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SPDP Crosslinker

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-100216
    SPDP
    5 Publications Verification

    SPDP Crosslinker; Py-ds-Prp-OSu

    		 ADC Linker Cancer
    SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs) .
    SPDP
  • HY-W800714
    SPDP-Gly-Gly-methoxy

    		Biochemical Assay Reagents Others
    SPDP-Gly-Gly-methoxy is a linker with SPDP and methyl ester moiety. The SPDP is an amine and thiol reactive crosslinker. It is also membrane permeable, allowing it to participate in intracellular crosslinking reactions.
    SPDP-Gly-Gly-methoxy
  • HY-126495
    Sulfo-LC-SPDP

    		ADC Linker Cancer
    Sulfo-LC-SPDP is a heterobifunctional, thiol-cleavable and membrane impermeable crosslinker.
    Sulfo-LC-SPDP
  • HY-W800711
    SPDP-Gly-Pro-NHS ester

    		Biochemical Assay Reagents Others
    SPDP-Gly-Pro-NHS ester is a linker with SPDP and NHS ester moieties. The SPDP is an amine and thiol reactive crosslinker. It is also membrane permeable, allowing it to participate in intracellular crosslinking reactions. The NHS ester is amine reactive and forms stable amide bonds.
    SPDP-Gly-Pro-NHS ester
  • HY-W800713
    SPDP-Gly-Pro-acid

    		Biochemical Assay Reagents Others
    SPDP-Gly-Pro-acid is a linker with SPDP and carboxylic acid moieties. The SPDP is an amine and thiol reactive crosslinker. It is also membrane permeable, allowing it to participate in intracellular crosslinking reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
    SPDP-Gly-Pro-acid
  • HY-126493
    DM4-SPDP

    		Drug-Linker Conjugates for ADC Microtubule/Tubulin Cancer
    DM4-SPDP is a agent-linker conjugate composed of a potent antitubulin agent DM4 and a linker SMCC to make antibody agent conjugate . SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls .
    DM4-SPDP

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