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Results for "

SbmA

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Androgen Receptor (1) Bacterial (1) HSP (1) Keap1-Nrf2 (1) Mitophagy (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Infection (1) Metabolic Disease (1)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Rosolutamide ASC-JM17; ALZ-003	Keap1-Nrf2 Androgen Receptor HSP Mitophagy	Metabolic Disease
Rosolutamide (ASC-JM17), a curcumin analog, is an orally active, potent Nrf1 and Nrf2 activator. Rosolutamide activates Nrf1, Nrf2 and heat shock factor 1 (Hsf1), thereby activating the expression of proteasome subunits, antioxidant enzymes and molecular chaperones. Rosolutamide degrades the polyglutamine (polyQ) androgen receptor (AR) via the ubiquitin-proteasome pathway and improves motor function in mouse models of spinal and bulbar muscular atrophy (SBMA). Rosolutamide improves mitochondrial function and promotes autophagy, decreases mutant protein aggregates, and attenuates intracellular/mitochondrial reactive oxygen species (ROS) levels .

Citrocin	Bacterial	Infection
Citrocin is a potent bacterial RNA polymerase (RNAP) inhibitor. Citrocin shows significant inhibitory activity against Escherichia coli RNAP with an MIC range of 16-125 μM. Citrocin specifically binds to and inhibits RNA polymerase to block bacterial transcription and enters cells mainly through inner membrane protein SbmA. Citrocin is promising for research of Gram-negative bacterial infections, such as enterohemorrhagic E. coli .

AR Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
AR Human Pre-designed siRNA Set A contains three designed siRNAs for AR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AR Human Pre-designed siRNA Set A AR Human Pre-designed siRNA Set A

Cat. No.	Product Name	Target	Research Area

Citrocin	Bacterial	Infection
Citrocin is a potent bacterial RNA polymerase (RNAP) inhibitor. Citrocin shows significant inhibitory activity against Escherichia coli RNAP with an MIC range of 16-125 μM. Citrocin specifically binds to and inhibits RNA polymerase to block bacterial transcription and enters cells mainly through inner membrane protein SbmA. Citrocin is promising for research of Gram-negative bacterial infections, such as enterohemorrhagic E. coli .

Cat. No.	Compare	Product Name	Species	Source

	Androgen receptor Protein, Human (His-SUMO, Myc) AIS; ANDR_HUMAN; Androgen nuclear receptor variant 2; Androgen receptor dihydrotestosterone receptor; testicular feminization; SbmA; SMAX1; Testicular Feminization TFM; TFM	Human	E. coli
	The androgen receptor protein is a steroid hormone receptor that acts as a ligand-activated transcription factor that regulates gene expression and affects cell proliferation and differentiation. Coactivators and corepressors such as ZBTB7A negatively regulate androgen receptor signaling by recruiting NCOR1 and NCOR2 to androgen response elements on target genes. Androgen receptor Protein, Human (His-SUMO, Myc) is the recombinant human-derived Androgen receptor protein, expressed by E. coli , with N-10*His, N-SUMO, C-Myc labeled tag.

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AR Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
AR Human Pre-designed siRNA Set A contains three designed siRNAs for AR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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