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RIPK1-IN-32

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-175007
    RIPK1-IN-32

    		RIP kinase NF-κB p38 MAPK TNF Receptor Interleukin Related Infection Inflammation/Immunology
    RIPK1-IN-32 is a RIPK inhibitor with anti-inflammatory activity. RIPK1-IN-32 inhibits nitric oxide (NO) release with an IC50 of 3.26 μM. RIPK1-IN-32 significantly alleviates acute liver injury associated with sepsis through the RIPK1/NF-κB/MAPK pathway, therefore preventing the nuclear translocation of p65 and c-fos, which results in reduced expression of TNF-α and IL-6. RIPK1-IN-32 can be used for the study of acute liver injury and sepsis .
    RIPK1-IN-32

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