of lipid nanoparticles (LNPs). C14-490 LNPs is used as the basis for subsequent study of in utero gene editing in HSCs. C14-490 LNPs are used to encapsulate SpCas9 mRNA and TTR sgRNA using optimized B5 formulation parameters and surface conjugation to CD45 antibody F(ab’)2 fragments-Systematically optimized Targeted Editing Machinery LNPs (STEM LNPs) .
    C14-490

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