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Results for "

S. pyogenes

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (10) Bacterial (12) Beta-lactamase (4) Biochemical Assay Reagents (2) DNA/RNA Synthesis (1) Fungal (1) HCV (1) Parasite (1) Reference Standards (2) Topoisomerase (2)
By Research Areas:	Cancer (3) Infection (15)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-E70069

Endo S2, Streptococcus pyogenes	Others	Others
Endo-β-N-acetylglucosaminidase (Endo S2) is a key enzyme involved in the processing of free oligosaccharides in the cytosol. Endo-β-N-acetylglucosaminidase catalyzes hydrolysis of N-linked oligosaccharides .

HY-B1256A

Cefuroxime 5+ Cited Publications Kefurox	Beta-lactamase Bacterial Antibiotic	Infection Cancer
Cefuroxime is an orally active second-generation cephalosporin antibiotic with increased stability to β-lactamase. Cefuroxime has a broad spectrum activity against Gram-positive and Gram-negative bacteria .

HY-E70069GL

Endo S2, Streptococcus pyogenes (GMP Like)	Biochemical Assay Reagents	Others
Endo S2, Streptococcus pyogenes (GMP Like) is Endo S2, Streptococcus pyogenes (HY-E70069) produced by using GMP like guidelines. Endo-β-N-acetylglucosaminidase (Endo S2) is a key enzyme involved in the processing of free oligosaccharides in the cytosol. Endo-β-N-acetylglucosaminidase catalyzes hydrolysis of N-linked oligosaccharides .

HY-125569

Leucomycin A5	Fungal Antibiotic	Infection
Leucomycin A5 has antifungal activity, with the MIC for Staphylococcus pyogenes pen S, Staphylococcus pyogenes pen R, and Staphylococcus faecalis being 0.8, 3.2, and 0.8 μg/mL, respectively .

HY-123216

Cefmatilen S-1090 free base	Antibiotic Bacterial	Infection
Cefmatilen (S-1090) is an orally-active cephalosporin antibiotic that shows high activity against a variety of Gram-positive and Gram-negative bacteria, including Streptococcus pyogenes and Neisseria gonorrhoeae .

HY-162457

Mn007	DNA/RNA Synthesis	Infection
Mn007 is a potent inhibitor of bovine pancreatic DNase I, with the IC₅₀ of 45 μM, by forming molecular aggregation. Mn007 shows suppression of S. pyogenes growth in human whole blood .

HY-119894

Althiomycin NSC 102809	Antibiotic	Infection
Althiomycin is a polyketide synthase-derived thiazole antibiotic originally isolated from S. althioticus. It is active against Gram-positive bacteria, including S. aureus, S. epidermidis, and S. pyogenes (MICs=25, 25, and 3.1 μg/mL, respectively).2 Althiomycin inhibits protein synthesis in E. coli when used at concentrations of 1 and 10 μg/mL but not in isolated rabbit reticulocytes at 100 μg/mL.

HY-125733

Thiocillin I	Bacterial Antibiotic	Infection
Thiocillin I is a thiopeptide antibiotic and has in vitro antibacterial activity against Gram-positive bacterial strains. The MIC values of Thiocillin I against *S. aureus* 1974149, E. faecalis 1674621, B. subtilis ATCC 6633 and S. pyogenes 1744264 are 2 μg/mL, 0.5 μg/mL, 4 μg/mL and 0.5 μg/mL, respectively .

HY-B1256AR

Cefuroxime (Standard) Kefurox (Standard)	Beta-lactamase Reference Standards Bacterial Antibiotic	Infection Cancer
Cefuroxime (Standard) is the analytical standard of Cefuroxime. This product is intended for research and analytical applications. Cefuroxime is an orally active second-generation cephalosporin antibiotic with increased stability to β-lactamase. Cefuroxime has a broad spectrum activity against Gram-positive and Gram-negative bacteria .

HY-B1256R

Cefuroxime sodium (Standard)	Beta-lactamase Reference Standards Bacterial Antibiotic	Infection
Cefuroxime (sodium) (Standard) is the analytical standard of Cefuroxime (sodium). This product is intended for research and analytical applications. Cefuroxime sodium is an orally active second-generation cephalosporin antibiotic with increased stability to β-lactamase. Cefuroxime sodium has a broad spectrum activity against Gram-positive and Gram-negative bacteria .

HY-B1256

Cefuroxime sodium 5+ Cited Publications	Beta-lactamase Bacterial Antibiotic	Infection Cancer
Cefuroxime sodium is an orally active second-generation cephalosporin antibiotic with increased stability to β-lactamase. Cefuroxime sodium has a broad spectrum activity against Gram-positive and Gram-negative bacteria .

HY-174407

Antibacterial agent 281	Bacterial	Infection
Antibacterial agent 281 (Compound 95,186) can bacteriostatically inhibit the growth of GAS. Antibacterial agent 281 binds to the ligand binding pocket of SPs0871 and competes with the ligand. Antibacterial agent 281 shows concentration-dependent growth inhibition against S. pyogenes .

HY-E70573

Endo SH	Biochemical Assay Reagents	Others
Endo SH is a fusion protein of Endo S (from Streptococcus pyogenes) and Endo H (from Streptomyces plicatus), expressed in Escherichia coli. Endo SH can cleave the chitobiose core structure of high mannose, complex and some hybrid oligosaccharides in N-glycoproteins, remove N-linked high mannose in glycoproteins, and can completely replace Endo S and Endo H.

HY-136251

BRD0539	Bacterial	Infection
BRD0539 is a Streptococcus pyogenes Cas9 (SpCas9) inhibitor with an IC₅₀ of 22 μM in an in vitro DNA cleavage assay .

HY-E70068

Endo-β-N-acetylglucosaminidase (Endo S)	Others	Others
Endo-β-N-acetylglucosaminidase (Endo S) is a family 18 glycosyl hydrolase secreted by Streptococcus pyogenes. Endo-β-N-acetylglucosaminidase (Endo S) exclusively hydrolyzes the β-1,4-di-N-acetylchitobiose core of the asparagine-linked complex-type glycan on Asn-297 of the γ-chains of IgG antibody .

HY-106410A

Zabofloxacin hydrochloride DW-224a	Bacterial Topoisomerase Antibiotic	Infection
Zabofloxacin hydrochloride (DW-224a) is a potent and seletive inhibitor of the bacterial type II and IV topoisomerases. Zabofloxacin hydrochloride has excellent activity against gram-positive pathogens including Steptococcus aureus, Streptococcus pyogenes and S.pneumonia. Zabofloxacin hydrochloride is a novel fluoronaphthyridone quinolone that is considered as an alternative antibiotic for treatment of quinolone-susceptible (QSSP) and quinolone-resistant gonorrhea (QRSP) .

HY-106410

Zabofloxacin DW-224a Free base	Bacterial Topoisomerase Antibiotic	Infection
Zabofloxacin (DW-224a Free base) is a potent and seletive inhibitor of the bacterial type II and IV topoisomerases. Zabofloxacin has excellent activity against gram-positive pathogens including Steptococcus aureus, Streptococcus pyogenes and S.pneumonia. Zabofloxacin is a novel fluoronaphthyridone quinolone that is considered as an alternative antibiotic for treatment of quinolone-susceptible (QSSP) and quinolone-resistant gonorrhea (QRSP) .

HY-125728

Micrococcin P1	Bacterial Parasite HCV	Infection
Micrococcin P1 is a macrocyclic peptide antibiotic and is a potent hepatitis C virus (HCV) inhibitor with an EC₅₀ range of 0.1-0.5 μM . Micrococcin P1 has in vitro antibacterial activity against Gram-positive bacterial strains. The MIC values of Micrococcin P1 against *S. aureus* 1974149, E. faecalis 1674621 and S. pyogenes 1744264 are 2 μg/mL, 1 μg/mL and 1 μg/mL, respectively . Micrococcin P1 is also a potent inhibitor of the malaria parasite Plasmodium falciparum .

HY-116863

KKL-40	Bacterial	Infection
KKL-40 is a small molecule inhibitor that targets the trans-transcription process and is effective against methicillin-sensitive and -resistant Staphylococcus aureus (S. aureus) as well as other Gram-positive pathogens including vancomycin-resistant Enterococcus faecium, Bacillus subtilis, and Streptococcus pyogenes. KKL-40 synergizes with the human antimicrobial peptide LL-37 to inhibit S. aureus, but does not synergize with other antibiotics such as daptomycin, kanamycin, or erythromycin. Trans-transcription is an extreme form of recoding, and KKL-40 inhibits trans-transcription but is nontoxic to HeLa cells .

Cat. No.	Product Name	Type

HY-E70069GL

*Endo S2, Streptococcus pyogenes* (GMP Like)**	Fluorescent Dye
Endo S2, Streptococcus pyogenes (GMP Like) is Endo S2, Streptococcus pyogenes (HY-E70069) produced by using GMP like guidelines. Endo-β-N-acetylglucosaminidase (Endo S2) is a key enzyme involved in the processing of free oligosaccharides in the cytosol. Endo-β-N-acetylglucosaminidase catalyzes hydrolysis of N-linked oligosaccharides .

Cat. No.	Product Name	Type

HY-E70069GL

*Endo S2, Streptococcus pyogenes* (GMP Like)**	Biochemical Assay Reagents
Endo S2, Streptococcus pyogenes (GMP Like) is Endo S2, Streptococcus pyogenes (HY-E70069) produced by using GMP like guidelines. Endo-β-N-acetylglucosaminidase (Endo S2) is a key enzyme involved in the processing of free oligosaccharides in the cytosol. Endo-β-N-acetylglucosaminidase catalyzes hydrolysis of N-linked oligosaccharides .

HY-125569

Leucomycin A5	Microbial Culture
Leucomycin A5 has antifungal activity, with the MIC for Staphylococcus pyogenes pen S, Staphylococcus pyogenes pen R, and Staphylococcus faecalis being 0.8, 3.2, and 0.8 μg/mL, respectively .

Leucomycin A5	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Source classification	Fungal Antibiotic
Leucomycin A5 has antifungal activity, with the MIC for Staphylococcus pyogenes pen S, Staphylococcus pyogenes pen R, and Staphylococcus faecalis being 0.8, 3.2, and 0.8 μg/mL, respectively .

Tag:	His (3) Tag Free (1)
Source:	Sf9 insect cells (1) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P701235

	*Cas9 Protein, S. pyogenes* (NLS)** cas9; SpCas9; SpyCas9	Others	E. coli
	Cas9 protein is part of an immune system that defends against genetic elements. It processes RNA and aids in cleaving DNA targets. Protein and guide RNAs are necessary for its function. The protein recognizes specific sequences to distinguish self from nonself and provides immunity against matching genetic elements. Cas9 Protein, S. pyogenes (NLS) is the recombinant Cas9 protein, expressed by E. coli , with tag free.

HY-P77727

	*Cas9 Protein, S. pyogenes* (His)** endonuclease Cas9/Csn1; cas9; SpCas9; SpyCas9	Others	E. coli
	The Cas9 protein is part of an immune system that defends against genetic elements. It processes RNA and aids in cleaving DNA targets. Protein and guide RNAs are necessary for its function. The protein recognizes specific sequences to distinguish self from nonself and provides immunity against matching genetic elements. Cas9 Protein, S. pyogenes (His) is the recombinant Cas9 Protein protein, expressed by E. coli , with His tagged.

HY-P75328

	*Cas9 Protein, S. pyogenes* (sf9, NLS, His)** Cas9; endonuclease Cas9/Csn1; SpyCas9	Others	Sf9 insect cells
	The Cas9 protein is part of an immune system that defends against genetic elements.It processes RNA and aids in cleaving DNA targets.Protein and guide RNAs are necessary for its function.The protein recognizes specific sequences to distinguish self from nonself and provides immunity against matching genetic elements. Cas9 Protein, Streptococcus pyogenes M1 (sf9, NLS, His) is the recombinant Cas9 protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P79064

	*Endo S2 Protein, S. pyogenes* (His)** Secreted Endo-beta-N-acetylglucosaminidase (EndoS); endoS; Spy49_1414c; Endo-beta-N-acetylglucosaminidase S2	Others	E. coli
	Endo S2, secreted by Streptococcus pyogenes, deglycosylates the conserved N-linked glycan at Asn297 on IgG Fc to eliminate its effector functions and evade the immune system. EndoS2 specifically hydrolyzes diverse glycans on the Fc region of IgG antibodies using a mechanism that relies on its glycoside hydrolase domain and a coevolved carbohydrate-binding module. Endo S2 Protein, S. pyogenes (His) is the recombinant Endo S2 protein, expressed by E. coli , with N-6*His labeled tag.

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S. pyogenes

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

NaturalProducts

Recombinant Proteins

Natural
Products