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SIK2/3-IN-1

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-159657
    PF-07899895

    		Salt-inducible Kinase (SIK) Others
    PF-07899895 (compound 34) is a SIK inhibitor, with IC50 values of 1.2 nM, 0.9 nM and 1.8 nM for SIK1, SIK2 and SIK3, respectively .
    PF-07899895
  • HY-139253
    MRIA9

    		Salt-inducible Kinase (SIK) PAK Apoptosis Cancer
    MRIA9, a chemical probe, is an ATP-competitive, pan Salt-Inducible kinase (SIK) and PAK2/3 inhibitor, with IC50 values of 516 nM, 180 nM and 127 nM for SIK1, SIK2 and SIK3, respectively .
    MRIA9
  • HY-129141
    YKL-06-062
    1 Publications Verification

    		 Salt-inducible Kinase (SIK) Inflammation/Immunology
    YKL-06-062 is a second-generation salt-inducible kinase (SIK) inhibitor with an IC50 of 2.12 nM/1.40 nM/2.86 nM for SIK1, SIK2 and SIK3, respectively .
    YKL-06-062
  • HY-120877
    MRT199665

    		MARK Salt-inducible Kinase (SIK) AMPK Apoptosis Cancer
    MRT199665 is a potent and ATP-competitive, selective MARK/SIK/AMPK inhibitor with IC50s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for MARK1/MARK2/MARK3/MARK14, AMPKα1/AMPKα2, and SIK1/SIK2/SIK3, respectively . MRT199665 causes apoptosis in MEF2C-activated human acute myeloid leukemias (AML) cells . MRT199665 inhibits the phosphorylation of SIK substrate CRTC3 at S370 .
    MRT199665
  • HY-170237
    SIK2/3-IN-1

    		Salt-inducible Kinase (SIK) Cancer
    SIK2/3-IN-1 (Compound 7S) is a selectively inhibitory agent of SIK2/3 with oral activity. SIK2/3-IN-1 can significantly inhibit tumor growth (without any body weight loss) in the MV4-11 AML mice CDX model. SIK2/3-IN-1 can be used in the research of MEF2C-dependent acute myeloid leukemia .
    SIK2/3-IN-1
  • HY-178014
    SIK1-IN-1

    		Salt-inducible Kinase (SIK) Src Others
    SIK1-IN-1 (Compound 27) is a selective Salt-inducible kinase 1 (SIK1) inhibitor with an IC50 of 0.7  nM for SIK1 over SIK2 and SIK3. SIK1-IN-1 has no cytotoxicity against HEK293 cells and PBMCs (maximum concentration of 30 μM). SIK1-IN-1 also has potent inhibitory activities for 392 kinases, in particular tyrosine kinases, such as FGR, HCK and LYN) .
    SIK1-IN-1

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