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Results for "

SMCC-DM1

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

1

Inhibitory Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-101070
    SMCC-DM1
    Maximum Cited Publications
    11 Publications Verification

    DM1-SMCC

    		 Drug-Linker Conjugates for ADC Cancer
    SMCC-DM1 (DM1-SMCC) is a agent-linker conjugate composed of a potent microtubule-disrupting agent DM1 and a linker SMCC to make antibody agent conjugate (ADC) [1].
    SMCC-DM1
  • HY-101982A
    (Rac)-Lys-SMCC-DM1

    (Rac)-Lys-Nε-MCC-DM1

    		 Drug-Linker Conjugates for ADC Cancer
    (Rac)-Lys-SMCC-DM1 ((Rac)-Lys-Nε-MCC-DM1) is the racemate of Lys-SMCC-DM1 (HY-101982). Lys-SMCC-DM1 is a linker-payload component that has the potential to inhibit tubulin polymerization. Lys-SMCC-DM1 is the active metabolite of T-DM1 [1].
    (Rac)-Lys-SMCC-DM1
  • HY-101982
    Lys-SMCC-DM1
    1 Publications Verification

    Lys-Nε-MCC-DM1

    		 Drug-Linker Conjugates for ADC Cancer
    Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) is a agent-linker conjugates for ADC that can inhibit tubulin polymerization. Lys-SMCC-DM1 is the active metabolite of T-DM1. T-DM1 is a HER2-targeting ADC with a tubulin polymerization inhibitor DM1. Lys-SMCC-DM1 can be used in the research of breast cancer [1] .
    Lys-SMCC-DM1
  • HY-159774
    ADC Control human IgG1-DM1

    		Antibody-Drug Conjugates (ADCs) Cancer
    ADC Control human IgG1-DM1 is the ADC control, which is composed of Human IgG1 kappa, Isotype Control (HY-P99001) and the linker-payload conjugate SMCC-DM1 (HY-101070) [1].
    ADC Control human IgG1-DM1
  • HY-P9921A
    Trastuzumab emtansine (solution)
    3 Publications Verification

    Ado-Trastuzumab emtansine (solution); PRO132365 (solution); T-DM 1 (solution)

    		 Antibody-Drug Conjugates (ADCs) EGFR Cancer
    Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1 (derivative of maytansine), and the drug-linker conjugate for ADC is SMCC-DM1 (HY-101070). Trastuzumab emtansine can be used for the research of advanced breast cancer [1] .
    Trastuzumab emtansine (solution)
  • HY-171680
    Anti-CCL2 (Carlumab)-SMCC-DM1

    		Antibody-Drug Conjugates (ADCs) CCR Microtubule/Tubulin Cancer
    Anti-CCL2 (Carlumab)-SMCC-DM1 is an antibody-drug conjugate (ADC) consisting of the humanized anti-CCL2 (chemokine ligand 2) antibody Carlumab (HY-P99188) conjugated to the linker SMCC (HY-42360) and the cytotoxic microtubule inhibitor DM1 (HY-19792). The ADC toxic molecule and linker part are SMCC-DM1 (HY-101070). Anti-CCL2 (Carlumab)-SMCC-DM1 can be used in the research of cancer, especially prostate cancer [1] .
    Anti-CCL2 (Carlumab)-SMCC-DM1
  • HY-171735
    Anti-SLC34A2 (Lifastuzumab)-SMCC-DM1

    		Antibody-Drug Conjugates (ADCs) Sodium Channel Microtubule/Tubulin Cancer
    Anti-SLC34A2 (Lifastuzumab)-SMCC-DM1 is an antibody-drug conjugate (ADC) consisting of the humanized anti-SLC34A2 (sodium-dependent phosphate transporter 2) antibody Lifastuzumab (HY-P99970) conjugated to the linker SMCC (HY-42360) and the the cytotoxic microtubule inhibitor DM1 (HY-19792). The ADC toxic molecule and linker part are SMCC-DM1 (HY-101070). Anti-SLC34A2 (Lifastuzumab)-SMCC-DM1 can be used in the research of cancer [1] .
    Anti-SLC34A2 (Lifastuzumab)-SMCC-DM1
  • HY-P99685
    Laprituximab emtansine

    IMGN-289; J2898A-SMCC-DM1

    		 EGFR Antibody-Drug Conjugates (ADCs) Cancer
    Laprituximab emtansine (IMGN-289) is an immunotoxin targeting HER1. Laprituximab emtansine is an EGFR antibody-drug conjugate (ADC) consisting of the J2898A antibody, DM1 (anti-microtubule agent) and the SMCC thioether linker. Laprituximab emtansine can be used for cancer research [1] .
    Laprituximab emtansine

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