SP3

By Targets:	Aldose Reductase (1) Drug Metabolite (1) Endogenous Metabolite (1) FKBP (2) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (5)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-161794A

SP3N hydrochloride	FKBP	Cancer
SP3N hydrochloride is a specific degrader of the prolyl isomerase (FKBP12). The alkylamine of SP3N hydrochloride is metabolized to a reactive aldehyde (SP3CHO), which recruits the SCF ^FBXO22 ligase for FKBP12 degradation. SP3N hydrochloride may be used in research for cancer .

HY-RS25079

Sp3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sp3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sp3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sp3 Rat Pre-designed siRNA Set A Sp3 Rat Pre-designed siRNA Set A

HY-RS18594

Sp3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sp3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sp3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sp3 Mouse Pre-designed siRNA Set A Sp3 Mouse Pre-designed siRNA Set A

HY-RS13606

SP3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SP3 Human Pre-designed siRNA Set A contains three designed siRNAs for SP3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SP3 Human Pre-designed siRNA Set A SP3 Human Pre-designed siRNA Set A

HY-161794

SP3N	FKBP	Cancer
SP3N is a specific degrader of the prolyl isomerase FKBP12. The alkylamine of SP3N is metabolized to a reactive aldehyde (SP3CHO), which recruits the SCFFBXO22 ligase for FKBP12 degradation. SP3N may be used in research for cancer .

HY-161795

SP3CHO	Drug Metabolite	Cancer
SP3CHO is an active metabolite generated by the metabolism of SP3N in cell culture by the action of amine oxidase. SP3CHO can induce polyubiquitination of specific proteins by recruiting the SCFFBXO22 E3 ligase complex. SP3CHO can be used in cancer therapy research .

HY-125400

Zaragozic acid C L-697350	Endogenous Metabolite	Cancer
Zaragozic acid C (L-697350) is a potent sterol synthase inhibitor with potential antitumor activity. Zaragozic acid C contains multiple hydroxyl and alkyl substituents in its chemical structure, demonstrating complex functionalization capabilities. The synthesis of zaragozic acid C involves a photochemical C(sp3)-H acylation reaction, which resolves the challenging carbon substitution problem in the synthesis .

HY-173132

AKR1Cs-IN-1	Aldose Reductase	Cancer
AKR1Cs-IN-1 (Compound 29) is a potent and broad-spectrum inhibitor targeting members of the Aldo-Keto Reductase 1C family (AKR1C1-1C4). By simultaneously occupying the SP2 and *SP3* pockets, it effectively inhibits multiple isoforms and disrupts metabolic pathways associated with drug resistance. In enzymatic activity assays, AKR1Cs-IN-1 exhibited significant inhibitory potency, with IC₅₀ values of 0.09, 0.28, 0.05, and 0.51 µM against AKR1C1, AKR1C2, *AKR1C3, and AKR1C4*, respectively. In the doxorubicin (DOX)-resistant breast cancer cell line MCF-7/ADR, AKR1Cs-IN-1 showed remarkable resensitization effects and significantly enhanced the cytotoxicity of DOX. AKR1Cs-IN-1 holds promise for research on overcoming drug resistance in breast cancer .

Cat. No.	Product Name

HY-L0104V

UORSY New Generation Screening Library	1,900,000 compounds
UORSY New Generation Screening Library contains about 1,900,000 compounds. The library is a revolutionary collection of lead-like molecules with outstanding structural quality and diversity—New Generation Screening Library (NGSL). Its core is decorated with interesting building blocks, including important medicinal fragments such as peptide bonds, amino groups and hydroxyl groups. and designed for discovery of new Voltage-gated calcium channel blockers.

UORSY New Generation Screening Library

1,900,000 compounds

UORSY New Generation Screening Library contains about 1,900,000 compounds. The library is a revolutionary collection of lead-like molecules with outstanding structural quality and diversity—New Generation Screening Library (NGSL). Its core is decorated with interesting building blocks, including important medicinal fragments such as peptide bonds, amino groups and hydroxyl groups. and designed for discovery of new Voltage-gated calcium channel blockers.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-125400

Zaragozic acid C L-697350	Structural Classification Natural Products Microorganisms Source classification	Endogenous Metabolite
Zaragozic acid C (L-697350) is a potent sterol synthase inhibitor with potential antitumor activity. Zaragozic acid C contains multiple hydroxyl and alkyl substituents in its chemical structure, demonstrating complex functionalization capabilities. The synthesis of zaragozic acid C involves a photochemical C(sp3)-H acylation reaction, which resolves the challenging carbon substitution problem in the synthesis .

Cat. No.	Product Name		Classification

HY-RS25079

Sp3 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Sp3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sp3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS18594

Sp3 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Sp3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sp3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS13606

SP3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
SP3 Human Pre-designed siRNA Set A contains three designed siRNAs for SP3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
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SP3

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