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STING-IN-2

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-138682
    STING-IN-2
    5 Publications Verification

    		 STING Inflammation/Immunology
    STING-IN-2 (C-170) is a potent and covalent STING inhibitor. STING-IN-2 efficiently inhibits both mouse STING (mmSTING) and human STING (hsSTING). STING-IN-2 can be used for autoinflammatory disease research .
    STING-IN-2
  • HY-112906
    C-176
    75+ Cited Publications

    		 STING Inflammation/Immunology
    C-176 is a selective and blood-brain barrier permeable STING inhibitor. C-176 covalently targets transmembrane cysteine residue 91 and thereby blocking activation-induced palmitoylation of STING .
    C-176
  • HY-158036
    PROTAC STING Degrader-2

    		PROTACs STING Others Inflammation/Immunology
    PROTAC STING degrader-2 is a protein Degrader that targets Stimulator of interferon genes (STING) (DC50=0.53 μM). PROTAC STING Degrader-2 is combined with STING protein and E3 ubiquitin ligase in a covalent manner to induce the degradation of STING protein. PROTAC STING Degrader-2 can be used to investigate the role of STING in autoinflammation and autoimmune diseases (PINK: STING binder (HY-145009); Blue: VHL ligand (HY-164043); Black: linker) [2].
    PROTAC STING Degrader-2
  • HY-174136
    STING Degrader-2

    		STING Inflammation/Immunology
    STING Degrader-2 (Compound SI-43) is a STING inhibitor and mutant-specific degrader. STING Degrader-2 can effectively inhibit cGAMP-induced STING activation and significantly reduce the release of IFN-β and CXCL-10. It inhibits the activity of STING by binding to two pockets of the STING dimer and induces proteasome-independent degradation of mutants STING S154 and STING M155 (DC50 values are 0.31 and 0.76 μM, respectively). STING Degrader-2 can be used to study STING-related autoimmune diseases .
    STING Degrader-2
  • HY-168676
    STING ligand-2

    		STING Ligands for Target Protein for PROTAC Cancer
    STING ligand-2 is the ligand for STING, that can be used as target protein ligand in synthesis of PROTAC degrader STING-IN-10 (HY-168554) .
    STING ligand-2
  • HY-164043
    (S,R,S)-AHPC(Me)-amido-C2-acid

    		Ligands for E3 Ligase Cancer
    (S,R,S)-AHPC(Me)-amido-C2-acid is an VHL (E3 ligase) ligand, and can be used for synthesis of PROTACs, such as PROTAC STING Degrader-2 (HY-158036) .
    (S,R,S)-AHPC(Me)-amido-C2-acid

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