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Results for "

ROS/JNK activation

" in MedChemExpress (MCE) Product Catalog:

By Targets:	JNK (11) Reactive Oxygen Species (ROS) (12) Akt (3) Antibiotic (1) Antifolate (1) Apoptosis (14) Autophagy (8) Bacterial (4) Caspase (1) Endogenous Metabolite (2) Ferroptosis (1) GSK-3 (1) IRE1 (1) Isotope-Labeled Compounds (1) MAP3K (1) MHC (1) NF-κB (2) NO Synthase (1) Oxidative Phosphorylation (2) p38 MAPK (3) Parasite (3) PERK (1) Reference Standards (5) Sirtuin (1) β-catenin (1)
By Research Areas:	Cancer (17) Cardiovascular Disease (2) Infection (1) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (5)

Inhibitors & Agonists

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: ROS Kinase JNK Reactive Oxygen Species (ROS) FAP LAG-3 VISTA

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0052A

Sanguinarine chloride 10+ Cited Publications Sanguinarin chloride; Sanguinarium chloride; Pseudochelerythrine chloride	Apoptosis Autophagy Bacterial Parasite	Cancer
Sanguinarine (Sanguinarin) chloride, a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.

HY-120349

LL-Z1640-4	p38 MAPK JNK Apoptosis Reactive Oxygen Species (ROS)	Cancer
LL-Z1640-4 is a potent *p38/JNK* signaling inhibitor. LL-Z1640-4 significantly diminishes p38 and *JNK* activation in HCC cells transfected with MLK4 siRNA. LL-Z1640-4 markedly attenuates *ROS* production induced by MLK4 knockdown. LL-Z1640-4 significantly reduces the apoptotic cells in HCC cells transfected with siMLK4 .

HY-W762011

BDE 47	Apoptosis Reactive Oxygen Species (ROS) JNK Oxidative Phosphorylation	Neurological Disease Cancer
BDE 47 targets mitochondria, inhibits mitochondrial oxidative phosphorylation (OXPHOS), decreases mitochondrial membrane potential (MMP) and induces apoptosis in embryonic cell. BDE 47 induces the generation of *ROS, and activates* the *JNK* signaling pathway. BDE 47 exhibits embryonic developmental toxicity in zebrafish .

HY-159605

Autophagy inducer 5	Autophagy JNK Reactive Oxygen Species (ROS)	Cancer
Autophagy inducer 5 (compound 21o) is a potent MCF-7 inhibitor (IC₅₀: 2 μM), and a potential breast cancer inhibitor. Autophagy inducer 5 induces cellular autophagy by activating the *ROS/JNK* signaling pathway, which increases ROS generation and JNK phosphorylation, exerting cytotoxic effects .

HY-N0052C

Sanguinarine (gluconate) Sanguinarin (gluconate); Sanguinarium (gluconate); Pseudochelerythrine (gluconate)	Apoptosis Reactive Oxygen Species (ROS)	Cancer
Sanguinarine (Sanguinarin) gluconate, a benzophenanthridine alkaloid, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB .

HY-N0052

Sanguinarine Sanguinarin; Sanguinarium; Pseudochelerythrine	Apoptosis Autophagy	Cancer
Sanguinarine (Sanguinarin), a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.

HY-136901

Fusarochromanone FC-101	Reactive Oxygen Species (ROS)	Cardiovascular Disease Cancer
Fusarochromanone (FC-101) is a fungal metabolite with potent anti-angiogenic and anti-cancer activity . Fusarochromanone-activated JNK pathway is attributed to induction of reactive oxygen species (ROS) .

HY-162886

BSO-07	JNK Reactive Oxygen Species (ROS)	Cancer
BSO-07 is a *ROS/JNK* activator with significant anticancer effects, having an IC₅₀ value of 24.81 μM against human breast cancer (BC) cells. BSO-07 induces apoptosis (Apoptosis) and paraptosis by activating *JNK* and increasing *ROS* levels, including enhancing the expression of apoptosis-associated proteins such as PARP, Bax, phosphorylated p53, ATF4, and CHOP, while decreasing the levels of anti-apoptotic proteins like Bcl-2, Bcl-xL, and Survivin. BSO-07 holds promise for research in the field of breast cancer .

HY-136341R

7,8-Dihydroneopterin (Standard)	Reference Standards Apoptosis NO Synthase Endogenous Metabolite	Neurological Disease Inflammation/Immunology
Sanguinarine (Standard) is the analytical standard of Sanguinarine. This product is intended for research and analytical applications. Sanguinarine (Sanguinarin), a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.

HY-N0052AR

Sanguinarine chloride (Standard) Sanguinarin chloride (Standard); Sanguinarium chloride (Standard); Pseudochelerythrine chloride (Standard)	Reference Standards Apoptosis Autophagy Bacterial Parasite	Cancer
Sanguinarine (chloride) (Standard) is the analytical standard of Sanguinarine (chloride). This product is intended for research and analytical applications. Sanguinarine (Sanguinarin) chloride, a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.

HY-N6872

Actein	JNK Akt Apoptosis Autophagy Reactive Oxygen Species (ROS)	Cancer
Actein, a triterpene glycoside, shows an inhibitory effect on cancer cells, which is isolated from the rhizomes of Cimicifuga foetida. Actein suppresses cell proliferation, induces autophagy and apoptosis through promoting *ROS/JNK* activation, and blunting AKT pathway in bladder cancer. Actein has little toxicity in vivo .

HY-W768895

Sanguinarine chloride-13C,d3 Sanguinarin chloride-¹³C,d₃; Sanguinarium chloride-¹³C,d₃; Pseudochelerythrine chloride-¹³C,d₃	Isotope-Labeled Compounds Apoptosis Bacterial Autophagy Parasite	Cancer
Sanguinarine chloride- ¹³C,d₃ (Sanguinarin chloride- ¹³C,d₃) is the deuterium labeled Sanguinarine chloride (HY-N0052A). Sanguinarine (Sanguinarin) chloride, a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.

HY-W762011R

BDE 47 (Standard)	Reference Standards Apoptosis Reactive Oxygen Species (ROS) JNK Oxidative Phosphorylation	Neurological Disease Cancer
BDE 47 (Standard) is the analytical standard of BDE 47. This product is intended for research and analytical applications. BDE 47 targets mitochondria, inhibits mitochondrial oxidative phosphorylation (OXPHOS), decreases mitochondrial membrane potential (MMP) and induces apoptosis in embryonic cell. BDE 47 induces the generation of ROS, and activates the JNK signaling pathway. BDE 47 exhibits embryonic developmental toxicity in zebrafish .

HY-N6872R

Actein (Standard)	Reference Standards JNK Akt Apoptosis Autophagy Reactive Oxygen Species (ROS)	Cancer
Actein (Standard) is the analytical standard of Actein. This product is intended for research and analytical applications. Actein, a triterpene glycoside, shows an inhibitory effect on cancer cells, which is isolated from the rhizomes of Cimicifuga foetida. Actein suppresses cell proliferation, induces autophagy and apoptosis through promoting ROS/JNK activation, and blunting AKT pathway in bladder cancer. Actein has little toxicity in vivo .

HY-B0510CR

Trimethoprim lactate (Standard)	Reference Standards Antifolate Bacterial Antibiotic	Infection Cancer
Actein (Standard) is the analytical standard of Actein. This product is intended for research and analytical applications. Actein, a triterpene glycoside, shows an inhibitory effect on cancer cells, which is isolated from the rhizomes of Cimicifuga foetida. Actein suppresses cell proliferation, induces autophagy and apoptosis through promoting ROS/JNK activation, and blunting AKT pathway in bladder cancer. Actein has little toxicity in vivo .

HY-N0753

Eupalinolide B	Others Apoptosis Autophagy Reactive Oxygen Species (ROS) GSK-3 β-catenin MAP3K JNK NF-κB p38 MAPK	Neurological Disease Inflammation/Immunology Cancer
Eupalinolide B is a germ sesquiterpene. Eupalinolide B can be isolated from Eupatorium lindleyanum. Eupalinolide B induces Apoptosis, elevates *ROS, promotes Autophagy. regulates GSK-3β/β-catenin, targets UBE2D3* and TAK1, activates *ROS-ER-JNK, inhibits NF-κB* and MAPKs. Eupalinolide B has anticancer activity against pancreatic cancer and liver cancer. Eupalinolide B relieves rheumatoid arthritis, acute lung injury, periodontitis, depression .

HY-19696B

Tauroursodeoxycholate dihydrate Maximum Cited Publications 79 Publications Verification Tauroursodeoxycholic acid dihydrate; TUDCA dihydrate; UR 906 dihydrate	Caspase Apoptosis Endogenous Metabolite IRE1 NF-κB JNK Reactive Oxygen Species (ROS) Akt	Neurological Disease Metabolic Disease Inflammation/Immunology
Tauroursodeoxycholate dehydrate is an orally active taurine conjugate of Ursodeoxycholic acid (HY-13771). Tauroursodeoxycholate dehydrate inhibits caspase-3/7, Apoptosis, IRE1α/TRAF2/NF-κB, prevents *JNK* phosphorylation, inhibits *ROS* generation, and activates Akt signaling. Tauroursodeoxycholate dehydrate prevents cataract formation, reduces renal tubular damage in type 2 diabetic mice, reduces I/R injury in liver, and inhibits intestinal inflammation and barrier disruption in nonalcoholic fatty liver disease .

HY-158426

2-APQC	Sirtuin	Cardiovascular Disease
2-APQC is an orally active and selective agonist of Sirtuin-3 (SIRT3) (K_d=2.756 μM), antagonizes Isoproterenol/ISO (HY-B0468)-induced cytotoxicity. 2-APQC activates the SIRT3-PYCR1 axis to enhance mitochondrial proline metabolism and inhibit the *ROS-p38MAPK pathway by inhibiting signaling pathways such as mTOR-p70S6K, JNK, and TGF-β/Smad3. 2-APQC also activates* the AMPK-Parkin axis to alleviate myocardial hypertrophy and fibrosis and protect cardiac function. 2-APQC can be used in the study of heart failure .

HY-P991590

1D09C3	MHC Apoptosis JNK	Cancer
1D09C3 is a fully human anti-HLA-DR monoclonal antibody. 1D09C3 induces apoptosis and cell death involving a cascade of events, including ROS generation, JNK activation, mitochondrial membrane depolarization, and AIF release from mitochondria. 1D09C3 shows potent anti-tumor activity and increases overall survival and median survival in JVM-2 cells and GRANTA-519 cells xenograft mice models. 1D09C3 can be used for the researches of cancer, such as chronic lymphocytic leukemia (CLL) ^{[1] ^{^{[2] ^{^{[3] ^.}}}}}

HY-106159

SB-T-101141	Reactive Oxygen Species (ROS) p38 MAPK JNK PERK Ferroptosis	Cancer
SB-T-101141 is a novel taxane. SB-T-101141 effectively induces a noncanonical ferroptosis to overcome Paclitaxel (HY-B0015) resistance of breast cancer. SB-T-101141 facilitates the production of iron and ferrous ions and ROS. SB-T-101141 stably binds to KHSRP to inhibit the iron-dependent expression of CISD1 related to iron homeostasis. SB-T-101141 synergistically enhances the iron-dependent activation of JNK and PERK pathways via KHSRP. SB-T-101141 suppresses breast tumor growth in MCF-7(PR)/MDA-MB-231(PR) or KHSRP knock-down MCF-7 xenograft mice model .

Cat. No.	Product Name	Target	Research Area

HY-P991590

1D09C3	MHC Apoptosis JNK	Cancer
1D09C3 is a fully human anti-HLA-DR monoclonal antibody. 1D09C3 induces apoptosis and cell death involving a cascade of events, including ROS generation, JNK activation, mitochondrial membrane depolarization, and AIF release from mitochondria. 1D09C3 shows potent anti-tumor activity and increases overall survival and median survival in JVM-2 cells and GRANTA-519 cells xenograft mice models. 1D09C3 can be used for the researches of cancer, such as chronic lymphocytic leukemia (CLL) ^{[1] ^{^{[2] ^{^{[3] ^.}}}}}

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0052A

Sanguinarine chloride 10+ Cited Publications Sanguinarin chloride; Sanguinarium chloride; Pseudochelerythrine chloride	Structural Classification Alkaloids Classification of Application Fields Pyridine Alkaloids Sanguinaria canadensis Plants Disease Research Fields Papaveraceae Cancer	Apoptosis Autophagy Bacterial Parasite
Sanguinarine (Sanguinarin) chloride, a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.

HY-N6872

Actein	Triterpenes Structural Classification Classification of Application Fields Terpenoids Ranunculaceae Source classification Cimicifuga foetida Linn. Plants Disease Research Fields Cancer	JNK Akt Apoptosis Autophagy Reactive Oxygen Species (ROS)
Actein, a triterpene glycoside, shows an inhibitory effect on cancer cells, which is isolated from the rhizomes of Cimicifuga foetida. Actein suppresses cell proliferation, induces autophagy and apoptosis through promoting *ROS/JNK* activation, and blunting AKT pathway in bladder cancer. Actein has little toxicity in vivo .

HY-N0753

Eupalinolide B	Structural Classification Classification of Application Fields Melilotus albus Desr. Terpenoids Sesquiterpenes Source classification Plants Compositae Disease Research Fields Cancer	Others Apoptosis Autophagy Reactive Oxygen Species (ROS) GSK-3 β-catenin MAP3K JNK NF-κB p38 MAPK
Eupalinolide B is a germ sesquiterpene. Eupalinolide B can be isolated from Eupatorium lindleyanum. Eupalinolide B induces Apoptosis, elevates *ROS, promotes Autophagy. regulates GSK-3β/β-catenin, targets UBE2D3* and TAK1, activates *ROS-ER-JNK, inhibits NF-κB* and MAPKs. Eupalinolide B has anticancer activity against pancreatic cancer and liver cancer. Eupalinolide B relieves rheumatoid arthritis, acute lung injury, periodontitis, depression .

HY-19696B

Tauroursodeoxycholate dihydrate Maximum Cited Publications 79 Publications Verification Tauroursodeoxycholic acid dihydrate; TUDCA dihydrate; UR 906 dihydrate	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Steroids Cancer	Caspase Apoptosis Endogenous Metabolite IRE1 NF-κB JNK Reactive Oxygen Species (ROS) Akt
Tauroursodeoxycholate dehydrate is an orally active taurine conjugate of Ursodeoxycholic acid (HY-13771). Tauroursodeoxycholate dehydrate inhibits caspase-3/7, Apoptosis, IRE1α/TRAF2/NF-κB, prevents *JNK* phosphorylation, inhibits *ROS* generation, and activates Akt signaling. Tauroursodeoxycholate dehydrate prevents cataract formation, reduces renal tubular damage in type 2 diabetic mice, reduces I/R injury in liver, and inhibits intestinal inflammation and barrier disruption in nonalcoholic fatty liver disease .

HY-N0052C

Sanguinarine (gluconate) Sanguinarin (gluconate); Sanguinarium (gluconate); Pseudochelerythrine (gluconate)	Structural Classification Alkaloids Source classification Macleaya cordata (Willd.) R. Br. Plants Isoquinoline Alkaloids Papaveraceae	Apoptosis Reactive Oxygen Species (ROS)
Sanguinarine (Sanguinarin) gluconate, a benzophenanthridine alkaloid, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB .

HY-N0052

Sanguinarine Sanguinarin; Sanguinarium; Pseudochelerythrine	Alkaloids Structural Classification Classification of Application Fields Source classification Macleaya cordata (Willd.) R. Br. Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae Cancer	Apoptosis Autophagy
Sanguinarine (Sanguinarin), a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.

HY-136901

Fusarochromanone FC-101	Cardiovascular Disease Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	Reactive Oxygen Species (ROS)
Fusarochromanone (FC-101) is a fungal metabolite with potent anti-angiogenic and anti-cancer activity . Fusarochromanone-activated JNK pathway is attributed to induction of reactive oxygen species (ROS) .

HY-136341R

7,8-Dihydroneopterin (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Reference Standards Apoptosis NO Synthase Endogenous Metabolite
Sanguinarine (Standard) is the analytical standard of Sanguinarine. This product is intended for research and analytical applications. Sanguinarine (Sanguinarin), a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.

HY-N0052AR

Sanguinarine chloride (Standard) Sanguinarin chloride (Standard); Sanguinarium chloride (Standard); Pseudochelerythrine chloride (Standard)	Structural Classification Alkaloids Pyridine Alkaloids Sanguinaria canadensis Plants Papaveraceae	Reference Standards Apoptosis Autophagy Bacterial Parasite
Sanguinarine (chloride) (Standard) is the analytical standard of Sanguinarine (chloride). This product is intended for research and analytical applications. Sanguinarine (Sanguinarin) chloride, a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.

HY-N6872R

Actein (Standard)	Triterpenes Structural Classification Terpenoids Ranunculaceae Source classification Cimicifuga foetida Linn. Plants	Reference Standards JNK Akt Apoptosis Autophagy Reactive Oxygen Species (ROS)
Actein (Standard) is the analytical standard of Actein. This product is intended for research and analytical applications. Actein, a triterpene glycoside, shows an inhibitory effect on cancer cells, which is isolated from the rhizomes of Cimicifuga foetida. Actein suppresses cell proliferation, induces autophagy and apoptosis through promoting ROS/JNK activation, and blunting AKT pathway in bladder cancer. Actein has little toxicity in vivo .

Cat. No.	Product Name	Chemical Structure

HY-W768895

Sanguinarine chloride-13C,d3
Sanguinarine chloride- ¹³C,d₃ (Sanguinarin chloride- ¹³C,d₃) is the deuterium labeled Sanguinarine chloride (HY-N0052A). Sanguinarine (Sanguinarin) chloride, a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.

Sanguinarine chloride-13C,d3

Sanguinarine chloride- ¹³C,d₃ (Sanguinarin chloride- ¹³C,d₃) is the deuterium labeled Sanguinarine chloride (HY-N0052A). Sanguinarine (Sanguinarin) chloride, a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.

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ROS/JNK activation

Inhibitors & Agonists

Inhibitory Antibodies

NaturalProducts

Isotope-Labeled Compounds

Natural
Products