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Results for "

SOD1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (1) Apoptosis (1) Calcium Channel (1) DNA/RNA Synthesis (2) Dopamine β-hydroxylase (1) FKBP (1) Keap1-Nrf2 (1) Nuclear Hormone Receptor 4A/NR4A (1) ROCK (1) Small Interfering RNA (siRNA) (3) SOD (8)
By Research Areas:	Cancer (3) Inflammation/Immunology (1) Neurological Disease (13)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) Antisense Oligonucleotides (2) siRNAs (3)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-123982

SOD1-Derlin-1 inhibitor-2	SOD	Neurological Disease
SOD1-Derlin-1 inhibitor-2 (compound 56-59) is an inhibitor of *SOD1-Derlin-1* interaction. SOD1-Derlin-1 inhibitor-2 attenuates the interactions between Derlin-1 and SOD1 ^mut. SOD1-Derlin-1 inhibitor-2 can be used for the research of amyotrophic lateral sclerosis (ALS) ^[1].

HY-138131

SOD1-Derlin-1 inhibitor-1	SOD	Neurological Disease
SOD1-Derlin-1 inhibitor-1 (compound 56-20) is an inhibitor of *SOD1-Derlin-1* interaction. SOD1-Derlin-1 inhibitor-1 inhibits SOD1 ^G93A-Derlin-1 complex with an IC₅₀ value of 7.11 μM. SOD1-Derlin-1 inhibitor-1 can be used for the research of amyotrophic lateral sclerosis ^[1].

HY-132580A

Tofersen sodium BIIB067 SODium; ISIS-SOD1Rx SODium	DNA/RNA Synthesis	Neurological Disease
Tofersen sodium is an antisense oligonucleotide that mediates RNase H-dependent degradation of *superoxide dismutase 1 (SOD1) mRNA* to reduce the synthesis of SOD1 protein. Tofersen sodium can be used for the research of amyotrophic lateral sclerosis (ALS) ^[1].

HY-132580

Tofersen BIIB067; ISIS-SOD1Rx	DNA/RNA Synthesis	Neurological Disease
Tofersen (BIIB067) is an antisense oligonucleotide that mediates RNase H-dependent degradation of *superoxide dismutase 1 (SOD1) mRNA* to reduce the synthesis of SOD1 protein. Tofersen can be used for the research of amyotrophic lateral sclerosis (ALS) ^[1].

HY-153019

NUCC-0000323	SOD	Neurological Disease
NUCC-0000323 is a potent superoxide dismutase 1 (SOD1) inhibitor. NUCC-0000323 inhibits SOD1 expression. NUCC-0000323 can be used in research of amyotrophic lateral sclerosis (ALS) ^[1].

HY-169904

AKV-9	SOD	Neurological Disease
AKV-9 is the inhibitor for mutated Cu/Zn superoxide dismutase (SOD1), that inhibits SOD1-induced protein aggregation and exhibits protective efficacy against SOD1-induced cytotoxicity in PC-12 with an EC₅₀ of 0.3 μM. AKV-9 ameliorates amyotrophic lateral sclerosis in mouse models and extends their lifespan ^[1].

HY-P10627

SOD1 (147-153) human	Amyloid-β	Neurological Disease
SOD1 (147-153) human is a peptide fragment of Cu/Zn superoxide dismutase (SOD1) with a high propensity to form amyloid fibrils. SOD1 (147-153) human may trigger the aggregation of full-length SOD1 and is a common molecular determinant of familial amyotrophic lateral sclerosis (fALS) and sporadic amyotrophic lateral sclerosis (sALS) ^[1].

HY-RS13559

SOD1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SOD1 Human Pre-designed siRNA Set A contains three designed siRNAs for SOD1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SOD1 Human Pre-designed siRNA Set A SOD1 Human Pre-designed siRNA Set A

HY-RS23369

Sod1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sod1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sod1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sod1 Rat Pre-designed siRNA Set A Sod1 Rat Pre-designed siRNA Set A

HY-RS16926

Sod1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sod1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sod1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sod1 Mouse Pre-designed siRNA Set A Sod1 Mouse Pre-designed siRNA Set A

HY-E70377

Cu/Zn Superoxide dismutase Cu/Zn SOD	SOD	Inflammation/Immunology Cancer
Cu/Zn Superoxide dismutase (Cu/Zn SOD; SOD1) is a cytosolic copper-zinc dimer form of superoxide dismutase enzyme. Cu/Zn Superoxide dismutase has oxygen radical enzymatic dismutation ^[1].

HY-16074

ATN-224 4 Publications Verification Bis(choline)tetrathiomolybdate	SOD	Cancer
ATN-224 is an orally active Cu ²⁺/Zn ²⁺-superoxide dismutase 1 (SOD1) inhibitor. ATN-224 inhibits SOD1 activity in endothelial cells, an effect that is dose dependent with an IC₅₀ of 17.5 nM.

HY-115445

LCS-1 1 Publications Verification	Apoptosis SOD	Cancer
LCS-1 is a superoxide dismutase 1 (SOD1) inhibitor. LCS-1 inhibits SOD1 activity with an IC₅₀ value of 1.07 μM. LCS-1 induces the early- and late-stage apoptosis of multiple myeloma (MM.1S) cells ^[1] .

HY-148901

CMB-087229	SOD	Neurological Disease
CMB-087229 is a mutant superoxide dismutase 1 (SOD1) protein aggregation inhibitor with IC₅₀ of 67 nM, which can be used in the research of amyotrophic lateral sclerosis ^[1].

HY-145294

ROCK2-IN-5	ROCK	Neurological Disease
ROCK2-IN-5 (compound 1d) is a hybrid compound containing structural fragments of the Rho kinase inhibitor fasudil and the NRF2 inducers caffeic and ferulic acids. ROCK2-IN-5 has good multitarget profile and good tolerability. ROCK2-IN-5 has the potential for thr research of Amyotrophic lateral sclerosis (ALS) with a SOD1 mutation ^[1].

HY-163772

Fraxinellone analog 1	Keap1-Nrf2	Neurological Disease
Fraxinellone analog 1 (compound 2) is a potent and rapid activator of the Nrf2 mediated antioxidant defense system, which protects against glutamate-mediated excitotoxicity and induces the expression of antioxidant genes Gpx4, *Sod1, and Nqo1*. Fraxinellone analog 1 has neuroprotective effects and regulatory effects against oxidative stress and inflammation, and can be used in the study of neurodegenerative diseases ^[1].

HY-172152

MP-010	FKBP Calcium Channel	Neurological Disease
MP-010 is a FKBP12 ligand that regulates cytosolic calcium by stabilizing RyR channel activity. MP-010 promotes functional improvement in SOD1 ^G93A amyotrophic lateral sclerosis (ALS) mice, as evidenced by improved motor coordination, increased integrity of neuromuscular junctions, and significantly enhanced survival of spinal motor neurons. MP-010 can be used for research in the field of neurological diseases ^[1].

HY-W115718

Cuprizone 3 Publications Verification	Dopamine β-hydroxylase	Neurological Disease
Cuprizone is a copper chelating agent that forms a deep blue copper ketone complex with copper (II). The copper ketone reaction can be used in colorimetric tests for the presence of trace copper. Cuprizone can be used to induce some schizophrenia-like behavior in mice. Cuprizone acts on copper enzymes, including SOD1, cytochrome oxidase, and DβH, thereby causing oxidative stress and increasing DA levels in certain brain regions such as the medial prefrontal cortex (PFC) ^[1].

HY-173025

Nurr1 agonist 12	Nuclear Hormone Receptor 4A/NR4A	Neurological Disease
Nurr1 agonist 12 (Compound 37) is the agonist for nuclear receptor-associated protein 1 (Nurr1) that activates the transcriptional activity of Nurr1 with an EC₅₀ of 0.06 μM. Nurr1 agonist 12 activates the human response elements NBRE, NurRE, and DR5 with EC₅₀ of 0.07 μM, 0.027 μM, and 0.014 μM, respectively. Nurr1 agonist 12 induces the expression of Nurr1-regulated neurotrophic genes, such as tyrosine hydroxylase (TH), SOD1/2, BDNF, Sestrin 3, and BIRC5 (Survivin). Nurr1 agonist 12 exhibits neuroprotective efficacy against Paraquat-induced neurotoxicity ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P10627

SOD1 (147-153) human	Amyloid-β	Neurological Disease
SOD1 (147-153) human is a peptide fragment of Cu/Zn superoxide dismutase (SOD1) with a high propensity to form amyloid fibrils. SOD1 (147-153) human may trigger the aggregation of full-length SOD1 and is a common molecular determinant of familial amyotrophic lateral sclerosis (fALS) and sporadic amyotrophic lateral sclerosis (sALS) ^[1].

Species:	Human (2)
Tag:	His (2)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P71048

	SOD1 Protein, Human (His) Superoxide Dismutase [Cu-Zn]; Superoxide Dismutase 1; hSOD1; SOD1	Human	E. coli
	SOD1 Protein, an enzyme crucial for cellular defense, operates as a superoxide dismutase, neutralizing radicals to safeguard cells from oxidative stress. Its enzymatic activity underscores the importance of SOD1 in maintaining cellular homeostasis and protecting biological systems from the harmful effects of reactive oxygen species accumulation. SOD1 Protein, Human (His) is the recombinant human-derived SOD1 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P71048A

	SOD1 Protein, Human (N-His) Superoxide Dismutase [Cu-Zn]; Superoxide Dismutase 1; hSOD1; SOD1	Human	E. coli
	SOD1 Protein, an enzyme crucial for cellular defense, operates as a superoxide dismutase, neutralizing radicals to safeguard cells from oxidative stress.Its enzymatic activity underscores the importance of SOD1 in maintaining cellular homeostasis and protecting biological systems from the harmful effects of reactive oxygen species accumulation.SOD1 Protein, Human (N-His) is the recombinant human-derived SOD1 protein, expressed by E.coli , with N-6*His labeled tag.

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81228

	SOD1 Antibody (YA3541) ALS antibody; ALS1 antibody; Amyotrophic lateral sclerosis 1 adult antibody; Cu/Zn SOD antibody; Cu/Zn superoxide dismutase antibody; Epididymis secretory protein Li 44 antibody; HEL S 44 antibody; Homodimer antibody; hSOD1 antibody; Indophenoloxidase A antibody; IPOA antibody; Mn superoxide dismutase antibody; SOD antibody; SOD soluble antibody; SOD1 antibody; SOD2 antibody; SODC antibody; SODC_HUMAN antibody; Superoxide dismutase [Cu-Zn] antibody; Superoxide dismutase 1 antibody; Superoxide dismutase 1 soluble antibody; Superoxide dismutase Cu Zn antibody; Superoxide dismutase cystolic antibody;	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	SOD1 Antibody is an unconjugated, approximately 17 kDa, rabbit-derived, anti-SOD1 monoclonal antibody. SOD1 Antibody can be used for: WB, IF-Cell, IF-Tissue, IHC-P, FC expriments in human, mouse, rat background without labeling.

HY-P83888

	SOD1 Antibody (YA3585) ALS; SOD; ALS1; IPOA; homodimer	WB, ICC/IF, FC, ELISA	Human, Mouse