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Isoforms Recommended:	ROCK1

Results for "

ROCK I

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ROCK (16) Apoptosis (3) Autophagy (1) ERK (1) GSK-3 (1) Isotope-Labeled Compounds (1) Monoamine Transporter (1) Organoid (4) Reference Standards (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (6) Cardiovascular Disease (5) Metabolic Disease (1) Neurological Disease (6)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: ROCK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-153011

ROCK-IN-5	ROCK ERK GSK-3	Cardiovascular Disease Neurological Disease
ROCK-IN-5 (compound I-B-37) is a potent inhibitor of *ROCK, ERK, GSK, and AGC* protein kinases. ROCK-IN-5 has the potential for proliferative, cardiac and neurodegenerative diseases research .

HY-139170

CAY10746	ROCK	Metabolic Disease
CAY10746 is a selective Rho kinase (ROCK) inhibitor. CAY10746 has inhibitory activity for ROCK I, ROCK II with IC₅₀ values of 0.014 μM and 0.003 μM, respectively. CAY10746 can be used for the research of diabetic retinopathy (DR) .

HY-10583

Y-27632 dihydrochloride 415+ Cited Publications	Organoid ROCK	Neurological Disease Cancer
Y-27632 dihydrochloride is an orally active and ATP-competitive *ROCK* (Rho-kinase) inhibitor (ROCK-I K_i=220 nM; ROCK-II K_i=300 nM). Y-27632 dihydrochloride shows antiepileptic effects .

HY-109191A

Sovesudil hydrochloride PHP-201 hydrochloride; AMA0076 hydrochloride	ROCK	Neurological Disease
Sovesudil (PHP-201) hydrochloride is a potent, ATP-competitive, locally acting Rho kinase *(ROCK)* inhibitor with IC₅₀s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. Sovesudil hydrochloride lowers intraocular pressure (IOP) without inducing hyperemia .

HY-109191

Sovesudil PHP-201; AMA0076	ROCK	Others
Sovesudil (PHP-201) is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor with IC₅₀s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. Sovesudil lowers intraocular pressure (IOP) without inducing hyperemia .

HY-10583R

Y-27632 dihydrochloride (Standard) 415+ Cited Publications	ROCK Organoid Reference Standards	Cancer
Y-27632 (dihydrochloride) (Standard) is the analytical standard of Y-27632 (dihydrochloride). Y-27632 dihydrochloride is an orally active and ATP-competitive *ROCK* (Rho-kinase) inhibitor (ROCK-I K_i=220 nM; ROCK-II K_i=300 nM). Y-27632 dihydrochloride shows antiepileptic effects .

HY-12798

Netarsudil AR-13324	Monoamine Transporter ROCK	Cardiovascular Disease Neurological Disease
Netarsudil (AR-13324) is a competitive inhibitor of Rho-associated protein kinases (ROCK I and ROCK II) and a reversible inhibitor of the norepinephrine transporter (NET). Netarsudil reduces intraocular pressure by inhibiting *ROCK*, causing relaxation of trabecular meshwork cells and dilation of episcleral veins, thereby increasing the ease of aqueous humor outflow, while inhibiting NET to reduce aqueous humor production. Netarsudil is mainly used in the study of ocular hypertension and primary open-angle glaucoma .

HY-12798B

Netarsudil hydrochloride AR-13324 hydrochloride	ROCK	Cardiovascular Disease Neurological Disease
Netarsudil (AR-13324) hydrochloride is a competitive inhibitor of Rho-associated protein kinases (ROCK I and ROCK II) and a reversible inhibitor of the norepinephrine transporter (NET). Netarsudil hydrochloride reduces intraocular pressure by inhibiting *ROCK*, causing relaxation of trabecular meshwork cells and dilation of episcleral veins, thereby increasing the ease of aqueous humor outflow, while inhibiting NET to reduce aqueous humor production. Netarsudil hydrochloride is mainly used in the study of ocular hypertension and primary open-angle glaucoma .

HY-12798A

Netarsudil dimesylate AR-13324 dimesylate	ROCK	Cardiovascular Disease Neurological Disease
Netarsudil (AR-13324) dimesylate is a competitive inhibitor of Rho-associated protein kinases (ROCK I and ROCK II) and a reversible inhibitor of the norepinephrine transporter (NET). Netarsudil dimesylate reduces intraocular pressure by inhibiting *ROCK*, causing relaxation of trabecular meshwork cells and dilation of episcleral veins, thereby increasing the ease of aqueous humor outflow, while inhibiting NET to reduce aqueous humor production. Netarsudil dimesylate is mainly used in the study of ocular hypertension and primary open-angle glaucoma .

HY-13300A

SR-3677 dihydrochloride	ROCK Autophagy	Cancer
SR-3677 dihydrochloride (compound 5) is a potent and selective *ROCK-I* and *ROCK-II* inhibitor with an IC₅₀ values of 56 nM and 3 nM .

HY-RS12114

ROCK1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) ROCK	Others
ROCK1 Human Pre-designed siRNA Set A contains three designed siRNAs for ROCK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ROCK1 Human Pre-designed siRNA Set A ROCK1 Human Pre-designed siRNA Set A

HY-RS12116

Rock1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Rock1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Rock1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Rock1 Rat Pre-designed siRNA Set A Rock1 Rat Pre-designed siRNA Set A

HY-RS12115

Rock1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) ROCK	Others
Rock1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rock1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Rock1 Mouse Pre-designed siRNA Set A Rock1 Mouse Pre-designed siRNA Set A

HY-10071

Y-27632 Maximum Cited Publications 419 Publications Verification	Organoid ROCK Apoptosis	Cancer
Y-27632 is an orally active, ATP-competitive inhibitor of *ROCK-I* and *ROCK-II, with K_is of 220 and 300 nM, respectively. Y-27632 attenuates Doxorubicin-induced apoptosis* of human cardiac stem cells. Y-27632 also suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells. Y-27632 primes human induced pluripotent stem cells (hIPSCs) to selectively differentiate towards mesendodermal lineage via epithelial-mesenchymal transition-like modulation .

HY-10071A

Y-27632 hydrochloride hydrate	Organoid ROCK Apoptosis	Cancer
Y-27632 hydrochloride hydrate is an orally active, ATP-competitive inhibitor of *ROCK-I* and *ROCK-II, with K_is of 220 and 300 nM, respectively. Y-27632 hydrochloride hydrate attenuates Doxorubicin-induced apoptosis* of human cardiac stem cells. Y-27632 hydrochloride hydrate also suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells. Y-27632 hydrochloride hydrate primes human induced pluripotent stem cells (hIPSCs) to selectively differentiate towards mesendodermal lineage via epithelial-mesenchymal transition-like modulation .

HY-W700452

Y-27632-d4 hydrochloride hydrate	Isotope-Labeled Compounds Apoptosis ROCK	Cancer
Y-27632-d₄ hydrochloride hydrate is the deuterium labeled Y-27632 hydrochloride hydrate (HY-10071A). Y-27632 hydrochloride hydrate is an orally active, ATP-competitive inhibitor of ROCK-I and ROCK-II, with Kis of 220 and 300 nM, respectively. Y-27632 hydrochloride hydrate attenuates Doxorubicin-induced apoptosis of human cardiac stem cells. Y-27632 hydrochloride hydrate also suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells. Y-27632 hydrochloride hydrate primes human induced pluripotent stem cells (hIPSCs) to selectively differentiate towards mesendodermal lineage via epithelial-mesenchymal transition-like modulation .

HY-W047432

5-Nitro-1H-indazole-3-carbonitrile DL0805	ROCK	Cardiovascular Disease
5-Nitro-1H-indazole-3-carbonitrile (DL0805) is a Rho kinase(ROCK) inhibitor with an IC₅₀ of 6.67 μM for ROCK-I. 5-Nitro-1H-indazole-3-carbonitrile reduces Norepinephrine (HY-13715)-induced transient contraction and inhibits contraction induced by increasing external calcium in the endothelium-denuded rings of rat models. 5-Nitro-1H-indazole-3-carbonitrile has a vasorelaxant activity but high toxicity. 5-Nitro-1H-indazole-3-carbonitrile can be used for cardiovascular diseases, especially hypertension research .

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P701769

	ROCK1 Protein, Human (sf9) ROCK1; Rho-associated protein kinase 1; Renal carcinoma antigen NY-REN-35; Rho-associated; coiled-coil-containing protein kinase 1; Rho-associated; coiled-coil-containing protein kinase I; ROCK-I; p160 ROCK-1; p160ROCK	Human	Sf9 insect cells
	The ROCK1 protein is a key kinase that regulates the actin cytoskeleton, cell polarity, smooth muscle contraction, and multiple cellular functions. It controls stress fibers, focal adhesion formation, neurite retraction, and cell motility by phosphorylating substrates such as DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1, and PPP1R12A. ROCK1 Protein, Human (sf9) is the recombinant human-derived ROCK1 protein, expressed by sf9 insect cells , with tag free.

HY-P701770

	ROCK1 Protein, Human (sf9, His) ROCK1; Rho-associated protein kinase 1; Renal carcinoma antigen NY-REN-35; Rho-associated; coiled-coil-containing protein kinase 1; Rho-associated; coiled-coil-containing protein kinase I; ROCK-I; p160 ROCK-1; p160ROCK	Human	Sf9 insect cells
	The ROCK1 protein is a key kinase that regulates the actin cytoskeleton, cell polarity, smooth muscle contraction, and multiple cellular functions. It controls stress fibers, focal adhesion formation, neurite retraction, and cell motility by phosphorylating substrates such as DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1, and PPP1R12A. ROCK1 Protein, Human (sf9, His) is the recombinant human-derived ROCK1 protein, expressed by sf9 insect cells , with N-8*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-W700452

Y-27632-d4 hydrochloride hydrate
Y-27632-d₄ hydrochloride hydrate is the deuterium labeled Y-27632 hydrochloride hydrate (HY-10071A). Y-27632 hydrochloride hydrate is an orally active, ATP-competitive inhibitor of ROCK-I and ROCK-II, with Kis of 220 and 300 nM, respectively. Y-27632 hydrochloride hydrate attenuates Doxorubicin-induced apoptosis of human cardiac stem cells. Y-27632 hydrochloride hydrate also suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells. Y-27632 hydrochloride hydrate primes human induced pluripotent stem cells (hIPSCs) to selectively differentiate towards mesendodermal lineage via epithelial-mesenchymal transition-like modulation .

Y-27632-d4 hydrochloride hydrate

Y-27632-d₄ hydrochloride hydrate is the deuterium labeled Y-27632 hydrochloride hydrate (HY-10071A). Y-27632 hydrochloride hydrate is an orally active, ATP-competitive inhibitor of ROCK-I and ROCK-II, with Kis of 220 and 300 nM, respectively. Y-27632 hydrochloride hydrate attenuates Doxorubicin-induced apoptosis of human cardiac stem cells. Y-27632 hydrochloride hydrate also suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells. Y-27632 hydrochloride hydrate primes human induced pluripotent stem cells (hIPSCs) to selectively differentiate towards mesendodermal lineage via epithelial-mesenchymal transition-like modulation .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P86538

	ROCK1 Antibody (YA6230) ROCK1; Rho-associated protein kinase 1; Renal carcinoma antigen NY-REN-35; Rho-associated; coiled-coil-containing protein kinase 1; Rho-associated, coiled-coil-containing protein kinase I; ROCK-I; p160 ROCK-1; p160ROCK	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	ROCK1 Antibody (YA6230) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ROCK1.

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ROCK1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
ROCK1 Human Pre-designed siRNA Set A contains three designed siRNAs for ROCK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Rock1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Rock1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Rock1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Rock1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Rock1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rock1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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