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Results for "

SF3b

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Payload (1) Apoptosis (4) Bcl-2 Family (1) Ceramidase (1) Cuproptosis (1) DNA/RNA Synthesis (2) DYRK (1) Fluorescent Dye (1) LPL Receptor (1) PROTACs (1) SF3B1 (5) Small Interfering RNA (siRNA) (10)
By Research Areas:	Cancer (10) Cardiovascular Disease (1) Neurological Disease (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (2) Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (6) siRNAs (10)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-RS12764

SF3B5 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SF3B5 Human Pre-designed siRNA Set A contains three designed siRNAs for SF3B5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SF3B5 Human Pre-designed siRNA Set A SF3B5 Human Pre-designed siRNA Set A

HY-RS17082

Sf3b1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sf3b1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sf3b1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sf3b1 Mouse Pre-designed siRNA Set A Sf3b1 Mouse Pre-designed siRNA Set A

HY-RS12761

SF3B2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SF3B2 Human Pre-designed siRNA Set A contains three designed siRNAs for SF3B2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SF3B2 Human Pre-designed siRNA Set A SF3B2 Human Pre-designed siRNA Set A

HY-RS26997

Sf3b3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sf3b3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sf3b3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sf3b3 Rat Pre-designed siRNA Set A Sf3b3 Rat Pre-designed siRNA Set A

HY-RS23526

Sf3b1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sf3b1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sf3b1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sf3b1 Rat Pre-designed siRNA Set A Sf3b1 Rat Pre-designed siRNA Set A

HY-RS20489

Sf3b3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sf3b3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sf3b3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sf3b3 Mouse Pre-designed siRNA Set A Sf3b3 Mouse Pre-designed siRNA Set A

HY-RS12760

SF3B1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SF3B1 Human Pre-designed siRNA Set A contains three designed siRNAs for SF3B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SF3B1 Human Pre-designed siRNA Set A SF3B1 Human Pre-designed siRNA Set A

HY-RS12763

SF3B4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SF3B4 Human Pre-designed siRNA Set A contains three designed siRNAs for SF3B4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SF3B4 Human Pre-designed siRNA Set A SF3B4 Human Pre-designed siRNA Set A

HY-RS12765

SF3B6 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SF3B6 Human Pre-designed siRNA Set A contains three designed siRNAs for SF3B6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SF3B6 Human Pre-designed siRNA Set A SF3B6 Human Pre-designed siRNA Set A

HY-RS12762

SF3B3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SF3B3 Human Pre-designed siRNA Set A contains three designed siRNAs for SF3B3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SF3B3 Human Pre-designed siRNA Set A SF3B3 Human Pre-designed siRNA Set A

HY-111517

H3B-8800	Apoptosis SF3B1	Cancer
H3B-8800 is a potent and orally active SF3B splicing modulator. H3B-8800 direct interaction with the SF3b complex and shows anti-cancer activity. H3B-8800 has the potential for the research of acute myeloid leukemia (AML) with SF3B1 mutant .

HY-19828

Herboxidiene GEX1A	DNA/RNA Synthesis	Cancer
Herboxidiene (GEX1A) is a potent phytotoxic polyketide from Streptomyces sp. A7847 with a diverse range of activities, including herbicidal, anti-cholesterol, anti-tumor effects. Herboxidiene inhibits the pre-mRNA splicing process by binding to spliceosome-associated protein (SAP) 155, a subunit of SF3b, in the splicesome .

HY-129589

Thailanstatin A 2 Publications Verification	ADC Payload	Cancer
Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC₅₀=650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC₅₀s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding “linker-less” ADC ^[3].

HY-133924

18-Deoxyherboxidiene RQN-18690A	SF3B1	Cardiovascular Disease Cancer
18-Deoxyherboxidiene (RQN-18690A) is a potent angiogenesis inhibitor. 18-Deoxyherboxidiene targets SF3b, a spliceosome component that is a subcomplex of the U2 small nuclear ribonucleoprotein (snRNP) in the spliceosome. 18-Deoxyherboxidiene inhibits the migration and tube formation of human umbilical vein endothelial cells (HUVECs) without significant cell toxicity. 18-Deoxyherboxidiene has the potential for cancer research .

HY-148384A

UHMCP1 dihydrochloride	DNA/RNA Synthesis	Cancer
UHMCP1 dihydrochloride is a potent UHM domain splicing inhibitor with a K_d value of 79 μM. UHMCP1 dihydrochloride prevents the SF3b155/U2AF ⁶⁵ interaction. UHMCP1 dihydrochloride impacts cell viability and RNA splicing .

HY-162386

UM4118	Cuproptosis	Cancer
UM4118 is a copper ionophore that can initiate a mitochondrial-based noncanonical form of cell death known as cuproptosis. UM4118 exhibits high sensitivity in SF3B1-mutated and adverse risk acute myeloid leukemia (AML), and can be used for AML research .

HY-148384

UHMCP1	Fluorescent Dye	Cancer
UHMCP1 is a chemical probe of U2AF homology motifs (UHM) with a K_d of 79 μM. UHMCP1 prevents the SF3b155/U2AF65 interaction, impacts RNA splicing and cell viability. UHMCP1 has potential anticancer properties .

HY-16466

Spliceostatin A	SF3B1	Cancer
Spliceostatin A, the FR901464 (HY-16212) methylated derivative, is a potent anti-tumor agent. Spliceostatin A inhibits splicing and promotes pre-mRNA accumulation by binding *SF3B1. SF3B1* is a subcomplex of U2 small nuclear ribonucleoprotein in the spliceosome. Spliceostatin A induces Apoptosis in chronic lymphocytic leukemia (CLL) cells ^[3].

HY-141881

PROTAC-O4I2	PROTACs Apoptosis SF3B1	Cancer
PROTAC-O4I2 is a PROTAC targets splicing factor 3B1 (SF3B1). PROTAC-O4I2 induces FLAG-SF3B1 degradation with an IC₅₀ value of 0.244 μM in K562 cells. PROTAC-O4I2 also induces cellular apoptosis in K562 WT cells .

HY-16399

Pladienolide B 1 Publications Verification	Apoptosis SF3B1	Cancer
Pladienolide B is a potent cancer cell growth inhibitor that targets the *SF3B1* subunit of the spliceosome. Pladienolide B exerts antitumor activities mediated through the inhibition of pre-mRNA splicing. Pladienolide B induces apoptosis ^[3].

HY-146221

Dyrk1A-IN-5 1 Publications Verification	DYRK	Neurological Disease
Dyrk1A-IN-5 (compound 5j) is a potent and selective DYRK1A inhibitor, with an IC₅₀ of 6 nM. Dyrk1A-IN-5 dose-dependently reduces the phosphorylation of Thr434 in SF3B1, with an IC₅₀ of 0.5 μM. Dyrk1A-IN-5 inhibits phosphorylation of tau at Thr212, with an IC₅₀ of 2.1 μM. Dyrk1A-IN-5 can be used for Down syndrome research .

HY-158783

SACLAC	Ceramidase Bcl-2 Family LPL Receptor Apoptosis	Neurological Disease
SACLAC, a Ceramide analog, is a potent and covalent acid ceramidase (ASAH1; AC) inhibitor with a K_i of 97.1 nM. SACLAC effectively blocks AC activity and induces a decrease in sphingosine 1-phosphate (S1P) and total ceramide levels. SACLAC reduces the levels of splicing factor SF3B1 and alternative Mcl-1 mRNA splicing, increases pro-apoptotic Mcl-1S levels to induce apoptosis in acute myeloid leukemia (AML) cells. SACLAC reduces the leukemic burden in human AML xenograft mouse models .

Herboxidiene GEX1A	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Biological Pesticide Research Cancer Agricultural Research	DNA/RNA Synthesis
Herboxidiene (GEX1A) is a potent phytotoxic polyketide from Streptomyces sp. A7847 with a diverse range of activities, including herbicidal, anti-cholesterol, anti-tumor effects. Herboxidiene inhibits the pre-mRNA splicing process by binding to spliceosome-associated protein (SAP) 155, a subunit of SF3b, in the splicesome .

Species:	Human (2)
Tag:	His (1) Tag Free (1) Strep (1)
Source:	Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P701567

	SF3B3 Protein, Human (sf9, His, StrepII) SF3b3; Splicing factor 3b subunit 3; Pre-mRNA-splicing factor SF3b 130 kDa subunit; SF3b130; STAF130; Spliceosome-associated protein 130; SAP 130	Human	Sf9 insect cells
	SF3B3 protein is a key splicing factor in the SF3B complex and plays a central role in pre-mRNA splicing. It is essential for "A" complex assembly and stabilizes U2 snRNP binding to branch point sequences. SF3B3 Protein, Human (sf9, His, Strep) is the recombinant human-derived SF3B3 protein, expressed by sf9 insect cells , with N-Strep, N-8*His labeled tag.

HY-P701566

	SF3B3 Protein, Human (sf9) SF3b3; Splicing factor 3b subunit 3; Pre-mRNA-splicing factor SF3b 130 kDa subunit; SF3b130; STAF130; Spliceosome-associated protein 130; SAP 130	Human	Sf9 insect cells
	SF3B3 protein is a key splicing factor in the SF3B complex and plays a central role in pre-mRNA splicing. It is essential for "A" complex assembly and stabilizes U2 snRNP binding to branch point sequences. SF3B3 Protein, Human (sf9) is the recombinant human-derived SF3B3 protein, expressed by sf9 insect cells , with tag free.

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82511

	SF3B1 Antibody (YA2256) SF3b1; SAP155; Splicing factor 3b subunit 1; Pre-mRNA-splicing factor SF3b 155 kDa subunit; SF3b155; Spliceosome-associated protein 155; SAP 155	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	SF3B1 Antibody (YA2256) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2256), targeting SF3B1, with a predicted molecular weight of 146 kDa (observed band size: 155 kDa). SF3B1 Antibody (YA2256) can be used for WB, IHC-P, ICC/IF, FC experiment in human, mouse, rat background.

HY-P81426

	SF3B3 Antibody (YA1171) SF3b3; KIAA0017; SAP130; Splicing factor 3b subunit 3; Pre-mRNA-splicing factor SF3b 130 kDa subunit; SF3b130; STAF130; Spliceosome-associated protein 130; SAP 130	IHC-P	Human
	SF3B3 Antibody (YA1171) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1171), targeting SF3B3. SF3B3 Antibody (YA1171) can be used for IHC-P experiment in human background.