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RSV A2

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-15970
    Verdinexor
    2 Publications Verification

    KPT-335

    		 CRM1 Apoptosis RSV Infection Inflammation/Immunology Cancer
    Verdinexor (KPT-335) is an orally active inhibitor for selective inhibitor of nuclear export (SINE). Verdinexor inhibits the respiratory syncytial virus A2 (RSV A2) replication with an IC50 of 0.96 µM. Verdinexor inhibits the function of nuclear export protein Exportin 1 (XPO1/CRM1), inhibiting pro-inflammatory responses. Verdinexor exhibits antitumor effciency .
    Verdinexor
  • HY-178151
    CGR-51

    		RSV Infection
    CGR-51 is an orally active potent RSV fusion glycoprotein (F protein) inhibitor (EC50 = 19.4 nM against RSV A2 in HEp-2 cells). CGR-51 blocks RSV entry by binding to the F protein (KD = 0.1 μM) and inhibiting membrane fusion, a mechanism distinct from farnesyltransferase inhibition. CGR-51 selects for the K399N resistance mutation in the RSV F protein during in vitro passage. CGR-51 effectively suppresses RSV replication in a BALB/c mouse model of RSV infection. CGR-51 can be used for RSV infection research .
    CGR-51
  • HY-114721
    BTA-9881

    MEDI-564

    		 RSV Infection
    BTA-9881 (MEDI-564) is a RSV inhibitor, with an EC50: 48 nM, 59 nM and 160 nM for RSV A2, RSV Long, and RSV B1. BTA-9881 has favorable pharmacokinetics property .
    BTA-9881
  • HY-119375
    Syncytial Virus Inhibitor-1

    		Bacterial Infection
    Syncytial Virus Inhibitor-1 is a potent, orally bioavailable respiratory syncytial virus (RSV) fusion inhibitor with EC50s of 0.002 μM, 0.004 μM, and 0.002 μM for RSV Long, RSV A2, and RSV B strains, respectively .
    Syncytial Virus Inhibitor-1
  • HY-171983
    RSV-IN-13

    		RSV Infection
    RSV-IN-13 (compound 24) is a selective RSV fusion protein inhibitor with antiviral activity. RSV-IN-13 has an EC50 of 444.2 nM against RSV A2 strain and a CC90 of 23.7 μM in HepG2 cells. RSV-IN-13 can block the virus from entering host cells. RSV-IN-13 can be used to study RSV infection .
    RSV-IN-13
  • HY-146108
    RSV-IN-5

    		RSV Infection
    RSV-IN-5 (Compound 4) is a potent dual inhibitor of wild-type and mutant respiratory syncytial virus (RSV) fusion proteins. RSV-IN-5 exhibits potent anti-RSV activities against not only wild-type A2 F protein (EC50=2.0 nM), but also D486N-mutant F protein (EC50=8.1 nM) .
    RSV-IN-5
  • HY-169313
    HRSV/HMPV-IN-1

    		RSV Infection
    HRSV/HMPV-IN-1 (compound 3) is a HRSV/HMPV inhibitor with the EC50 values of ＜ 0.2 μM and ＜ 0.5 μM for human RSV-A and human MPV A2 TN/94-49, respectively. HRSV/HMPV-IN-1 can be used for study of bronchiolitis and pneumonia .
    HRSV/HMPV-IN-1

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