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SGC stimulator-1

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-178191
    SGC stimulator 1

    		Guanylate Cyclase Autophagy AMPK TGF-β Receptor Cardiovascular Disease
    sGC stimulator 1 is a carbonyl sulfide (COS)/H2S-donor hybrid soluble guanylyl cyclase (sGC) stimulator (EC50 = 496 nM). sGC stimulator 1 exhibits a well-characterized H2S-releasing property. sGC stimulator 1 reduces fibrosis in TGF-β1-treated cardiac fibroblasts by increasing cGMP and H2S levels. sGC stimulator 1 can exert anti-fibrotic effects by activating sGC and increasing H2S. sGC stimulator 1 can be used for the study of heart failure (HF) .
    SGC stimulator 1

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