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SHP2-IN-26

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-145162
    SHP2-D26
    1 Publications Verification

    		 PROTACs SHP2 Phosphatase Cancer
    SHP2-D26 is a first, potent and effective SHP2 PROTAC degrader. SHP2-D26 induces SHP2 degradation requires binding to VHL-1 and SHP2 proteins. SHP2-D26 is also neddylation- and proteasome-dependent. SHP2-D26 can be used for the study of esophageal cancer and acute myeloid leukemia (Pink: SHP2 ligand (HY-176797); Blue: VHL ligand (HY-150803); Black: linker) .
    SHP2-D26
  • HY-145703
    SHP2 protein degrader-2

    		PROTACs SHP2 Cancer
    SHP2 protein degrader-2 is an isoform of SHP2-D26 (HY-145162). SHP2 protein degrader-2 is a PROTAC molecule. (Pink: SHP2 ligand (HY-176797); Blue: VHL ligand (HY-W935425); Black: linker) .
    SHP2 protein degrader-2
  • HY-157888
    SHP2-IN-26

    		SHP2 Phosphatase Cancer
    SHP2-IN-26 (Compound 4b) is a highly selective SHP2 allosteric inhibitor with a IC50 value of 3.2 nM. SHP2-IN-26 inhibits the phosphorylation of ERK and AKT in NCI-H358 cells. SHP2-IN-26 has antitumor activity .
    SHP2-IN-26
  • HY-176796
    SHP2-IN-43

    		Ligands for Target Protein for PROTAC SHP2 Cancer
    SHP2-IN-43 (Compound 5) is a SHP2 inhibitor with an IC50 of 98.7 nM. SHP2-IN-43 can be used as a PROTAC target ligand in the synthesis of SHP2-D26 (HY-145162) .
    SHP2-IN-43

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